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Ep. 33: Brain Imaging of Chronic Pain with Anton Rogachov and Connor Wander

The Straight from a Scientist Podcast

Release Date: 09/02/2018

Ep 52 - Diabetes and Placental Epigenetics show art Ep 52 - Diabetes and Placental Epigenetics

The Straight from a Scientist Podcast

  This weeks episode combines several topics you may have heard of, but never thought about in the same context!  Diabetes and epigenetics are two well-researched topics, but not in the context of fetal development.  During pregnancy, the placenta is the highway that connects a mother and fetus, so when epigenetics act on the placenta, they could have huge effects on development of the fetus and/or the mother.   We break it down straight from a scientist in this episode with Laetitia Myeyruix from UNC's School of Global Public Health, in the Department of...

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Ep. 51 – New Cancer Therapies & Targeting Cancer Biology show art Ep. 51 – New Cancer Therapies & Targeting Cancer Biology

The Straight from a Scientist Podcast

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Ep.50 - Alzheimer's disease FAQ show art Ep.50 - Alzheimer's disease FAQ

The Straight from a Scientist Podcast

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Ep. 49 - Alzheimer's disease overview with Konner Blunt show art Ep. 49 - Alzheimer's disease overview with Konner Blunt

The Straight from a Scientist Podcast

This week's episode is with the host of The Blunt Report podcast: Konner Blunt.  Connor and Konner talked about ALzheimer's disease, the experience of podcasting, science communication, and Jiu Jitsu among other things.    Check out The Blunt Report here: http://www.thebluntreport.com/   More about Alzheimer's disease: https://www.straightfromascientist.com/alzheimers-disease/    

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Ep. 48- Are Herbal Supplements Effective? Using Modern Science to Investigate Ancient Medicines with Tayler Catherine show art Ep. 48- Are Herbal Supplements Effective? Using Modern Science to Investigate Ancient Medicines with Tayler Catherine

The Straight from a Scientist Podcast

Tayler is a PhD candidate in the College of Veterinary Medicine at Murdoch University in Perth, Western Australia. Her research focuses on the pharmacology and toxicology of supposed ‘fertility-boosting’ herbal supplements on sperm cells, using flow cytometry to elucidate their effects at a cellular level. She is also a science communicator in her spare time, and posts regular pharmacology-based series online. You can find her on Instagram at @taylercatherine Link to a good general review on oxidative stress: https://www.nature.com/articles/35041687 Link to a review of herbal medicine...

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The Straight from a Scientist Podcast

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The Straight from a Scientist Podcast

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Ep. 45: Applications and Limitations of GWAS with Dr. Liz Tunbridge show art Ep. 45: Applications and Limitations of GWAS with Dr. Liz Tunbridge

The Straight from a Scientist Podcast

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Ep. 44: Sex Differences in Alzheimer's Disease with Dr. Roberta Diaz Brinton and Connor Wander show art Ep. 44: Sex Differences in Alzheimer's Disease with Dr. Roberta Diaz Brinton and Connor Wander

The Straight from a Scientist Podcast

Women are almost twice as likely to develop Alzheimer's disease as men. However, this is NOT because they live longer. When we look into the aging brain, males and females experience different timelines. The molecular underpinnings of these sex differences could make a huge impact on our understanding of Alzheimer's disease. Dr. Roberta Diaz Brinton is spearheading research into sex differences in Alzheimer's disease.

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Ep. 43: Down Syndrome and Alzheimer's Disease with Dr. Elizabeth Head and Connor Wander show art Ep. 43: Down Syndrome and Alzheimer's Disease with Dr. Elizabeth Head and Connor Wander

The Straight from a Scientist Podcast

This week's episode features another throwback recorded in San Diego, CA, where Connor Wander attended the BrightFocus Alzheimer's Disease Fast Track conference, followed by the Society for Neuroscience annual meeting. We talked with Dr. Elizabeth Head, who studies the link between Down Syndrome and Alzheimer's disease with the hopes of improving lives for both patient classes. Listen to hear about this super interesting and very promising work!

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More Episodes

This week we talked with Anton Rogachov, a 5th year PhD student in Dr. Karen Davis’s Lab at the University of Toronto.  The Davis Lab focuses on using brain imaging like resting-state fMRI to understand functional abnormalities in the brains of chronic pain patients.  The majority of Dr. Davis’s work looks at the functional communication between different brain regions and networks in order to understand how these communications break down in chronic pain.  In comparison, Anton's research looks at regional brain oscillation and fluctuations an alternative approach to studying mechanistic brain function.

Listen in to hear us discuss Anton's recent paper, Abnormal Low-Frequency Oscillations Reflect Trait-Like Pain Ratings in Chronic Pain Patients Revealed through a Machine Learning Approach.  This research discovered that chronic pain patients do indeed have functional abnormalities in pain-related brain networks, but more importantly it showed that these abnormalities can be used to make inferences about the degree of pain the patients experience on a weekly basis.  We cover what it's like to work directly with patients and to both administer and be tested via fMRI.  We also talk about important caveats and considerations with work such as ours.

More information

Read Anton’s recent paper on abnormal low-frequency oscillations

Learn more in another publication by Anton on regional brain signal variability

Check out a related episode on the molecular side of pain research, Ep. 30: Breaking the Vicious Cycle of Pain and Addiction with Waylin Yu.

Listen to the Raw Talk Podcast run by scientists and medical students at the University of Toronto.

Watch the TED Ed. video from Anton's supervisor Dr. Karen Davis on how your brain responds to pain.

Thanks to Leigh at BrainPost for connecting us with Anton!

Any other questions?  Let us know!  We appreciate your feedback.

You can now support the podcast at https://www.patreon.com/sfspodcast.  Many thanks to our past and present supporters! 

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