#095 What Microplastics Are Doing to Your Brain, Body, and Reproductive Systems
Release Date: 09/19/2024
FoundMyFitness
One minute of vigorous exercise may be worth up to ten minutes of “moderate” cardio for extending lifespan and preventing chronic disease. In this Journal Club episode, Rhonda Patrick, PhD and endurance athlete Brady Holmer dissect a new Nature Communications study of more than 70,000 adults showing that vigorous intensity is roughly 4–10x more potent than moderate activity for reducing all-cause mortality, cardiovascular events, type 2 diabetes, and cancer outcomes—far beyond the long-standing 1:2 rule embedded in global exercise guidelines. Timestamps: (00:00) Introduction (07:01)...
info_outlineFoundMyFitness
Chronic insomnia and untreated sleep apnea profoundly accelerate cognitive decline, impair performance, and diminish resilience. In this episode, Dr. Michael Grandner outlines practical, scientifically validated interventions, including CBT-I and stimulus control strategies, to retrain your body for consistently restorative sleep. He provides critical insights into detecting hidden sleep apnea and explains how precise timing of morning light, caffeine, and supplements like melatonin can dramatically enhance sleep quality and daytime performance. Dr. Grandner also shares actionable tips for...
info_outlineFoundMyFitness
When testosterone runs low, libido isn’t the only casualty—muscle mass drops, fat accumulates, insulin resistance rises, and motivation declines. In this episode, Derek from More Plates More Dates highlights common pitfalls that suppress testosterone and evaluates popular testosterone-boosting supplements like Tongkat Ali, boron, and ashwagandha, clarifying what's evidence-based versus overhyped. He also details practical strategies for testosterone replacement therapy (TRT), covering optimal delivery methods, benefits, risks, fertility implications, and key biomarkers to monitor....
info_outlineFoundMyFitness
In this special episode, you'll get an exclusive 30-minute preview of my latest Ask Me Anything (AMA) session, normally reserved for FoundMyFitness Premium Members. Each month, Premium Members join me live to receive direct answers to their most pressing questions on nutrition, supplements, longevity, sleep, fitness—no topic is off-limits. In today's sneak peek, you'll hear why I've started taking exogenous ketones, details about my personal coffee routine (from bean choices to brewing methods), optimal supplement dosages (including ubiquinol, berberine, and vitamin K2), and whether some...
info_outlineFoundMyFitness
Insulin resistance silently shapes the trajectory of nearly every major chronic disease, yet it's often overlooked until blood sugar abnormalities become obvious. In this episode, Dr. Ben Bikman exposes the dietary culprits that drive metabolic dysfunction and highlights actionable, evidence-based tactics for improving metabolic health. Ben also addresses pressing questions about popular weight loss medications like Ozempic and other GLP-1 agonists: Are they groundbreaking solutions, or shortcuts with hidden metabolic consequences? Timestamps: (0:00) Introduction (4:51) Can you be insulin...
info_outlineFoundMyFitness
Coffee is one of the most powerful longevity tools we have, potentially reducing epigenetic age by up to one year in regular coffee drinkers, but its effectiveness hinges entirely on how you brew it. In this episode, I outline precisely how coffee reduces DNA damage, a key driver of cancer and cellular aging, and why choosing filtered coffee over methods like French press significantly lowers cholesterol risk. I’ll discuss exactly which beans and roasts pack the highest antioxidant punch, plus a practical tip on a specific supplement that amplifies coffee’s cognitive benefits. You’ll...
info_outlineFoundMyFitness
Vitamin D is far more than just a vitamin—it's a potent steroid hormone regulating nearly 5% of our genome. Yet, remarkably, up to 70% of Americans aren't getting enough, placing them at increased risk for dementia and Alzheimer's disease. In this episode, I explore compelling new evidence from a study involving over 12,000 participants, demonstrating that vitamin D supplementation can reduce dementia risk by an impressive 40%, protecting even adults with genetic Alzheimer's risk (ApoE4 carriers). Timestamps: (00:00) Can vitamin D supplements reduce dementia risk? (00:46) How common is...
info_outlineFoundMyFitness
Nutrition, supplementation, and recovery are foundational for enhancing exercise performance, but their full potential often remains untapped. In this episode, Dr. Andy Galpin, a renowned expert who has coached Olympians, world champions, and professional athletes across major sports, breaks down exactly how to leverage these critical elements to meaningfully enhance your results. Timestamps: (00:00) Introduction (05:01) Eating to perform vs. eating to live longer—do you have to choose? (08:20) Training fasted—are the mitochondrial benefits worth it? (14:53) What should you eat...
info_outlineFoundMyFitness
Creatine is renowned for enhancing strength, but its benefits extend far beyond muscle power. In this episode, Dr. Darren Candow, a leading researcher with over 140 peer-reviewed publications, explores creatine’s diverse physiological impacts, from bolstering cognitive resilience under stress to mitigating symptoms of depression and protecting against cognitive decline caused by sleep deprivation. He explains why the conventional dosage of 5 grams per day might be insufficient, and how higher doses (10–25 grams) could unlock additional therapeutic effects. Timestamps: (00:00)...
info_outlineFoundMyFitness
For decades, exercise was considered an optional part of cancer care—something beneficial for general health but not essential. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes. With over 600 peer-reviewed studies, Dr. Kerry Courneya's work has fundamentally reshaped our understanding of how structured exercise—whether aerobic, resistance training, or high-intensity intervals—can mitigate treatment side effects, enhance immune function, and...
info_outlineDiscover my premium podcast, The Aliquot
Every week, the average person ingests the equivalent weight of a credit card in plastic.* While certain preventive measures can significantly reduce your intake of these harmful substances, it’s crucial to acknowledge a more daunting concern: the bioaccumulation of microplastics in the brain, potentially at ten times the rate of other organs. Microplastics and their associated chemicals are alarmingly ubiquitous — they permeate breast milk, sperm, the hippocampus, the prefrontal cortex, the air we breathe, medications, the water supply, and our bloodstream, accumulating in most major organ systems. During this episode, we’ll explore the unsettling realities of microplastics and their associated chemicals, diving into how they infiltrate nearly every facet of our environment and body, and discuss actionable strategies to reduce exposure.
Timestamps:
- (00:00) The extent of the problem
- (02:12) Top sources of exposure
- (04:00) Contamination of our water
- (05:04) BPA, phthalates, & PFAS (forever chemicals)
- (07:06) How heating plastic affects BPA exposure
- (09:21) Our unfortunate habit of eating credit cards
- (11:33) Microplastics in major organs
- (14:05) Crossing the blood-brain barrier
- (15:01) How microplastics affect a developing fetus
- (15:55) The bloodstream is a highway for microplastics
- (18:12) Endocrine and hormonal effects
- (23:09) Consequences in pregnant women
- (25:35) How phthalates affect reproductive health
- (26:36) BPA's involvement in autism spectrum disorder
- (29:58) Side effects of prenatal BPA exposure
- (32:18) The brain may be a super-accumulator of plastic
- (34:50) Human brain microplastic levels are rising
- (36:06) Lost fertility in women
- (38:07) Changes in sperm quality
- (39:23) Microplastics in sperm
- (40:59) Why the heart suffers
- (42:51) Microplastics in arterial plaque
- (43:56) How BPA affects blood pressure
- (45:58) Risk of cancer
- (50:31) Topo Chico sparkling water
- (53:02) Reverse osmosis filtration
- (54:56) Food-based strategies for limiting microplastics
- (56:32) The "myth" of BPA-free plastics
- (58:14) Is salt a source of microplastics?
- (59:18) HEPA filters
- (1:00:52) Choose your clothing wisely
- (1:01:47) How to prevent release of microplastics (from laundry)
- (1:02:32) Receipts and thermal paper
- (1:04:17) Microplastic excretion and breakdown
- (1:06:28) Sulforaphane for detoxifying
- (1:08:38) Can dietary fiber increase microplastic excretion?
- (1:10:15) Are plastic chemicals excreted through sweat?
- (1:11:21) Do excretion strategies work for "forever chemicals"?
Show notes are available by clicking here
* Some sources suggesting this figure may need to be revised downward as a result of some disagreement on the math used. However, in spite of this lack of consensus, the human and animal intake of microplastics is substantial and pervasive.