The CRISPR Babies
Distillations | Science History Institute
In 2018 news broke that a Chinese scientist, He Jiankui, had used CRISPR to edit human embryos, and twin girls had been born as a result. The story set off an explosive bioethical controversy. As gene editing expert Kiran Musunuru put it, “He Jiankui’s genetic misadventures were the biggest medical story of the century so far.” Both scientists and the public had a lot of questions. What was the unmet medical need that justified the gene editing? Was the science ready for prime time? And, if it was, was He Jiankui the right scientist to do it? Seven years later these questions are far...
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Humans and Monsters: An Interview with Surekha Davies
Distillations | Science History Institute
The fears about genetic engineering were stoked when experiments took off in the 1970s. From lab leaks to disease epidemics to the ability to make “Frankenstein creations,” many of those fears are still with us today. We talk to author Surekha Davies about her latest book, why she thinks of monsters as category breakers and why blurring boundaries can be so terrifying for us, but maybe doesn't have to be. Credits Host: Executive Producer: Producer: Associate Producer: Audio Engineer: Music by Resource List Davies, Surekha. . University of California...
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IVF: An Interview with Robin Marantz
Distillations | Science History Institute
Our producer Rigoberto Hernandez spoke with Robin Marantz, the author of Pandora’s Baby: How the First Test Tube Babies Sparked the Reproductive Revolution. She tells us about the history of IVF, from the first known artificial insemination by donor produced in Philadelphia in the 19th century to the scientific race in the 1960s and 1970s that resulted in the first so-called “test-tube baby.” Credits Host: Executive Producer: Producer: Associate Producer: Audio Engineer: Music by Resource List Henig, Robin Marantz. . Cold Spring Harbor Laboratory...
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Gene Therapy’s Families
Distillations | Science History Institute
When Rebekah and Evan Lockard’s daughter, Naomi, was diagnosed with a devastating ultra-rare genetic disease, they didn’t know where to turn. Then they found Terry Pirovolakis, an IT professional who had made a gene therapy for his son with the same disease. But the process of getting Naomi treated has been an uphill battle, full of financial and logistical obstacles. The Lockard’s story flips the question we’ve been asking all season on its head. Instead of wondering, "if we could do something, should we," we're now asking, "if we can do something that helps patients, should we do it...
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Gene Therapy’s Dark Ages
Distillations | Science History Institute
Gene therapy is based on a simple-sounding, yet deceptively complicated premise: adding or replacing faulty genes to fix medical problems. A compelling idea that came out of breakthroughs in DNA research, the field grew lightning fast. But the death of teenager Jesse Gelsinger after a gene therapy clinical trial left the public and scientists questioning the field’s promise. Why did researchers push ahead with clinical trials despite gene therapy still being in its infancy? What does the Jesse Gelsinger story tell us about the personal risk behind medical breakthroughs? Credits...
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'The Andromeda Strain': An Interview with Luis Campos
Distillations | Science History Institute
Producer Mariel Carr talks to historian of science and former Science History Institute fellow, , about his article “Strains of Andromeda: The Cosmic Potential Hazards of Genetic Engineering." He shares how Michael Crichton’s first novel and the subsequent film influenced the conversation and controversy around recombinant DNA research in the 1970s. Credits Host: Executive Producer: Producer: Associate Producer: Audio Engineer: Music by Resource List . IMDb. Campos, Luis A. "."
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The People vs. Recombinant DNA
Distillations | Science History Institute
In 1976, Harvard University wanted to build a specialized lab for recombinant DNA research. But first, it had to get permission from the city of Cambridge. The resulting city council hearings drew TV stations and captured the attention of the whole country. At the center of the controversy? A wise-talking mayor, a young outspoken molecular biologist, and an important question: in scientific research, how much say should the public have? Credits Host: Executive Producer: Producer: Associate Producer: Audio Engineer: Resource List Cobb, Matthew. New York: Basic...
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Science, Interrupted: Part 2
Distillations | Science History Institute
Genetic engineering breakthroughs in the late 1960s and early 1970s came with a lot of promise—and peril too. Fears about what could happen with recombinant DNA experiments put scientists in the middle of a moral dilemma. Did they have a responsibility to consider how others might use their work? Or was their place simply to be on the lab bench? In this two-part episode, we’ll share the story about the first time scientists stopped and considered the ramifications of their work, with a self-imposed moratorium. And we’ll explore all the controversy that led to the historic pivotal...
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Science, Interrupted: Part 1
Distillations | Science History Institute
Genetic engineering breakthroughs in the late 1960s and early 1970s came with a lot of promise—and peril too. Fears about what could happen with recombinant DNA experiments put scientists in the middle of a moral dilemma. Did they have a responsibility to consider how others might use their work? Or was their place simply to be on the lab bench? In this two-part episode, we’ll share the story about the first time scientists stopped and considered the ramifications of their work, with a self-imposed moratorium. And we’ll explore all the controversy that led to the historic pivotal...
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New Season Trailer! Coming August 5th.
Distillations | Science History Institute
Check out our new season, dropping weekly on Tuesdays, starting August 5th.
info_outlineCertain medical instruments have built-in methods of correcting for race. They’re based on the premise that Black bodies are inherently different from White bodies. The tool that measures kidney function, for example, underestimates how severe some Black patients’ kidney disease is, and prevents them from getting transplants. Medical students and doctors have been trying to do away with race correction tools once and for all. And they’re starting to see some success.
About Innate: How Science Invented the Myth of Race
“Correcting Race” is Episode 9 of Innate: How Science Invented the Myth of Race, a podcast and magazine project that explores the historical roots and persistent legacies of racism in American science and medicine. Published through Distillations, the Science History Institute’s highly acclaimed digital content platform, the project examines the scientific origins of support for racist theories, practices, and policies. Innateis made possible in part by the National Endowment for the Humanities: Democracy demands wisdom.
Credits | Resource List | Transcript
Credits
Hosts: Alexis Pedrick and Elisabeth Berry Drago
Senior Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Padmini Raghunath
Audio Engineer: Jonathan Pfeffer
“Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.
Resource List
A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease, by Cynthia Delgado, Mukta Baweja, Deidra C Crews, Nwamaka D Eneanya, Crystal A Gadegbeku, Lesley A Inker, Mallika L Mendu, W Greg Miller, Marva M Moxey-Mims, Glenda V Roberts, Wendy L St Peter, Curtis Warfield, Neil R Powe
A Yearslong Push to Remove Racist Bias From Kidney Testing Gains New Ground, by Theresa Gaffney
‘An entire system is changing’: UW Medicine stops using race-based equation to calculate kidney function, by Shannon Hong
Breathing Race into the Machine: The Surprising Career of the Spirometer from Plantation to Genetics, by Lundy Braun
Expert Panel Recommends Against Use of Race in Assessment of Kidney Function, by Usha Lee McFarling
Hidden in Plain Sight – Reconsidering the Use of Race Correction in Clinical Algorithms, by Darshali A. Vyas, Leo G. Eisenstein, and David S. Jones
Medical student advocates to end racism in medicine, by Anh Nguyen
Precision in GFR Reporting Let’s Stop Playing the Race Card, by Vanessa Grubbs
Reconsidering the Consequences of Using Race to Estimate Kidney Function, by Nwamaka Denise Eneanya, Wei Yang, Peter Philip Reese