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In the News.. Arthritis drug studied for T1D, calls to poison control over Ozempic, Tandem Source released, and more!

Diabetes Connections Type 2

Release Date: 12/15/2023

From Restrictive Diets to Realistic Solutions with Dr. Mike Roussell show art From Restrictive Diets to Realistic Solutions with Dr. Mike Roussell

Diabetes Connections Type 2

What you eat is an important part of managing diabetes. By now, we all know being super restrictive doesn’t work, so let’s talk about some easier ways to work in more healthy foods without turning your life upside down. My guest this week is , an author and nutrition consultant who holds a degree in biochemistry and a PHD in nutrition.  We’ll also define insulin resistance and explain why this is an important part of understanding diabetes. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider. Please visit our...

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In the News.. Tandem Mobi released, surprising outcomes for type 2 surgery, exercise and diabetes studies, T1D at the Super Bowl, and more! show art In the News.. Tandem Mobi released, surprising outcomes for type 2 surgery, exercise and diabetes studies, T1D at the Super Bowl, and more!

Diabetes Connections Type 2

It’s In the News, a look at the top stories and headlines from the diabetes community happening now. Top stories this week: Tandem announces it's taking orders and starting to ship the Mobi pump, Insulet gets European approval for the Abbott Libre integration with Omnipod 5, new study looks at type 2 remission and gastric bypass surgery, one type of medication seems to do a much better job preventing kidney stones in people with type 2, big new grant to look at exercise and type 1 and a look back at diabetes at the Super Bowl. Find out more about  Please visit our Sponsors &...

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A new CGM made for people with type 2 - Learn about Dexcom's Stelo show art A new CGM made for people with type 2 - Learn about Dexcom's Stelo

Diabetes Connections Type 2

Dexcom is planning a new CGM system called Stelo, aimed at people with type 2 diabetes who don't use insulin. This week, we're talking to the Chief Operating Officer Jake Leach all about this. Dexcom is the leading CGM used with insulin pumps, so this is an interesting new direction for them. What’s the difference between this device and those made for people who dose insulin? plus a lot more information about their existing product lines. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider. Our previous episodes with...

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Need a CGM? Ask your pharmacist. A new pilot program aims to improve access show art Need a CGM? Ask your pharmacist. A new pilot program aims to improve access

Diabetes Connections Type 2

Getting a CGM is, more and more, becoming a routine part of a diabetes diagnosis. But figuring out if your insurance will pay can be anything but routine. A new pilot program is recruiting pharmacists to be a big part of this process, helping educate patients about their options, even writing prescriptions. Plus, with all the talk about CGM, you may have heard about time in range. What is that and why is it inching out A1C as a gold standard measurement. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider. More about ...

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In the News.. weight loss & cancer study for T2D, new pump submitted, Summer Olympic hopeful with T1D and more! show art In the News.. weight loss & cancer study for T2D, new pump submitted, Summer Olympic hopeful with T1D and more!

Diabetes Connections Type 2

It’s In the News, a look at the top stories and headlines from the diabetes community happening now. Top stories this week: a look at how weight loss might lower cancer risk in people with type 2, a new study that says BG spikes are good(?!), Modular Medical submits a new insulin pump the FDA, another look at COVID-19's effects on people with diabetes, a marathoner with type 1 heads to the last trial for this summer's Olympics, and more! Find out more about Please visit our Sponsors & Partners - they help make the show possible! from extreme temperatures Learn more about Here's where...

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Adjusting to a Type 2 Diabetes Diagnosis - PR Pro Matt Friedman show art Adjusting to a Type 2 Diabetes Diagnosis - PR Pro Matt Friedman

Diabetes Connections Type 2

My guest is Matt Friedman, an expert in public relations who lives with type 2 – we get his take on what’s going on in PR these days – with social media, crisis control, and even CHatGPT and AI – and of course we’ll talk about diabetes, and the bone Matt has to pick with restaurants. I love talking abou technology and the majority of these episodes will be about management tools and techniques, but I’ve also learned that personal stories – talking to people JUST living with diabetes – can be extremely helpful. This episode is one of those people focused ones. We'll also talk...

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Insulin Use with Type 2 Diabetes: Navigating Solutions, Avoiding Stigma show art Insulin Use with Type 2 Diabetes: Navigating Solutions, Avoiding Stigma

Diabetes Connections Type 2

Let’s talk about using insulin. For some, that can feel like a huge failure or that they have the bad type of diabetes. But sometimes, diet and exercise isn’t enough to manage type 2 diabetes. My guest this week is Dr. Arthi Thangudu and she’s going to talk about how she approaches these conversations with her patients and some of the newer options out there for administering insulin. Also this week, as long as we’re talking about insulin, we’ll define the different kinds. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health...

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In the News... Spray insulin tested, Dexcom T2D sensor submitted, A1C period pads... and more! show art In the News... Spray insulin tested, Dexcom T2D sensor submitted, A1C period pads... and more!

Diabetes Connections Type 2

It’s In the News, a look at the top stories and headlines from the diabetes community happening now. Top stories this week: Vertex pauses their stem cell transplantation trials after a patient death, spray insulin is tested, learning more about Dexcom's sensor for type 2, measuring A1C through menstrual blood and more! Find out more about Please visit our Sponsors & Partners - they help make the show possible! from extreme temperatures Learn more about Here's where to find us: Learn more about everything at our home page Reach out with questions or comments:...

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Get Kitchen Confident! The Happy Diabetic's Recipe for Living Well with Type 2 Diabetes show art Get Kitchen Confident! The Happy Diabetic's Recipe for Living Well with Type 2 Diabetes

Diabetes Connections Type 2

When you get a diabetes diagnosis, eating well is usually at the top of the “to-do” list. But then you get home and look around the kitchen and – let’s face it – most of us aren’t sure where to start. What’s easy to cook that will taste good? What will my family actually eat? This week I’m talking to Chef Robert Lewis, who calls himself the happy diabetic. He lives with type 2 and he’ll explain why he started off very unhappy! And what changed.. Also this week, we’re explaining the term post prandial  blood sugar. What does it mean and why is your doctor so concerned...

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Diabetes + Weight Loss: Inside the new partnership between WeightWatchers and Abbott show art Diabetes + Weight Loss: Inside the new partnership between WeightWatchers and Abbott

Diabetes Connections Type 2

This time of year diets are the center of a lot of conversations. So when I heard WeightWatchers was specifically offering something for people with diabetes, I wanted to learn more. WeightWatchers is teaming up with Abbott to use the Freestyle Libe CGM as part of their newest program. What does really mean for people with type 2? What are they offering and will it make a difference? I’m talking to the Chief Science Officer of WeightWatchers and Chief Medical Officer of Abbott. Also this week, why is the fasting blood glucose test so important? And what are it’s limitations? This podcast...

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More Episodes

It’s In the News, a look at the top stories and headlines from the diabetes community happening now. Top stories this week: an existing drug for arthritis is being studied for treatment of T1D, poison control centers report a big increase in calls about misdosing of Ozmepic and semaglutides, Tandem releases it's Tandem Source software, we've got an update on a possible non invasive glucose monitoring system, ADA releases it's standards of care and more!

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Episode transcript:

Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now.
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In the news is brought to you by Edgepark simplify your diabetes journey with Edgepark
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Our top story this week…
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A world-first clinical trial has found a common drug used to treat rheumatoid arthritis can suppress the progression of type 1 diabetes in recently diagnosed patients. Australian reserachers say they’ve discovered that baricitinib *bare-uh-sit-en-ub* can preserve the body's own insulin production.
The scientists recruited 91 people, aged between 10 and 30 years old, to take part in the double-blind randomised trial.
All patients had been diagnosed with type 1 diabetes within the last 100 days and continued with their prescribed insulin therapy throughout the study.
The results showed those in the baricitinib group were able safely and effectively to preserve their body's own insulin production and suppress the progression of type 1 diabetes.
"Our trial showed that, if started early enough after diagnosis, and while the participants remained on the medication, their production of insulin was maintained.

"People with type 1 diabetes in the trial who were given the drug required significantly less insulin for treatment."

Dr Faye Riley, research communications manager at Diabetes UK, said of the latest trial: "These findings show by tackling the root of type 1 diabetes - an immune system attack - an existing drug can help to shield the pancreas, in people recently diagnosed with type 1, so they can continue making more insulin for longer.

"This can give people with type 1 diabetes much steadier blood sugar levels and help to protect against serious diabetes complications down the line.

"Immunotherapies are edging us towards a new era in type 1 diabetes treatment, and could help us overcome a major hurdle en route to finding a cure for the condition.

"This trial takes us another step closer."

The study was funded by JDRF, a non-profit organization which focuses on type 1 diabetes research.

The research has been published in the New England Journal of Medicine.
https://news.sky.com/story/world-first-trial-finds-arthritis-drug-may-help-treat-type-1-diabetes-13024706

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Earlier this month, Dexcom’s G7 became compatible with two pump systems: Beta Bionic’s ilet pump and Tandem Diabetes tslim X2. Current customers should have received instructions on how to download the updated software – new pumps will be shipped with G7 software already loaded.
Tandem has also announced their new Tandem Source platform – full launch in the US with international rollout slated for next year. Anyone in the U.S. who uses a Tandem pump—as well as their respective healthcare providers—will now have access to the Source platform. On the patient side, insulin dosage data will automatically transfer from the pump to the platform, by way of the t:connect mobile app, where it’ll be compiled into three reports for your doctor. Patients will also be able to use the platform to access new software updates for their pumps and to reorder supplies as needed.
Long term, the company hopes to use the data from users – which would be blinded- to update automated insulin dosing algorithms.
https://www.fiercebiotech.com/medtech/tandem-begins-full-us-rollout-source-diabetes-management-platform
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New look at benefits from a plant based diet – this research says it can reduce the risk of type 2 diabetes by 24%. It’s not just about weight loss. They reviewed data on more than 113,000 participants in a large-scale British observational study, gathered over 12 years. They found that normal values for cholesterol, blood sugar, inflammation, and insulin are associated with a low risk of diabetes. They also found that good liver and kidney function is important in diabetes prevention. A plant based diet helped with all of those factors. The researchers do point out that there is such a thing as an unhealthy plant-based diet. Those that are still high in sweets, refined grains and sugary drinks are associated with an increased risk of type 2 diabetes, researchers found.

https://www.usnews.com/news/health-news/articles/2023-12-13/plant-based-diets-cut-diabetes-risk-by-24
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Reports of more patients with type 2 diabetes having trouble getting coverage for medication like Ozempic and Mounjaro – because health insurance companies are putting new restrictions in place.
Most U.S. health plans cover GLP-1s for type 2 diabetes but many providers will prescribe it off label for weight loss. There is another medication – Wegovy – approved for weight loss, it’s the same drug as Ozempic just packaged in a difference dose and name.
The average number of weekly Ozempic prescriptions rose 33% between the first and third quarters of this year, but has since dropped more than 6% to about 431,000, according to Iqvia Institute for Data Science.

Doctors and patients are bracing for changes in January, when individual health plans often set new coverage terms.

"It may be that January 1, all of a sudden something that was covered is no longer," said Dr. Robert Gabbay, chief science officer at the American Diabetes Association.
https://www.reuters.com/business/healthcare-pharmaceuticals/us-diabetes-patients-face-delays-insurers-tighten-ozempic-coverage-2023-12-12/
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Poison control centers across the US say they are seeing a steep increase in calls related to semaglutide, with some people reporting symptoms related to accidental overdoses. From January through November, the America’s Poison Centers reports nearly 3,000 calls involving semaglutide, an increase of more than 15-fold since 2019. In 94% of calls, this medication was the only substance reported.
The compounded versions of semaglutide are often different from the patented drug. Many contain semaglutide salts called semaglutide sodium and semaglutide acetate. The FDA says the salt forms of the drug have not been tested and approved to be safe and effective the way the patented form of the medication has, and thus they don’t qualify for the compounding exemption in the law for drugs in shortage. In other cases, the compounded versions are sold in unapproved dosages.
But these compounded versions are popular because they may cost less out-of-pocket, especially if the treatment isn’t covered by insurance.
The name-brand drugs are sold in pre-filled pens, which come with some safeguards. Patients dial to the correct dose and click to inject, so it’s harder to make mistakes. Compounded versions, however, typically come in multidose glass vials, and patients draw their own doses into syringes. It’s easy to get confused.
https://www.cnn.com/2023/12/13/health/semaglutide-overdoses-wellness/index.html

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Type 2 diabetes patients who received endocrinology care through telehealth alone had poor glycemic outcomes compared with those who received in-person or hybrid care, which contrasts with prior research findings, according to a new study.
Previous research has shown that telehealth is effective in improving glycemic control, but there has not been enough data on utilization and outcomes linked to routine telehealth care for type 2 diabetes since 2020, especially in the endocrinology setting, the researchers wrote.

One reason may be that the strategies to support glycemic improvement deployed during in-person appointments, like self-management education and sharing home blood glucose data, have not been consistently translated to telehealth.

“Implementation of approaches to overcome these differences, such as team-based virtual care and technological tools to automate blood glucose data sharing, are needed to ensure all patients receive high-quality diabetes care regardless of care modality,” they wrote.

These study findings contrast with previous research, including a study published in early 2022 that revealed that telehealth maintained quality of care and led to better health outcomes for patients with type 2 diabetes during the COVID-19 pandemic.

The study included 16,588 with type 2 diabetes who received care before or during the pandemic, with 7,581 having a telehealth visit with either a primary care physician or an endocrinologist.
https://mhealthintelligence.com/news/telehealth-only-care-fails-to-improve-type-2-diabetes-outcomes
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Medtronic’s deal to buy a South Korea based insulin patch pump maker is off. Back in May Medtrnoic announced a 738-million dollar deal to buy EOFlow, which makes EOPatch, a tubeless, wearable and fully disposable insulin delivery device.
EOFlow already launched its EOPatch insulin delivery system in Korea and Europe. The company submitted the insulin delivery device for U.S. FDA clearance in January.
https://www.massdevice.com/medtronic-nixes-738m-deal-for-insulin-patch-pump-maker-eoflow/
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Commercial
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Update on non invasive continuous glucose monitoring.
The most recent validation of the technology’s accuracy has been released as a preprint. In an experiment, researchers fed thousands of radio frequency glucose readings into a machine learning model to translate them into blood sugar values and compared the results against those from a Dexcom G6.

CGM accuracy is judged by mean absolute relative difference, or MARD. The statistic is reported as a percentage: a MARD of 10 percent, for example, means that the CGM is on average within 10 percent of the reference value. The Bio-RFID system scored a MARD of 11.27 percent.

In truth, this result is difficult to interpret. Though Bio-RFID’s MARD is not yet in the same neighborhood as its competitors’ (the Freestyle Libre 3 and the Dexcom G7 report MARDs of 7.9 percent and 8.7 percent, respectively), the experiment wasn’t a true test of the device’s capabilities, because it didn’t use a lab-drawn glucose measurement as its reference value. The volunteers also did not have diabetes, which meant that their blood sugar levels were likely more stable than those of most future customers.

The FDA has specific accuracy standards that it expects CGM manufacturers to meet for devices intended for “nonadjunctive” use and for use in a closed-loop insulin pump system. Know Labs’s product will need to meet these objective standards to be validated as a truly reliable CGM.

The Path to Approval
“Our expectation is that we’ll be in front of the FDA as we move into the second half of 2024,” says Erickson. Much larger trials will be needed to show that the device works and meets FDA standards. Erickson says, “We expect to have an FDA-cleared device in 2025.”

Though the business is still finalizing the form of the next generation, it expects that it can navigate the FDA approval process quickly. The FDA has already confirmed that RFID is quite safe and there should be little worry about side effects (though there could be a hazard of interference for patients already using electronic medical devices such as pacemakers).
https://www.diabetesdaily.com/blog/this-company-is-racing-to-create-the-worlds-first-non-invasive-cgm-718069/
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Today, the American Diabetes Association® (ADA) released the Standards of Care in Diabetes—2024 (Standards of Care), a set of comprehensive and evidence-based guidelines for managing type 1, type 2, gestational diabetes, and prediabetes based on the latest scientific research and clinical trials. It includes strategies for diagnosing and treating diabetes in both youth and adults, methods to prevent or delay type 2 diabetes and its associated comorbidities like cardiovascular disease (CVD) and obesity, and therapeutic approaches aimed at minimizing complications and enhancing health outcomes.

"The latest ADA guidelines present pivotal updates for health care professionals, ensuring comprehensive, evidence-based care for diabetes management. These changes reflect our ongoing commitment to optimizing patient outcomes through informed, adaptable, and patient-centered health care practices,” said Robert Gabbay, MD, PhD, the ADA’s chief scientific and medical officer. “The ADA’s Standards of Care ensures health care professionals, especially our primary care workforce, provide the best possible care to those living with diabetes.”

Notable updates to the Standards of Care in Diabetes─2024 include:

New updates in managing obesity in people with diabetes, including approaches to reduce therapeutic inertia, support more personalization, and incorporate additional obesity measurements beyond body mass index (i.e., waist circumference, waist-to-hip ratio, and/or waist-to-height ratio).
New screening recommendations for heart failure in people with diabetes.
Updated recommendations for peripheral arterial disease (PAD) screening in people with diabetes.
Guidance on screening and the use of teplizumab, approved to delay the onset of type 1 diabetes.
More guidance on the use of new obesity medications, glucagon-like peptide 1 (GLP-1) agonists or dual glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, to reach sustained weight management goals.
Updates in guidance on the diagnosis and classification of diabetes.
A focus on hypoglycemia prevention and management.
Emphasis on screening people with diabetes for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis at primary care and diabetes clinics.
New emphasis on the evaluation and treatment of bone health and added attention to diabetes-specific risk factors for fracture.
A focus on screening and management of people with diabetes and disability.
Emphasis on enabling health care providers to master diabetes technology, using artificial intelligence for retinal screenings with necessary referrals, and embracing telehealth and digital tools for diabetes self-management education.
New information on the possible association between COVID-19 infections and new onset of type 1 diabetes.
"As the ADA's chair of professional practice committee, I'm excited to share our latest updates to advance diabetes care through new scientific insights and technological innovation, all aimed at enhancing experience for people with diabetes and health care professionals in managing this complex condition," said Nuha A. El Sayed, MD, MM Sc, the ADA’s senior vice president of health care improvement.

Other noteworthy changes to the 2024 Standards of Care include:

Updated immunization guidance to include newly approved RSV vaccines in adults over 60 years of age with diabetes.
New emphasis on cultural sensitivity in diabetes self-management education, with considerations for changing reimbursement policies.
More detail and emphasis on psychosocial screening protocols to better identify diabetes distress.
The importance of diabetes technology, with an emphasis on continuous glucose monitors (CGMs) and automated insulin delivery (AID) systems.
Continued emphasis on inclusion and person-centered care.
“At the ADA, we are focused on improving the quality of care for anyone who lives with diabetes, prediabetes, or who is at risk of developing diabetes. The Standards of Care is critical to ensuring the improved treatment of diabetes, a chronic disease that requires continuous care through a well-informed and coordinated health care team. These standards equip health care professionals with the gold standard in diabetes care, ensuring the highest level of service and knowledge in the field,” said Chuck Henderson, the ADA’s chief executive officer.

The ADA annually updates its Standards of Care through the efforts of its Professional Practice Committee (PPC). Comprising 21 global experts from diverse professional backgrounds, the PPC includes physicians, nurse practitioners, certified diabetes care and education specialists, registered dietitians, pharmacists, and methodologists. Its members hold expertise in areas like adult and pediatric endocrinology, epidemiology, public health, cardiovascular risk management, kidney disease, microvascular complications, preconception and pregnancy care, weight management, diabetes prevention, behavioral and mental health, inpatient care, and technology in diabetes management. Additionally, the committee collaborates with 19 specialized content experts. The 2024 Standards of Care has garnered endorsements from the American College of Cardiology (Section 10), the American Society of Bone and Mineral Research (Bone section in Section 4), and the Obesity Society (Section 8).

Today, the Standards of Care in Diabetes—2024 is available online and is published as a supplement to the January 2024 issue of Diabetes Care®. A shortened version of the guidelines, known as the Abridged Standards of Care, will be made available for primary care providers in the journal Clinical Diabetes®, along with a convenient Standards of Care app as well as a Standards of Care pocket chart. The online version will be annotated in real-time with necessary updates if new evidence or regulatory changes merit immediate incorporation through the “living” Standards of Care process. Other Standards of Care resources, including a webcast with continuing education (CE) credit and a full slide deck, can be found on the ADA’s professional website, DiabetesPro®.
https://diabetes.org/newsroom/press-releases/american-diabetes-association-releases-standards-care-diabetes-2024
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