Tau measurements from skin biopsy to distinguish primary taupathies and alpha-synucleinopathies
Release Date: 11/15/2022
Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment
The Brain Podcast
Welcome to the 33rd episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr and senior author Associate Professor of the Brain article entitled: POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population We discuss a complex but important topic examining underlying mechanisms of neurodevelopmental and neuropsychiatric disorders, specifically the regulation of canonical Wnt signalling pathway. The authors...
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Neurotransmitter-informed connectivity maps and predicting stroke functional outcome
The Brain Podcast
Welcome to the 32th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Philipp J Koch of the Brain article entitled: Neurotransmitter-informed connectivity maps and their application for outcome inference after stroke We discuss a fascinating method to map neurotransmitter-informed brain network maps. From here, the authors examine two separate stroke cohorts and examine the degree of lesion-related disruption of these neurotransmitter connectomes. Of note,...
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Do seizures drive the neuropathology of dementia? Insights from a post-mortem study
The Brain Podcast
Welcome to the 31th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Ifrah Zawar of the Brain article entitled: The association of seizure control with neuropathology in dementia We discuss an impressive post-mortem investigation of the link between seizures and the associated neuropathology of dementia. Higher tau and beta-amyloid burden is associated with Alzheimer's disease and also other forms of dementia. Listen as Dr Zawah discusses how seizures may drive...
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Investigating autoimmune mechanisms underlying progressive supranuclear palsy
The Brain Podcast
Welcome to the 30th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Professor of the Brain article entitled: Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy Listen to the fascinating insights exploring the autoimmune side of progressive supranuclear palsy (PSP) following identification of cytotoxic T cells within the mid-brain of PSP post-mortem tissue. The pattern of T cells appears to follow both temporal...
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Can transcriptional analysis detect efficient remyelination in multiple sclerosis?
The Brain Podcast
Welcome to the 29th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author of the Brain article entitled: Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis Check out the full article on the Brain website as part of the June 2025 issue: This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston,...
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Nephrology Meets Neurology: how kidney health links to neurodegeneration
The Brain Podcast
Welcome to the 28th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with three authors of the Brain article entitled: The relationship between kidney health and neurodegenerative diseases , Dr Check out the full article on the Brain website and will be part of the August 2025 issue: This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original...
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Understanding traumatic brain injury with high dimensional proteomic analysis
The Brain Podcast
Welcome to the 27th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr of the Brain article entitled: High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury Listen to the fascinating insights into classifying traumatic brain injury (TBI) using high dimensional proteomic analysis. TBI may start with a head injury but evidence suggests that multiple different underlying pathophysiological pathways can emerge...
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Glymphatic homeostasis in heart failure- more in but not out?
The Brain Podcast
Welcome to the 26th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr of the Brain article entitled: Loss of glymphatic homeostasis in heart failure This academic duo from Lund University discuss their fascinating findings exploring glymphatic homeostasis in a mouse model of heart failure. Counter-intuitively, there may be more influx but not efflux associated with reduced ejection fraction. This has interesting implications on heart failure associated cognitive...
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Adult congenital myasthenic syndromes - discussing the diagnostic dilemma and other findings from a longitudinal cohort
The Brain Podcast
Welcome to the 25th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Tanya Stojkovic of the Brain article entitled: Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis Dr Stojkovic discusses findings from an impressive longitudinal adult cohort of congenital myasthenia syndrome and important issues around accurate diagnosis of congenital myasthenic syndromes and use of electromyography and muscle biopsy. Check out the full...
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Nociceptors are functionally male or female: from mouse to monkey to man?
The Brain Podcast
Welcome to the first episode of 2025 for The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Frank Porreca of the Brain article entitled: Nociceptors are functionally male or female: from mouse to monkey to man? Dr Porreca discusses important findings into the  sexual dimorphic nature of nociception and how it could and indeed should affect clinical trial participant design, precision medicine and need for more sex specific studies to unravel the regulation of pain nociception...
info_outlineWelcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications.
In this episode we chat with Dr Georgia Melli, senior author of the article entitled: Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies
She discusses the use of skin biopsy to quantify pathological tau protein as an accessible and useful clinical tool in the diagnosis of neurodegenerative diseases.
Check out the full article on the Brain website: https://doi.org/10.1093/brain/awac161
This episode was hosted, edited and produced by Xin You Tai; co-hosted by Sarosh Irani; co-produced by Joanne Bell; original music by Ammar Al-Chalabi.