The Hidden Heart Benefits of GLP-1s (with Dr. Ralph DeFronzo)
The Holistic GLP-1 Podcast with Elizabeth McGann
Release Date: 06/30/2025
GLP-1 for Severe Obesity, PCOS and Binge Eating Disorder (with Rachael Gullette)
The Holistic GLP-1 Podcast with Elizabeth McGann
If you’ve been hearing about GLP-1 medications and wondering whether they might help you—but you feel nervous, skeptical, or unsure—this episode is a powerful place to begin. In this deeply personal conversation, Elizabeth sits down with GLP-1 advocate and content creator Rachael Gullette, who has lost more than 160 pounds on a GLP-1 medication. Rachael shares what life felt like before treatment, how food noise ruled her inner world, and how discovering that obesity is a disease—not a character flaw—changed everything. This is a raw, hopeful, eye-opening episode about food noise,...
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How to Stop GLP-1's Without Gaining the Weight Back (with Dr. Holly Wyatt)
The Holistic GLP-1 Podcast with Elizabeth McGann
One of the biggest fears women have when starting GLP-1 medications isn’t losing the weight —it’s what happens after. Do I have to stay on this forever? Will I regain the weight if I stop? Is there a right way to transition into maintenance? In this powerful, science-grounded episode, Elizabeth sits down with Dr. Holly Wyatt—endocrinologist, obesity medicine physician, and author of Losing the Weight Loss Meds—to explore what actually helps people keep weight off long-term, with or without medication. This conversation bridges medical science with real-world behavior change, mindset,...
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Holistic GLP-1 Success Story: 140 lbs Down, The Breakthrough (with Shelley Carling)
The Holistic GLP-1 Podcast with Elizabeth McGann
In this deeply personal and inspiring episode, Elizabeth sits down with her dear friend, former co-host, and creative collaborator Shelley Carling for a raw, honest conversation about what actually creates lasting weight release. Shelley shares her remarkable journey of releasing 140 pounds—not through willpower or dieting, but through medical support, low-dose GLP-1s, bariatric surgery, emotional healing, mindset shifts and a truly holistic approach to change. This is not just a weight-loss story. It’s a freedom story about identity, self-trust, healing emotional eating, releasing shame...
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9 GLP-1 Truths I Wish I’d Known Sooner (From a 52-Year-Old Nutritionist)
The Holistic GLP-1 Podcast with Elizabeth McGann
If you've been doing everything “right” and your body still feels stuck…This episode is for you. Low energy. Weight that won’t budge. Bloating, joint pain, inflammation. Food noise that feels louder than ever. That was me too. I’m a 52-year-old holistic nutritionist & Life Coach—and I was deeply skeptical of GLP-1s. The side effects? Muscle loss? Ozempic-face? Dependence? Hard pass. But then something kept happening. More than a few of my forward-thinking clients quietly shared the same story. They were microdosing GLP-1s with progressive doctors — and their bodies were...
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Rethinking GLP-1's for Inflammation, Thyroid and Hormone Health (with McCall McPherson)
The Holistic GLP-1 Podcast with Elizabeth McGann
In this episode of The Holistic GLP-1 Podcast, Elizabeth sits down with McCall McPherson, PA—founder of Modern Thyroid Clinic and Modern Weight Loss—for a conversation that completely reframes what GLP-1 therapies actually do for the body. McCall explains why GLP-1s may be one of the most important medical breakthroughs of our time—not simply because of weight loss, but because of their powerful impact on inflammation, metabolism, hormones, chronic disease and even longevity. Together, they explore how GLP-1s affect thyroid health, insulin and leptin resistance, cardiovascular risk,...
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GLP-1 Side Effects Aren’t Inevitable: How to Avoid Them (with Dr. Matthea Rentea)
The Holistic GLP-1 Podcast with Elizabeth McGann
What if I told you that the side effects of nausea, constipation, muscle loss AND burnout on GLP-1s are not inevitable? That in many cases, they’re simply a sign the medication is being used the wrong way? In this week’s episode of The Holistic GLP-1 Podcast, I sit down with Dr. Matthea Rentea—a double board-certified obesity medicine physician who is quietly revolutionizing how GLP-1s are used in clinical practice. This is one of the most nuanced, compassionate and empowering conversations we’ve had about how using GLP-1 medications can be part of a true healing journey—not a...
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Stop Plateauing on GLP-1s: The Metabolic Reset (with Dr. Dean Jones)
The Holistic GLP-1 Podcast with Elizabeth McGann
Why is it that nearly every woman hitting a GLP-1 weight-loss plateau thinks she needs more medication? And what if the real solution is actually… more metabolic health? I hear this all the time when I’m coaching clients inside our Finally F**king Free program. And the truth is—your body isn’t failing you. It’s signaling it needs deeper support. That’s why I brought on today’s guest, Dr. Dean Jones. He’s a holistic obesity specialist who understands metabolic repair because he’s lived this journey himself. And what I love is how aligned his...
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Eat Like a GLP-1 Super Responder (with Erin Palinski-Wade)
The Holistic GLP-1 Podcast with Elizabeth McGann
Welcome back to The Holistic GLP-1 Podcast— where we elevate your GLP-1 journey and your whole life: body, mind, and soul. One question I get asked constantly when I start working with a new client in our practice is: 'Why am I doing everything right but still not seeing results?'—If you’re feeling stuck, I want you to know you are not broken. There’s just some things you need to learn. And that’s why I brought on our guest today Erin Palinski-Wade —she’s a serious badass - a powerhouse registered dietitian, certified diabetes specialist (this women understand blood sugar...
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The Future of GLP-1: Retatrutide, Revita & Rejuva (with David Knapp)
The Holistic GLP-1 Podcast with Elizabeth McGann
Sometimes the breakthrough isn’t in doing more — it’s in letting go. In this week’s episode of The Holistic GLP-1 Podcast, we sit down with David Knapp, creator of On The Pen and author of Decoding GLP-1 — two of the most influential sources of news, science and soul in the GLP-1 conversation. Together, we explore: ● What’s coming next — from gene-therapy-based weight loss drugs to Retatrutide, the most powerful GLP-1 yet; ● the evolving FDA position on compounding and access ● David’s inspiring personal journey — how giving up alcohol reignited his...
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How GLP-1s Transform Obesity into a Treatable Disease (with Kim Carlos)
The Holistic GLP-1 Podcast with Elizabeth McGann
In one of the most emotionally raw and empowering conversations yet, we sit down with Kim Carlos—host of the award-winning Plus Sidez Podcast— for an unforgettable deep dive into how GLP-1 medications are changing the way the world understands obesity. Kim’s journey began with a lifetime of diets, shame and self-blame, until a single prescription flipped the switch. The “food noise” that had dominated her thoughts since childhood finally went silent. What followed was nothing short of transformational: 110 pounds lost, mental clarity restored, and a mission to educate millions...
info_outlineIn this breakthrough episode, Dr. Ralph DeFronzo—one of the most respected names in metabolic health—joins Elizabeth to discuss the real story behind GLP-1 medications.
If you’ve ever wondered:
Do I have to stay on GLP-1s forever?
Are lower doses (or “microdoses”) actually effective?
Can I activate GLP-1 naturally—without prescriptions?
Is it really safe for long-term use?
…this episode gives you honest answers, straight from an expert who helped define modern diabetes treatment.
Dr. D explains how GLP-1s not only facilitate weight loss by reducing one’s appetite, but also protect your heart, liver, brain and kidneys—and why most people overlook this crucial benefit. You’ll learn what makes someone a “super responder,” the link between cortisol and weight loss resistance, and how to finally quiet “Food Noise” for good. ✨
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CLICK HERE TO GET ==> FREE "Freedom From Food Noise" Masterclass:
https://go.elizabethmcgann.com/start
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SHOW NOTES:
[ 00:00 ] Introduction
[ 01:45 ] GLP-1s: Not just for weight loss—they also protect your heart, liver, kidneys & brain
[ 03:40 ] People often forget: GLP-1s were originally created to treat diabetes
[ 07:35 ] Are low doses (aka “microdosing”) effective? DeFronzo’s take on trending wellness practices
[ 10:55 ] Significant benefits of GLP-1s for non-diabetics
[ 13:25 ] How much weight do you really need to lose to help your heart? The 10% threshold explained
[ 15:55 ] “Weighted” Question: Once on them, do you need to be on GLP-1s forever? The real answer from an expert who knows
[ 19:30 ] Why diet and exercise alone don’t work long-term for most people—and what actually does work
[ 22:30 ] Can you “reverse” diabetes or insulin resistance naturally? The symptoms, YES... but it’s complicated!
[ 25:00 ] How GLP-1s reduce inflammation and rewire your metabolism at the cellular level
[ 28:00 ] The truth about “natural” GLP-1 boosters like berberine, fiber and protein
[ 31:00 ] Dr. DeFronzo’s surprising eating habit—and what it reveals about fasting myths
[ 35:00 ] How GLP-1s may help food addiction by rewiring brain circuitry
[ 39:45 ] Insights from four-year safety data: What we do and don’t know about long-term use
[ 42:00 ] Black box warnings and thyroid cancer risk—what’s real and what’s hype?
[ 44:50 ] Can someone taper off of GLP-1s successfully? Who are the 10–15% that do—and how?
[ 49:00 ] Will future GLP-1s render current meds obsolete? Why retatrutide may change the game
[ 56:00 ] Super-responders vs. non-responders—and the cortisol connection you’ve never heard
[ 59:00 ] Why Dr. DeFronzo thinks the next big breakthrough will be insulin-sensitizers
[ 01:02:00 ] Final thoughts: a hopeful but cautionary note about access, cost and a new generation of GLP-1s on the way
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🔗 Mentioned in This Episode:
Learn how to activate GLP-1 naturally and silence cravings!
CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start
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Learn more about Dr. Ralph DeFronzo:
University of Texas Health San Antonio Bio : https://directory.uthscsa.edu/academics/profile/defronzo
Appearance on Dr. Peter Attia’s THE DRIVE Podcast: https://www.youtube.com/watch?v=vYQaLV3Fm00
Dr. DeFronzo’s Work: Just Google him—you’ll find over 900 scientific publications!