KarXT: A New Dawn in Antipsychotic Treatment
Psychopharmacology and Psychiatry Updates
Release Date: 01/26/2025
Beyond Benzos: New Frontiers in Agitation Management
Psychopharmacology and Psychiatry Updates
In this episode, we explore the pharmacological management of agitation in emergency settings, focusing on benzodiazepines and the novel medication dexmedetomidine. Did you know there's now a sublingual option that works through an entirely different mechanism than traditional anti-agitation medications? Faculty: Scott Zeller, M.D. Host: Richard Seeber, M.D.
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KarXT: A New Dawn in Antipsychotic Treatment
Psychopharmacology and Psychiatry Updates
In this episode, we explore KarXT, a groundbreaking experimental antipsychotic that works through the cholinergic system rather than dopamine pathways. Could this novel approach revolutionize schizophrenia treatment by offering similar efficacy to current antipsychotics but without the motor side effects? Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
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Rethinking Agitation Management: From Force to Partnership
Psychopharmacology and Psychiatry Updates
In this episode, we explore evidence-based pharmacologic strategies for managing acute agitation in emergency settings, challenging the stigmatizing concept of “chemical restraints” and providing practical approaches to achieve optimal patient outcomes. Did you know that many agitated patients can actively participate in medication decisions, even during a crisis? Faculty: Scott Zeller, M.D. Host: Richard Seeber, M.D.
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COVID Brain Fog: Repurposing Famotidine
Psychopharmacology and Psychiatry Updates
In this episode, we explore how famotidine, a common heartburn medication, might help treat post-COVID brain fog. New research suggests this H2 blocker could improve cognitive function in recovering patients. But how does a stomach acid reducer potentially clear mental haziness? Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.
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Beyond Restraints: De-Escalation in Behavioral Emergencies
Psychopharmacology and Psychiatry Updates
In this episode, we explore nonpharmacologic strategies for managing agitated patients, focusing on verbal de-escalation techniques. Did you know that using physical restraints adds an average of four hours to an emergency department stay? Dr. Scott Zeller shares evidence-based approaches to transform crisis intervention in emergency settings. Faculty: Scott Zeller, M.D. Host: Richard Seeber, M.D.
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Rethinking Antipsychotic Dosing: Lessons from the RADAR Trial
Psychopharmacology and Psychiatry Updates
In this episode, we explore the RADAR trial's findings on antipsychotic dose reduction in schizophrenia. Can patients with chronic schizophrenia safely reduce or discontinue their antipsychotic medications without increasing relapse risk? The trial's results challenge common assumptions about medication reduction and provide crucial guidance for clinical practice. Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
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Unraveling Agitation: Mania vs. Substance Use
Psychopharmacology and Psychiatry Updates
In this episode, we explore the challenges of diagnosing and managing agitation in emergency settings, focusing on mood disorders and substance use. Dr. Scott Zeller shares insights on differentiating acute mania from substance-induced psychosis. How can clinicians navigate the complex interplay between psychiatric symptoms and substance effects in emergencies? Faculty: Scott Zeller, M.D. Host: Richard Seeber, M.D.
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Pushing the Boundaries: Exploring High-Dose Antipsychotics
Psychopharmacology and Psychiatry Updates
In this episode, we explore the use of high-dose olanzapine as a potential alternative to clozapine for treatment-resistant schizophrenia. We discuss a systematic review that examines the efficacy and safety of olanzapine doses above the FDA-approved maximum. Could high-dose olanzapine be a viable option when patients refuse clozapine? Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
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The Psychodynamic Prescriber
Psychopharmacology and Psychiatry Updates
In this episode, we explore how integrating psychodynamic principles into pharmacotherapy can enhance treatment outcomes. We discuss seven key features of psychodynamic psychotherapy and their application in routine psychiatric practice. How might understanding a patient's fantasies about their illness impact their response to medication? Faculty: David Mintz, M.D. Host: Richard Seeber, M.D.
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From Inpatient to Outpatient: Initiating Benzodiazepine Tapering
Psychopharmacology and Psychiatry Updates
In this episode, we explore strategies for discontinuing benzodiazepines in hospitalized elderly patients. We discuss a recent Israeli study that tested two interventions during inpatient stays. Can a simple hospital-based intervention lead to successful long-term medication changes? Faculty: Paul Zarkowski, M.D. Host: Richard Seeber, M.D.
info_outlineIn this episode, we explore KarXT, a groundbreaking experimental antipsychotic that works through the cholinergic system rather than dopamine pathways. Could this novel approach revolutionize schizophrenia treatment by offering similar efficacy to current antipsychotics but without the motor side effects?
Faculty: Oliver Freudenreich, M.D.
Host: Richard Seeber, M.D.