IATDMCT annual meeting in Singapore. I’ve got a meeting (I’ve got a feeling)
Eight Drugs a Week Podcast
We gather the two chairs of the upcoming IATDMCT annual meeting in Singapore, Sophie Stocker and Jana Stojanova, plus Cindy Lau, who contribute to the organization of the young scientists’ part of the event to discuss the content, urbi et orbi, of our annual meeting. In this episode we’ll hear about: The journey from an inspiration to the building of a real conference dedicated to creating innovative solutions in therapeutic drug monitoring and clinical toxicology. The keynote lectures, main topics and hosts selected highlights of a scientific program going from biosensors applications...
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IATDMCT annual meeting in Singapore. I’ve got a meeting (I’ve got a feeling)
Eight Drugs a Week Podcast
We gather the two chairs of the upcoming IATDMCT annual meeting in Singapore, Sophie Stocker and Jana Stojanova, plus Cindy Lau, who contribute to the organization of the young scientists’ part of the event to discuss the content, urbi et orbi, of our annual meeting. In this episode we’ll hear about: The journey from an inspiration to the building of a real conference dedicated to creating innovative solutions in therapeutic drug monitoring and clinical toxicology. The keynote lectures, main topics and hosts selected highlights of a scientific program going from biosensors applications...
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Pharmacogenetics: Here, There and Everywhere
Eight Drugs a Week Podcast
Pharmacogenetics now surrounds us and is an efficient tool to prevent disease or to guide drug therapy. By studying polymorphisms in the genes coding for metabolism enzymes and drug transporters, we can have clues to help choose the right drug or adjust drug dosage. Not to mention that pharmacogenetics is the ideal companion for therapeutic drug monitoring for a comprehensive treatment optimization. Treatment failure and adverse drug reactions may, at least partly, be explained with pharmacogenetics and we have never been so close to large-scale implementation of this strategy. In this...
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TDM for beta-lactams in critical care: You know my name (Look up the number)
Eight Drugs a Week Podcast
Given we traditionally only monitored particular antibiotics to spare toxicity, and that beta lactams were widely considered such safe drugs, it was once difficult to imagine this drug class would become important TDM candidates. A bit more than a decade ago we started to see the first reports about augmented renal clearance in critically ill patients, often in situations in which antibiotic treatment was crucial, such as sepsis. TDM of beta lactams in the critical care is now recognised as a valuable tool to ensure adequate drug exposure and optimise therapeutic outcomes for these vulnerable...
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Exploring new frontiers in TDM and toxicology (IATDMCT Banff 2024): Not a second time!
Eight Drugs a Week Podcast
This time, it’s the right time - not a second time, but a unique time - to take the road to Banff, Canada, for the This time, following a very successful virtual edition in 2020, we are very glad to be meeting in person. And what a place to meet! - surrounded by Banff’s mountainous splendour. We are so grateful the congress organizing committee accepted the mission to make the show happen again, and we acknowledge the incredible work they’ve put behind two wonderful congresses. We hope attendees will be inspired by the location, and we are certain it will be a very special IATDMCT...
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Machine learning and AI for individualised therapy: Now and then
Eight Drugs a Week Podcast
There was a time when we performed laborious pharmacokinetic hand calculations to tailor drug dosages and regimens – a practice that can still be useful for those brave enough to perform logarithmic calculator manipulations. These days, we are fortunate to have an increasing number of software tools to help us with the task, however many rely on population pharmacokinetic models typically built with relatively small data sets, and often necessarily representing subpopulations with niche requirements. Tomorrow, our work will no doubt be helped by artificial intelligence and machine learning...
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IATDMCT Young Scientists: When I’m 64!
Eight Drugs a Week Podcast
This episode we're excited to introduce you to the young guns, the bright minds of the Young Scientist Committee of the IATDMCT, who are making waves in this ever-evolving field. Our guests are Lea Wagmann, Hualin Cai, and Sumith Mathew, each bringing their unique perspectives and experiences from Germany, China, and India, respectively. From their early inspirations to their current endeavours, we'll uncover what drives them and the impact they're making on the future of pharmacology and toxicology. We’ll delve into their expectations for the years ahead, exploring the forefront of...
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Got to get microsampling into my life: Got to get you into my life!
Eight Drugs a Week Podcast
This episode is about a fairly recent development in TDM and clinical toxicology that has huge potential, which has actually been used for many decades. It was recently the 50th anniversary of the Guthrie method, where dried blood spots are used to screen inborn errors of metabolism in neonatal infants. Thanks to instrumental developments, dried blood spots, and more generally microsampling approaches, have been increasingly applied to quantify a wide range of drug entities. Although these approaches offer plenty of novel opportunities in our field, they are not without challenges and...
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Back to when it all started: Get back!
Eight Drugs a Week Podcast
The recent congress in Oslo was a huge success. We were very glad to catch up with colleagues and hear about some really excellent science. We also bumped into Steve Wong and Phil Walson, first and third presidents of the IATDMCT, and we were delighted they obliged us with an interview about the origins of the Association. Like with any good origin story, Steve and Phil are true superheroes. Both have held numerous leadership positions in their professions and in professional associations, achieved international cooperation agreements, and advocated nationally and internationally for...
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Personalized Under The Northern Sky! (IATDMCT Oslo 2023): Norwegian Wood
Eight Drugs a Week Podcast
In this bonus episode, we delve into the upcoming that will take place September 24th to 27th in Oslo, Norway . It promises to be an exciting event with varied and highly novel sessions. Joining us today are esteemed IATDMCT scientists and local members of the congress organizing committee: Stein Bergan, Ida Robertson, and Anders Åsberg. We delve into their motivations to host the congress and discuss the inspiration behind the theme: 'Personalized under the Northern Sky.' Our guests elaborate on how they will weave this overarching theme through the whole event. We explore some captivating...
info_outlineThis episode is about the TDM of biologics, a therapeutic class that only really emerged into widespread use about 20 years ago – but that as a class represents a breakthrough for many therapeutic challenges. This area has some differences compared to traditional TDM of small molecules, and although it’s established for some biologics, the role for TDM in the space is, in a sense, still being determined. Florian has consequently titled this episode ‘Tomorrow never knows’ – a great song and a fitting title.
Our guests today are Annick de Vries and Murray Barclay, and both have made important contributions in the space. Once again, our guests coincided on their favourite Beatle – one that we haven’t heard mentioned in previous episodes!
In this episode we hear about:
- the differences between small molecule drugs and biologics, and the implications this has for TDM of the latter
- how disease severity may influence pharmacodynamics, and ultimately how we might ultimately select treatment targets despite challenges in obtaining measurements of disease activity
- anti-drug antibodies and the role of TDM there
- disease dependent clearance and whether concentrations of biologics might possibly be a marker of disease activity
Eight Drugs a Week is supported by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT). The personal views of the hosts and guests do not necessarily reflect the position of the Association.
To join IATDMCT, visit https://www.iatdmct.org/member-join
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About our guests:
Annick de Vries is director of Diagnostic Services at Sanquin in Amsterdam, The Netherlands. Sanquin is a not-for-profit that provides blood products nationwide, but also develop specialized pharmaceutical products and provide diagnostic services. She is the current chair of the IATDMCT Biologics Committee.
Murray Barclay is a clinical pharmacologist and a gastroenterologist at Christchurch Hospital in New Zealand, and a Clinical Professor at the University of Otago. Murray was the previous chair of the Biologics Committee.