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Science Under Pressure, Humanity at Stake: An Interview with John Ioannidis

Mad in America: Rethinking Mental Health

Release Date: 09/10/2025

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Mad in America: Rethinking Mental Health

Musician and artist Kev G Mor joins us to discuss his experience of psychosis, his daily support strategies, and the pros and cons of having a hundred-pound pit bull terrier for emotional support. Kev is a suicide survivor who grew up with early childhood trauma and has experienced homelessness as a teen, is a single father, and is now again in recovery. His work is about showing what staying well looks like on hard days and keeping it practical for people who live with psychosis. *** Thank you for being with us to listen to the podcast and read our articles this year. MIA is funded entirely...

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Science Under Pressure, Humanity at Stake: An Interview with John Ioannidis show art Science Under Pressure, Humanity at Stake: An Interview with John Ioannidis

Mad in America: Rethinking Mental Health

John Ioannidis is a Stanford professor, a physician, and one of the most eminent scholars in the world in the field of evidence-based medicine. Ioannidis has spent his career exposing the weak foundations of much of modern medicine. His 2005 paper, "Why Most Published Research Findings Are False," became the  and helped spark a global reckoning with reproducibility. He has since warned about how by industry influence, how in academia favor quantity over quality, and how even . His critiques extend to psychiatry, where , , and . He is a tenured professor at Stanford and has an...

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Talia Weiner is a psychological anthropologist, licensed professional counselor, and assistant professor of psychology at the University of West Georgia. As a medical and psychological anthropologist, her work focuses on the intersection of social-structural forces and how those forces show up in lived experience, particularly in relation to mental health care. Weiner studies these and other topics with students in the Clinical Ethnography Lab within the University of West Georgia’s psychology program. Weiner has an upcoming book titled , scheduled for release Jan. 6, 2026, through NYU...

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Welcome to MIA Radio. Today, we are pleased to have as our guest Jaakko Seikkula. Jaakko is a psychologist who helped develop the Open Dialogue practice at Keropudas Hospital in Tornio, Finland, in the 1990s, and he is the person who  has conducted the research that told of remarkable longer-term outcomes with this form of care. For the past 15 years, he has developed and led training programs that have seen Open Dialogue practices adopted in 40 countries. He recently published a book titled, . In this interview, we discuss how Open Dialogue came to be, the research that shows its...

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John Ioannidis is a Stanford professor, a physician, and one of the most eminent scholars in the world in the field of evidence-based medicine.

Ioannidis has spent his career exposing the weak foundations of much of modern medicine. His 2005 paper, "Why Most Published Research Findings Are False," became the most-viewed article in the history of PLOS Medicine and helped spark a global reckoning with reproducibility. He has since warned about how evidence-based medicine can be hijackedby industry influence, how biased reward systems in academia favor quantity over quality, and how even systematic reviews can recycle flawed data. His critiques extend to psychiatry, where pharma-funded trials often tilt toward positive results, guidelines are shaped by insiders, and neuroscience findings are more fragile than they appear.

He is a tenured professor at Stanford and has an extensive background in medicine, epidemiology, population health, and data sciences. As much as he is a champion of good science, Ioannidis is also a lover of the arts and humanities. He's a novelist, teaches poetry, loves operas, and has written libretti for four operas himself.

In this interview, he discusses the extensive bias that pervades scientific research, the problematic practices and pressures that enable flawed science, and the significant issues with antidepressant research. At the same time, he reminds us why good science is a gift to humanity and something we must protect for our well-being and dignity.

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Thank you for being with us to listen to the podcast and read our articles this year. MIA is funded entirely by reader donations. If you value MIA, please help us continue to survive and grow. https://www.madinamerica.com/donate/

To find the Mad in America podcast on your preferred podcast player, click here: https://pod.link/1212789850

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