141: A Thermostat for Your Body Fat with Dr. Stephan J. Guyenet
Release Date: 06/23/2025
162: The Habits of Healthy Aging with Dr. Kate Wolin
Longevity Roadmap
We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world. From frictionless habit design and daily self-monitoring to movement, sleep, and the muscle-preserving realities of GLP-1s, she reveals the behavioral strategies that truly move the needle on long-term metabolic and overall health. Watch the full episode to learn how evidence-based behavior science can transform your healthspan. Learn more about Dr. Kate Wolin: - Download Dr. Buck Joffrey's FREE ebook, Living...
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161: The Future of Tissue Regeneration with Dr. Jennifer Elisseeff
Longevity Roadmap
In this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine. She explains the shift from using stem cells to focusing on immune cells for tissue repair, the challenges of regenerating cartilage, and the importance of vascularity in tissue health. The discussion also covers the impact of aging on tissue repair, the role of senescent cells, and the future of personalized medicine in tissue engineering. Dr. Elisseeff emphasizes the need for innovative approaches and the integration of immunotherapies to...
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160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum
Longevity Roadmap
Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging. She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that also exist in humans. The conversation dives into the balance between stress and resilience, the role of IGF-1 in muscle health and lifespan, and why she believes true longevity breakthroughs will require understanding how the body’s systems communicate as a whole. Learn more about Dr. Heidi...
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159: How DNA Mutations and Epigenetic Drift Cause Aging with Prof. Jan Vijg
Longevity Roadmap
This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes. The conversation also touches on the implications of somatic mutations and the future of longevity research, particularly in relation to DNA repair mechanisms. Learn more about Professor Jan Vijg: - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: Book a FREE longevity coaching...
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158: Sitting Is the New Smoking with Dr. Keith Diaz
Longevity Roadmap
In this episode, we are joined by Dr. Keith Diaz to discuss the significant health risks associated with prolonged sitting, likening it to smoking in terms of its dangers. He emphasizes the importance of regular movement, introducing the concept of 'movement snacks'—short bursts of activity that can mitigate the negative effects of sitting. We also cover the physiological mechanisms behind how movement affects blood sugar levels and inflammation, as well as insights from blue zones where people naturally incorporate more movement into their daily lives. Dr. Diaz advocates for personalized...
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157: The Role of Surgery in Diabetes and Obesity with Dr. Mitchell Roslin
Longevity Roadmap
In this episode, we are joined by Dr. Mitchell Roslin to discuss the complexities of obesity. We explore the role of GLP-1 medications in weight management, the evolution of bariatric surgery, and the innovative SIPS procedure. Dr. Roslin emphasizes that obesity is not merely a result of poor lifestyle choices but involves intricate biological and hormonal mechanisms. He also highlights the importance of functional assessments in determining appropriate treatment for obesity, advocating for a more systematic approach to obesity management. Learn more about Dr. Mitchell Roslin: -...
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156: Investing in the Business of Aging with Dr. Karl Pfleger
Longevity Roadmap
In this episode, Dr. Karl Pfleger joins us to discuss the evolving landscape of longevity research and investment. He emphasizes the shift from disease-specific approaches to understanding aging as a multifaceted process that underpins many chronic diseases. Dr. Pfleger outlines his investment strategies in the aging biotech sector, highlighting the importance of addressing various sub-pathologies of aging. He also discusses the concept of longevity escape velocity, the challenges of proving longevity therapies, and the role of aging clocks in research. Learn more about Dr. Karl Pfleger:...
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155: Can Psilocybin Extend Cellular Lifespan? with Dr. Louise Hecker
Longevity Roadmap
In this episode, Dr. Louise Hecker joins us to discuss her groundbreaking research on psilocybin, exploring its potential to extend cellular lifespan and improve health outcomes in aging. We delve into the mechanisms behind psilocybin's effects, findings from animal studies, and the challenges faced in conducting research on this Schedule I substance. Dr. Hecker emphasizes the importance of understanding optimal dosing protocols and safety considerations for future applications of psilocybin in geroprotection. Learn more about Dr. Louise Hecker: - Download Dr. Buck Joffrey's FREE ebook,...
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154: Is Telomere Length Shortening the Master Switch of Aging? with Dr. Bill Andrews
Longevity Roadmap
In this episode, Dr. Bill Andrews joins Dr. Buck Joffrey to discuss the critical role of telomeres and telomerase in aging and cellular health. He explains how telomeres shorten with each cell division, leading to aging and cellular senescence. Dr. Andrews emphasizes the importance of inducing telomerase to potentially reverse aging and shares insights from his research on telomerase inducers. He also addresses the challenges in longevity research, the relationship between telomeres and the hallmarks of aging, and the potential of gene therapy. The conversation concludes with a discussion on...
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153: T Cells, Aging, and Extreme Life Extension with Dr. Derya Unutmaz
Longevity Roadmap
Dr. Derya Unutmaz joins Dr. Buck Joffrey to discuss the critical role of T cells in the immune system, their changes with aging, and the implications for chronic diseases. He emphasizes the importance of thymus regeneration and the microbiome's influence on health. The discussion also covers advancements in engineering immune cells for cancer treatment and the potential of AI in revolutionizing aging research and drug discovery. Unutmaz expresses optimism about the future of aging research, highlighting the need for a shift in how aging is perceived in the medical community. Learn more about...
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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0
Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/