The Cost Curve, Flu, and Other News
Health & Veritas
Howie and Harlan discuss the outlook for U.S. healthcare spending over the next five years, the state of seasonal and avian flu, and an expensive AI-based cardiac test. Show notes: Life expectancy and expenditures ACOs and cost savings World Prematurity Day AI concerns Bird flu Cardiology and AI Free speech and drug promotion Medicare premiums In the Yale School of Management’s , you’ll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's offers a rigorous public health education for working...
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Jerry Avorn: Countering the Drug Marketing Machine
Health & Veritas
Howie and Harlan are joined by Harvard internist Jerry Avorn to discuss his research on the pharmaceutical industry and his work promoting evidence-based prescribing. Harlan highlights new results from the American Heart Association meeting, including a one-time CRISPR-based therapy for high cholesterol; Howie reports on an outbreak of infant botulism. Show notes: Research from the American Heart Association Meeting Jerry Avorn Infant Botulism In the Yale School of Management’s , you’ll get a full MBA education in 22 months while applying new skills to your...
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Ali Rahimi: A Cardiologist in Your Pocket
Health & Veritas
Howie and Harlan are joined by cardiologist Ali Rahimi, the founder of ALYKA Health, which uses a personalized mobile app to help patients manage their heart health between doctor's visits. Harlan discusses new developments in GLP-1 obesity drugs, including untested microdose treatments; Howie reviews a landmark study investigating whether broad prostate cancer screening saves lives. Show notes: GLP-1 Drugs Ali Rahimi New Evidence on Prostate Cancer Screening and Breast Cancer Treatment In the Yale School of Management’s , you’ll get a full MBA education in 22...
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Nate Wood: Cooking Lessons for Better Health
Health & Veritas
Howie and Harlan are joined by Nate Wood, a Yale School of Medicine internist and trained chef, to discuss his work combining lifestyle guidance with hands-on training in making healthy, tasty food. Harlan shares new guidance on what counts as a healthy blood pressure; Howie provides an update on rising health insurance costs. Links: Blood Pressure Obesity Drugs Culinary Medicine Health Insurance Costs .
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Akiko Iwasaki: What Have We Learned About Long COVID?
Health & Veritas
Howie and Harlan are joined by Yale School of Medicine immunologist Akiko Iwasaki, a leading authority on vaccines and long COVID. Harlan reflects on America’s crisis of trust in federal agencies; Howie provides some good news about bird flu. Links: Losing Trust Akiko Iwasaki Bird Flu .
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Rajlakshmi Krishnamurthy: Coordinated Care, Better Care
Health & Veritas
Howie and Harlan are joined by Rajlakshmi Krishnamurthy, the Yale School of Medicine's associate dean for population health, to discuss her work building holistic systems for care at multiple institutions. Harlan discusses healthcare headlines including the launch of "TrumpRX"; Howie reports on a new study taking a novel approach to understanding the impact of the COVID-19 vaccine. Links: Healthcare Headlines Population Health The COVID-19 Vaccine .
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Crowded Emergency Rooms and Other News
Health & Veritas
Howie and Harlan discuss the roots of the crisis in emergency departments, the lack of oversight for hydration spas, new approaches in blood pressure treatment, an ingenious method to prevent malaria, and the CDC’s backward steps on vaccines. Links: Emergency Departments The Revolving Door Hydration Spas New Developments in Blood Pressure Treatment AI in Medicine: Doximity, OpenEvidence, and UpToDate Congenital syphilis MMR Vaccine Nobel Prizes and Science at Yale .
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Vanessa Cooper: The Science of Headaches
Health & Veritas
Howie and Harlan are joined by Vanessa Cooper, a Yale School of Medicine neurologist, to discuss the causes of migraines and promising new treatments for the disorder. Harlan discusses his approach as a journal editor to the use of AI in academic writing; Howie reports on the premium tax credits for insurance purchased through Affordable Care Act exchanges that are at stake in the government shutdown. Links: The Government Shutdown Headaches ACA Tax Credits and the Government Shutdown .
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Kate Heilpern: Jumping into the Deep End
Health & Veritas
Howie and Harlan are joined by Kate Heilpern, president of Yale New Haven Hospital, to discuss the innovation and adaption needed to lead NewYork-Presbyterian Hospital through the worst of the COVID-19 pandemic, and how Yale New Haven Health structures itself to provide quality care across five hospitals. Harlan reflects on the many biotech startups emerging from Yale; Howie responds to the Trump administration's assertion of a link between acetaminophen and autism. Links: Biotech at Yale and Beyond . Kate Heilpern Tylenol and Autism .
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Barry Wu: The Questions to Ask the Elderly
Health & Veritas
Howie and Harlan are joined by Yale School of Medicine geriatrician Barry Wu, who provides a framework for family caregivers and physicians to understand the needs of older adults. Harlan reports on Congress's shifting approach to funding research; Howie reflects on a survey showing that many college students believe that violence is an acceptable way to protest a campus speaker. Links: Congressional Directives on Funding Research Supporting Older Adults Violence and Speech ACA Subsidies .
info_outlineHowie and Harlan are joined by Harvard internist Jerry Avorn to discuss his research on the pharmaceutical industry and his work promoting evidence-based prescribing. Harlan highlights new results from the American Heart Association meeting, including a one-time CRISPR-based therapy for high cholesterol; Howie reports on an outbreak of infant botulism.
Show notes:
Research from the American Heart Association Meeting
“Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3”
“First-in-human trial of CRISPR gene-editing therapy safely lowered cholesterol, triglycerides”
“Cardiac Allograft Vasculopathy Inhibition with Alirocumab: The CAVIAR Trial”
“PCSK9 medication plus statin may help lower cholesterol after heart transplant”
“Investigational daily pill lowered bad cholesterol as much as injectables”
Jerry Avorn
Science Direct: Academic Detailing
Jerry Avorn: Rethinking Medications: Truth, Power, and the Drugs You Take
FDA: Direct-to-Consumer (DTC) Advertisements
H.R.5952 - Prescription Drug User Fee Act of 1992
FDA: FY 2025 FDA Budget Summary
Centers for Medicare & Medicaid Services: Open Payments
H.R.3590 - Patient Protection and Affordable Care Act
“Aducanumab Discontinued as an Alzheimer's Treatment”
Amazon.com: Featured comments on Rethinking Medications
Infant Botulism
California Department of Public Health: Infant Botulism Treatment and Prevention Program
CDC: “Infant Botulism Outbreak Linked to Infant Formula, November 2025”
“ByHeart recalls all baby formula sold nationwide as infant botulism outbreak grows”
California Department of Public Health: What is BabyBIG?
California Department of Public Health: Postponement of BabyBIG Fee Increase
California Department Of Public Health: Invoice and Purchase Agreement for BabyBIG
In the Yale School of Management’s MBA for Executives program, you’ll get a full MBA education in 22 months while applying new skills to your organization in real time.
Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings.
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