Butyrate — The Gut-Brain Axis Connector That Influences Mood and Cognition
Dr. Joseph Mercola - Take Control of Your Health
Release Date: 12/29/2025
Can Menopause Be Reversed?
Dr. Joseph Mercola - Take Control of Your Health
Emerging research shows that human egg cells resist mitochondrial aging, challenging the idea that menopause is irreversible Scientists have successfully reactivated dormant ovarian follicles in women with premature ovarian insufficiency using stem cell strategies and metabolic interventions Mitochondrial health, not egg depletion, may be the key to reversing menopause symptoms and restoring reproductive function Hormones like DHEA, T3, and progesterone, along with nutrients like vitamin A and E, are being studied for their role in rejuvenating ovaries These findings suggest menopause may be...
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Reducing Social Media Use for Just a Week Can Improve Mental Health
Dr. Joseph Mercola - Take Control of Your Health
A new JAMA Network Open study found that cutting down social media use to roughly 30 minutes per day had measurable effects on mental health, reducing anxiety by about 16%, depression by about 25%, and insomnia symptoms by 15% Loneliness scores did not change much, which shows that social media can be a lifeline for connection as well as a source of stress Earlier randomized trials from the University of Bath and others also found that a one-week break from platforms like TikTok, Instagram, and Facebook improved wellbeing, depression, and anxiety A short reset is not a cure for depression or...
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FDA Takes Action to Restrict Fluoride Supplements for Children
Dr. Joseph Mercola - Take Control of Your Health
Fluoridated water has shaped U.S. dental policy since the 1940s, when officials began adding fluoride to public water supplies in an effort to reduce childhood cavities.1 As of 2022, the U.S. Centers for Disease Control and Prevention (CDC) reported that 72.3% of Americans on community water systems (about 62.8% of the entire population) received fluoridated water,2 making systemic exposure nearly unavoidable. Mounting evidence now shows that fluoride offers little measurable benefit for dental health while introducing significant risks, particularly for children. Many countries,...
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Your Gut Nervous System Helps Regulate Intestinal Barrier and Allergy Risk
Dr. Joseph Mercola - Take Control of Your Health
Your gut’s nervous system directly influences whether you tolerate foods or react to them, making it a key factor in food sensitivities and allergy risk A tiny nerve messenger called the vasoactive intestinal peptide (VIP) tells your gut stem cells how to rebuild the intestinal lining; when VIP drops, your gut produces too many tuft cells that trigger allergy like inflammation Everyday exposures — like microplastics, seed oils, and emulsifiers found in processed foods — damage tight junction proteins, weaken your gut barrier, and increase the flow of irritants into your bloodstream Low...
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How Genetics Affects Men's Risk of Erectile Dysfunction
Dr. Joseph Mercola - Take Control of Your Health
About 24.2% of U.S. men today screen positive for erectile dysfunction (ED), while global rates range from 3% to 76.5%, showing it’s a common health problem that affects men of all ages A 2025 study in the American Journal of Clinical and Experimental Urology found that ED is influenced by genes that also raise risk for obesity, diabetes, heart disease, and addiction, tying erection problems to long-term heart health ED is usually multifactorial, with vascular, neurogenic, hormonal, and psychogenic forms, and is strongly associated with conditions like heart disease, obesity, sleep apnea,...
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Nearly 1 in 5 Urinary Tract Infections Linked to Contaminated Meat, Study Finds
Dr. Joseph Mercola - Take Control of Your Health
Nearly 1 in 5 urinary tract infections (UTIs) are caused by E. coli strains that originated in contaminated meat, confirming what earlier research has shown Poultry is the main source of these dangerous bacteria, with chicken and turkey accounting for more than 74% of meat-linked UTI cases, while all retail meats showed high contamination levels These bacteria, known as extraintestinal pathogenic E. coli (ExPEC), survive processing and cooking to enter your body, where they colonize your urinary tract and can spread to your bloodstream Overuse of antibiotics in concentrated animal feeding...
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Study Finds Surprising Differences in Knee Injuries Between Men and Women
Dr. Joseph Mercola - Take Control of Your Health
A 2025 analysis of over 13,500 knee MRI scans revealed that men have more anterior cruciate ligament (ACL) tears overall, including ACL plus meniscus combinations, contrary to earlier data focused on female athletes Men under 40 were more likely to have trauma-driven medial collateral ligament (MCL) and meniscus injuries, while women over 40 had a higher rate of degenerative MCL and meniscus damage These patterns suggest trauma dominates in male injuries, while age-linked tissue breakdown plays a bigger role in older female patients These results can aid clinicians and radiologists in...
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Why Arthritis Gets Worse in the Winter Months
Dr. Joseph Mercola - Take Control of Your Health
Cold weather worsens arthritis symptoms by thickening joint fluid, slowing blood flow, and tightening muscles, which amplifies pain and stiffness Drops in barometric pressure cause tendons and muscles to expand, adding extra pressure to already inflamed joints and increasing discomfort Reduced sunlight during winter lowers vitamin D levels, weakening bones and increasing inflammation, while inactivity further restricts circulation Eliminating seed oils, boosting vitamin K2, optimizing vitamin D, and sipping warm bone broth help reduce inflammation, strengthen cartilage, and restore...
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Meal Fat Content Influences Muscle Building After Exercise
Dr. Joseph Mercola - Take Control of Your Health
Low-fat protein after exercise delivers amino acids into your bloodstream faster, giving your muscles a stronger signal to repair and grow High-fat meals slow digestion and weaken your muscle-building response, even when the total amount of protein is the same A stronger and faster leucine surge from lean protein helps activate muscle repair more effectively, improving your recovery window Higher daily protein intake — around 0.8 grams per pound of ideal body weight — supports better muscle gain, fat loss, bone strength, and metabolic stability Simplifying your post-workout meal and...
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Metformin Could Lessen Some of the Benefits People Get from Exercise
Dr. Joseph Mercola - Take Control of Your Health
Metformin is a widely prescribed Type 2 diabetes drug that works by lowering liver glucose production and improve insulin sensitivity A 16-week Rutgers trial in 72 adults found that metformin dulled exercise benefits, reducing the usual improvements in aerobic fitness Long-term risks for prolonged metformin use include vitamin B12 deficiency, rare lactic acidosis, and hypoglycemia Skipping breakfast, not getting enough sleep, consuming too much alcohol, and social isolation can greatly disturb glucose regulation and increase the risk of developing diabetes over time Lifestyle strategies such...
info_outline- Butyrate, produced by gut bacteria when they ferment dietary fiber, acts as a signaling molecule in the gut-brain axis, influencing stress, pain tolerance, immunity, and brain health
- Through multiple mechanisms, including specific enzyme inhibition and NF-κB pathway regulation, butyrate reduces neuroinflammation and protects against neurodegenerative conditions like Alzheimer's and Parkinson's disease
- Butyrate influences key neurotransmitters including GABA, serotonin, and dopamine, while also increasing brain-derived neurotrophic factor (BDNF), which supports neuronal growth and cognitive function
- The vagus nerve serves as a communication highway between the gut and the brain, transmitting signals about butyrate levels that affect mood regulation, stress response, and immune function
- Optimizing gut health through dietary fiber and homemade fermented foods helps promote butyrate production and maintain a healthy gut-brain connection