Significance of Regulatory RNA in Protein Production in Specific Genes with Dr. Yuri Maricich CAMP4 Therapeutics TRANSCRIPT
Release Date: 10/31/2025
How AI is Transforming Medical Coding and Impacting Hospital Revenue Cycle Management with Linda Schatz AKASA TRANSCRIPT
Empowered Patient Podcast
Linda Schatz, Director of AKASA, explains the role of Clinical Documentation Integrity (CDI) specialists in ensuring accurate coding and bridging the gap between clinical documentation and specific, accurate codes to ensure proper reimbursement. The complexity of medical coding often leads to errors, which can be nearly eliminated by using AI to review 100% of patient encounters to identify inconsistencies and help CDI and coding professionals process more accurate claims quickly. Accurate documentation is important for hospital revenue, patient care quality, and perception of the hospital's...
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How AI is Transforming Medical Coding and Impacting Hospital Revenue Cycle Management with Linda Schatz AKASA
Empowered Patient Podcast
Linda Schatz, Director of AKASA, explains the role of Clinical Documentation Integrity (CDI) specialists in ensuring accurate coding and bridging the gap between clinical documentation and specific, accurate codes to ensure proper reimbursement. The complexity of medical coding often leads to errors, which can be nearly eliminated by using AI to review 100% of patient encounters to identify inconsistencies and help CDI and coding professionals process more accurate claims quickly. Accurate documentation is important for hospital revenue, patient care quality, and perception of the hospital's...
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Extending Transplant Access with Diagnostics and Living Donors with Tina Liedtky Thermo Fisher Scientific TRANSCRIPT
Empowered Patient Podcast
Tina Liedtky, President of Transplant Diagnostics at Thermo Fisher Scientific, identifies the significant challenges in the US organ transplant system that must be addressed to meet the demand for organs. Patient access to transplant care is hindered by geography, the need to match donors and recipients, and the threat of organ rejection. Living donations, particularly of kidneys and livers, are a solution to address the organ shortage, as organs from living donors often lead to better outcomes and can be scheduled to avoid damage caused by organ transportation. Tina explains, "So first...
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Extending Transplant Access with Diagnostics and Living Donors with Tina Liedtky Thermo Fisher Scientific
Empowered Patient Podcast
Tina Liedtky, President of Transplant Diagnostics at Thermo Fisher Scientific, identifies the significant challenges in the US organ transplant system that must be addressed to meet the demand for organs. Patient access to transplant care is hindered by geography, the need to match donors and recipients, and the threat of organ rejection. Living donations, particularly of kidneys and livers, are a solution to address the organ shortage, as organs from living donors often lead to better outcomes and can be scheduled to avoid damage caused by organ transportation. Tina explains, "So first...
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Using Big Data and AI to Uncover Disease Patterns and Improve Predictive Analytics with Dr. Sev MacLaughlin DeLorean AI TRANSCRIPT
Empowered Patient Podcast
Dr. Sev MacLaughlin, the CEO of DeLorean AI, has developed an AI platform to identify at-risk patients, including those with renal disease, cardiovascular disease, and mental health conditions. Serving smaller and mid-sized provider clinics, this approach supports the shift to value-based care by predicting adverse events, recommending preventive measures, and reducing hospitalizations and healthcare costs. By analyzing entire populations instead of samples, the platform avoids biases and overlooked subgroups inherent in traditional analytical methods. Sev explains, "So I think there's an...
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Using Big Data and AI to Uncover Disease Patterns and Improve Predictive Analytics with Dr. Sev MacLaughlin DeLorean AI
Empowered Patient Podcast
Dr. Sev MacLaughlin, the CEO of DeLorean AI, has developed an AI platform to identify at-risk patients, including those with renal disease, cardiovascular disease, and mental health conditions. Serving smaller and mid-sized provider clinics, this approach supports the shift to value-based care by predicting adverse events, recommending preventive measures, and reducing hospitalizations and healthcare costs. By analyzing entire populations instead of samples, the platform avoids biases and overlooked subgroups inherent in traditional analytical methods. Sev explains, "So I think there's an...
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How Connected Medical Devices are Changing Impact of Remote Patient Monitoring with Antoine Pivron Withings TRANSCRIPT
Empowered Patient Podcast
Antoine Pivron, Vice President of Health Solutions in the B2B division at Withings, highlights the clinical-grade connected devices that are changing the remote patient monitoring market. The equipment and AI-enhanced tools are designed to focus on personalized patient engagement and retention, ultimately leading to improved health outcomes. The data made available identifies trends over time, allowing for intervention when necessary, and is presented in a form that emphasizes prevention rather than reaction. Antoine explains, "We are very well known for our connected devices, especially the...
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How Connected Medical Devices are Changing Impact of Remote Patient Monitoring with Antoine Pivron Withings
Empowered Patient Podcast
Antoine Pivron, Vice President of Health Solutions in the B2B division at Withings, highlights the clinical-grade connected devices that are changing the remote patient monitoring market. The equipment and AI-enhanced tools are designed to focus on personalized patient engagement and retention, ultimately leading to improved health outcomes. The data made available identifies trends over time, allowing for intervention when necessary, and is presented in a form that emphasizes prevention rather than reaction. Antoine explains, "We are very well known for our connected devices, especially the...
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Turning Cold Tumors Hot to Effectively Treat Triple-Negative Breast Cancer with Dr. Jay Lalezari CytoDyn TRANSCRIPT
Empowered Patient Podcast
Dr. Jay Lalezari, CEO of CytoDyn, is focused on solid tumor immunology, particularly in triple-negative breast cancer, where their lead drug, leronlimab, is showing significant long-term survival benefits. This monoclonal antibody targets the CCR5 receptor, converting cold tumors into hot tumors and making them more susceptible to immunotherapy checkpoint inhibitors. Work with leronlimab for 20 years has demonstrated the potential for use in colorectal cancer as well as TNBC, and to vastly expand the patient population that could benefit from immunotherapy. Jay explains, "When I became...
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Turning Cold Tumors Hot to Effectively Treat Triple-Negative Breast Cancer with Dr. Jay Lalezari CytoDyn
Empowered Patient Podcast
Dr. Jay Lalezari, CEO of CytoDyn, is focused on solid tumor immunology, particularly in triple-negative breast cancer, where their lead drug, leronlimab, is showing significant long-term survival benefits. This monoclonal antibody targets the CCR5 receptor, converting cold tumors into hot tumors and making them more susceptible to immunotherapy checkpoint inhibitors. Work with leronlimab for 20 years has demonstrated the potential for use in colorectal cancer as well as TNBC, and to vastly expand the patient population that could benefit from immunotherapy. Jay explains, "When I became...
info_outlineDr. Yuri Maricich, Chief Medical Officer at CAMP4 Therapeutics, describes regulatory RNA, a new area of biology that recognizes the role of Reg RNA in the production of proteins from specific genes. This technology is well-suited for haploinsufficient diseases such as SYNGAP1-related disorders, in which there is a lack of healthy protein and both parents carry a copy of the mutated gene. The goal is to create disease-modifying treatments that correct the underlying genetic cause rather than treating the symptoms.
Yuri explains, "What was really unique about CAMP4's scientific approach is that we're focused on a whole new and emerging area of biology called regulatory RNA. And these are control elements for the expression of genes. In other words, how much protein we get from a particular gene. And there's been a lot of work in the past on how to have less protein made, particularly if it's a protein that has a mutation that causes a problem. But in medicine, there have been very few opportunities to actually increase the amount of protein, but there are many diseases that need more healthy protein."
"The backdrop of CAMP4 is that there was work done just over eight years ago at the Whitehead Institute at the Massachusetts Institute of Technology in a lab by Rick Young, and he was working with a colleague at Boston Children's Hospital, Lenson, and they noticed that there was this group of so-called regRNAs. These were non-coding regions that historically have been really ignored. And as they looked and explored their function further, what they discovered was that, in fact, these regRNA elements play a critical role in controlling how much protein is produced. And so the story of CAMP4 has been to continue to understand and map different cell lines so that we could take a particular target gene and, by using tools or established medicines, for example, like antisense oligonucleotides, we could actually increase the amount of a gene's protein back up to normal."
#CAMP4 #CAMP4Therapeutics #SYNGAP1 #CuresSYNGAP1 #regRNA #RegulatoryRNA
