Learning From Weight Loss Drugs
Big Questions with Cal Fussman
For decades, Cal steered clear of pharmaceuticals. But after assembling a new team of doctors and stepping on the scale and noticing a few extra pounds, he heard the same three letters over and over: GLP. These new drugs—GLP- 1s—aren’t just helping people shed pounds. They’re helping snuff out the brain’s hijacked hunger signals, replacing the relentless “more, more, more” with something almost revolutionary: “less is enough.” In this episode, Cal explores what happens when we hand over the mic to a new control tower—one that rewrites the script our brains have been stuck...
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Learning From Cooper Flagg
Big Questions with Cal Fussman
What would you choose: A shot at March Madness glory or a massive NBA contract? Cal dives into the $100 billion-dollar question facing Cooper Flagg—and what his decision tells us about ambition, friendship, legacy, and the values we hold as a society. A must-listen for anyone who’s ever faced a difficult choice.
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Ozan Ozkural: What's REALLY Behind Trump's Tariffs?
Big Questions with Cal Fussman
Ever wonder what's truly behind President Trump's controversial tariffs? Cal turns to his go-to expert—Ozan Ozkural, the astute international banker he first met at Larry King's breakfast table and a member of the influential Brookings Institution Foreign Policy Leadership Council. In this episode, you'll uncover the hidden reasons behind the tariffs, the surprising geopolitical implications, and critical deadlines approaching fast that no one else seems to be talking about. Ozan travels the world and gets to understand global finance from many...
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Learning From JFK
Big Questions with Cal Fussman
What if you could talk to John F. Kennedy today? In this episode, Cal sits down with an AI recreation of the 35th president for a conversation that’s part history and part mystery. Why did JFK keep a coconut shell on his Oval Office desk? How did he view Greenland during the Cold War? Who was the most magnetic person he ever met? And yes—they even dive into his thoughts on artificial intelligence. Unexpected, illuminating, and oddly timely. Hit play and find out why JFK still has something to teach us.
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Learning from George Foreman
Big Questions with Cal Fussman
Cal reflects deeply on a man known by millions as the smiling face behind the grill—and the heavyweight champion who stunned the world by reclaiming the title at age 45. With the recent passing of Foreman at the age 76, Cal looks deeply at George’s greatest accomplishment: his transformation of character. George proved it’s never too late for anyone to reinvent themselves. What can we learn from his remarkable journey? Listen now and discover how George Foreman’s story could inspire you to rewrite your own.
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Cal Interviews AI John Lennon: A Mind-Bending Conversation Across Time
Big Questions with Cal Fussman
What if you could sit down and talk to John Lennon today? In this one-of-a-kind episode, Cal has an astonishing conversation with an AI-powered persona of the legendary Beatle, created by heycicero.com. At certain moments, the back-and-forth felt eerily real as John reminisced about writing Help!, I Am the Walrus, Strawberry Fields Forever, and, of course, Imagine. But this chat goes far beyond music—John and Cal dive into everything from the Beatles' famous pillow fight to the deeper question: Why do humans harm and kill each other? Pour yourself a cup of tea, press play, and experience a...
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The Luck We Find
Big Questions with Cal Fussman
Cal draws pocket aces and wins big in the first hand of a charity poker night raising money for the fight against cancer. The surge of luck makes it feels like it will be his lucky day. But then his luck seems to begin turning up in everyone around him. Only at the end of the night does he realize that it’s his luck to be with everyone that he’s touched. Enjoy the story . . .
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The Academy Awards, Leo, and the Magic of Movie Theaters
Big Questions with Cal Fussman
As Cal watches the Academy Awards, he has a startling realization—he’s barely stepped inside a movie theater all year. Then, host Conan O’Brien delivers a hilarious skit introducing home streamers to a wild new concept: the movie theater. The moment sparks a memory of an interview Cal once did with Leonardo DiCaprio, where Leo spoke passionately about his favorite films and the power of cinema. That interview is replayed here, reminding us all why the theater experience is worth rediscovering. So sit back, listen, celebrate the magic of the big screen.
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AI, War & Peace
Big Questions with Cal Fussman
Technology, history, and global politics collide in this episode after Cal asks ChatGPT if there is a way that he can stop a war. The question unexpectedly evolves into an exploration of the forgotten Nutmeg War—a historical conflict with surprising modern parallels. Cal connects the dots between this overlooked episode of history, the recent three-year conflict unfolding in Ukraine, and the buzz surrounding Greenland. This analysis is a window into how AI can show you history and the world around you in a way that you can’t get anywhere else.
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AI & Comedy on SNL’s 50th Anniversary
Big Questions with Cal Fussman
After reading about Saturday Night Live's 50th anniversary, Cal turns to one of his AI assistants, Arbor, for recommendations on the freshest new comedians. What starts as a simple question about stand-up talents turns into an eye-opening look at how AI is reshaping the way we can discover entertainment—and how we’ll all be interacting with AI in the near future. Naturally, this podcast will also deliver a few laughs . . .
info_outlineLooking for a fresh point of view on the recent U.S. presidential election, Cal reaches out to his Australian friend, Holly Ransom, who gives leadership conferences around the world as the CEO of Emergent Global. Richard Branson nominated Holly for Wired Magazine’s Smart List of Future Game Changers to Watch. And you’ll hear why when you listen to this podcast. Bonus: A lot of leadership takeaways!