283: Slowing Aging, Mastering Health - with Chris Mirabile
BIOptimizers - Awesome Health Podcast
Release Date: 05/08/2025
297: Insurance Rigged Against You - with Chris Hamilton
BIOptimizers - Awesome Health Podcast
Health insurance in America is expensive on purpose, not by accident. Chris Hamilton argues that confusion and hidden incentives are the real products big carriers sell… and employers and employees pay the price. How Insurance Giants Game the System Under federal rules, large insurers in the USA can only keep about 15 percent of premiums as profit, which sounds protective until you realize it pushes them to grow the total cost of care. To do that, they've built a "massive ecosystem that's able to bill the insurance company" by buying physician groups, pharmacies, and pharmacy benefit...
info_outline
296: Emerge From Behind Logo - with Paige Velasquez Budde
BIOptimizers - Awesome Health Podcast
The old playbook of "buy ads, rank for keywords, and wait for patients" is failing. According to Paige Velasquez Budde, CEO of Zilker Media and author of The Strategic Business Influencer, we've entered an era of "corporate suspicion." Trust in institutions is at an all-time low, while trust in individuals is skyrocketing. For health and wellness organizations, you can no longer rely on your company brand alone. AI Search Demands Leader Visibility Patients now find health providers through AI platforms like ChatGPT, not just Google. Budde calls this Generative Engine Optimization (GEO). Unlike...
info_outline
295: Your Fatigue Has Hidden Roots - with Martha Carlin
BIOptimizers - Awesome Health Podcast
Are you constantly battling fatigue, brain fog, and persistent bloating? You might be dealing with a silent instigator: LPS endotoxins. We recently dove deep into this topic with Martha Carlin, a pioneering microbiome researcher and founder of The BioCollective. Here's what you need to know about this stealthy driver of chronic inflammation. What is LPS? LPS, or lipopolysaccharide, is an endotoxin—a component of the cell wall of gram-negative bacteria in your gut. While these bacteria are normal, problems arise when they die and release inflammatory debris. In a healthy gut, this isn't a...
info_outline
294: Oral Health “Mouth Mapping” - Jonathan Levine
BIOptimizers - Awesome Health Podcast
With long-term health, the mouth is often overlooked. For most people, the dentist is someone only seen for a cleaning or to fix a problem like a cavity or crown. However, according to Dr. Jonathan B. Levine, a world-renowned oral health expert, we are undergoing a massive paradigm shift. It is time to stop seeing the mouth as separate and recognize it as a critical data center for your entire body's well-being. This new approach, which Dr. Levine's practice calls "mouth mapping," is poised to change how we manage everything from heart disease to sleep. The Biological Connection: Mouth...
info_outline
293: Not Willpower, Your Roots - with Amber Romaniuk
BIOptimizers - Awesome Health Podcast
It is a staggering statistic that an estimated 90% of women and up to 50% of men in North America struggle with binge and emotional eating. For those caught in this exhausting cycle—marked by shame, frustration, and the feeling of being completely out of control—the common response is often another diet, followed by self-blame for lacking willpower. However, according to emotional eating and hormone expert Amber Romaniuk, focusing on willpower is exactly the wrong approach. Individuals are attempting to fix a deep, multi-layered issue with a surface-level solution. The true healing, she...
info_outline
292: The Key to Aging Strong - with Alan Rozanski
BIOptimizers - Awesome Health Podcast
We all want to age with vitality and independence. Yet, there's a stark statistic looming over Americans: 1 in 3 people over 65 will suffer a fall. This "overlooked aging crisis" isn't just about a broken bone; it's often the starting point for a decline in health, confidence, and independence. According to Dr. Alan Rozanski, a distinguished professor of medicine, the solution isn't a new drug or a complex medical procedure. It's a proactive, powerful strategy he calls "muscle care." The Real Reason We Fall The primary driver behind this crisis is a natural process that we've accepted for too...
info_outline
291: Master Your Marriage, Health, Business - with Keith Yackey
BIOptimizers - Awesome Health Podcast
Keith Yackey is a 20-year veteran of high-performance philosophy and the founder of Married Game. His journey was forged in failure. "Jesse left 8 years ago. I messed up this relationship. I was selfish." When Yackey met his wife, he was "185 pounds of tiger meat wrapped in barbed wire." Five years later, he was 250 pounds. The man she married was gone. Only after doing the hard work did other high-performers start noticing his "code." What is that code? Your marriage, health, and business reflect your personal standard. The Health and Marriage Connection Why do successful men fail at home?...
info_outline
290: How Wholeness Leads To Healing - with Udo Erasmus
BIOptimizers - Awesome Health Podcast
The Quest for Harmony Born amid the chaos of World War II, Udo Erasmus's journey began with trauma and survival. Fleeing Poland as a child, dodging bullets and bombs, he experienced fear, hunger, and deep mistrust in the world. By age six, he was already wondering, "There must be a way people can live in harmony." That question became the compass of his life. As Erasmus grew, so did his search for answers. He studied science, biology, psychology, and medicine, only to find these disciplines offered fragmented insights—not the holistic understanding he craved. Psychology taught thoughts and...
info_outline
289: Reclaiming Your Power In Perimenopause - with Chemaine Linnie
BIOptimizers - Awesome Health Podcast
Perimenopause is a significant transition for many women, bringing with it a series of hormonal and physical challenges, including often-unexplained weight gain, particularly around the midsection. Health expert Chemaine Linnie, a certified hormone specialist and fitness coach, offers valuable insights from her own 165-pound weight loss journey and years of guiding women through this hormonal shift. Rock Bottom to Transformation Chemaine's personal journey began at her lowest point as a teenage mother in Dublin, weighing 280 pounds. A pivotal moment—her sister cutting her out of a...
info_outline
288: Heal Fascia, Recharge Your Energy - with Cathy Goldstein
BIOptimizers - Awesome Health Podcast
In the wellness world, many chase surface-level fixes, like creams, cleanses, and crash diets, while ignoring the internal systems that actually drive energy, detoxification, and glow. Cathy Goldstein, a holistic practitioner with over 40 years of experience, sees the body differently. She believes the real fix lies in supporting two overlooked systems: fascia and lymph. Cathy describes most people as walking around with a “traffic jam of toxins.” This buildup in the fascia and lymphatic system can lead to puffiness, swelling, fatigue, dull skin, and even emotional heaviness. Fascia is...
info_outlineChris Mirabile's journey to achieving a biological age 13.6 years younger than his chronological age is not a tale of luck but of deliberate action and deep scientific understanding. His transformation extends beyond mere youthful appearance. He’s aging 31% slower than average.
This remarkable feat is rooted in intense self-education and a disciplined lifestyle geared towards optimizing health at a molecular level. His story began at 16, when a severe seizure led to the discovery and surgical removal of a brain tumor. This life-altering event shifted his focus from basic fitness to a profound understanding of human biology and aging.
A Scientific Awakening
Chris transitioned from merely wanting to look fit to optimizing his long-term well-being. Utilizing academic databases like PubMed, he educated himself on the science of aging and its biological processes. The "Hallmarks of Aging" paper was a turning point, revealing aging not as inevitable, but as a series of manageable biological processes. This realization drove him to a proactive approach to health, aiming to manage and slow aging.
Targeting the 12 Aging Mechanisms
Today, Chris's lifestyle and biotechnology company NOVOS are structured around the 12 mechanisms that drive aging. Here’s a quick look at how he addresses each:
- Mitochondrial Dysfunction: Enhanced through exercise and specific nutrients.
- Cellular Senescence: Reduced via supplements and fasting.
- Loss of Proteostasis: Improved by autophagy-activating practices.
- Intercellular Communication: Maintained by limiting inflammation.
- Genomic Instability: Addressed with hormetic stress like cold exposure.
- Epigenetic Alterations: Supported with lifestyle changes.
- Telomere Shortening: Minimized with diet and recovery.
- Deregulated Nutrient Sensing: Balanced through feeding/fasting cycles.
- Stem Cell Exhaustion: Preserved with low-inflammation living.
- Inflammaging: Reduced with anti-inflammatory strategies.
- Disabled Autophagy: Enhanced by intermittent fasting and polyphenols.
- Gut Dysbiosis: Improved through diet diversity and probiotics.
By targeting these mechanisms, Chris actively works to slow and even reverse biological aging.
Lifestyle as Medicine
For Chris, lifestyle is the foundation of health optimization. His daily routine reflects the principles he has gleaned from his research. His diet follows a Mediterranean model, emphasizing whole plants, healthy fats, and moderate protein. He integrates periodic fasting to optimize longevity pathways. His exercise regimen is multifaceted, combining resistance training four times a week, cardio three times a week, and daily walking. Sleep is prioritized, with seven to nine hours tracked via the Oura Ring. Stress management is crucial, as well as incorporating journaling, meditation, and reframing challenges as opportunities for growth. He also utilizes specific supplements, such as NOVOS Core, developed from biotech research to support the hallmarks of aging.
NOVOS: Measuring and Managing Aging
NOVOS embodies Chris's belief in the scientific manageability of aging. The company offers precise formulations like NOVOS Core, which has shown lifespan extension in animal studies, and biological age testing via epigenetic analysis. The NOVOS Life app provides digital guidance, using AI to generate personalized longevity plans and estimate biological age, making longevity accessible and manageable.
In this podcast, you'll learn...
- How Chris Mirabile reduced his biological age by 13.6 years and its importance.
- The 12 aging mechanisms Chris targets with NOVOS.
- Practical lifestyle adjustments for longevity, including diet, exercise, and stress management.
- The role of scientific innovation in managing aging.
- How to reframe challenges and use adversity for personal growth.
EPISODE RESOURCES: