How the Patient Perspective Led to a Hemophilia Medical Breakthrough

Please see https://www.pfi.sr/HYMPAVZI_PI for Full PI.

#HYMPAVZISponsored William S. Somers, Ph.D., was a biotherapeutics research and development leader with more than 30 years of experience across biotechnology and pharmaceutical organizations, including Pfizer.

As a scientist living with hemophilia, Dr. Somers played a key role in driving the patient-centric and purposeful design of HYMPAVZI (marstacimab-hncq). This episode will explore how the patient perspective influenced the scientific journey, with a special focus on Will’s research and why it was personally important for him to bring HYMPAVZI to people with hemophilia.

HYMPAVZI may cause serious side effects, including blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. To learn more about this risk and additional safety information visit HYMPAVZI.com.

This post is directed to a U.S. audience and may not be suitable outside of the U.S. This video is intended to be viewed as it was originally produced in partnership with Pfizer. Remember, this content is for educational purposes only and does not replace discussions with a healthcare provider.

PP-HYM-USA-1267

Show Notes:

For safety information visit: https://labeling.pfizer.com/ShowLabeling.aspx?id=20916&Section=PPI

For information on how to navigate your treatment journey, visit the Shared Decision-making Guide here.

Listen and subscribe where you get your podcasts! #Hemophilia

IMPORTANT SAFETY INFORMATION

Important: Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products or “bypassing agents” (products that help blood clot but work in a different way than HYMPAVZI).

Your healthcare provider may prescribe factor VIII or factor IX medicines or bypassing agents to treat episodes of breakthrough bleeding during your treatment with HYMPAVZI. Carefully follow your healthcare provider’s instructions regarding when to use these medicines and the prescribed dose during your treatment with HYMPAVZI. Do not use additional doses of HYMPAVZI to treat breakthrough bleeds.

Before using HYMPAVZI, tell your healthcare provider about all of your medical conditions, including if you:

• have a planned surgery. Your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery.

• have a severe short-term (acute) illness such as an infection or injury.

• have been told that you have a risk for blood clots.

• are pregnant or plan to become pregnant. HYMPAVZI may harm your unborn baby.

Females who are able to become pregnant:

• Your healthcare provider will do a pregnancy test before you start your treatment with HYMPAVZI.

• Use effective birth control (contraception) during treatment with HYMPAVZI and for at least 2 months after the last dose of HYMPAVZI.

• Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with HYMPAVZI.

• are breastfeeding or plan to breastfeed. It is not known if HYMPAVZI passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

If you inject too much HYMPAVZI, call your healthcare provider or the Poison Help Line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

What are the possible side effects of HYMPAVZI? HYMPAVZI may cause serious side effects, including:

• blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. Blood clots have happened in people using HYMPAVZI. You may have an increased risk of blood clots if you have certain risk factors. Stop using HYMPAVZI and get medical help right away if you develop any of these signs or symptoms of blood clots:

• swelling or pain in your arms or legs

• redness or discoloration in your arms or legs

• shortness of breath

• pain in chest or upper back

• fast heart rate

• cough up blood

• feeling faint

• headache

• numbness in your face

• eye pain or swelling

• trouble seeing
  

• allergic reactions. HYMPAVZI may cause allergic reactions, including rash and itching. Stop using HYMPAVZI and get medical help right away if you develop any of the following symptoms of a severe allergic reaction:

• swelling of your face, lips, mouth, or tongue

• trouble breathing

• wheezing

• dizziness or fainting 

• fast heartbeat or pounding in your chest 

• sweating

The most common side effects of HYMPAVZI include:

• swelling, hardening, redness, bruising, bleeding, and pain at injection site

• headache

• fever

• joint pain 

• diarrhea 

• itching 

• rash 

These are not all the possible side effects of HYMPAVZI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What is HYMPAVZI?

HYMPAVZI is a prescription medicine used regularly to prevent or reduce the frequency of bleeding episodes in adults and children 6 years of age and older with:

• hemophilia A with or without factor VIII inhibitors, or

• hemophilia B with or without factor IX inhibitors.

It is not known if HYMPAVZI is safe and effective in people receiving ongoing Immune Tolerance Induction (ITI). 

It is not known if HYMPAVZI is safe and effective in children younger than 6 years of age.