What is the Placebo Effect and How Can it be Harnessed? with Joe Kossowsky, Ph.D.
The Mind, Body and Soul in Healing
Release Date: 10/22/2021
The Mommy (and Daddy) Brain Controversies: Adaptation not Deficit with Bridget Callaghan, PhD (Los Angeles)
The Mind, Body and Soul in Healing
"We trained pregnant and never pregnant women and we tested them on their memory for these items immediately after they learned them and then we tested them two weeks later, looking at their long term autobiographical memory. What we found was that for the immediate test, the pregnant women did better than the never pregnant women on the baby relevant items, but they had equal performance on the adult oriented items. That gives some support to our hypothesis that when you actually test for benefits in cognition for ecologically relevant items you see them in pregnancy. But very surprisingly to...
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Two Psychiatrists Face the Illness of Their Daughter with Philip Lister, MD (New York)
The Mind, Body and Soul in Healing
"The universality of guilt - I think that my life as a child therapist has a lot of advantages; we carry the idea that ‘we are all the ages we've ever been’ and those magic years never disappear. There are some great things about that - there are some problems with it too. That kind of irrational self-centered construction to explain what is intolerable and difficult to grasp comes from that. Early in this whole process, I remember talking to the pediatrician taking care of us: ‘Was it something in the environment? Was it the street we lived on? Was it that we lived in the basement?...
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Stigma: How Support Groups for Mental Illness are Helpful with John Tamerin, MD
The Mind, Body and Soul in Healing
"Because I couldn't help my son, I couldn't do anything for him, I thought maybe I could start this group and help other people and other parents deal with this problem. What I wasn't prepared to face was just how lonely, how alone, how sad, and feeling hopeless I was. In a way, when the group began, I needed the group as much as the group needed me. I've continued the group although I need it for different reasons - at that point I needed it because I felt overwhelmed because of the problem with my son. Now I need it because I’ve grown to love the people of the group and I feel a...
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How Rituals Attach us to our Communities with Dimitris Xygalatas, Ph.D.
The Mind, Body and Soul in Healing
"If you randomly assign people in two groups and you give them different insignia or you have them go through different practices, as we saw in this study, they come to like each other more. It's very easy to create this basic sense of belonging and identity. Ritual is particularly good at eliciting that kind of sense also because it triggers our intuitions about what we call phenotypic matching, this is the idea that we have ways, psychological mechanisms, that allow us to recognize those that are members of our groups, especially kin, so if you think about it who are your kin, they're the...
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Might Rapamycin Extend our Lifespan, Healthspan, and Cognitive Functioning? with Arlan Richardson, PhD
The Mind, Body and Soul in Healing
"One of the things that is very exciting is that this is a very robust finding. In other words, sometimes in science people see something and then it's not replicated - Rapamycin’s impact on lifespan has been replicated. When I started researching this area 50 years ago, I never felt that we would find a pill that would have an impact on aging and lifespan. Aging is very complex - to find one thing that would have an impact was highly unlikely. So when this happened in 2009, I had a small part in this, it was really very exciting because for the first time we had something that could...
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An Analyst's Novel: Resilience in the Face of a Mother's Death with Kerry Malawista, PhD
The Mind, Body and Soul in Healing
"One way a child of Jody’s age deals with loss is that you don’t miss the person, in a sense you can become them. So, I have her step into the mother role, immediately trying to look after the younger ones and then wearing her mother sunglasses - it’s like she becomes her and then you don’t miss her so much. The neighbor is like an analyst figure, and she goes over and talks to this woman, Juliette, a very kind woman. I had Juliette say to her: ‘The way I see it, a death doesn’t happen just once, it’s like we have to keep being reminded that someone is gone - remember her - miss...
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Bipolar Disease, Insulin Resistance and Metformin: New Research with Cynthia Calkin, MD
The Mind, Body and Soul in Healing
"The best way to think about insulin resistance is that it’s pre-diabetes. In the course of developing type 2 diabetes, which we see in much higher rates in people with bipolar disorder compared to the general population, one starts off with normal blood sugar levels but elevated insulin. It is the elevated insulin that pushes the blood sugar down into the normal range. This is typically something that is missed by physicians because there’s been no medical indication to test for it [insulin level]. After the metabolic dysregulation progresses, patients become glucose intolerant, and at...
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The Value of Paternity Leave for Children and Families with Richard Petts, PhD
The Mind, Body and Soul in Healing
"When paternity leave comes into the picture you have a situation where parents are home together. Those processes are able to develop for both the mother and the father - there’s time for fathers to bond with their children, there’s time for parents to figure out how to be parents together. It’s not so lopsided where mothers become the experts because they are there all the time. Mothers and fathers can develop that expertise together because they are both there at home at the same time. At this sort of crucial point where you figure everything out for the first time, I think it...
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The Role of Technology in Mental Health Care with Isaac Galatzer-Levy, PhD
The Mind, Body and Soul in Healing
"There is a company called NightWare, that developed a feature for PTSD that uses components from Apple Watch. One of the primary symptoms in PTSD is intense nightmares which are very distressing, they disrupt their sleep and really drive a lot of symptomatology. This company created an app that detects when people with PTSD are having nightmares. It uses the existing sleep function [on the watch] to detect when they are having disruptive sleep. Then it uses the vibrating haptic to wake the patient up. So it is simply just disrupting their sleep, waking them up from a nightmare, and by...
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Disability, Psychotherapy, and Resilience with H. Penny Mishkin, MS, OTR
The Mind, Body and Soul in Healing
"I would say to any parent who has a child now or any adult who has a disability now - disabilities are looked at quite differently. They are accepted much more than they were when I was growing up. So, you can’t take things out of context, but I was just living a secret life and that wasn’t good, it really wasn’t. That was why I was remote, so what I would do is dissociate when I felt the pain of being so different and I really paid a price for that. I am not sure there was any way to get through it, I was a successful child by other standards, but emotionally I was very...
info_outline"We used [open-label placebo] in kids with Irritable Bowel Syndrome and the interesting thing about these patients is that they were only allowed to enroll in our study at Boston Children’s if all other treatments had failed. Basically. we had a population that had undergone numerous treatments with all of them not helping much. These are patients that didn’t have a positive classical conditioning that you would be hoping for - they came in with negative expectations about whether this would work. Yet, we were able to elicit in many, not all, a clinical change that they were never able to achieve with any other medication."
Episode Description: We begin with recounting the etymology of the word placebo and then describe two dramatic instances where 'mind over matter' determines the body's physical responses. Joe elucidates the impact of culture and setting on the psychology of the subject and then the impact of their psychology on neuro-biologic mechanisms. His research emphasizes the power of the provider-patient relationship, and we discuss this similarity with the psychotherapeutic relationship. We consider open-label placebos where the individual is told that what they are receiving is an inert substance. Nevertheless, in a number of medical conditions, this proves to be an effective intervention. We conclude with Joe sharing his genealogy of 40 generations of rabbis and of his continuing their healing tradition.
Our Guest: Joe Kossowsky, Ph.D. is a clinical investigator in the Division of Pain Medicine in the Department of Anesthesiology, Critical Care, and Pain Medicine at Boston Children’s Hospital. Following his graduate studies in Clinical Psychology and Neuroscience, Dr. Kossowsky obtained his Ph.D. in Clinical Psychology at the University of Basel, Switzerland, and a Master's degree in Biomedical Informatics from Harvard Medical School. He completed postdoctoral fellowships in the areas of pediatric pain, placebo research, and biomedical informatics at Boston Children’s Hospital and Harvard Medical School. He is currently an Assistant Professor of Anaesthesia at Harvard Medical School.
Dr. Kossowsky's research revolves around the evaluation of the progression of acute, chronic pain and comorbid psychiatric conditions, including the benefits of interventions.