Ozempic, Wegovy, Mounjaro: How They Affect Your Gut
Release Date: 07/22/2025
The Gastro Girl Podcast
Fecal incontinence (FI) affects nearly 8% of adults worldwide, yet many people suffer in silence due to embarrassment, confusion, or the belief that nothing can be done. This episode is here to change that. We’re joined by Dr. John William Blackett, gastroenterologist and lead author of “Fecal Incontinence in Adults: New Therapies,” published in The American Journal of Gastroenterology. Dr. Blackett offers a compassionate, patient-centered overview of FI, including common causes, diagnostic testing, and the full range of treatment options available today—highlighting newer and emerging...
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Living with IBS-C isn’t just about managing physical symptoms, it’s also about navigating the fear, worry, and emotional toll that often come with the condition. In this powerful episode, host Jacqueline Gaulin is joined by Dr. Sarah Ballou, clinical psychologist and Director of the GI Psychology Service at Beth Israel Deaconess Medical Center, to explore how fear shows up along the IBS-C journey and what you can do to face it with confidence and support. In this episode, you’ll learn: The most common fears IBS-C patients experience and how they influence daily life and...
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In this follow-up to one of our most popular episodes, host Jacqueline Gaulin welcomes back Dr. Mark Pimentel, Executive Director of the Medically Associated Science and Technology (MAST) Program at Cedars-Sinai, to dive deeper into the science behind SIBO (Small Intestinal Bacterial Overgrowth) and IMO (Intestinal Methanogen Overgrowth). Dr. Pimentel answers listener questions and explains how these complex conditions relate to IBS-D and IBS-M, why methane and archaea matter for gut health, and how motility and the Migrating Motor Complex (MMC) play a crucial role in prevention and...
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In this inspiring episode of the Gastro Girl Podcast, host Jacqueline Gaulin sits down with Mel, an award-winning dog enthusiast from Valrico, Florida, who has earned more than 40 American Kennel Club titles with her beloved Schnauzers. After life-changing surgery that left her with a permanent colostomy, Mel refused to let fear or stigma hold her back. She shares how she reclaimed her confidence, advocated for her own healthcare, and found strength through her passion for dogs. This episode offers hope and insight for anyone learning to live fully after surgery—and a reminder that...
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Starting a new IBS-C treatment can bring a mix of hope and uncertainty. How soon will it work? What if side effects appear? Should you keep going or call your doctor? Host Jacqueline Gaulin sits down with Dr. Brian Lacy, gastroenterologist at Mayo Clinic in Jacksonville, FL, to answer the real questions patients ask when starting treatment. In this episode, we discuss: • What patients can realistically expect in the first days and weeks of treatment • What “feeling better” truly means for each individual • Common challenges and side effects patients may experience • How to stay...
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Hemorrhoids are one of the most common—and misunderstood—digestive conditions, yet many patients still suffer in silence. In this candid, patient-focused episode, host Jacqueline Gaulin talks with Mitch Guttenplan, MD, FACS, a general surgeon and Medical Director for the CRH O’Regan System, to break the stigma and share clear, evidence-based guidance about hemorrhoids. Dr. Guttenplan explains the difference between internal and external hemorrhoids, how to recognize common symptoms, and which lifestyle changes can help reduce discomfort and prevent recurrence. He also walks through...
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Gravity keeps us grounded—but it also shapes our bodies, minds, and even our gut health in surprising ways. In this fascinating episode, Dr. Brennan Spiegel, Director of Health Services Research at Cedars-Sinai and author of PULL: The Science of Gravity and How It Shapes Our Health and Happiness, joins Jacqueline Gaulin, host of the Gastro Girl Podcast, to explore how gravity influences digestion, mood, metabolism, and mental resilience. Discover what “gravity resilience” means, why astronauts help us understand life on Earth, and how this invisible force could hold the key to living...
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When a child has trouble eating, gaining weight, or explaining discomfort while swallowing, it can be heartbreaking for parents and confusing for the child. These may be early signs of Eosinophilic Esophagitis (EoE) — a chronic inflammatory condition of the esophagus that affects how food moves through the digestive tract. In this episode, pediatric gastroenterologist Dr. Joshua B. Wechsler from Northwestern Medicine shares what families need to know about recognizing EoE early, getting an accurate diagnosis, and navigating treatment options. He also offers guidance on helping children...
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What happens when physicians and advanced practice providers (APPs) truly work as a team in managing inflammatory bowel disease (IBD)? In this episode, we’re joined by Dr. Jennifer Seminerio, Director of Inflammatory Bowel Disease and Associate Professor of Medicine, and Megan Pearce, DNP, APRN, FNP-C, from the AdventHealth IBD Clinic in Orlando, FL. Together, they share how collaborative APP/MD relationships enhance patient trust, streamline care, and support shared decision-making for those living with Crohn’s disease and ulcerative colitis. We’ll explore: How APP/MD teamwork...
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What’s it really like for a child to live with eosinophilic esophagitis (EoE)? In this inspiring episode, we sit down with Jeni and her son Joshua, who share their family’s journey navigating the challenges of pediatric EoE. From the earliest warning signs to Joshua preparing for life at college, their story sheds light on the resilience it takes to manage this condition day-to-day. Together, we explore: Why getting the right diagnosis can take time The pros and cons of today’s treatment options How parents can interpret symptoms when children struggle to describe them Tips for...
info_outlineGLP-1 medications like Ozempic (semaglutide), Wegovy, and Mounjaro (tirzepatide) have transformed treatment for type 2 diabetes and weight loss — but they can also cause digestive side effects like nausea, diarrhea, constipation, bloating, and stomach pain that leave many patients confused or worried.
In this episode, we’re joined by Dr. Catherine Hudson from LSU Health New Orleans to separate fact from fiction and provide clear, evidence-based guidance. Dr. Hudson breaks down:
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How GLP-1 receptor agonists work
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Common digestive side effects—and how to manage them
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Why lifestyle changes still matter
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What you need to know before surgery or GI procedures when taking these medications
Whether you’re a patient, caregiver, or healthcare provider, this episode offers practical insights to help you navigate the GLP-1 journey with confidence.
This episode is presented in collaboration with the American College of Gastroenterology’s Patient Care Committee.