Next-Gen GLP-1 Stack: CGM, Peptides & Psilocybin (w/Lauren Sambataro)
The Holistic GLP-1 Podcast with Elizabeth McGann
Release Date: 08/25/2025
GLP-1 for Severe Obesity, PCOS and Binge Eating Disorder (with Rachael Gullette)
The Holistic GLP-1 Podcast with Elizabeth McGann
If you’ve been hearing about GLP-1 medications and wondering whether they might help you—but you feel nervous, skeptical, or unsure—this episode is a powerful place to begin. In this deeply personal conversation, Elizabeth sits down with GLP-1 advocate and content creator Rachael Gullette, who has lost more than 160 pounds on a GLP-1 medication. Rachael shares what life felt like before treatment, how food noise ruled her inner world, and how discovering that obesity is a disease—not a character flaw—changed everything. This is a raw, hopeful, eye-opening episode about food noise,...
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How to Stop GLP-1's Without Gaining the Weight Back (with Dr. Holly Wyatt)
The Holistic GLP-1 Podcast with Elizabeth McGann
One of the biggest fears women have when starting GLP-1 medications isn’t losing the weight —it’s what happens after. Do I have to stay on this forever? Will I regain the weight if I stop? Is there a right way to transition into maintenance? In this powerful, science-grounded episode, Elizabeth sits down with Dr. Holly Wyatt—endocrinologist, obesity medicine physician, and author of Losing the Weight Loss Meds—to explore what actually helps people keep weight off long-term, with or without medication. This conversation bridges medical science with real-world behavior change, mindset,...
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Holistic GLP-1 Success Story: 140 lbs Down, The Breakthrough (with Shelley Carling)
The Holistic GLP-1 Podcast with Elizabeth McGann
In this deeply personal and inspiring episode, Elizabeth sits down with her dear friend, former co-host, and creative collaborator Shelley Carling for a raw, honest conversation about what actually creates lasting weight release. Shelley shares her remarkable journey of releasing 140 pounds—not through willpower or dieting, but through medical support, low-dose GLP-1s, bariatric surgery, emotional healing, mindset shifts and a truly holistic approach to change. This is not just a weight-loss story. It’s a freedom story about identity, self-trust, healing emotional eating, releasing shame...
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9 GLP-1 Truths I Wish I’d Known Sooner (From a 52-Year-Old Nutritionist)
The Holistic GLP-1 Podcast with Elizabeth McGann
If you've been doing everything “right” and your body still feels stuck…This episode is for you. Low energy. Weight that won’t budge. Bloating, joint pain, inflammation. Food noise that feels louder than ever. That was me too. I’m a 52-year-old holistic nutritionist & Life Coach—and I was deeply skeptical of GLP-1s. The side effects? Muscle loss? Ozempic-face? Dependence? Hard pass. But then something kept happening. More than a few of my forward-thinking clients quietly shared the same story. They were microdosing GLP-1s with progressive doctors — and their bodies were...
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Rethinking GLP-1's for Inflammation, Thyroid and Hormone Health (with McCall McPherson)
The Holistic GLP-1 Podcast with Elizabeth McGann
In this episode of The Holistic GLP-1 Podcast, Elizabeth sits down with McCall McPherson, PA—founder of Modern Thyroid Clinic and Modern Weight Loss—for a conversation that completely reframes what GLP-1 therapies actually do for the body. McCall explains why GLP-1s may be one of the most important medical breakthroughs of our time—not simply because of weight loss, but because of their powerful impact on inflammation, metabolism, hormones, chronic disease and even longevity. Together, they explore how GLP-1s affect thyroid health, insulin and leptin resistance, cardiovascular risk,...
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GLP-1 Side Effects Aren’t Inevitable: How to Avoid Them (with Dr. Matthea Rentea)
The Holistic GLP-1 Podcast with Elizabeth McGann
What if I told you that the side effects of nausea, constipation, muscle loss AND burnout on GLP-1s are not inevitable? That in many cases, they’re simply a sign the medication is being used the wrong way? In this week’s episode of The Holistic GLP-1 Podcast, I sit down with Dr. Matthea Rentea—a double board-certified obesity medicine physician who is quietly revolutionizing how GLP-1s are used in clinical practice. This is one of the most nuanced, compassionate and empowering conversations we’ve had about how using GLP-1 medications can be part of a true healing journey—not a...
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Stop Plateauing on GLP-1s: The Metabolic Reset (with Dr. Dean Jones)
The Holistic GLP-1 Podcast with Elizabeth McGann
Why is it that nearly every woman hitting a GLP-1 weight-loss plateau thinks she needs more medication? And what if the real solution is actually… more metabolic health? I hear this all the time when I’m coaching clients inside our Finally F**king Free program. And the truth is—your body isn’t failing you. It’s signaling it needs deeper support. That’s why I brought on today’s guest, Dr. Dean Jones. He’s a holistic obesity specialist who understands metabolic repair because he’s lived this journey himself. And what I love is how aligned his...
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Eat Like a GLP-1 Super Responder (with Erin Palinski-Wade)
The Holistic GLP-1 Podcast with Elizabeth McGann
Welcome back to The Holistic GLP-1 Podcast— where we elevate your GLP-1 journey and your whole life: body, mind, and soul. One question I get asked constantly when I start working with a new client in our practice is: 'Why am I doing everything right but still not seeing results?'—If you’re feeling stuck, I want you to know you are not broken. There’s just some things you need to learn. And that’s why I brought on our guest today Erin Palinski-Wade —she’s a serious badass - a powerhouse registered dietitian, certified diabetes specialist (this women understand blood sugar...
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The Future of GLP-1: Retatrutide, Revita & Rejuva (with David Knapp)
The Holistic GLP-1 Podcast with Elizabeth McGann
Sometimes the breakthrough isn’t in doing more — it’s in letting go. In this week’s episode of The Holistic GLP-1 Podcast, we sit down with David Knapp, creator of On The Pen and author of Decoding GLP-1 — two of the most influential sources of news, science and soul in the GLP-1 conversation. Together, we explore: ● What’s coming next — from gene-therapy-based weight loss drugs to Retatrutide, the most powerful GLP-1 yet; ● the evolving FDA position on compounding and access ● David’s inspiring personal journey — how giving up alcohol reignited his...
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How GLP-1s Transform Obesity into a Treatable Disease (with Kim Carlos)
The Holistic GLP-1 Podcast with Elizabeth McGann
In one of the most emotionally raw and empowering conversations yet, we sit down with Kim Carlos—host of the award-winning Plus Sidez Podcast— for an unforgettable deep dive into how GLP-1 medications are changing the way the world understands obesity. Kim’s journey began with a lifetime of diets, shame and self-blame, until a single prescription flipped the switch. The “food noise” that had dominated her thoughts since childhood finally went silent. What followed was nothing short of transformational: 110 pounds lost, mental clarity restored, and a mission to educate millions...
info_outlineIn today's installment of The Holistic GLP-1 Podcast, we’re celebrating a milestone—Episode # 50—with a very special returning guest, functional health expert and Biohacker Babes co-host Lauren Sambataro.
Some of you may remember Lauren from way back in December 2022, when she joined us for a masterclass on biohacking metabolism with continuous glucose monitors. Almost three years later, she’s back—and this time, we’re going even further…
In today’s episode, we explore the cutting edge of metabolic health: how CGMs can guide a personalized approach to GLP-1s, why microdosing peptides might be the key to long-term success, and how psilocybin and mycology integration can shift not only your biology but your mindset and soulscape. We talk about protein, hormones, emotional eating and the future of biohacking—all with the help of Lauren’s signature clarity and insight.
📌 Whether you're on a GLP-1 journey or just starting to optimize your health, this episode will give you the tools and mindset shifts to move forward with clarity, precision and compassion.
So, take a breath, settle in, and enjoy the show!
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CLICK HERE TO GET ==> FREE "Freedom From Food Noise" Masterclass:
https://go.elizabethmcgann.com/start
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SHOW NOTES:
[ 00:00 ] Introduction
[ 01:55 ] The Bigger Picture of Metabolic Health: How Lauren’s focus has expanded from food to environmental toxins and chronic stress as primary drivers of dysregulation.
[ 06:00 ] Food Noise & Real-Time Data from CGMs: How stress (not just food) impacts blood sugar and how CGMs can help track it.
[ 10:40 ] Toxins, Testing & Metabolic Triggers: From heavy metals to mold exposure, Lauren walks through how to investigate toxin load and when to go deeper with functional testing.
[ 11:56 ] GLP-1s & the Case for Microdosing: Both Elizabeth and Lauren advocate for minimum effective dosing, how CGMs can guide it and why metabolic health should come first.
[ 15:14 ] Why So Many People Plateau on GLP-1s: Lauren explains the flattening effect of GLP-1s on the body’s metabolism, and why the "magic pill" approach can only go so far without habit change.
[ 20:00 ] Weight as a Symptom, Not the Problem: Weight gain is not the issue, but the result of deeper imbalances like stress, toxins and poor recovery.
[ 23:34 ] What a CGM Can Reveal About You: From food sensitivities and stress to sleep and exercise response, CGMs are “lifestyle monitors” that decode your body’s feedback.
[ 29:35 ] A Balanced Take on GLP-1s: Lauren’s nuanced view is a must-hear for anyone weighing the pros and cons of these medications.
[ 31:20 ] Peptide Treatments Beyond GLP-1: Lauren shares her take on the peptide boom, her cautious optimism on where it is going and why lifestyle interventions must come first.
[ 43:42 ] Psilocybin to Treat Emotional Eating? Lauren introduces the concept of mycology integration, how microdosing mushrooms can quiet food noise and rewire emotional triggers.
[ 47:27 ] How to Get Started with Psychedelic Support: Lauren recommends the platform she partners with as a useful way of beginning.
[ 50:32 ] Sub-Perceptual Dosing and Presence: How microdosing can help you slow down, rewire decision patterns and reclaim connection to your body’s innate intelligence.
[ 52:56 ] Spiritual Intelligence & the Soul of Weight Loss: Being fully present is spiritual, Lauren says, and that connection can be the missing key to stainable transformation.
[ 57:22 ] What’s Next for Lauren Sambataro: Lauren reflects on shifting from chronic illness cases to deeper emotional healing, microdosing and slowing down personally.
[ 58:28 ] About the Biohacker Babes Podcast: Lauren and her sister co-host a top-ranked podcast on hormones, energy and functional health. 305 episodes and counting!
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Get Connected with Elizabeth McGann:
Coaching Website: http://www.ElizabethMcGann.com
Instagram: http://www.instagram.com/elizabethmcgann
Facebook: https://www.facebook.com/ElizabethMcGannWellness
LinkedIn: https://www.linkedin.com/in/elizabethmcgann
X/Twitter: https://twitter.com/ElizabethMcGann
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Learn more about Lauren Sambataro
Website: https://laurensambataro.com/
Instagram: @lauren_sambataro