2934: GLP-1 Drugs Are Killing People — Here Is What Nobody Is Telling You
Release Date: 08/29/2026
Mind Pump: Raw Fitness Truth
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My Maps Program: https://mymapsprogram.com $297 for a fully customized MAPS program. Answer 20 questions, get a program built for your specific goals and equipment, plus a 1-on-1 call with a trainer to review it. Dr. Mike Israetel — co-founder of RP Strength, sport science PhD and competitive bodybuilder — joins the guys in person for a wide-ranging conversation that covers everything from vanity and body image to AI, GLP-1, UFOs and the future of humanity. Mike shares the thesis of his new book on vanity — that caring about your appearance is not inherently bad, that most people...
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MAPS Abs and Butt: https://mapsabsandbutt.com Code: LAUNCH for 40% off. Includes Butt Building Diet Guide, Women's Supplement Guide, at-home dumbbell version and a free second program at checkout (Muscle Mommy or Muscle Mommy 15). In this episode the guys break down five common hypertrophy study findings that do not hold up in the real world — why 15-20 sets per body part per week works in 8-12 week studies but burns out real people within months, why light weight and heavy weight producing the same results ignores how fatigue affects the big compound lifts, why training close to failure...
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info_outlineMind Pump: Raw Fitness Truth
MAPS Abs and Butt: https://mapsabsandbutt.com Code: LAUNCH for 40% off. Includes Butt Building Diet Guide, Women's Supplement Guide, at-home dumbbell version and a free second program at checkout (Muscle Mommy or Muscle Mommy 15). In this episode the guys break down the secrets for training in a calorie deficit — why bodyweight lifts are psychologically and physically the best choice when cutting, what it actually feels like to train depleted and why anticipating it helps you push through, why low reps beat high reps in a deficit because they preserve muscle with far less stress on the body,...
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In this episode the guys break down the dangers of GLP-1 drugs — covering who they are actually for, who they are not for, the real risks including muscle loss, bone density decline and gastroparesis, and the only right way to use them with resistance training and behavioral change. They also get into Sal's Collective shoes situation that led into an unexpected swinger conversation, the new federal income brackets and what it says about inflation, why owning a home is quietly becoming a luxury not a right, a massive 236-country demographic study showing global fertility has fallen below replacement rate for the first time in 60,000 years, why going to church is the biggest predictor of economic upward mobility, and the guys sharing their personal Caldera Lab favorites. Then they coach live callers submitted through mplivecaller.com.
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0:00 - Intro
2:09 - GLP-1 drugs are killing people — and they're not the panacea everyone thinks
5:17 - Who GLP-1 is actually for and who is using it wrong
11:44 - The risks: muscle loss, bone density, gastroparesis and behavioral dependency
16:14 - The only right way to use GLP-1 — resistance training, protein and behavior change
27:58 - Sal's Collective shoes situation — and the unexpected swinger conversation
37:24 - New federal income brackets and what they reveal about real inflation
41:00 - Why owning a home is quietly becoming a luxury rather than a right
48:10 - 236-country study: global fertility below replacement rate for the first time in 60,000 years
51:18 - Church attendance as the single biggest predictor of economic upward mobility
54:30 - The guys share their personal Caldera Lab favorites
1:11:40 - Caller: Kennedy (Missouri) — returning caller, up from 1,600 to 2,800 calories, strength gains
1:21:24 - Caller: RSI (Colorado) — 6-7 years lifting, approaching intermediate plateau, needs a program change
1:29:48 - Caller: Autumn (Ohio) — no lower body strength progress in 2 years after a lean phase
1:37:10 - Caller: Hunter (Utah) — training around a recurring injury, wants to stay consistent