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525: Most Thyroid Medications Fail: The Thyroid–Menopause Collision Destroying Women in Midlife with Dr. Amie Hornaman

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Release Date: 05/12/2026

538: Fat Loss in Midlife - What the Last 20 Years Has Taught Me show art 538: Fat Loss in Midlife - What the Last 20 Years Has Taught Me

Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Join us for a LIVE interactive fat loss workshop to continue this conversation:   What if everything you were taught about losing weight in your 20s and 30s is actually working against you now? I've spent almost 20 years coaching midlife women through fat loss, and I've lived every bit of it myself, ten years of perimenopause, post-menopause, injuries, autoimmune issues, and all. Today I'm done watching the internet sell midlife women quick fixes that were never built for our bodies. I'm laying out the five pillars I've seen actually work, in the order they matter, and the why behind each...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

You guys know I am a HUGE believer in the right supplements and the right protocols. So when I tell you that today's episode is about the FOUNDATION underneath ALL of it, lean in. Modern scientists believe we are operating at only thirty-seven to forty percent of the mineral levels our bodies actually need. Minerals are the only nutrient class your body cannot make. They are the foundation under hormones, gut, sleep, energy, hair, and yes, even under the great supplements you are already taking. This is the conversation midlife women have been waiting for. I sat down with Caroline Alan,...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

In this episode I share something I never thought I would talk about on this microphone: quantum physics. Not the wellness version. The actual physics. The kind that won the 2022 Nobel Prize. I walk you through why some of us feel things in our bodies that other people do not, why midlife makes us more sensitive (not less), how quantum entanglement actually works in plain English, and what happened when I flew to Germany and got my brain measured in a high-density EEG lab. The data is on paper. The lab is real. The results are mine. And I think every midlife woman who has ever been told she is...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

What if the thing you've been calling a midlife crisis is actually the most important reckoning of your life? In this episode, Natalie sits down with Star Monroe, a self-identity expert and somatic psychotherapist who helps midlife women face the crisis underneath the crisis, the version of themselves they abandoned decades ago just to feel safe, loved, and chosen. Star opens up about her own unfiltered history, including addiction, two marriages, financial collapse, and the moment she finally understood that her self-destructive patterns were never about the substance itself. They were about...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Tired of choking down pills and wondering if any of it is showing up? Transdermal could be the answer. The Patch Method bypasses our digestion and liver completely. Super easy, just slap it on. Code NATALIEJILL for 20% off at  PLUS… DM "NatalieJill" to @the.patchmethod on Instagram and the first 50 people will receive a free patch kit of their choice plus four free samples. What if the drawer full of supplements you have been faithfully taking every morning is actually making your liver work harder without making you feel any better? If you have ever walked out of a functional medicine...

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What if the supplements you've been taking to feel better are actually the reason you feel worse? That's exactly what happened to me, and it sent me down a rabbit hole that led to one of the most important conversations I've had about my own health. Today I'm sitting down with my close friend and personal doctor, Dr. Sabrina Solt, a regenerative medicine physician and peptide expert who has been in this field for over a decade. We start with the question that started everything for me: why was I wired at 3am, crashing every afternoon, and reacting to the exact supplements I thought were...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Don't miss the free live hydrogen workshop with Kashif. Save your seat at   What if every biohack you've tried has been missing the one piece that actually makes it work? Red light, peptides, cold plunges, NAD, wellness IVs. You've tried some of them. Some worked. Some didn't. And here's the maddening part: your friend is thriving on the same protocol that made you feel worse. That's not random, and you're not broken. There's a reason, and it's rooted in your unique biology in ways most practitioners never explain. In this episode, I sit down with Kashif Khan, founder of The DNA Company...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

If you have ever come back from Europe and thought, why do I feel BETTER over there, this episode is for you. Natalie and her husband Brooks just got back from one of the most incredible trips of their lives. Germany, Switzerland, Lake Como, Piedmont, Lake Lucerne, Basel and Heidelberg. And it was not just beautiful. It rearranged some things in their bodies that they want to break down for you. In this conversation we go through every stop on the route, why pasta in Italy feels different than bread in the US, why dairy in Europe digests so much better, the hormone shift Natalie had to make...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Get the oral biome test we talked about in the show at  This is the conversation I have been waiting to have. If you are doing the breathwork, the meditation, the supplements, the protocols, and you are STILL feeling anxious, inflamed, bloated, and exhausted, this episode will explain why. My guest is Dr. Pedram Shojai, The Urban Monk. He is a New York Times bestselling author and a Doctor of Oriental Medicine, and the man who first came on this show talking about stress and the nervous system. Years later, after a wild full-circle moment in a group coaching call, we are back together to...

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Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

Special offer for Midlife Conversations listeners: for up to 38% off - a special savings of $5 off each bottle of Dream Cream purchased and is the lowest savings you will find.  If you have ever turned a "clean" skincare bottle around, read the back, and not been able to pronounce a single ingredient, this episode is for you. The European Union has banned over 1,300 ingredients from skincare. The United States has banned 11. ELEVEN. So what are we actually putting on our faces every single day? And in midlife, when our hormones are already in flux, what are those ingredients doing to...

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Save your seat in the free Thyroid and Hormone class https://fixyourthyroid.com/natalie 

If you are a woman in midlife who has been told everything is fine when you know in your body that something is NOT fine, this episode is going to change everything.

I have Dr. Amie Hornaman, The Thyroid Fixer, back on the show, and we are going somewhere we have never gone before. One in eight women will develop a thyroid condition in her lifetime. Eighty-eight percent of us are metabolically unhealthy. And yet most doctors run ONE test, look at one number, tell us we are normal, and send us home with an antidepressant.

Meanwhile we are gaining weight, losing our hair, can't sleep, can't think, can't lose a pound to save our lives, and being told it is just stress, just aging, just menopause.

Today we are tearing that apart.

Dr. Amie saw SEVEN doctors before she was finally diagnosed. She is now licensed to prescribe thyroid and bioidentical hormones in all 50 states and most of Canada. She built the Better Thyroid and Hormone Institute, hosts The Thyroid (and Hormone) Fixer Podcast, and has helped thousands of women globally finally get answers.

We go DEEP on:

  • Why the standard TSH-only test misses almost everyone, and the six tests you need to ask for by name

  • THYROPAUSE: Dr. Amie's term for what happens when thyroid dysfunction collides with perimenopause and menopause (and why so many women are being treated for the wrong one)

  • The T4-only medication trap: why Synthroid and levothyroxine fail an estimated 98% of patients

  • Reverse T3, the silent saboteur that blocks your active thyroid hormone from getting into your cells

  • Natural desiccated thyroid, the controversy, FDA scrutiny of animal-derived medications, and where Dr. Amie stands

  • T2: the FORGOTTEN thyroid hormone with 30+ years of research that burns fat at the mitochondrial level, does not suppress your own thyroid, does not jack up your heart rate, does not require a prescription, and is showing up in studies as a potential anti-obesity treatment

  • What Ozempic, Wegovy, and Mounjaro are actually doing to your thyroid (and why some women lose ZERO weight on GLP-1s no matter how high they push the dose)

  • The estrogen, progesterone, testosterone, cortisol, and insulin connection: why you cannot fix the thyroid without addressing the whole hormonal system

  • Antibody-support strategies: gluten elimination, black cumin seed oil, low-dose naltrexone, and thymosin alpha

  • Iodine titration cautions, medical gaslighting, and what to say when your doctor refuses to run the full panel

  • The Monday morning action plan: exactly what to do this week if you suspect your thyroid is the missing piece

This is not a thyroid 101 episode. This is the conversation I wish every midlife woman was given the day her labs came back normal.

You are not broken. You are not crazy. And you are not alone.

Sign up for the free Thyroid and Hormone class https://fixyourthyroid.com/natalie 

 

Connect with Dr. Amie:

 

APPROXIMATE TIMESTAMPS:

  • 00:00 — The medical gaslighting that is keeping midlife women sick

  • 06:00 — The full thyroid panel: the six tests to ask for by name

  • 12:00 — Introducing THYROPAUSE: where thyroid meets menopause

  • 20:00 — How estrogen, progesterone, testosterone, and cortisol all impact your thyroid

  • 28:00 — Why T4-only medication (Synthroid, levothyroxine) fails 98% of patients

  • 34:00 — Natural desiccated thyroid, FDA scrutiny, and individualized dosing

  • 40:00 — T2: the forgotten thyroid hormone that burns fat without touching your gland

  • 48:00 — Who should consider T2 (and why it does not require a prescription)

  • 52:00 — What Ozempic and the GLP-1s are actually doing to your thyroid

  • 58:00 — How to protect your thyroid if you are currently on a GLP-1

  • 62:00 — Lifestyle non-negotiables: morning sun, protein, resistance training, sleep, blood sugar

  • 67:00 — Your Monday morning action plan if you suspect your thyroid is the missing piece

 

Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube

 

Learn More About Dr. Amie Hornaman 

Instagram ➜ https://www.instagram.com/dramiehornaman

Website ➜ https://fixyourthyroid.com/natalie 

 

 

Thank you to our show sponsors: 



Free Gifts for being a listener of Midlife Conversations!

 

Connect with me on social media!

Instagram: www.Instagram.com/Nataliejllfit

Facebook: www.Facebook.com/Nataliejillfit  

For advertising inquiries: https://www.category3.ca/ 



Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen. 

Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.