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Emergency Medical Minute

Podcast # 350: Pressors and Ischemia

Emergency Medical Minute
Released on Jul 9, 2018

Author: Nick Hatch, MD.

Educational Pearls:

 

  • A common concern using vasopressors is the risk of digital and mesenteric ischemia.
  • The absolute risk of digital ischemia and/or mesenteric ischemia is pretty low. Norepinephrine at its highest doses carries a 5% digital ischemia rate and a 2% mesenteric ischemia rate.
  • The studies demonstrating this complication were predominately patients with pre-existing liver disease.
  • Providers commonly mistake purpura fulminans, a common complication of sepsis, for digital ischemia.

 

References

Brown, SM. et al.  Survival After Shock Requiring High-Dose Vasopressor Therapy. Chest. 2013. 143(3), 664–671. http://doi.org/10.1378/chest.12-1106.

Malay MB et al. Heterogeneity of the vasoconstrictor effect of vasopressin in septic shock. Critical Care Medicine. 2004. 32(6), 1327-31.

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