Gene Therapy’s Dark Ages
Distillations | Science History Institute
Gene therapy is based on a simple-sounding, yet deceptively complicated premise: adding or replacing faulty genes to fix medical problems. A compelling idea that came out of breakthroughs in DNA research, the field grew lightning fast. But the death of teenager Jesse Gelsinger after a gene therapy clinical trial left the public and scientists questioning the field’s promise. Why did researchers push ahead with clinical trials despite gene therapy still being in its infancy? What does the Jesse Gelsinger story tell us about the personal risk behind medical breakthroughs? Credits...
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'The Andromeda Strain': An Interview with Luis Campos
Distillations | Science History Institute
Producer Mariel Carr talks to historian of science and former Science History Institute fellow, , about his article “Strains of Andromeda: The Cosmic Potential Hazards of Genetic Engineering." He shares how Michael Crichton’s first novel and the subsequent film influenced the conversation and controversy around recombinant DNA research in the 1970s. Credits Host: Executive Producer: Producer: Associate Producer: Audio Engineer: Music by Resource List . IMDb. Campos, Luis A. "."
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The People vs. Recombinant DNA
Distillations | Science History Institute
In 1976, Harvard University wanted to build a specialized lab for recombinant DNA research. But first, it had to get permission from the city of Cambridge. The resulting city council hearings drew TV stations and captured the attention of the whole country. At the center of the controversy? A wise-talking mayor, a young outspoken molecular biologist, and an important question: in scientific research, how much say should the public have? Credits Host: Executive Producer: Producer: Associate Producer: Audio Engineer: Resource List Cobb, Matthew. New York: Basic...
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Science, Interrupted: Part 2
Distillations | Science History Institute
Genetic engineering breakthroughs in the late 1960s and early 1970s came with a lot of promise—and peril too. Fears about what could happen with recombinant DNA experiments put scientists in the middle of a moral dilemma. Did they have a responsibility to consider how others might use their work? Or was their place simply to be on the lab bench? In this two-part episode, we’ll share the story about the first time scientists stopped and considered the ramifications of their work, with a self-imposed moratorium. And we’ll explore all the controversy that led to the historic pivotal...
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Science, Interrupted: Part 1
Distillations | Science History Institute
Genetic engineering breakthroughs in the late 1960s and early 1970s came with a lot of promise—and peril too. Fears about what could happen with recombinant DNA experiments put scientists in the middle of a moral dilemma. Did they have a responsibility to consider how others might use their work? Or was their place simply to be on the lab bench? In this two-part episode, we’ll share the story about the first time scientists stopped and considered the ramifications of their work, with a self-imposed moratorium. And we’ll explore all the controversy that led to the historic pivotal...
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New Season Trailer! Coming August 5th.
Distillations | Science History Institute
Check out our new season, dropping weekly on Tuesdays, starting August 5th.
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The History of the School Lunch
Distillations | Science History Institute
Feeding kids a healthy lunch every school day is a feat of science and logistics. Molded into shape by nutrition scientists who wanted to optimize children’s health, the school lunch has endured war, economic depression, and even a global pandemic. Some might say it’s all the stronger for it. So how did all these crises shape school lunch? And is there any room to give our rectangle pizzas and frozen chicken patties a little grace? Credits Host: Executive Producer: Producer: Associate Producer: Audio Engineer: Music by . Resource List YouTube video. 1:54. Posted...
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ALS Patients Take on the FDA
Distillations | Science History Institute
ALS is a fatal neurological disease that kills motor neurons. Even though it was first described more than 150 years ago, there is no cure, and the few drugs available only dampen the symptoms or slow the progression by a few months. In recent years new drugs have emerged. However, there is one problem: the life expectancy is just two to five years after diagnosis. This timeline is incompatible with the FDA drug approval process, which takes years and even decades. This has created a tense situation for desperate patients who are demanding the FDA approve unproven drugs. What’s the harm in...
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The Fraud that Transformed Psychiatry
Distillations | Science History Institute
In 1973 a bombshell study appeared in the premier scientific journal Science. It was called “On Being Sane in Insane Places.” Its author, a Stanford psychology professor named David Rosenhan, claimed that by faking their way into psychiatric hospitals, he and eight other pseudo-patients had proven that psychiatrists were unable to diagnose mental illness accurately. Psychiatrists panicked, and, as a result, re-wrote what’s known as “psychiatry’s bible”—the Diagnostic and Statistical Manual of Mental Disorders, or DSM. The study and the subsequent overhaul of the DSM changed...
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Cancer Virus Hunters: An Interview with Gregory J. Morgan
Distillations | Science History Institute
For more than 100 years, biologists who suggested that some cancers may be caused by viruses were the pariahs of genetics. However, they persevered and incrementally built their knowledge, leading to the discovery of retroviruses, the development of a test to diagnose HIV, and the creation of the HPV vaccine. Join us as we interview Gregory J. Morgan about his book Cancer Virus Hunters: A History of Tumor Virology. Credits Host: Senior Producer: Producer: Associate Producer: Audio Engineer: “Color Theme” composed by . Additional music by ...
info_outlineFeeding kids a healthy lunch every school day is a feat of science and logistics. Molded into shape by nutrition scientists who wanted to optimize children’s health, the school lunch has endured war, economic depression, and even a global pandemic. Some might say it’s all the stronger for it. So how did all these crises shape school lunch? And is there any room to give our rectangle pizzas and frozen chicken patties a little grace?
Credits
Host: Alexis Pedrick
Executive Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Sarah Kaplan
Audio Engineer: Jonathan Pfeffer
Music by Blue Dot Sessions.
Resource List
1930s Farmer Talks About the Great Depression and Poverty. YouTube video. 1:54. Posted by Timeless Footage, March 10, 2020.
ABC Evening News. May 14, 1969. Vanderbilt Television News Archive.
CBS News. CBS Evening News. September 4, 1981. Vanderbilt Television News Archive.
CBS News. September 25, 1981. Vanderbilt Television News Archive.
C-SPAN. House Session, Part 1.
Daily School Meals During Coronavirus Closures. YouTube video. 4:59. CBS Sacramento.
Great Depression, Film Archives NYC. YouTube video. 6:46. Posted by Reel America, October 30, 2020.
Hunger in America. CBS News. "Hunger in America: The 1968 CBS Documentary That Shocked America."
Levine, Susan. School Lunch Politics: The Surprising History of America’s Favorite Welfare Program. Princeton, NJ: Princeton University Press, 2008.
Lunch Line. Directed by Michael Graziano and Ernie Park. Uji Films, 2010.
Mitman, Greg. YouTube video. 2:44. Posted January 13, 2023.
Mrs. Croft talks to parents about the need to provide hot lunch to students at a school in Pittsford, Vermont. Critical Past.
NBC News. December 21, 1981. Vanderbilt Television News Archive.
Nixon Addresses Hunger, 1969. YouTube video. 3:02. Posted by AP Archive, November 5, 2015.
Poppendieck, Janet. Free for All: Fixing School Food in America. Berkeley: University of California Press, 2010.
“Ronald Reagan on Big Government: ‘Government is the Problem.’” YouTube video, 0:15.
Ruis, Andrew R. Eating to Learn, Learning to Eat: The Origins of School Lunch in the United States. New Brunswick, NJ: Rutgers University Press, 2017.
“The Twisted History of School Lunch, Part 1.” Pressure Cooker. Podcast audio, 35:17. Hosted by Jane Black and Liz Dunn. Omny Studio, February 6, 2024.