Uncovering Insights into Cancer and Alzheimer's with Marcus Peter, PhD
Release Date: 05/20/2024
The Art and Science of Bedside Medicine with Brian Garibaldi, MD
Breakthroughs
Brian Garibaldi, MD, the founding director of Northwestern Medicine's new Center for Bedside Medicine, discusses the importance and future of bedside medicine. A renowned pulmonologist and medical educator, Garibaldi addresses how modern technology can integrate with traditional clinical skills to improve diagnosis, deepen patient relationships and reduce physician burnout. He also explains how the new center aims to train the next generation of physicians to understand and embrace the power of the physical examination and the doctor-patient relationship.
info_outline
Rewind: Leading Neuroscience Research to Inform Mental Health Treatment with Sachin Patel, MD, PhD
Breakthroughs
Sachin Patel, MD, PhD, is the chair and Lizzie Gilman Professor of Psychiatry and Behavioral Sciences at Feinberg and diretor of the Stephen M. Stahl Center for Psychiatric Neuroscience. In this episode, he talks about the current mental health crisis in this country, his research and vision for the department. Since this episode was originally released, Patel has in the journal, Cell Reports, which uncovered new insights into the synaptic connections of subgroups of interneurons. These findings may improve the understanding of fear responses and could inform new targeted...
info_outline
Studying T-Cell Therapy for Potential Lung Tissue Repair with Benjamin Singer, MD
Breakthroughs
Viral pneumonia can cause severe lung damage and make recovery long and life-threatening for patients. Current treatments only provide support, not repair, but Northwestern Medicine scientist Benjamin Singer, MD, wants to change that. In this episode, he details a recent discovery from his team that found laboratory-modified T-cells or induced regulatory T-cells (iTregs), can promote lung tissue repair in mice with severe influenza pneumonia. Singer discusses this breakthrough and how it could lead to an effective cellular therapy for patients with severe viral...
info_outline
Rewind: The Role of Dopamine in Habit Formation and Compulsive Behavior with Talia Lerner, PhD
Breakthroughs
We're resharing an episode from October 2022. How are habits – both good and bad – formed in the brain, and what role do habits play in diseases of the brain? These are some of the questions neuroscientist, Talia Lerner, PhD, is investigating in her lab. Her recent study, published in , may change the overall understanding of how habits are formed and could be broken. Since this episode was first recorded in fall 2022, Lerner’s team has published new research looking at sex differences. In a paper in , her team discovered how novel sex-specific mechanisms...
info_outline
Rewind: Exploring Immune Tolerance and Food Allergy Pathways with Stephanie Eisenbarth, MD, PhD
Breakthroughs
Uniting scientists and harnessing the power of the immune system to fight disease is at the heart of the Center for Human Immunobiology (CHI). leads the center, and she is also the in the . Since this episode was first recorded in fall 2022, Eisenbarth's team has launched to study a new treatment for food allergy. She has also brought together more than 150 trainees and faculty through the CHI. Here, she discusses the variety of immunology research taking place within the center and the continued work to discover and translate...
info_outline
A Promising Drug for Alzheimer's Disease with William Klein, PhD, and Richard Silverman, PhD
Breakthroughs
An experimental drug called NU-9 was invented at Northwestern University by Richard Silverman, PhD. It has been approved for clinical trials for the treatment of ALS and found to improves neuron health in animal models of Alzheimer's disease according to a new Northwestern Medicine study published in PNAS. This discovery is giving scientists hope that the drug could be effective in multiple neurodegenerative diseases by addressing the underlying mechanisms of these diseases. Silverman and Northwestern University Alzheimer disease expert, William Klein, PhD, discuss the potential of NU-9...
info_outline
Medical Research Funding at Risk with Rod Passman, MD
Breakthroughs
A Northwestern Medicine clinical trial led by Rod Passman, MD, could improve the way we care for millions of people with atrial fibrillation, but it is facing an unexpected challenge. There has been a pause in federal funding to Northwestern University that could impact this study's progress. While the trial has not been ordered to stop, all National Institutes of Health funding to Northwestern University has been frozen, raising questions about how long this potential life-saving work can go on without a resolution.
info_outline
Improving Cardiac Health through Immune System Precision with Edward Thorp, PhD
Breakthroughs
Each year, more than 800,000 Americans suffer a heart attack and many of those who survive are left with irreversible scarring and the slow progression towards heart failure. In this episode, Edward Thorp, PhD, explains how his team is exploring immune cells that influence the heart’s ability to heal after such injuries. In Thorp’s lab, they are uncovering fundamental molecular mechanisms by which the immune system regulates wound repair, reduces inflammation and regenerates tissue.
info_outline
Can a Single Session Impact Mental Health for Teens? with Jessica Schleider, PhD
Breakthroughs
New evidence shows that a one-time intervention can lead to lasting improvement in the lives of young people struggling with mental health problems. In this episode, Jessica Schleider, PhD, associate professor of Medical Social Sciences, explains how she is using this approach to scale single-session interventions (SSIs) to reach more people in need of mental health services.
info_outline
The Science Behind Sleep Health with Minjee Kim, MD
Breakthroughs
In this episode, Minjee Kim, MD, shares results of recent studies she has conducted to better understand the role of inadequate sleep on long-term metabolic health in pregnant women and middle-aged adults. She also discusses a new AI-based intervention that could bring a better night of sleep to those who need it.
info_outlineFor decades, Marcus Peter, PhD, has drilled into an area of research focused on cell death and the roles of toxic and protective short RNAs, with the goal of developing a novel form of cancer treatment. Now, this same line of research has led Peter’s team to uncover new insights into the cause of Alzheimer's disease. In this episode, Peter explains his pioneering work in investigating RNA interference in diseases and explains how his lab’s latest novel discovery may have relevance to an array of neurodegenerative diseases beyond Alzheimer’s.