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Mental Health Monthly #7: Urine Toxicology in the ED

Emergency Medical Minute

Release Date: 02/10/2021

Episode 988: Infant Botulism show art Episode 988: Infant Botulism

Emergency Medical Minute

Contributor: Aaron Lessen, MD Educational Pearls: A 2025 multistate outbreak of infant botulism has been linked to ByHeart infant formula As of December 10-17th, there have been at least 51 infants with suspected or confirmed botulism who were exposed to this formula across 19 states All reported cases resulted in hospitalization but no deaths reported to date Infant botulism  Occurs when C. botulinum spores germinate in the infant’s intestine, producing toxin Spores are classically found in honey but can also be in dirt or contaminated in infant formula Infants are...

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Carepoint Journal Club: Trauma Discussion show art Carepoint Journal Club: Trauma Discussion

Emergency Medical Minute

Carepoint Journal Club is a quarterly series with discussions about a medical topic, brought to you by Carepoint's Emergency Physicians.

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Episode 987: Cough Suppressants show art Episode 987: Cough Suppressants

Emergency Medical Minute

Contributor: Meghan Hurley, MD Educational Pearls:  OTC Medications Dextromethorphan (DM) Most common OTC cough suppressant Minimal efficacy: Little evidence that it shortens the duration or severity of cough. Potential side effects: At recommended doses: Mild dizziness, drowsiness, GI symptoms Higher doses: Decreased consciousness, dissociative effects Guaifenesin Found in Mucinex and other severe cough/cold products Thins secretions and loosens mucus in airways No more effective than increasing oral fluid intake Prescription Medications Codeine-containing products ...

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Episode 986: Lateral Canthotomy in Emergency Settings show art Episode 986: Lateral Canthotomy in Emergency Settings

Emergency Medical Minute

Contributor: Taylor Lynch, MD Educational Pearls: What is orbital compartment syndrome, and how is it assessed in the emergency room? Orbital compartment syndrome (OCS) is an emergent ophthalmic condition in which intraorbital pressure in the orbital compartment rises dramatically, compromising perfusion of the optic nerve and retina, leading to risk of irreversible vision loss. OCS occurs in the context of traumatic lesions with retrobulbar hemorrhage. Intraocular pressures (IOP) are measured via tonometry as a surrogate for intraorbital pressures, with emergent pathology being present when...

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Episode 985: Amiodarone vs. Lidocaine show art Episode 985: Amiodarone vs. Lidocaine

Emergency Medical Minute

Contributor: Aaron Lessen, MD Educational Pearls: How do amiodarone and lidocaine work on the heart? Amiodarone Blocks potassium channels (Class III effect). Also blocks sodium and calcium channels. Additional noncompetitive beta-blocker effects. Stabilizes cardiac tissue, slows heart rate, and suppresses both atrial and ventricular arrhythmias. Lidocaine Blocks fast sodium channels in ventricular tissue (Class Ib). Shortens the action potential in ventricular myocardium, especially in ischemic tissue. Suppresses abnormal automaticity in damaged/irritable myocardium. Which one should...

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Episode 984: Fish Hooks show art Episode 984: Fish Hooks

Emergency Medical Minute

Contributor: Megan Hurley, MD Educational Pearls: Assess first: confirm the hook isn’t near vital structures. Automatic subspecialty consult for eye involvement or proximity to carotid artery, radial artery, peritoneum, testicle, or urethra Barbed hook: cannot be pulled back through the entry without disengaging the barb Removal Techniques String-Pull: best for superficial, single-barbed hooks Depress shank and eye of hook to disengage barb and then pull string taut and jerk suddenly along the long axis Can only be used when the hook is in a body part that can be firmly secured so it...

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Episode 983: Head-of-Bed Position in Large Vessel Occlusion Strokes show art Episode 983: Head-of-Bed Position in Large Vessel Occlusion Strokes

Emergency Medical Minute

Contributor: Aaron Lessen MD Educational Pearls:  Recent prospective randomized clinical trial assessed optimal head-of-bed positioning in patients with LVO 0º vs. 30º elevation Objective was to determine superiority of the two angles in stability prior to thrombectomy for LVO patients 45 patients randomized to the group with 0° head positioning and 47 patients randomized to the group with 30° head positioning Patients in the 30º group experienced worsening of NIHSS by 2 points or more Patients with head position at 0° showed score stability Hazard ratio 34.40; 95% CI,...

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Episode 982: Epistaxis Management show art Episode 982: Epistaxis Management

Emergency Medical Minute

Contributor: Meghan Hurley, MD Educational Pearls: 1. Initial Assessment Start with a physical examination: Determine if the bleed is anterior or posterior. Perform a primary survey: assess airway, breathing, and circulation (ABCs). Airway compromise = intubation immediately. If the patient is stable, have them blow out any clots, then re-examine the nares. 2. Topical Medications Anesthetics: provide local anesthesia and pain relief. Lidocaine Tetracaine Vasoconstrictors: reduce bleeding. LET (Lidocaine, Epinephrine, Tetracaine) is ideal because it provides...

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Episode 981: Electrical Burns show art Episode 981: Electrical Burns

Emergency Medical Minute

Contributor: Travis Barlock, MD Educational Pearls: Quick Statistics on Electrical Burns: Electrical burns compose roughly 2 to 9% of all burns that come into emergency departments. The majority of patients who receive electrical burns are male, typically aged 20’s to 30’s, accounting for 80 to 90% of all electrical burn victims. The majority of burns are linked to occupational exposure. The upper extremities are more commonly impacted by electrical burns, accounting for 70 to 90% of entry points into the body during an exposure. What are some of the key considerations in electrical...

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Tox Talks 2025 Recap 1, Digoxin and Beta Blockers show art Tox Talks 2025 Recap 1, Digoxin and Beta Blockers

Emergency Medical Minute

Contributors: Preeya Prakash MD, Adam Greenhaw PharmD, Travis Barlock MD, and Jeffrey Olson MS4 In this episode, cardiologist Preeya Prakash and medical student Jeffrey Olson listen in as two cases are presented from EMM’s recent event, Tox Talk 2025.  Talk 1- Digoxin Overdose Dr. Adam Greenhaw presents a case of a Digoxin overdose along with many pearls. During the studio listen in, Dr. Prakash helps to answer the questions of: How does digoxin work? Why might a patient still be on digoxin in 2025? What are the EKG findings of digoxin toxicity? Is there any utility in atropine...

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More Episodes

This episode of Mental Health Monthly we will be discussing drugs screens in the Emergency Department with Dr. Justin Romano and Eddie Carillo. Dr. Justin Romano is a current psychiatry resident and Eddie Carillo is a licensed mental health therapist. Check out their podcast Millennial Mental Health Channel on all major podcast platforms. Shout out to Dr. Dave Marshall whose grand round presentation this was based on. 

Key Points: 

  • Try not to judge your patient based on the results of their drug screen 
  • Drug screens are used a lot; they are not always accurate 
  • Based on one study there was no significant change in outcome, treatment, disposition or psychiatric course when a drug screen was obtained 
  • Specific good uses for drug screens include new onset of psychiatric symptoms 

Educational Pearls: 

  • 1 in 8 ED visits are due to psychiatric complaints which is up 44% since mid 2000’s 
  • 63% of new psychiatric complaints had a medical cause 
  • Physicians use drug screens commonly in the Emergency Department, but often do not understand their limitations and are often not using them in the most clinically effective manner 
  • Urine is by far the most commonly used in the Emergency Department 
  • UA drug screens are notorious for having false positives and false negatives 
  • Length of clearance from the urine: 
    • Alcohol 12 hours 
    • Methamphetamines/Amphetamines 48 hours 
    • Benzodiazepines 3 days 
    • Opiates 2-3 days 
    • Cocaine 2-4 days 
    • Marijuana dependent on use: 3- 15 days 
    • Phencyclidine (PCP) 8 days 
  • Urine drug screens have a false positive rate of 5-10 % and a false negative rate of 10-15% 
  • False Positive; urine drug screen positive, but drug is not in their body 
    • False positives for amphetamines: bupropion, trazodone, metformin, promethazine, pseudoephedrine, phentermine and atomoxetine 
    • False positives for benzodiazepines: sertraline
    • False positives for cannabis: ibuprofen, naproxen, proton pump inhibitors 
    • False positives for opiates: poppy seeds, antibiotics, Benadryl 
    • False positives for PCP: venlafaxine, ibuprofen and Ambien 
    • False positives for cocaine: amoxicillin 
  • False Negative; urine drug screen negative, but drug is in the body 
    • Benzodiazepines: such as alprazolam, clonazepam, lorazepam or triazolam
    • Cannabinoids: CBD, synthetic marijuana such as K2
    • Opiates: oxycodone, fentanyl, methadone and tramadol 
  • If you get a test that you don’t think is accurate you can always send off for a confirmatory test

References

Summarized by Emily Mack OMSIII | Edited by Mason Tuttle

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