Gene Drives: A Sharper Tool for the Malaria Toolkit?
Release Date: 08/13/2024
Johns Hopkins Malaria Minute
In Kwale, Kenya, where bed nets alone can’t stop malaria, researchers are testing ivermectin – a drug long used to treat parasitic infections – as a new way to kill mosquitoes. Trials show a 26% drop in malaria cases and added benefits against other mosquito-borne diseases, suggesting ivermectin could be a scalable, community-driven tool in the fight against insecticide resistance. With Carlos Chaccour (researcher at the Navarra Center for International Development) and Joseph Mwangangi (scientist at KEMRI) About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns...
info_outlineJohns Hopkins Malaria Minute
About The Podcast The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
info_outlineJohns Hopkins Malaria Minute
Focusing on patients in Mali, researchers examine why some children develop life-threatening complications like cerebral malaria or severe malarial anemia. With Mark Travassos (University of Maryland School of Medicine), Mahamadou Ali Thera (University of Science Techniques and Technologies of Bamako), and Rafal Sobota (Northwestern University). About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
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Although severe malaria presents in different clinical forms – such as cerebral malaria or severe malarial anemia – a new study reveals that all severe cases have one thing in common: a shared inflammatory signature Transcript Whilst most cases of malaria are mild, some take a dangerous turn. In severe cases, the malaria parasite can overwhelm the body, disrupting the blood-brain barrier and leading to cerebral malaria, or destroying so many red blood cells that it triggers life-threatening anemia. Now, a new study has taken a closer look at this progression – from uncomplicated malaria...
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Dr. Alexandra Probst discusses a breakthrough in malaria prevention: bed nets coated with anti-parasitic drugs that stop transmission by curing infected mosquitoes. With Alexandra Probst, former graduate student at Harvard University. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
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How next-generation bed nets could stop malaria by killing the parasites inside mosquitoes, not just the mosquitoes themselves. Transcript Bed nets have long been a cornerstone of vector control. Coated with insecticide, they serve a dual purpose: preventing bites and killing mosquitoes. But what if those nets could do more – not only kill the mosquitoes, but for those they don’t kill because of increasing insecticide resistance, at least kill the parasites hidden inside them? Researchers assembled a library of antiparasitic compounds active against the form of the parasite in the mosquito...
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The extent to which malaria vaccines reduce cases and deaths is a key consideration. But there’s another factor, too. with Dr. Lemu Golassa, Head of Medical Parasitology at Addis Ababa University. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
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A recent study in Ethiopia reveals that local malaria parasite strains differ genetically from those targeted by current vaccines, potentially reducing their effectiveness. Transcript The recent introduction of two malaria vaccines in sub-Saharan Africa represents a major success in global health, and the culmination of decades of research and development. The two jabs – RTS,S and R21 – target a protein on the surface of the malaria parasite as it enters the skin, called the circumsporozoite protein, or CSP. The vaccines are based on a specific form of CSP. The challenge is that there are...
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The podcast explores the importance of advocacy for malaria research and control. It follows over 120 advocates gathering in Washington, DC, as part of the ‘United to Beat Malaria’ campaign, urging Congress to continue supporting global malaria efforts. Key topics include: The US President’s Malaria Initiative (PMI), founded in 2005, which provides bed nets, test kits, and treatments to combat malaria The role of global partnerships, including the Global Fund, in distributing resources efficiently. How Uganda’s malaria response is supported by international funding for the...
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With a shortage of entomologists in malaria-endemic regions, could AI fill the gap? We explore VectorCam, an offline tool powered by a Convolutional Neural Network that aims to support local vector surveillance. with Dr. Soumya Acharya and Sunny Patel of Johns Hopkins University. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
info_outlinePeople often talk about the 'malaria toolkit' - how might gene drives fit?
Transcript
When people talk about malaria, they often mention the 'malaria toolkit' – a set of tools, like bed nets and indoor residual spraying, that are available to help curb the spread of disease. In the past, these tools were trusty go-to's – thanks to their efficacy, scalability and cost. Like the antimalarial drugs used to prevent and treat the disease, they’re primarily aimed at protecting individuals. Yet, a new technology called gene drives – which releases and spreads genetically modified mosquitoes that can't transmit the disease – aims to protect whole communities. How might they fit into the toolkit? Dr Damaris Matoka-Muhia of the Kenya Medical Research Institute considers gene drives a potentially sustainable, long-term and cost-effective solution for malaria – especially as resistance dulls other tools. And in Kenya, there are regulations in place to support gene drive implementation. The National Biosafety Authority, already used for GM crops like cotton can be leveraged, ready to roll out this innovation in the future.
Source
How could genetic approaches be integrated in the malaria toolkit?
About The Podcast
The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.