This Startup Fused Human Brain Cells with Silicon Chips | E2295
Release Date: 06/01/2026
The AI Securing Your Workforce Before a Mistake Ever Becomes a Breach | E2314
This Week in Startups
This Week In Startups is made possible by: Vanta Superhuman YSecurity Today’s show: *Cybersecurity has long focused on cleaning up a system AFTER a breach but Ent founder Brandon Dixon says that’s backwards. He just raised a $100M seed round to put an AI agent on everyone’s company laptops that catches the risky clicks, leaked files, or rogue agents BEFORE they wreck havoc. PLUS Clawra creator David Im return swith his new project, Sume’s Avatar, a multi-model orchestration layer that generates 60-second UGC videos from a single prompt… and gets it right on the first try, rather...
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The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313
This Week in Startups
The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313 This Week In Startups is made possible by: Northwest Registered Agent CLA MongoDB Today’s show: *Andromeda Surgical is building the autonomy layer that could one day allow robots to perform surgery. Rather than building their own intricate, complex hardware, Andromeda uses off-the-shelf arms from a German manufacturer, and focuses on the software that will allow doctors to operate it from an iPad. Plus Mogul co-founder and CEO Alex Blackwood shows Jason how his platform lets anyone buy fractional shares...
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A Startup Is Trying to Buy PayPal… Craziest Deal of 2026! | E2312
This Week in Startups
This Week In Startups is made possible by: MongoDB - Rippling - - Today’s show: Hustle Fund’s Eric Bahn and Chapter One’s Jeff Morris Jr. join our venture capital roundtable directly following the news breaking that Stripe wants to buy PayPal. The possible transaction highlights how little interest today’s leading startups have in going public any time soon. With host Alex Wilhelm, Bahn and Morris dug into when startups should burn the boats à la Fin, physical AI as the next frontier, the power of Silicon Valley groupthink, and how startups are approaching the first days of...
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Jason turned $11 and one tweet into 1.1M views | E2311
This Week in Startups
This Week In Startups is made possible by: Quo PayPal Open Northwest Registered Agent Today’s show: *Jason spent $11 building out PodMeme, an AI tool that tracks down the best segments from top podcasts about a specific topic, then stitches them together into a single stream. His post laying out how he did it, featuring a simple screenshot of the product, got all the way to 1.1M views in just a few days. It’s a simple fact: builders love to see what other people are building, and growing your new project “in public,” sharing your journey on social media, is a great way to develop...
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Danny Bernstein left Big Tech to fund farm-bots | E2310
This Week in Startups
This Week In Startups is made possible by: NetSuite Squarespace YSecurity Today’s show: *America posted 400,000 farm jobs last year, and fewer than 1% got a single domestic applicant. Danny Bernstein of Reservoir believes it’s time to start automating this backbreaking labor, like picking stone fruit in 110°F temperatures. So he built the world’s first on-farm robotics incubator on 40 acres of California farmland. Here’s why he argues that automating farms isn’t just a new opportunity, it’s a national security issue. PLUS Jason responded to Gal Shir’s viral “AI beat me at...
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Why Data Is the Next $1 Trillion Market
This Week in Startups
This Week In Startups is made possible by: Digital Ocean - - - . Today’s show: How many startups matter in tech? Fewer than you think. That’s why venture capitalists are tripping over themselves to get onto their cap tables, no matter the cost. Why? Footwork’s Nikhil Basu Trivedi argues that the Valley has never been more “power-law-pilled” than it is today. Basu Trivedi joined Cendana Capital’s Michael Kim and TWiST’s Alex Wilhelm to go deep on secondary markets, the state of startup M&A, why the SaaSpocalypse may be temporary, and what could trigger a...
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$100T is managed by “human duct tape” | E2308
This Week in Startups
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Northwest Registered Agent https://northwestregisteredagent.com/twist
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Sentry https://sentry.io/twist
Today’s show:
*There are $100 trillion in global assets sitting on top of what Hanover Park co-founder/CEO Chris Hladcz
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Why the VC Hype Cycle Always Gets It Wrong | VC Roundtable | E2307
This Week in Startups
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CLA - www.claconnect.com/withyou
Northwest Registered Agent - www.northwes
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Chamath on why young people need more agency, risk, and adventure
This Week in Startups
This Week In Startups is made possible by:
Shopify
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Northwest Registered Agent
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Today’s show:
*It’s another All Star Summer, as we wel
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Why F1 Teams are Replacing Wind Tunnels with Smart Tape | E2305
This Week in Startups
This Week In Startups is made possible by:
Plaud - https://Plaud.ai/twistSentry - https://sentry.io/twistNorthwest Registered Agent-https://northwestregisteredagent.com/twistDigitalOcean - https://do.co/twist
Today’s show:
F1 teams spend up to a third of their budgets on aerodynamics, often utilizing wind tunnels to simulate what happens on the track.
But Lyall Davenport of SKN Systems created a sensor-embedde
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LinkedIn Jobs https://LinkedIn.com/twist
Today’s show:
Cortical Labs is the world’s first company selling biological computers. Their CL1 fuses lab-grown human neurons (derived from stem cells, not actual folks) with silicon hardware to create Synthetic Biological Intelligence (SBI).
Founder Dr. Hon Weng Chong walks us through how the system works and why neurons are more efficient than GPUs at reinforcement learning. (Also… is this computer alive?)
PLUS Pyka co-founder and CEO Michael Norcia explains the various uses for his autonomous aircraft, from crop-spraying drones in Brazil to a a hybrid-electric defense UAV for the military.
Guests:
Cortical Labs: ****https://corticallabs.com/
Dr. Hon Weng Chong on X: https://x.com/dr1337
Pyka: https://www.flypyka.com/
Pyka on Instagram: https://www.instagram.com/flypyka/?hl=en
Further Reading:
2022 Pong paper in Neuron: https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6
2017 Paper: “Attention is All You Need”; https://arxiv.org/abs/1706.03762
The “Barista Test” for Artificial Intelligence: Chris Rourk: https://medium.com/predict/the-turing-test-is-so-last-century-the-barista-test-for-artificial-general-intelligence-faf91034fa8c
Notable Links:
Playing “DOOM” on CL1: https://www.youtube.com/watch?v=yRV8fSw6HaE
DayOne Data Center: https://dayonedc.com/
NeurIPS 2026 Conference: https://neurips.cc/
Neuralink: https://neuralink.com/
CliniCloud Digital Stethoscope and Thermometer: https://www.design-industry.com.au/clinicloud
Air Force Research Laboratory (AFWERX): https://afwerx.com/
Joby Aviation: https://www.jobyaviation.com/
Prime Movers Lab: https://www.primemoverslab.com/
Timestamps:
0:00 What is "biological computing"?
2:49 Cortical's new $30 million raise
4:15 The world's first biological data center
9:48 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.
10:51 Biological computers have a learning advantage
19:43 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST
29:15 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist
38:46 From paper airplanes to Group 4 UAVs
52:20 Introducing the DropShip defense drone
58:28 How regulations block US drones
1:00:40 Why Pyka builds everything in-house
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