ILD for the rheumatologist: Digging through the past and making sense of the present
Healio Rheuminations
In this week’s episode we interview Joseph Parambil, MD, staff member in the department of pulmonary, allergy and critical care medicine at Cleveland Clinic, about the current challenges of interstitial lung disease, or ILD. · Intro by Adam J. Brown, MD 0:12 · Welcome back Joseph Parambil, MD 0:32 · But first, some medical history on ILD 1:04 · ILD vs. IPF 2:26 · A quick...
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Healio Community Book Club: A conversation between Leonard Calabrese, DO and Kevin Tracey, MD, author of The Great Nerve
Healio Rheuminations
This special edition episode features the latest installment of Healio Community’s book club. Physician author Kevin J. Tracey, MD, discussed his book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes in which he explores the potential of stimulating the vagus nerve to treat rheumatoid arthritis and other diseases. · Intro by Adam J. Brown, MD 0:14 · A warm welcome from Leonard H. Calabrese, DO 0:25 · Introducing Kevin...
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Celebrating 101 episodes of Healio Rheuminations with Dr. Leonard Calabrese
Healio Rheuminations
To celebrate 101 episodes, I sit with Leonard H. Calabrese, DO, to discuss his unique career in Rheumatology, spanning immunology, HIV, MECFS, IRES, CNS vasculitis and more. We also discuss how medical history shaped our careers. · Intro 0:12 · Welcome Leonard H. Calabrese, DO 3:11 · A quick friendship begins over medical history 4:14 · How Healio Rheuminations began and where the show is now 5:38 ...
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The history of giant cell arteritis: Infections, injections and the man who couldn't wear a hat
Healio Rheuminations
What does a goiter and syphilis have in common with the first descriptions of giant cell arteritis? Join us as we dive into the history of the most common type of vasculitis! Intro 0:13 GCA at ACR 2025 00:30 How Brown has approached framing this episode 1:01 A primer leading us to GCA 3:15 Let’s get to the story 4:02 The man who couldn’t wear a hat 4:57 Dr. Bayard Horton’s 7:40 A tangent on cluster headaches 8:27 Let’s get back to GCA 13:16 The first temporal artery biopsy 14:28 Vision loss and other puzzle pieces of GCA 16:27 What about jaw claudication? 21:15 Could GCA be...
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The Unnecessarily Complex Story of Rheumatoid Factor
Healio Rheuminations
The story of rheumatoid factor could be a 10 minute episode, but in this episode, we dig deep into the history of the lab techniques leading up to this discovery…that happened twice. Intro 0:15 Rheumatoid factor quick background and history 00:36 Rheumatology blood tests 3:02 What is Rheumatoid factor? 3:49 Spiderman and latex agglutination: Testing for rheumatoid factor 4:50 The double discovery of rheumatoid factor 8:03 Putting agglutination on the medical map in 1896 10:08 Pop Quiz! 11:21 Serotherapy 13:10 When did we start using...
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Don’t forget the toes: Managing patients with ANCA vasculitis
Healio Rheuminations
Active or not active, that is the question. In this week's episode we interview Alexandra Villa-Forte, MD, MPH, a staff physician in the Center for Vasculitis Care and Research at Cleveland Clinic and a leading vasculitis expert, on a pragmatic approach to recognizing disease activity in patients with ANCA vasculitis. · Intro 0:01 · Welcome Alexandra Villa-Forte, MD, MPH 0:10 · Dr. Brown sketches a potential patient that may be seen in practice 0:40 ...
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Healio Community Book Club: A conversation between Leonard Calabrese, DO and Eric Topol, MD, author of Super Agers
Healio Rheuminations
This special edition episode features the latest installment of Healio Community’s book club. Physician author Eric Topol, MD, discusses his book, a guide to the science of living a long life free of debilitating diseases with Leonard H. Calabrese, DO, chief medical editor of Healio Rheumatology. · Intro by Adam J. Brown, MD 0:01 · A warm welcome by Leonard H. Calabrese, DO 0:47 · Introducing Eric Topol, MD 1:12 ...
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The Astounding Account of the IL-17 and Spondylarthritis
Healio Rheuminations
In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA Intro 0:15 In this episode 0:27 Leonard Calabrese, DO, is listening! 1:07 Recap of last episode 3:23 Putting the pieces together 5:32 Quick overview of this science heavy episode 6:27 What is psoriasis? 7:42 Immunosuppressants for psoriasis/ Throwing meds at people and seeing what happens 10:20 In the modern world of 1986 – olive oil placebo trial 11:45...
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The Tumultuous Tale of Th17-and the IL23/IL17 immune axis
Healio Rheuminations
In this episode, we dive into a two-part story of intrigue starting from a paradigm shift in understanding of T cell biology because of a mouse model of post-measles encephalopathy, to the eventual recognition of the IL-23/17 immune axis. • Intro 0:01 • In this episode 0:12 • Interleukin-17 (IL-17) is a relatively recent discovery 1:34 • The beginning of TH-17 2:20 • Looking at autoimmune encephalopathy: A story of measles 03:30 • 1790’s woman with post measles inflammatory process in the brain...
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History of polymyalgia rheumatica: The origin of the pain & link to giant cell arteritis
Healio Rheuminations
In this episode, we dive into the history of polymyalgia rheumatica, how it was discovered and its link to giant cell arteritis. Intro 0:01 In this episode 0:10 What is polymyalgia rheumatica (PMR)? 0:24 The history of PMR 02:12 PMR in the 1950s: A formally recognized disease 04:52 What was probably PMR in the 1880s 06:27 Naming PMR: Senile rheumatic gout 07:26 1957: The witch’s shot and finally landing on polymyalgia rheumatica 08:30 Where is PMR coming from? 14:42 Injecting joins with saline 16:39 A biopsy study in 1964 19:54 Technetium bone scintigraphy in 1971 and bone scan history...
info_outlineIn this episode, we dig through the data of lupus in Africa and speak with experts on the Lupus Gradient, the impact of malaria and what we can learn from it all.
· Intro 0:12
· In the previous episode 0:30
· Lupus Gradient 2:01
· Back to Dr. Brian Greenwood 3:48
· Polyarthritis 4:04
· Rates of autoimmune diseases 6:00
· Malaria and mouse models 7:33
· Back to lupus 8:48
· First case of lupus 15:14
· Prevalence of lupus 17:15
· Papers on lupus 21:23
· Dr. Mickael Essouma 23:38
· Dr. Essouma, how did you conduct this study? 24:01
· Did you ever believe there was a gradient? 26:09
· Dr. Sandro Vento 30:56
· Dr. Vento, do you believe there was a lupus gradient? 31:51
· What are the connections to infectious disease? 38:51
· That’s a wrap! 43:04
· Coming up in part 4 44:55
· Thanks for listening 45:05
Disclosures: Brown reports no relevant financial disclosures. Healio could not confirm relevant financial disclosures for Essouma and Vento at the time of posting.
Mickael Essouma, MD, is physician from Cameroon specialized in internal medicine at the University of Yaounde I in Cameroon, with a complimentary certificate on rheumatology from the EULAR online course and a certificate on lupus from the European Lupus Society (SLEuro). He is an advocate of lupus and other autoimmune diseases in Africans.
Sandro Vento, MD, is the dean of faculty of medicine at the University of Puthisastra, Phnom Penh, Cambodia and a consultant and collaborating specialist at Mayo Clinic Center for Tuberculosis, WHO Collaborating Center.
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Bae SC, et al. Arthritis Rheum. 1998;doi:10.1002/1529-0131(199812)41:12<2091::AID-ART2>3.0.CO;2-D.
Bryc K, et al. Am J Hum Genet. 2015;doi:10.1016/j.ajhg.2014.11.010.
Essouma M, et al. J Autoimmun. 2020;doi:10.1016/j.jaut.2019.102348.
Gilkeson GS, et al. Lupus. 2011;doi:10.1177/0961203311404915.
Micheletti SJ, et al. Am J Hum Genet. 2020;doi:10.1016/j.ajhg.2020.06.012.
Symmons DP. Lupus. 1995;doi:10.1177/096120339500400303.
Vento S, et al. Front Med. 2020;doi:10.3389/fmed.2020.00202.