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The hottest running app has nothing to do with speed | E2303

This Week in Startups

Release Date: 06/22/2026

The AI Securing Your Workforce Before a Mistake Ever Becomes a Breach | E2314 show art The AI Securing Your Workforce Before a Mistake Ever Becomes a Breach | E2314

This Week in Startups

This Week In Startups is made possible by: Vanta Superhuman YSecurity Today’s show: *Cybersecurity has long focused on cleaning up a system AFTER a breach but Ent founder Brandon Dixon says that’s backwards. He just raised a $100M seed round to put an AI agent on everyone’s company laptops that catches the risky clicks, leaked files, or rogue agents BEFORE they wreck havoc. PLUS Clawra creator David Im return swith his new project, Sume’s Avatar, a multi-model orchestration layer that generates 60-second UGC videos from a single prompt… and gets it right on the first try, rather...

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The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313 show art The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313

This Week in Startups

The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313 This Week In Startups is made possible by: Northwest Registered Agent CLA MongoDB Today’s show: *Andromeda Surgical is building the autonomy layer that could one day allow robots to perform surgery. Rather than building their own intricate, complex hardware, Andromeda uses off-the-shelf arms from a German manufacturer, and focuses on the software that will allow doctors to operate it from an iPad. Plus Mogul co-founder and CEO Alex Blackwood shows Jason how his platform lets anyone buy fractional shares...

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A Startup Is Trying to Buy PayPal… Craziest Deal of 2026! | E2312 show art A Startup Is Trying to Buy PayPal… Craziest Deal of 2026! | E2312

This Week in Startups

This Week In Startups is made possible by: MongoDB - Rippling - -   Today’s show: Hustle Fund’s Eric Bahn and Chapter One’s Jeff Morris Jr. join our venture capital roundtable directly following the news breaking that Stripe wants to buy PayPal. The possible transaction highlights how little interest today’s leading startups have in going public any time soon. With host Alex Wilhelm, Bahn and Morris dug into when startups should burn the boats à la Fin, physical AI as the next frontier, the power of Silicon Valley groupthink, and how startups are approaching the first days of...

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Jason turned $11 and one tweet into 1.1M views | E2311 show art Jason turned $11 and one tweet into 1.1M views | E2311

This Week in Startups

This Week In Startups is made possible by: Quo PayPal Open Northwest Registered Agent Today’s show: *Jason spent $11 building out PodMeme, an AI tool that tracks down the best segments from top podcasts about a specific topic, then stitches them together into a single stream. His post laying out how he did it, featuring a simple screenshot of the product, got all the way to 1.1M views in just a few days. It’s a simple fact: builders love to see what other people are building, and growing your new project “in public,” sharing your journey on social media, is a great way to develop...

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Danny Bernstein left Big Tech to fund farm-bots | E2310 show art Danny Bernstein left Big Tech to fund farm-bots | E2310

This Week in Startups

This Week In Startups is made possible by: NetSuite Squarespace YSecurity Today’s show: *America posted 400,000 farm jobs last year, and fewer than 1% got a single domestic applicant. Danny Bernstein of Reservoir believes it’s time to start automating this backbreaking labor, like picking stone fruit in 110°F temperatures. So he built the world’s first on-farm robotics incubator on 40 acres of California farmland. Here’s why he argues that automating farms isn’t just a new opportunity, it’s a national security issue. PLUS Jason responded to Gal Shir’s viral “AI beat me at...

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Why Data Is the Next $1 Trillion Market show art Why Data Is the Next $1 Trillion Market

This Week in Startups

This Week In Startups is made possible by: Digital Ocean - - - .   Today’s show: How many startups matter in tech? Fewer than you think. That’s why venture capitalists are tripping over themselves to get onto their cap tables, no matter the cost. Why? Footwork’s Nikhil Basu Trivedi argues that the Valley has never been more “power-law-pilled” than it is today. Basu Trivedi joined Cendana Capital’s Michael Kim and TWiST’s Alex Wilhelm to go deep on secondary markets, the state of startup M&A, why the SaaSpocalypse may be temporary, and what could trigger a...

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$100T is managed by “human duct tape” | E2308 show art $100T is managed by “human duct tape” | E2308

This Week in Startups

This Week In Startups is made possible by:


Northwest Registered Agent https://northwestregisteredagent.com/twist

Vanta https://www.vanta.com/twist

Sentry https://sentry.io/twist


Today’s show:

*There are $100 trillion in global assets sitting on top of what Hanover Park co-founder/CEO Chris Hladcz

info_outline Why the VC Hype Cycle Always Gets It Wrong | VC Roundtable | E2307 show art Why the VC Hype Cycle Always Gets It Wrong | VC Roundtable | E2307

This Week in Startups

This Week In Startups is made possible by:


CLA - www.claconnect.com/withyou

Northwest Registered Agent - www.northwes

info_outline Chamath on why young people need more agency, risk, and adventure show art Chamath on why young people need more agency, risk, and adventure

This Week in Startups

This Week In Startups is made possible by:

Plaud
https://Plaud.ai/twist

Shopify
https://shopify.com/twist

LinkedIn Jobs
https://LinkedIn.com/twist

Northwest Registered Agent
https://northwestregisteredagent.com/twist


Today’s show:

*It’s another All Star Summer, as we wel

info_outline Why F1 Teams are Replacing Wind Tunnels with Smart Tape | E2305 show art Why F1 Teams are Replacing Wind Tunnels with Smart Tape | E2305

This Week in Startups

This Week In Startups is made possible by:

Plaud - https://Plaud.ai/twistSentry - https://sentry.io/twistNorthwest Registered Agent-https://northwestregisteredagent.com/twistDigitalOcean - https://do.co/twist


Today’s show:

F1 teams spend up to a third of their budgets on aerodynamics, often utilizing wind tunnels to simulate what happens on the track.

But Lyall Davenport of SKN Systems created a sensor-embedde

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More Episodes

This Week In Startups is made possible by:Agree - https://agree.comQuo - https://quo.com/TWiSTSuperhuman - https://superhuman.comToday’s show:In this double-header, Jason and Lon chat with Louis Phillips, founder of the gamified running app INTVL, which turns a quick job around the block into a worldwide turf war competition. Find out how he grew the app to over 1 million downloads without any paid ads, just making videos from his home office.PLUS Alex sits down with Alice Zhang, CEO of Verge Labs, which pivoted from making drugs to building the AI infrastructure that helps pharma companies develop their own treatments. Find out how they accumulated one of the world’s largest proprietary brain datasets and why brain tissue is the “LiDAR of neuroscience.”Guests:INTVL: https://www.intvl.com.au/INTVL on Instagram: https://www.instagram.com/intvl.appLouis Phillips on Instagram: https://www.instagram.com/louisphillips12Verge Labs: https://vergelabs.com/Alice Zhang on X: https://x.com/AliceXinliZhangRelevant LinksMeta’s Ad Library: https://www.facebook.com/ads/library/Strava: https://www.strava.com/Pokémon Go: https://pokemongo.com/Fitbod: https://fitbod.me/Tonebase: https://www.tonebase.co/Calm: https://www.calm.com/Hamilton Island official site: https://www.hamiltonisland.com.au/“Mr. Inbetween” trailer: https://www.youtube.com/watch?v=EooRG3QhQOYArticle: “Verge Genomics Rebrands as Verge Labs”: https://trial.medpath.com/news/verge-genomics-rebrands-as-verge-labs-following-als-drug-trial-failure-pivots-to-ai-driven-target-discoveryEli Lilly: https://www.lilly.com/Chai Discovery: https://www.chaidiscovery.com/Noetik: https://www.noetik.ai/Tempus: https://www.tempus.com/Timestamps:0:00 Louis on building in Melbourne, Australia

7:44 Why INTVL ignores how fast you run

9:59 Agree - Stop chasing invoices at https://agree.com and tell them Jason sent you to get 50% off for life!

15:52 Using gamification for good

19:10 Powering INTVL's impressive growth

19:55 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST

26:16 The future of TWiST Australia

27:14 Will AI ever cure cancer?

27:54 Inside Verge's rebrand

30:31 Superhuman - Get AI that works where you work. Unlock your Superhuman potential at https://superhuman.com

32:01 Brain tissue as "ground truth"

36:01 Why brain tissue is so valuable as data

43:52 Verge's Eli Lilly partnership

51:34 "You're going to tell me when I'm going to die"

56:11 How AI could impact drug prices

58:19 Clinical trial FAILS and how to move onSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com