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Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways

OTO Journal

Release Date: 05/21/2025

Optimal Timing of Cleft Lip Repair: Correlation With Scar Formation and Revision Rates show art Optimal Timing of Cleft Lip Repair: Correlation With Scar Formation and Revision Rates

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Saikrishna Gourishetti, MD, and Associate Editor Michael Brenner, MD, to discuss the investigation of whether performing cleft lip repair at an earlier age affects the likelihood of developing hypertrophic scarring,  as outlined in the paper "Optimal Timing of Cleft Lip Repair: Correlation With Scar Formation and Revision Rates" which published in the March 2026 issue of Otolaryngology–Head and Neck Surgery.  

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Does Smoking Influence Outcomes in Human Papillomavirus—Associated Oropharyngeal Cancer Treated with Transoral Robotic Surgery? show art Does Smoking Influence Outcomes in Human Papillomavirus—Associated Oropharyngeal Cancer Treated with Transoral Robotic Surgery?

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Kyle M. Hatten, MD, and Associate Editor Patrick Tassone, MD, to discuss the importance of the investigation findings in HPV associated oropharyngeal squamous cell carcinoma and smoking risk factors in oropharyngeal cancers, as outlined in the paper "Does Smoking Influence Outcomes in Human Papillomavirus—Associated Oropharyngeal Cancer Treated with Transoral Robotic Surgery?" which published in the April 2026 issue of Otolaryngology–Head and Neck Surgery.

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Association Between Weight Gain Trajectories and Severe Obstructive Sleep Apnea Among Adolescents show art Association Between Weight Gain Trajectories and Severe Obstructive Sleep Apnea Among Adolescents

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Romaine F. Johnson, MD, MPH, and Associate Editor M. Boyd Gillespie, MD, to discuss whether childhood obesity is associated with increased severity of obstructive sleep apnea during adolescence, as outlined in the paper "Association Between Weight Gain Trajectories and Severe Obstructive Sleep Apnea Among Adolescents" which published in the February 2026 issue of Otolaryngology–Head and Neck Surgery.

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Assessing the Impact of GLP-1R Agonists in Post-sinus Surgery Management show art Assessing the Impact of GLP-1R Agonists in Post-sinus Surgery Management

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Mohamad R. Chaaban, MD, and Associate Editor Dana L. Crosby, MD, to discuss the growing evidence that suggests there may be a meaningful connection between chronic rhinosinusitis and obesity as outlined in the paper "Assessing the Impact of GLP-1R Agonists in Post-sinus Surgery Management," which published in the January 2026 issue of Otolaryngology–Head and Neck Surgery.

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Out-of-Pocket Costs and Surprise Billing in Otolaryngology: A National Database Analysis show art Out-of-Pocket Costs and Surprise Billing in Otolaryngology: A National Database Analysis

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Michael J. Brenner, MD, and Associate Editor Christipher M. Johnson, MD, to discuss the challenges of financial stress patients face when they undergo common otolaryngology procedures, as outlined in the paper "Out-of-Pocket Costs and Surprise Billing in Otolaryngology: A National Database Analysis," which published in the December 2025 issue of Otolaryngology–Head and Neck Surgery.

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TI-RADS and Bethesda Classification System Correlate With Predicting Pediatric Papillary Thyroid Carcinoma show art TI-RADS and Bethesda Classification System Correlate With Predicting Pediatric Papillary Thyroid Carcinoma

OTO Journal

Editor in Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author John P. Dahl, MD, PhD, MBA, and Associate Editor Marissa Ryan, MD, to discuss their findings in "TI-RADS and Bethesda Classification System Correlate With Predicting Pediatric Papillary Thyroid Carcinoma," which was published in the October 2025 issue of Otolaryngology–Head and Neck Surgery. 

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Microsurgical Outcomes in 1000 Patients With Cerebellopontine Angle Tumors: A Comprehensive Cohort Analysis show art Microsurgical Outcomes in 1000 Patients With Cerebellopontine Angle Tumors: A Comprehensive Cohort Analysis

OTO Journal

Editor in Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Rick Friedman, MD, PhD, and Associate Editor James G. Naples, MD, to discuss their findings in "Microsurgical Outcomes in 1000 Patients With Cerebellopontine Angle Tumors: A Comprehensive Cohort Analysis," which was published in the November 2025 issue of Otolaryngology–Head and Neck Surgery. 

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Impact of Postoperative Weight Changes on Hypoglossal Nerve Stimulation Success for Obstructive Sleep Apnea show art Impact of Postoperative Weight Changes on Hypoglossal Nerve Stimulation Success for Obstructive Sleep Apnea

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Colin T. Huntley, MD, and Associate Editor Boyd Gillespie, MD, to discuss how long-term changes in body mass index (BMI) following hypoglossal nerve stimulation (HGNS) impact surgical success as outlined in the paper "Impact of Postoperative Weight Changes on Hypoglossal Nerve Stimulation Success for Obstructive Sleep Apnea," which published in the September 2025 issue of Otolaryngology- Head and Neck Surgery.

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Plain Language Summary: Update - Adult Sinusitis show art Plain Language Summary: Update - Adult Sinusitis

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc is joined by co-authors Margo McKenna, MD, and Maria Colandrea, DNP NP-C, to discuss the implications for non-otolaryngologists of the Clinical Practice Guideline "Adult Sinusitis Update,” which published as a supplement to the August 2025 issue of Otolaryngology–Head and Neck Surgery. A plain language summary of the guideline was published in the August 2025 issue as a companion to the full guideline.   

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Clinical Practice Guideline: Update-Adult Sinusitis show art Clinical Practice Guideline: Update-Adult Sinusitis

OTO Journal

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc is joined by co-authors Marc G. Dubin, MD, and Spencer C. Payne, MD, to discuss the Clinical Practice Guideline "Adult Sinusitis Update,” which published as a supplement to the August 2025 issue of Otolaryngology–Head and Neck Surgery. The guideline addresses diagnostic accuracy for adult rhinosinusitis, use of ancillary tests to confirm diagnosis and guide management, and systemic and topical therapy.

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More Episodes

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Bradford A. Woodworth, MD, and Associate Editor Dana L. Crosby, MD, MPH, to discuss how lipopolysaccharide can be used to generate a model of acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in murine nasal airways as outlined in the paper “Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways,” which published in the May 2025 issue of Otolaryngology–Head and Neck Surgery. They talk about CFTR as a potential driving process in recalcitrant chronic rhinosinusitis.

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