144: Why the Brain is Especially Vulnerable to Aging
Longevity Roadmap
In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain’s heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions....
info_outline
143: The Longevity Dividend with Prof. Jay Olshansky
Longevity Roadmap
In this conversation, Professor S. Jay Olshansky discusses the evolution of aging science, the realistic limits of human life expectancy, and the concept of the Longevity Dividend, which emphasizes the health and economic benefits of modulating the aging process. He also explores the potential of biomarkers in predicting longevity, the societal implications of an aging population, and the ethical considerations surrounding advancements in longevity science. Learn more about Professor S. Jay Olshansky: - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: Book a FREE...
info_outline
142: The Gut-Muscle Axis with Dr. Michael Lustgarten
Longevity Roadmap
In this episode, Dr. Michael Lustgarten discusses his research on the gut microbiome, serum metabolome, and muscle health in older adults. He shares insights from his journey into the world of aging, the importance of data in health optimization, and the emerging concept of the gut-muscle axis. Dr. Lustgarten emphasizes the significance of metabolites in predicting longevity and the need for personalized health tracking. He also addresses the balance of exercise and the role of fecal microbiota transplantation in health. Learn more about Dr. Michael Lustgarten: Email Dr....
info_outline
141: A Thermostat for Your Body Fat
Longevity Roadmap
In this conversation, Dr. Stephan J. Guyenet joins Dr. Buck Joffrey to discuss the complex mechanisms of body fat regulation, focusing on the role of the lipostat and leptin. He explains how the body regulates fatness through hormonal signals and the implications of leptin resistance in obesity. The discussion also covers practical strategies for weight management, the impact of stress and sleep on leptin levels, and critiques of the carbohydrate insulin model of obesity. Learn more about Dr. Stephan J. Guyenet: - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy...
info_outline
140: Inside the Inflammatory Clock - Measuring and Reversing Biological Age with Dr. David Furman
Longevity Roadmap
Dr. David Furman and Dr. Buck Joffrey discuss the complexities of immune aging, the role of inflammation in age-related diseases, and how artificial intelligence is being utilized to enhance research in this field. He introduces the concept of the inflammatory age clock, which measures biological aging through immune system signals, and explores potential therapeutic interventions, including nutraceuticals and therapeutic plasma exchange. The discussion also touches on the future of aging research, emphasizing personalized approaches and the democratization of diagnostics. Learn more about Dr....
info_outline
139: Rebuilding the Aging Brain - The Role of Neural Stem Cells
Longevity Roadmap
In this conversation, Dr. Tara Walker discusses the fascinating topic of adult neurogenesis, the brain's ability to produce new neurons throughout life. She explains how this process is crucial for cognitive function and how it declines with age. The discussion highlights the significant role of exercise in boosting neurogenesis and introduces selenium as a key factor in this process. Dr. Walker also explores the implications of her research for cognitive health, particularly in the context of neurodegenerative diseases, and the potential therapeutic strategies that could arise from...
info_outline
138: Sleep Impact on Longevity and Health with The Sleep Doctor
Longevity Roadmap
Sleep is the secret weapon for a longer, healthier life—and Dr. Michael Breus is here to show you how to use it. In this episode of Longevity Roadmap, Buck Joffrey dives deep into the science of sleep with the world-renowned sleep doctor himself. Discover why sleep is the third pillar of longevity, how REM sleep and deep sleep fuel physical and emotional restoration, and what your chronotype reveals about your ideal sleep patterns. From the effects of sleep deprivation on metabolism and aging to natural sleep tips, supplements, and cutting-edge alternatives to CPAP machines for sleep apnea,...
info_outline
137: Dr. Joan Mannick - Targeting mTOR to Improve Immune Function and Healthspan
Longevity Roadmap
What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unlock new possibilities in clinical longevity. Learn more about Dr. Joan Mannick:...
info_outline
136: Why is Vitamin D So Important in Health and Longevity?
Longevity Roadmap
Vitamin D is more than a vitamin—it's a hormone that influences everything from your immune system to cardiovascular health, cognition, and longevity. In this conversation, Dr. Michael Holick breaks down the science of vitamin D synthesis, the truth about sun exposure vs. supplements, and why vitamin D deficiency is far more common—and more dangerous—than most people realize. You'll learn how skin pigmentation, UVB exposure, and supplementation protocols impact your vitamin D levels, and why D3 is more effective than D2. Dr. Holick also dives...
info_outline
135: The Aging Brain - From Memory Lapses to Measurable Prevention
Longevity Roadmap
Is your memory decline normal—or something more? Clinical neuropsychologist Dr. Mitchell Clionsky breaks down what healthy aging looks like from a cognitive perspective and where concern might be warranted. He introduces the Memory Orientation Screening Test (MOST)—a powerful yet quick tool to assess cognitive health—and shares insights from decades of evaluating memory, dementia, brain injuries, and CTE. From preventive strategies that could reduce dementia risk by nearly 50%, to how technology is transforming neuropsychology, this conversation is a must-watch for anyone invested in...
info_outlineIn this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain.
They discuss the brain’s heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier.
The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions.
Dr. Andersen also underscores the critical role of lifestyle interventions—especially exercise—in maintaining brain health.
Learn more about Dr. Julie Andersen and the Buck Institute:
https://www.buckinstitute.org/lab/andersen-lab/
-
Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0
Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/