Jay Reno — Making A Point (EP.247)
Infinite Loops
My guest on Infinite Loops this week knew he wanted to be an entrepreneur from the time he was buying and selling things on eBay. Jay Reno claims he didn’t know what the word ‘arbitrage’ meant back then, but if you tug on the colourful threads of his career, you’d reveal the kind of tenacity and resourcefulness that allows special founders like him to repeatedly find value in places that have long been deserted by everybody else. If you listen in on today’s episode, it will become apparent why O’Shaughnessy Ventures invested in Jay and his current venture. Jay is the CEO and...
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Michael Garfield — Play the (Mind) Jazz (EP.246)
Infinite Loops
My guest today is Michael Garfield, a paleontologist, futurist, writer, podcast host and strategic advisor whose “mind-jazz” performances — essays, music and fine art — bridge the worlds of art, science and philosophy. This year, Michael received a for his “Humans On the Loop” discussion series, which explores the nature of agency, power, responsibility and wisdom in the age of automation. This whirlwind discussion is impossible to sum up in a couple of sentences (just look at the number of books & articles mentioned!) Ultimately, it is a conversation about a subject...
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Max Meyer Launched a Print Magazine in 2024. Here’s Why. (EP.245)
Infinite Loops
My guest today is Max Meyer, the proprietor of Arena Magazine, a new quarterly publication exploring technology, capitalism and civilization. Arena’s aim? To “make it okay to dream in public again.” Max and I discuss why he launched a print magazine in 2024, WTF happened to legacy media, the wisdom of Ratatouille and MUCH more. I hope you enjoy this conversation as much as I did. For the full transcript, episode takeaways, and bucketloads of other goodies designed to make you go, “Hmm, that’s interesting!”, check out our . Important Links: Show Notes: What is...
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Parmita Mishra — How to Think About Biology (EP.244)
Infinite Loops
Parmita Mishra is a computational biologist and the founder & CEO of Precigenetics, a company aiming to become a rocket to precision medicine. Parmita is deeply knowledgeable about cutting-edge biology, particularly epigenetics — how behavior and environment can affect gene function without altering genetic code. Her passion for advancing our understanding of diseases is inspiring (and contagious: OSV is an investor in Parmita’s company!) In our conversation, Parmita and I discuss everything from the curious case of male baldness to how her parents have saved 50,000 lives. I hope...
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Luis Seco — On Mathematical Beethovens, Decentralized Education & the Voyage to the Human Brain (EP.243)
Infinite Loops
Professor Luis Seco is a mathematician, educator, and investor. Among many other titles and achievements, he is the Professor of Mathematics at the University of Toronto, Director of the quant research hub Risklab, Chair of the Centre for Sustainable Development at the Fields Institute, and co-founder of the asset management firm Sigma Analysis & Management Ltd. Got all that?! This one was really fun, and not just because Luis is a fellow quant. We discuss how maths resembles Beethoven’s Fifth Symphony, the future of the ‘metaversity’, the most important lesson Luis gives his...
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Anthony Pompliano — How to Live an Extraordinary Life (EP.242)
Infinite Loops
Anthony Pompliano — investor, entrepreneur, and media powerhouse — returns four years and 228 episodes later to discuss his new book, , a collection of 65 heartfelt letters to his two children. At just 36, Anthony has already invested in circa 200 companies, served in Iraq with the U.S. Army, built and sold multiple businesses, and created one of the world’s largest independent media platforms. You don’t accomplish all that without learning a thing or two, and in this episode we dig into his hard-earned insights — from the uniting traits of the world’s smartest people, to the...
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Sajith Pai — Exploring Indus Valley (Ep.241)
Infinite Loops
There’s a quote I heard a long time ago that goes something like this - “India has consistently disappointed both the optimists and the pessimists”. It is equal parts pithy and profound, and does a somewhat passable job of summarising the multitudes contained in 21st century India. It’s a quote that was brought to life for me numerous times in my conversation with this week’s guest on Infinite Loops - Sajith Pai. Sajith is a GP at Blume Ventures, one of India’s largest homegrown VC firms. He's known for his prolific writing and sharp frameworks that have become part of Indian...
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Scott Aaronson — Quantumania (EP.240)
Infinite Loops
My guest today is Scott Aaronson, a theoretical computer scientist, OG blogger, and quantum computing maestro. Scott has so many achievements and credentials that listing them here would take longer than recording the episode. Here's a select few: Self-taught programmer at age 11, Cornell computer science student at 15, PhD recipient by 22! Schlumberger Centennial Chair of Computer Science at The University of Texas at Austin. Director of UT Austin's Quantum Information Center. Former visiting researcher on OpenAI's alignment team (2022-2024). Awarded the ACM prize in computing in 2020 and...
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Danny Crichton — Player of Games (EP.239)
Infinite Loops
Danny Crichton is a man of many talents. He’s got a background in computer science, has worked in the worlds of foreign policy, was a managing editor at Techcrunch, and now serves as Head of Editorial at Lux Capital. As Lux’s de-facto games master, Danny also devises their Riskgames: strategic simulations that immerse players in complex scenarios reflecting real-world challenges and dynamics. These games – whose players include senators, major generals, congressmen and, think-tank CEOs – include scenarios like ‘Hamptons at the Cross-Roads’ (that deals with climate change and...
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Yuk Chi Chan — On Rockets, Dog Years & Robotic Space-Snakes (EP.238)
Infinite Loops
My guest today is the human Swiss Army Knife, Yuk Chi Chan, who has packed more into the last decade than many people do in a lifetime. Yuk Chi is the founder of Charter Space, the first British space company to graduate from the Techstars Space Accelerator. Before that, he served as an officer in the Singapore army (hmm, so maybe I should have described him as a Singaporean Army Knife) and practiced as a space lawyer (it’s funny how much cooler being a lawyer becomes when you preface it with the word “space”). Suffice to say, Yuk Chi knows a lot about space. We had a blast discussing...
info_outlineI’ve always tried to encourage curiosity in my three children and now six (!) grandchildren. My kids often reminisce about my default response to their childhood questions: pointing to the bookshelf that flanked our sofa and saying, “look it up in there!”
Luckily, natural curiosity was never lacking in our household. Over the years, however, I have become increasingly frustrated when I hear about the stultifying, rote, curiosity-killing nature of our education system.
It was a pleasure, therefore, to speak to Audrey Wisch, an impressive young founder who, after witnessing first-hand how kids’ curiosity was being crushed, decided to do something about it. She left Stanford University to build Curious Cardinals, a personalized service that matches children with university mentors. What started as a pandemic project has grown into something much bigger - Audrey and her co-founder were named to the 2022 Forbes 30 Under 30 List in education, and Curious Cardinals has now delivered over 20,000 hours of mentorship to over 2,000 kids.
As you’ll hear in our conversation, Audrey’s approach to education is a breath of fresh air, focusing on agency and empowerment, meeting kids where their interests lie, and harnessing the benefits of technology.
I hope you enjoy our conversation! For the full transcript alongside bucketloads of other stuff designed to make you go; “Hmm, that’s interesting!” check out our Substack.
Important Links:
Show Notes:
- The Classroom: Disengaging, Uninspiring and Regurgitating
- The Chicken Nugget Strategy: Learning Through Interests
- Are Attention Spans Shortening?
- Why Mentors Matter
- Rose, Bud, Thorn: How to Design an Effective Mentorship Session
- The Perks of Proximity
- The RBG Approach to Disruption
- Against a One-Size-Fits-All Approach
- Curiosity, Lifelong Learning & Openness to Change
- Shakespeare on Snapchat
- The Changing Role of Memory
- Prompting via Socratic Iteration; Tapping into the Why
- How Audrey Became Interested in AI
- Why the College System Restrains K-12 Progress
- Hiring for the Output vs Hiring for the Input
- Audrey as Empress of the World
- MUCH more!
Books Mentioned:
- The Anxious Generation: How the Great Rewiring of Childhood is Causing an Epidemic of Mental Illness; by Jonathan Haidt
- Paper Belt on Fire: How Renegade Investors Sparked a Revolt Against the University; by Michael Gibson