Maternal Obesity and Childhood Cancer
Critically Speaking
In this episode, Therese Markow interviews Dr. Shaina Stacy about her studies on cancer risks in children depending upon the body mass index (BMI) of their mothers before and during pregnancy. Dr. Stacy explains how she obtained a sample of nearly 2 million mother-child pairs in the state of Pennsylvania, the largest sample size ever for such a study. They discuss how children of women with a BMI of over 30 when pregnant had a significantly higher risk of cancers compared to children of lean mothers. This was notable for leukemia in children under 5, especially acute lymphoblastic leukemia...
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Dr. Cheryl Hawkes: Maternal Obesity Harms Fetal Brain Development
Critically Speaking
In this episode, Therese Markow and Dr. Cheryl Hawkes discuss the increasing scientific evidence that maternal obesity affects the developing fetal brain. While many of the effects manifest early, in infant temperament and childhood cognitive (IQ) decrements, other effects do not show up until years later, in adult psychiatric and neurodegenerative problems. The physical bases for these changes in fetal brains are also clearly evidenced in laboratory model systems, such as mice, where the maternal diets can be controlled, and the offspring not only can be given behavioral tests,...
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Dr. Diane Tober: Egg Donation Can Exploit Donors
Critically Speaking
In this episode, Therese Markow and Dr. Diane Tober discuss the global egg donation industry, highlighting its lack of regulations and exploitative nature. Dr. Tober details some of her research on egg donors, revealing severe risks and some life-threatening complications that can affect 10-12% of donors. They discuss how donors are often uninformed about the risks and the pressures faced by donors to donate beyond current guidelines. With compensation varying wildly, there are often financial pressures that donors face, too. Finally, Dr. Tober advocates for standardized informed consent,...
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Kim Mutcherson: Millions of Frozen Embryos!
Critically Speaking
In this episode, Therese Markow and Kim Mutcherson discuss the legal and ethical implications of the increasing number of frozen embryos and the complications of assisted reproductive technologies. With an estimated over 1 million frozen embryos in the United States, this is a complex topic, particularly around state laws, embryo disposition, the financial costs of IVF, and the potential increased regulation and legal challenges moving forward. Key Takeaways: There is no hard data on how many embryos are currently frozen around the world, but there are estimated to be...
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Dr. Chris Beyrer: Cuts to USAID Harm the Health and Prosperity of US Citizens
Critically Speaking
The opinions expressed by Dr. Beyrer are his own and not those of his employer. In this episode, Therese Markow and Dr. Chris Beyrer discuss the importance of USAID, highlighting its role in global health and development, particularly through programs like PEPFAR, which has saved 25 million lives and prevented millions of HIV infections. Dr. Beyrer emphasizes that the economic and security benefits of USAID, whose support amounts to less than 1% of the total US federal budget, have had important benefits at home in the United States. It protects us from infectious diseases like Ebola and...
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Dr. Adam Berinsky: Political Rumors and Misinformation
Critically Speaking
In this episode, Therese Markow and Dr. Adam Berinsky discuss political rumors and misinformation. Dr. Berinsky defines rumors as unsubstantiated claims without evidence, emphasizing their social transmission. He identifies two factors influencing rumor belief: conspiratorial thinking and partisan polarization. Berinsky's research reveals that while some people firmly believe rumors, others are ambivalent and more open to correction. He suggests focusing on these undecided individuals rather than entrenched believers. Berinsky also highlights the role of political leaders in spreading...
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Near Death Experiences
Critically Speaking
In this episode, Therese Markow and Dr. James Alcock discuss what near-death experiences are and the increase in them in recent years due to improvements in medical technology. While near-death experiences (NDEs) have been known about for a long time, we, as a scientific community, are starting to understand more about what they mean for neurological processes. However, despite knowing the science of what is happening, NDEs and how they are experienced are subject to one’s own beliefs, context, and even religious framework. Dr. Alcock and Therese also discuss the relationship between...
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Dr. Deborah Lang: What is Skin Cancer?
Critically Speaking
In this episode, Therese Markow and Dr. Deborah Lang discuss the rise of skin cancer, particularly melanoma, and its causes. Dr. Lang explains that skin cancers are derived from different skin cells: basal cell carcinoma and squamous cell carcinoma, both linked to UV exposure, and melanoma, which can be UV-independent and linked to genetic susceptibility. Dr. Lang emphasizes the importance of early detection and personalized medicine, noting that melanoma can metastasize early. She also highlights the role of genetic mutations in cancer development and the impact of funding cuts on cancer...
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Dr. Anice Lowen: Bird Flu - Should We Worry?
Critically Speaking
In this episode, Therese Markow and Dr. Anice Lowen discuss the bird flu outbreak, highlighting the virus’s spread from birds to dairy cattle and recorded cases of human infection. Dr. Lowen explains the differences between influenza A and influenza B viruses, talks about which type causes pandemics, and what we can do to try to prevent future pandemics from these flu strains. Key Takeaways: An epidemic affects a specific region, a pandemic is global. Only Influenza A viruses can cause pandemics and are often transmitted via birds and mammals. Humans can become...
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Dr. Joshua Weitz: Asymptomatic COVID-19 Spreaders
Critically Speaking
In this episode, Therese Markow and Dr. Joshua Weitz discuss his book "Asymptomatic: The Silent Spread of COVID-19 and the Future of Pandemics" and his work in understanding the risk of COVID spread from as early as spring of 2020. He highlights the double-edged sword of asymptomatic infections, discusses what governments could do to help mitigate at-risk populations, and what we, as individuals, can do to help keep everyone safe. Dr. Weitz criticizes early predictions of COVID-19's disappearance by mid-2020, attributing the error to underestimated infections and behavioral changes. He...
info_outlineIn this episode, Therese Markow and Dr. Adina Wise discuss the complexities of Parkinson’s disease, including its causes, symptoms, and the role of environmental factors, such as air pollution. They discuss who Parkinson’s primarily affects, the genetic factors at play, the higher incidents in specific regions, and the increase in the frequency of Parkinson’s cases. They also talk about the recent advancements including continuous infusion therapy and stress that early detection is crucial, though challenging due to ethical considerations.
Key Takeaways:
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Movement disorders are one of the few areas of medicine where diagnosis continues to rely heavily on careful observation.
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Parkinson’s is a heterogeneous disorder, not a single disease. Every case is a little different with the well-known motor symptoms - such as tremors, stiffness, and slowness, but also equally important non-motor symptoms - like sleep disturbances, mood changes, cognitive impairment, and more.
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Parkinson’s mostly appears in people over the age of 60. For early-onset Parkinson’s (before the age of 50) accounts for about 4-10% of all cases. In these early-onset cases, there tends to be a stronger genetic influence.
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The number one thing you can do to keep your brain healthy right now is regular aerobic exercise.
"Environmental factors, genes, lifestyle - these all may influence whether Parkinson’s manifests. This makes the Parkinson’s genetics quite complicated." — Dr. Adina Wise
Connect with Dr. Adina Wise:
Professional Bio: https://profiles.mountsinai.org/adina-wise
LinkedIn: https://www.linkedin.com/in/adinawise
Instagram: https://www.instagram.com/awise.md/
Connect with Therese:
Website: www.criticallyspeaking.net
Threads: @critically_speaking
Email: [email protected]
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