#55: Clinical Pearls from Dr. Dominic D'Agostino: Therapeutic Strategies and Clinical Success with the Ketogenic Diet
Release Date: 06/17/2025
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info_outlineClinical Pearls from Dr. Dominic D'Agostino: Therapeutic Strategies and Clinical Success with the Ketogenic Diet
For this week’s episode of the Clinician’s Corner, we’re doing something differently. We have gone into the archives and pulled out clinical pearls from some of our favorite episodes, and we’re starting today with one of our most popular interviews with Dr. Dominic D’Agostino - where we unpack the ketogenic diet in all its nuances.
This interview first aired back in 2023, and the full interview can be viewed here.
Clinical pearls we extracted from the original interview:
When the ketogenic diet is best used clinically; when it’s contraindicated; and how to structure it for best results
What the latest research is telling us about therapeutic application of this protocol - from metabolic health to neurological considerations and cancer
Exogenous ketones: when and how to use them
The intricacies of macronutrient ratios and when/how to cycle in and out of ketosis
Measurement: the best forms for tracking ketosis and other key biomarkers to monitor
The Clinician’s Corner is brought to you by Restorative Wellness Solutions.
Follow us: https://www.instagram.com/restorativewellnesssolutions/
Connect with Dr. D’Agostino:
Website: https://drdominicdagostino.com/
Instagram: https://www.instagram.com/dominic.dagostino.kt/
LinkedIn: https://www.linkedin.com/in/dominic-d-agostino-156014b/
Twitter: https://twitter.com/DominicDAgosti2
Learn more about the ketogenic diet here: https://ketonutrition.org/
Timestamps:
00:00 History and Uses of Ketogenic Diet
06:25 Liver's Role in Ketone Production
07:22 Preventing Kidney Stones on Keto
13:15 Ketogenic Diet Supplement Tips
14:58 Minimal Supplements for Ketogenic Diet
18:07 Misleading Marketing of 1,3-Butanediol
24:08 Advanced Hormone and Metabolomics Testing
27:20 Monitor Meds During Diet Changes
Speaker bio:
Dr. D’Agostino is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications.
Keywords:
ketogenic diet, therapeutic ketosis, blood ketone levels, exogenous ketones, metabolic therapies, epilepsy, neuroprotection, anti-seizure strategy, type 2 diabetes, weight loss, cancer, muscle wasting, Parkinson’s disease, Alzheimer’s disease, migraines, polycystic ovary syndrome, psychiatric disorders, bipolar disorder, anxiety, autism, traumatic brain injury, non-alcoholic fatty liver disease, stroke, GLUT1 deficiency, carnitine supplementation, kidney stones, electrolyte balance, MCT oil, creatine monohydrate, caffeine and ketone production, comprehensive blood work
Disclaimer:
The views expressed in the RWS Clinician’s Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician’s Corner series. The information and opinions expressed in the RWS Clinician’s Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician’s Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.