[Education] Hematopoietic Stem Cell Transplantation and Opportunistic Infections: Top 10 Clinical Pearls

HOPA Now is the official podcast of the Hematology/Oncology/Pharmacy Association, an organization dedicated to supporting pharmacy practitioners and promoting the advancement of Hematology/Oncology/Pharmacy to optimize the care of individuals impacted by cancer.

 

These educational podcasts are part of our BCOP Preparatory and Recertification Course, which is designed to prepare oncology pharmacists preparing to sit for the BCOP Certification Exam, as well as meet the BPS requirement to complete a BCOP Preparatory/Recertification Review Course.

 

In this episode of HOPA Now, Dr. Katie Gatwood offers a quick and convenient resource regarding hematopoietic stem cell transplantation and opportunistic infections to assist you in caring for your transplant patients. She highlights the indications for effective transplant, general indications, and strategies, and leading causes of transplant-related morbidity and infections. She also offers management and prevention tactics to help best overcome major infection concerns.

 

In this episode you will learn:

 

An overview of hematopoietic stem cell transplantation and opportunistic infections

• Indications for effective transplant, the curative treatment for over 70 different malignant and non-malignant conditions
• Stem cell mobilization strategies and general indications
• Intensity levels and other criteria of various transplant conditioning regimens, including the high-risk VOD
• Standard practices for prevention of GVHD and allogeneic transplantation
• Leading causes of transplant-related morbidity and mortality GVHD and effective treatment options
• Risks and management of CMV, including preemptive therapy
• Management of and major concerns regarding EBV reactivation
• The reason that reimmunization of vaccine-preventable diseases is required following transplantation

 

Mentioned in This Episode:

HOPA

 

Quotes:

 

“Acute leukemias are the most common indications for allogeneic transplant.” — Katie Gatwood

 

“For patients at high risk for mobilization failure … combination strategies are generally preferred.” — Katie Gatwood

 

“Despite prophylaxis, 30–80% of patients will develop GVHD.” — Katie Gatwood

 

“Following transplantation, patients are at a major risk for CMV reactivation and disease, which is associated with significant morbidity.” — Katie Gatwood