A Breath Of The Future
Big Questions with Cal Fussman
Cal takes a breath of fresh air after a friend goes through double lung-transplant surgery and comes out with a new life. This story will make anyone with a medical problem wonder about the possibilities of medicine in the age of AI.
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Two Marathons A Day For 12 Days — And A Bold Question About AI
Big Questions with Cal Fussman
What kind of person runs 1,000 kilometers in 12 days – twice? Meet Natalie Dau, a Guinness World Record holder who doesn’t just push the limits of human endurance — she redefines them. Cal dives deep with Natalie to uncover how she uses pain as fuel, movement as a message, and her voice — amplified by AI — to raise money, shift perspectives, and help people live better lives. But beneath the inspiration lies a bigger global question: What happens to a world divided between those who have access to AI – and those who don’t? This is...
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Education, Cheating & AI
Big Questions with Cal Fussman
In times when college students are using artificial intelligence to answer even introductory course questions like: “Briefly introduce yourself and say what you’re hoping to get out of this class?” we really have to wonder about how education is going to adapt to a future where students delegate nearly all their classwork to AI. Cal speaks with James D. Walsh after Walsh’s New York Magazine article revealed a seismic shift that’s redefining the word “cheating” and nudging teachers to think about finding new professions.
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Our AI Evolution
Big Questions with Cal Fussman
In ten years, we’ll create content as fast as we can think it. That’s what the owner of a cutting-edge AI studio told Cal—and something clicked. This wasn’t just about technology. It was about humanity, about carbon merging with code. That’s when Cal decided to document the great unfolding: The evolution of our species as we begin to step into the future with artificial minds. This podcast isn’t exactly Charles Darwin sketching “I think” above the first evolutionary tree before going on the path to write The Origin of The...
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From Paralyzed To Powerful
Big Questions with Cal Fussman
After a devastating rugby injury to his spine seven years ago to this day, Robert Paylor was told he'd never walk again and the best he could hope for would be to one day be able to pick up a slice of pizza. He’s defied every expectation—standing to receive his college diploma and walking today with the help of a walker. In this episode, Robert shares the mindset that rewired his future, and Cal explores how breakthroughs in AI could one day remove the walker entirely. This is more than a comeback story. It’s a masterclass in overcoming adversity, reshaping identity, and pushing past...
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How 2025 Will Shape History Forever
Big Questions with Cal Fussman
A single year can easily get lost in time or echo for centuries. A thought-provoking conversation with Simon Sinek makes Cal take a look back at 1925, 1825, 1725, and 1625 — and forward to wonder if 2025 will be the most transformational year humanity has ever seen. Artificial intelligence is accelerating us forward and making us wonder how we’re going to evolve. At the same time, it brings more value to the human touch and enhances our creativity. This is not the time to turn away from AI with fear, Cal concludes. It’s the time to be curious about how to understand it, regulate it and...
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Learning From Weight Loss Drugs
Big Questions with Cal Fussman
For decades, Cal steered clear of pharmaceuticals. But after assembling a new team of doctors and stepping on the scale and noticing a few extra pounds, he heard the same three letters over and over: GLP. These new drugs—GLP- 1s—aren’t just helping people shed pounds. They’re helping snuff out the brain’s hijacked hunger signals, replacing the relentless “more, more, more” with something almost revolutionary: “less is enough.” In this episode, Cal explores what happens when we hand over the mic to a new control tower—one that rewrites the script our brains have been stuck...
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Learning From Cooper Flagg
Big Questions with Cal Fussman
What would you choose: A shot at March Madness glory or a massive NBA contract? Cal dives into the $100 billion-dollar question facing Cooper Flagg—and what his decision tells us about ambition, friendship, legacy, and the values we hold as a society. A must-listen for anyone who’s ever faced a difficult choice.
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Ozan Ozkural: What's REALLY Behind Trump's Tariffs?
Big Questions with Cal Fussman
Ever wonder what's truly behind President Trump's controversial tariffs? Cal turns to his go-to expert—Ozan Ozkural, the astute international banker he first met at Larry King's breakfast table and a member of the influential Brookings Institution Foreign Policy Leadership Council. In this episode, you'll uncover the hidden reasons behind the tariffs, the surprising geopolitical implications, and critical deadlines approaching fast that no one else seems to be talking about. Ozan travels the world and gets to understand global finance from many...
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Learning From JFK
Big Questions with Cal Fussman
What if you could talk to John F. Kennedy today? In this episode, Cal sits down with an AI recreation of the 35th president for a conversation that’s part history and part mystery. Why did JFK keep a coconut shell on his Oval Office desk? How did he view Greenland during the Cold War? Who was the most magnetic person he ever met? And yes—they even dive into his thoughts on artificial intelligence. Unexpected, illuminating, and oddly timely. Hit play and find out why JFK still has something to teach us.
info_outlineAs we approach the fifth anniversary of Kobe Bryant’s passing, Cal dives deep into a fascinating discussion with Claude AI about the relentless spirit of competition that defined the NBA great. But the conversation takes an unexpected turn when Cal asks Claude if it competes with ChatGPT and other AI models. Join this thought- provoking journey as Cal uncovers lessons about the two sides to competition and simultaneously learns how to ask AI better questions to unlock its potential.