The Hidden Link Between Lyme Disease and Alzheimer’s (The MSIDS Protocol)

What if some people diagnosed with chronic fatigue, fibromyalgia, autoimmune disease, anxiety, or even early Alzheimer's are actually dealing with an underlying infection that was never properly identified?

Today, I’m sharing my conversation with Dr. Richard Horowitz, a board-certified internist who has treated more than 13,000 patients with Lyme and tick-borne disease over the last four decades, many of whom had already seen countless doctors and collected diagnoses like chronic fatigue syndrome, fibromyalgia, depression, anxiety, multiple sclerosis, and early dementia before discovering Lyme may have been part of the picture.

Dr. Horowitz calls Lyme “the great imitator” because its symptoms can overlap with so many other conditions, and since 2016, Dr. Horowitz has published 11 papers on treatment approaches. In one of his latest studies, he and his colleagues explored a possible connection between Lyme disease and Alzheimer's biomarkers, reporting major improvements in certain inflammatory and cognitive-related markers after treatment.

We discuss his broader “MSIDS” model, which looks at chronic illness through a much wider lens. Instead of looking for one single cause, the model examines multiple overlapping factors that may contribute to illness, including infections, toxins, gut dysfunction, nutrient deficiencies, sleep issues, immune imbalance, and inflammation.

In this podcast, Dr. Horowitz and I discuss:

• Why Lyme disease is called “the great imitator” and how it can resemble chronic fatigue syndrome, fibromyalgia, multiple sclerosis, anxiety, depression, and Alzheimer's disease

• The often-overlooked migratory pain that is one of the hallmark symptoms of chronic Lyme

• The Lyme symptom questionnaire, which he developed and validated on 6,400 patients

• How research from Johns Hopkins and other universities changed our understanding of Lyme as a persistent infection

• Why Dr. Horowitz began using drugs like dapsone and rifampin in Lyme treatment protocols

• His published research on dapsone combination therapy and the improvements he has observed in patients

• His recent findings on Lyme disease and Alzheimer's biomarkers, including reductions in tau217 levels

• Dr. Horowitz’s unique MSIDS model and the many overlapping factors that may drive chronic illness

• Why chronic illness rates continue rising and what conventional medicine may still be missing

• Why Dr. Horowitz believes recovery is possible, even for patients who have been sick for years