Libsyn Directory

Patrick Wyman: Lost Worlds

Release Date: 05/05/2026

Dr. Andrew Novick: Antidepressants and Mental Health

Critically Speaking

Have you or someone you loved considered taking antidepressants for mental health, but had concerns? Listen in as Dr. Andrew Novick talks about the research and the science behind these drugs and other options for those struggling with MDD and other mental health concerns. In this episode, Therese Markow and Dr. Andrew Novick discuss major depressive disorder (MDD) and its treatment options. Dr. Novick explains the key characteristics of MDD and discusses some of the many treatment options, which include psychotherapy, particularly cognitive-behavioral therapy, and pharmacological...

Dr. Justin Dubin: Men’s Sexual Health Q&A

Critically Speaking

From testosterone craze headlines to myths about prostate cancer, fertility, and aggression, men are getting a lot of confusing messages about their sexual health. Today, urologist and men’s health expert Dr. Justin Dubin cuts through the noise with science-backed answers to the questions men are often too embarrassed to ask. In this episode, Therese Markow and Dr. Justin Dubin discuss listener questions regarding men’s sexual health. Dr. Dubin explains the nuances of testosterone levels, noting that normal ranges vary and can impact overall health. He highlights the importance of...

Dr. Allison Daminger: Cognitive Labor in the Household: Is it Equal?

Critically Speaking

Do you ever feel exhausted by home life, even when the chores look “even”? This episode uncovers the hidden mental load running beneath every household and reveals how it quietly shapes stress, careers, and relationships. Today, Therese Markow and Dr. Allison Daminger discuss her research on cognitive labor, which reveals gender inequality in household decision-making. Allison interviewed 92 couples, and they discuss the results found between both queer and heterosexual couples throughout the study. These decisions were categorized into 10 domains, ranging from maintenance to...

Elizabeth Scott, Ph.D.: Beware of Narcissists

Critically Speaking

In this episode, Therese Markow and psychologist Dr. Elizabeth Scott discuss narcissism, its clinical definition, and the characteristics of “malignant narcissism”. Dr. Scott explains that narcissism involves patterns of grandiosity, a need for constant admiration, a lack of empathy, high levels of manipulation, and the narcissist’s “kryptonite” - criticism. They view themselves as the victim, never at fault. Despite their arrogance, they are very insecure. Dr. Scott also discusses why treatment is challenging and why therapy often focuses on managing symptoms rather than the deeper...

Dr. Matt Kaeberlein: Frontiers in Aging Research

Critically Speaking

What if the biggest risk factor for cancer, heart disease, and dementia isn’t your genes, diet, or blood pressure but aging itself? Listen in as biogerontologist Dr. Matt Kaeberlein reveals how understanding the biology of aging could add not just years to our lives, but healthy decades, and why your dog might hold some of the most important clues. In this episode, Therese Markow and Dr. Matt Kaeberlein discuss aging research. He explains that aging is characterized by damage accumulation and loss of resilience, leading to functional decline. Matt highlights the hallmarks of aging,...

Dr. Carrie McDonough: PFAS Contamination Everywhere

Critically Speaking

Hidden in your water, food, and even your blood, forever chemicals (PFAS) are nearly impossible to destroy - and now U.S. regulations are being rolled back. Listen in to how PFAS became unavoidable, what they’re doing to our health, and whether we can ever truly get rid of them. In this episode, Therese Markow and Dr. Carrie McDonough discuss perfluoroalkyl substances (PFAS), also known as forever chemicals. PFAS, which include PFOA and PFOS, are persistent organic pollutants used in various products, such as Teflon for your cooking pans and Scotchgard. While there are natural...

Dr. Leigh Baxt: The Peptide Craze

Critically Speaking

Peptides are being sold online as miracle fixes for energy, healing, and longevity—but what if the science behind them is shaky, or even dangerous? In this episode, Therese Markow and Dr. Leigh Baxt pull back the curtain on the peptide craze, revealing what we really know (and don’t know) about these heavily marketed “biohacks.” They discuss the complexities and risks of unapproved peptides, which are often marketed for health enhancement. Dr. Baxt explains what peptides are and speaks to those drugs that are FDA-approved, like GLP-1 agonists and insulin, but also...

Dr. Kate Mangino: Unequal Partnerships

Critically Speaking

Dr. Kate Mangino exposes the hidden burden of cognitive and emotional labor at home and explains how “benevolent sexism” and unequal household roles quietly push women to the breaking point. In this episode, Therese Markow and Dr. Kate Mangino discuss gender inequality in household responsibilities. Kate differentiates between structural and social inequalities, noting that societal norms perpetuate these “male” and “female” roles. She also emphasizes the importance of cognitive labor, which often falls on women, and addresses the emotional impact of household tasks on...

Dr. Dan Werb: Animals in the City

Critically Speaking

Our cities are anything but concrete jungles. Listen in as Therese Markow and Dr. Dan Werb reveal the hidden world of synanthropes - the wild animals that not only live alongside us, but thrive because of us. In this episode, Therese Markow and Dr. Dan Werb discuss Dan’s new book “Our Wild Familiars”, which explores how animals (and plants) adapt to urban environments. They dive into the history and impact of synanthropes, such as raccoons, coyotes, and rats. He also highlights the adaptability of these animals and why they have expanded into cities. Dr. Werb emphasizes the importance of...

Dr. Boris Konrad: Increase Your Memory

Critically Speaking

In this episode, Therese Markow and Dr. Boris Konrad discuss the striking impact of memorization on functional changes and connectivity in the brain. Dr. Konrad is a neuroscientist as well as an international Memory Champion. He not only studies brain connectivity, but also trains other memory athletes, as well as those who simply wish to improve their memories. They discuss more specific aspects of memorization and its benefits across a range of other activities and problem-solving, independent of the particular memorization training utilized. Dr. Konrad summarizes his recent study, published...

More Episodes

In this episode, Therese Markow and Patrick Wyman discuss Patrick’s latest book, Lost Worlds: How Humans Tried, Failed, Succeeded, and Built Our World. Patrick also discusses his journey as a historian from studying the Fall of Rome to popular history. He emphasizes the importance of understanding past climactic changes and their impact on human societies, including the development of agriculture and the rise of social hierarchies. Patrick also highlights the significance of migration and the diverse burial practices that reveal aspects of ancient societies’ beliefs and social structures.

Key Takeaways:

Human history is not stable, and it always starts with the climate. Climate and environment are the unavoidable parameters within which everyone is living, and, whether people are aware of them or not, they are responding to the pressures and shifts that are happening climatically around them.
Abandonment of sites and cities happens over time and often for a variety of reasons that are always specific to the climate systems and problems of that particular area.
Modern science, like ancient DNA extraction, now allows us to learn more about dynamics in ancient periods that we never could have seen before.
Funerary practices vary across the world in ancient times, as they do in modern times. Often, it is based on one of two poles: when people die, are their spirits potentially dangerous (ghost society) or potentially beneficial (ancestor society)?
Every single one of the billions of people who lived was living a life that was full, rich, sophisticated, and complex.
As humans, we have been through big, crazy stuff, and yet we are still here and still thriving. Humanity is incredibly durable, and we can make it through some really, really bad times if we work hard and work together.

"Migration is humanity's most basic tool for getting out of bad situations and finding better ones. The simplest possible thing you can do if things get bad wherever you're living is to move somewhere else. And this has been our response at every time and on every geographic scale over the course of human existence." — Patrick Wyman

Episode References: