loader from loading.io

Immunosenescence: Why Your Immune System Is Aging Faster Than You Think (And How to Reverse It)

Pushing The Limits

Release Date: 02/12/2026

Your Immune System Is Aging Faster Than You Are show art Your Immune System Is Aging Faster Than You Are

Pushing The Limits

Your Immune Age Is Lying To You. Here's How To Read Your Blood And Fix It. How old is your immune system, really? It's probably not the same age as you are β€” and that gap may be the single biggest hidden driver of how well you age, how fast you recover, and how long you stay healthy. In this episode I break down what actually happens to your immune system as the years tick over β€” immunosenescence (the immune system getting weaker) and inflammaging (the silent, smouldering inflammation that never switches off) β€” and why almost every disease of ageing sits somewhere on that spectrum. Then...

info_outline
Professor Julia Rucklidge: Micronutrients, Mental Health and Why the RDAs Are Broken show art Professor Julia Rucklidge: Micronutrients, Mental Health and Why the RDAs Are Broken

Pushing The Limits

The link between micronutrients and mental health is one of the most overlooked stories in modern medicine, and Professor Julia Rucklidge has spent more than two decades proving it matters. In this episode of Pushing the Limits, she shares the research on micronutrients and mental health that has challenged psychiatry's drug-first model, showing that broad-spectrum vitamins and minerals can treat ADHD, depression and anxiety, often as effectively as medication and without the side effects. If you have ever wondered how deeply micronutrients and mental health are connected, this conversation...

info_outline
R3HBG: The Bioidentical Ketone That Bypasses the Liver | Mike Chesne, Tecton Founder show art R3HBG: The Bioidentical Ketone That Bypasses the Liver | Mike Chesne, Tecton Founder

Pushing The Limits

What if there was an exogenous ketone that didn't go through the liver, didn't cause the GI distress of other ketones, and delivered bioidentical BHB directly to your cells? In this episode, Lisa sits down with Mike Chesne, founder of Tecton and retired US Army Special Forces combat medic, who spent 25 years in special operations before developing R3HBG β€” a patented ketone molecule that's categorically different from everything else on the market. Mike's journey from battlefield medicine to biotech is extraordinary. After suffering multiple traumatic brain injuries from IED blasts during...

info_outline
INUSpheresis: Removing Toxins, Heavy Metals & Microplastics From Blood/ Tash Simons show art INUSpheresis: Removing Toxins, Heavy Metals & Microplastics From Blood/ Tash Simons

Pushing The Limits

What if the reason you're not getting better isn't about what you're putting in β€” but what you can't get out? In this episode I sit down with Tash Simons from INUSpheresis Perth β€” the first clinic in Australia and the Southern Hemisphere to offer this advanced blood filtration therapy. We go deep into how double filtration plasmapheresis works, the two specialised filters (TKM58 and INUS 30), and the science behind removing autoantibodies, inflammatory cytokines, heavy metals, microplastics, PCBs, and oxidised LDL directly from your blood β€” without involving your kidneys or liver. We...

info_outline
Copper, Mitochondria Grey Hair & Autism: The Missing Link No One Is Talking About show art Copper, Mitochondria Grey Hair & Autism: The Missing Link No One Is Talking About

Pushing The Limits

Could a simple mineral deficiency be driving mitochondrial dysfunction in autism? In this episode I sit down with Melissa Atchley from MitoSynergy to hear her personal story of using BioCopper1 with her son on the autism spectrum β€” and the changes she saw that no one expected. I break down the science behind it: Dr Richard Frye's research showing Complex IV dysfunction in children with ASD, the brand new April 2026 Science Advances paper linking copper deficiency directly to ASD-like behaviours through mitochondrial damage and impaired myelination, and why the type of copper matters β€” Cu1+...

info_outline
Klotho, Peptides & Limitless Longevity β€” Dr. Alex Grinberg & Dr. Dave Jenkins show art Klotho, Peptides & Limitless Longevity β€” Dr. Alex Grinberg & Dr. Dave Jenkins

Pushing The Limits

These two doctors are building a clinic where the most advanced longevity therapies have no limits. Dr. Alexander Grinberg (Infinity Epigenetics, San Francisco) and Dr. Dave Jenkins (Bredesen-trained, 40+ years clinical experience) are combining peptide therapy, regenerative medicine, and personalised protocols at a level most people don't know exists. From Klotho protein restoring cognitive function in head injury patients to mitochondrial peptides that can rescue dying cells β€” this conversation covers the cutting edge of what's actually possible right now. About the Guests Dr. Alexander...

info_outline
The 7 Reasons Your Cells Age (And How to Stop It) Dr Sandra Kaufmann show art The 7 Reasons Your Cells Age (And How to Stop It) Dr Sandra Kaufmann

Pushing The Limits

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down β€” and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down β€” and how to stop it. πŸ‘‰ FREE Longevity Cheat Sheet β€” subscribe to my weekly newsletter:   Description: Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down β€” and how to stop it. Dr Sandra Kaufmann is a cell biologist, physician, and creator of the Kaufmann Protocol β€” the first comprehensive rating system for anti-aging supplements. In this episode...

info_outline
The One System Behind ALL 14 Hallmarks of Aging β€” And How to Target It | Courtney Van Bussum show art The One System Behind ALL 14 Hallmarks of Aging β€” And How to Target It | Courtney Van Bussum

Pushing The Limits

Your immune system isn't just fighting off colds. It's the foundational system that influences all 14 hallmarks of aging β€” and when it declines, everything downstream accelerates. In this episode, I sit down with Courtney Van Bussum, COO of Longevity Launch Labs, to dive deep into immunosenescence β€” the aging of the immune system β€” and why it starts far earlier than most people realise. We unpack what Stanford's landmark 1000 Immunomes Project revealed about the real driver of biological aging, why your supplement stack might be missing the most important piece, and how we built...

info_outline
Reverse Alzheimers with Dr Dave Jenkins show art Reverse Alzheimers with Dr Dave Jenkins

Pushing The Limits

What if you could know 20 YEARS before symptoms appear whether you're heading for Alzheimer's? And what if there was a proven way to reverse early cognitive decline? In this episode, I sit down with my dear friend Dr. Dave Jenkins β€” the leading Dr. Dale Bredesen Protocol practitioner in the Southern Hemisphere β€” to unpack the p-Tau 217 blood test revolution and the stunning results from Bredesen's latest randomised controlled trial. Dr. Dave breaks down how a simple finger-prick blood test can now detect the Alzheimer's process with 95% certainty up to TWO DECADES before memory symptoms...

info_outline
Robots in Healthcare: Tesla Optimus, Terafab - Cern Basher show art Robots in Healthcare: Tesla Optimus, Terafab - Cern Basher

Pushing The Limits

The global healthcare system is heading for a catastrophic workforce shortage β€” 10 to 15 million workers short by 2030. In this episode, financial analyst and Tesla expert Cern Basher (@cernbasher) returns to break down how humanoid robots like Tesla's Optimus could be the only scalable solution, why New Zealand is uniquely positioned to lead a healthcare robotics pilot, and what the Terafab chip factory and Digital Optimus mean for the timeline. From fleet learning to the privacy concerns, from Moxy robots already in 25+ US hospitals to Elon Musk's vision of billions of robots powered by...

info_outline
 
More Episodes

Your immune system doesn't just fight colds β€” it's the foundation of your longevity, brain health, and recovery capacity. But here's what most people don't realize: immune aging (immunosenescence) begins as early as your teenage years, and your thymus gland β€” the training ground for your T-cells β€” is already shrinking. Your thymus shrinks 3% every year from your teens and 80% of adults carry a dormant virus silently hijacking their immune capacity.

In this episode, Lisa dives into the Immunosenescence Paradox: why aging makes your body less effective at fighting infections while simultaneously driving chronic inflammation (inflammaging). She also uncovers the CMV Factor - a silent virus carried by roughly 80% of adults that "occupies" your immune system's resources, leaving you increasingly vulnerable to new threats.

What you'll learn in this episode:

  • What immunosenescence is and why it accelerates faster than most people expect

  • How your thymus gland deteriorates and what that means for T-cell production

  • The CMV Factor: how cytomegalovirus silently depletes your immune reserves

  • Why aging triggers more inflammation, not less β€” the inflammaging paradox

  • Four actionable strategies to slow and reverse immune decline

  • The role of colostrum, carnosic acid, and New Zealand-grown kawakawa in immune rebuilding

  • Which blood markers reveal your true immune age

Resources mentioned:

πŸ”¬ Shop Rejuvenate Pro: Rejuvenate Pro by Aevum Labs

πŸ“‹ Your Health Compass (health risk assessment): yourhealthcompass.org

πŸ“° Free Longevity Cheat Sheet β€” subscribe at Longevity Cheat Sheet

πŸ“š Healthspan Hacks Course: Health Span Hacks Course

Related episodes:

Reverse Aging Naturally with Dr Rod Claycomb

Dr Elizabeth Yurth on Immune Aging and How to Reverse It

🧬 Know your health risks before they become problems

Your Health Compass: 11 Health Screenings. 10 Minutes. Zero Guesswork

Your Health Compass gives you 11 clinically validated health screenings in about 10 minutes β€” covering diabetes, autoimmune conditions, brain health, cancer risk, mental health, and more.

No blood tests. No doctor's visit. No waiting.

Just science-backed questionnaires used in real medical research β€” now available to you for a one-time $19 payment.

βœ“ Instant personalised risk scores

βœ“ Downloadable report you can share with your doctor

βœ“ 100% private β€” your data never leaves your browser

Stop wondering "should I be worried about this?" and start knowing where to focus your prevention efforts.

β†’ Take the assessment now at: yourhealthcompass.org

πŸ“Œ  Topics Lisa can help with: 

Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach.

She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking.

She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing.

πŸ”¬ Testing Options

  • Comprehensive Thyroid testing

  • DUTCH Hormone testing

  • Adrenal Testing

  • Organic Acid Testing

  • Microbiome Testing

  • Cell Blueprint Testing

  • Epigenetics Testing

  • DNA testing

  • Basic Blood Test analysis

  • Heavy Metals 

  • Nutristat

  • Omega 3 to 6 status

and more 

Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine .

She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa 

🀝  Join our Patron program and support the show

Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission. 

Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two

You can join by going to  Lisa's Patron Community

Or if you just want to support Lisa with a "coffee" go to 

https://www.buymeacoffee.com/LisaT to donate $3

 

🌟 Lisa’s Anti-Aging and Longevity Supplements 

Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. 

This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that’s what it’s in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimise your life.

 

πŸŽ₯  Subscribe to our popular Youtube channel 

with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel.

Youtube

πŸ“š Order Lisa's Books

Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" 

Check them all out at 

https://shop.lisatamati.com/collections/books

πŸ”΄ Red Light Therapy:

Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try

Flexbeam: A wearable Red Light Device

https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38

Or Try Vielights’ advanced Photobiomodulation Devices

Vielight brain photobiomodulation devices combine electrical engineering and neuroscience.

To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to

www.vielight.com and use code β€œtamati” to get 10% off

πŸŽ™οΈEnjoyed This Podcast?

If you did, subscribe and share it with your friends!

If you enjoyed tuning in, then leave us a review and share this with your family and friends.

Have any questions? You can contact my team through email (support@lisatamati.com) or find me on FacebookTwitterInstagram ad YouTube.

For more episode updates, visit my website. You may also tune in on Apple Podcasts.

 To pushing the limits,

  • Lisa and team