Critical Care Reviews Podcast

The Critical Care Reviews Podcast discusses the biggest critical care trials, either planned or in progress, with their chief investigators. It's hosted by Rob Mac Sweeney, an intensivist in Belfast, Northern Ireland. We also release audio versions of the presentations from the Critical Care Reviews Meetings and ad hoc livestreams

ACIOS Study 03/21/2025

ACIOS Study Rob Mac Sweeney discusses the ACIOS study with Tim Baker, the study lead. ACIOS is a point prevalence study describing the burden of critical illness in Africa. It was published in the Lancet in March, 2025. /episode/index/show/ccrpodcast/id/35807120

IVIO Trial 11/13/2024

IVIO Trial Rob Mac Sweeney discusses the IVIO trial with investigators Lars Wiuff Andersen and Mikael Fink Valentine from Aarhus, Denmark. The IVIO trial compared intraosseous with intravenous vascular access in adult patients suffering an out-of-hospital cardiac arrest. It was presented at the 2024 European Resuscitation Council congress in Athens and simultaneously published in the New England Journal of Medicine. /episode/index/show/ccrpodcast/id/33917902

PARAMEDIC 3 Trial 11/12/2024

PARAMEDIC 3 Trial Rob Mac Sweeney discusses the PARAMEDIC 3 trial with it's investigators Keith Couple and Ranjit Lall from the University of Warwick, England. PARAMEDIC 3 compared intravenous with intraosseous vascular access in adult patients suffering cardiac arrest and requiring drug administration during ongoing resuscitation. It was presented at the European Resuscitation Council meeting in Athens on October 31st and simultaneously published in the New England Journal of Medicine. /episode/index/show/ccrpodcast/id/33896057

B-FREE Trial 04/07/2024

B-FREE Trial Rob Mac Sweeney chats with Jessica Spence about the B-FREE trial, investigating benzodiazepine-free anaesthesia for the prevention of delirium in cardiac surgery /episode/index/show/ccrpodcast/id/30719768

Beyond Platform Trials Panel Discussion 03/13/2024

Beyond Platform Trials Panel Discussion Bala Venkatesh (Brisbane) hosts a panel discussion entitled "Beyond Platform Trials" at the Critical Care Reviews Meeting 2023. The panellists include Bronagh Blackwood (Belfast), Susan Rowell (Chicago), Fernando Zampieri (Edmonton), Marion Campbell (Aberdeen), David Harrison (London), Roger Lewis (Los Angeles), Derek Angus (Pittsburgh) & Kathy Rowan (London). /episode/index/show/ccrpodcast/id/30362968

Causality Panel Discussion 03/13/2024

Causality Panel Discussion Kathy Rowan (London) hosts a fascinating panel discussion on causality at the Critical Care Reviews Meeting 2023. The panellists include Bronwen Connolly (Belfast), Ewan Goligher (Toronto), Flavia Machado (Sao Paulo), Kath Maitland (Kalifi), John Norrie (Edinburgh), Victoria Cornelius (London), Andrew Althouse (Pittsburgh) and Chris Seymour (Pittsburgh). /episode/index/show/ccrpodcast/id/30359938

REMAP-CAP Trial Long Term Outcomes 03/13/2024

REMAP-CAP Trial Long Term Outcomes Dr Lisa Higgins (Melbourne) presents the long term outcomes of the REMAP-CAP domains at the Critical Care Reviews Meeting 2023. Prof Howard Bauchner (Boston) delivers an editorial. Prof Christopher Seymour (Pittsburgh) chairs the session. /episode/index/show/ccrpodcast/id/30359693

AID-ICU Trial 03/13/2024

AID-ICU Trial Nina Christine Andersen-Ranberg presents the AID-ICU trial, investigating haloperidol for the management of delirium in the ICU. Danny McAuley delivers an editorial. Anders Perner joins the discussion and the session is chaired by Paul Mouncey. /episode/index/show/ccrpodcast/id/30359333

John Hinds Lecture 2023 03/13/2024

John Hinds Lecture 2023 Prof Flavia Machado (Sao Paulo) delivers the John Hinds Lecture at the Critical Care Reviews Meeting 2023, describing the story of BRICNET, the Brazilian Critical Care Trials Group. The session commences with Dr Chris Nutt remembering our friend, Dr John Hinds. /episode/index/show/ccrpodcast/id/30358563

PROCOAG Trial 02/05/2024

PROCOAG Trial You're listening to the audio version of the PROCOAG trial presentation from the Critical Care Reviews Meeting 2023. The PROCOAG trial investigated the efficacy and safety of early administration of 4-factor prothrombin complex concentrate in trauma patients at risk of massive transfusion. The trial is presented by Pierre Bouzat from Grenoble. Susan Rowell from Chicago, delivers the editorial. The session is chaired by Chris Seymour (Pittsburgh). PROCOAG was published in JAMA in March 2023. /episode/index/show/ccrpodcast/id/29809433

TEAM Trial 02/05/2024

TEAM Trial You're listening to the audio version of the TEAM trial presentation from the Critical Care Reviews Meeting 2023. The TEAM trial investigated early active mobilisation in critically ill mechanically ventilated patients. The trial is presented by Carol Hodgson from Melbourne. Darren Taichman from Philadelphia, delivers the editorial. The session is chaired by Paul Mouncey (Pittsburgh). /episode/index/show/ccrpodcast/id/29803608

PILOT Trial 01/26/2024

PILOT Trial Matthew Semler (Nashville, USA) presents the PILOT trial at the Critical care Reviews Meeting 2023, in Titanic Belfast. The PILOT trial compared low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Kath Maitland from Kigali, Kenya, delivers an independent editorial. The session is chaired by Chris Seymour from Pittsburgh, USA. PILOT was published in the New England Journal of Medicine on November 10th, 2022. /episode/index/show/ccrpodcast/id/29660268

REMAP-CAP / LOVIT-COVID Vitamin C Trial 01/16/2024

REMAP-CAP / LOVIT-COVID Vitamin C Trial Dr Francois Lamontagne joins Rob Mac Sweeney to discuss the harmonised REMAP-CAP / LOVIT-COVID vitamin C trial. The trial was presented at the European Society of Intensive Care Medicine annual congress and simultaneously published in the New England Journal of Medicine. /episode/index/show/ccrpodcast/id/28618518

NICO Trial 12/31/2023

NICO Trial /episode/index/show/ccrpodcast/id/29199798

OXY-PICU Trial Presentation 12/03/2023

OXY-PICU Trial Presentation Mark Peters and Doug Gould (both London) present the results of the OXY-PICU trial, comparing conservative with liberal oxygenation targets (SpO2 88-92% vs >94%) in critically ill children receiving invasive mechanical ventilation. Luregn Schlapbach (Zurich) delivers an independent editorial. They are joined by Victoria Cornelius (London), Bronagh Blackwood (Belfast), & Matthew Semler (Nashville) for a panel discussion. The session is chaired by Howard Bauchner (Boston). /episode/index/show/ccrpodcast/id/28903243

REMAP-CAP Statin Domain 10/25/2023

REMAP-CAP Statin Domain Scott Berry (Austin) and Danny McAuley (Belfast) join Rob Mac Sweeney to discuss the results of the statin domain of the REMAP-CAP trial, investigating 80mg once daily of simvastatin in critically ill patients with COVID-19. /episode/index/show/ccrpodcast/id/28423070

UK-REBOA Trial Presentation 10/12/2023

UK-REBOA Trial Presentation Jan Jansen (Birmingham, USA) & Marion Campbell (Aberdeen) present the results of the UK-REBOA trial, investigating the use of REBOA in trauma patients with severe non-compressible torso haemorrhage. The editorial is delivered by John Holcomb (also from Birmingham, USA) and the session is chaired by Catriona Kelly from Dublin. The panel discussing the trial are Diana Cimpoesu (Ilsa, Romania), Caroline Leech (Coventry), Stephen Bernard (Melbourne) and Roger Lewis (Los Angeles). /episode/index/show/ccrpodcast/id/28298375

CRYOSTAT-2 Trial Presentation 10/12/2023

CRYOSTAT-2 Trial Presentation Profs Nikki Curry (Oxford) and Karim Brohi (London) present the results of the CRYOSTAT-2 trial, evaluated early & empiric high-dose cryoprecipitate in patients with major traumatic haemorrhage. The editorial is delivered by Susan Rowell (Chicago) and the session is chaired by Phil Gillen from Belfast. The panel discussing the trial are Russell Gruen (Canberra), Caroline Leech (Coventry), John Holcomb (Birmingham, USA), Andrew Althouse (Pittsburgh) and co-investigator Simon Stanworth from Oxford. /episode/index/show/ccrpodcast/id/28298273

CLOVERS Trial 09/08/2023

CLOVERS Trial Prof Ivor Douglas (Denver, USA) presents the CLOVERS trial, comparing an early restrictive fluid strategy with an early liberal fluid strategy in adult patients with sepsis-induced hypotension. Prof Fernando Zampieri (Edmonton, Canada), delivers an editorial. The session is chaired by Dr Paul Mouncey (London, England). /episode/index/show/ccrpodcast/id/27978237

PATCH-Trauma Trial Presentation 07/27/2023

PATCH-Trauma Trial Presentation Russell Gruen, Brian Burns and Stephen Bernard present the results of the PATCH-Trauma trial, investigating tranexamic acid in severe trauma. An independent editorial is delivered by Karim Brohi (London). Caroline Leech (Coventry) chairs a panel discussion consisting of Susan Rowell (Chicago), Carol Hodgson (Melbourne), John Holcomb (Birmingham, USA) and John Norrie (Edinburgh). /episode/index/show/ccrpodcast/id/27582927

TAME Trial Presentation 07/24/2023

TAME Trial Presentation Glenn Eastwood presents the results of the TAME cardiac arrest trial, investigating mild hypercapnoea post cardiac arrest. He is joined by senior investigators Alistair Nichol (Dublin) and Stephen Bernard (Melbourne). An independent editorial is delivered by Lars Andersen (Aarhus). Darren Taichman (Philadelphia) chairs a panel discussion consisting of Flavia Machado (Sao paulo), Joyce Yeung (Birmingham, UK) and Andrew Althouse (Pittsburgh), as well as the other speakers. /episode/index/show/ccrpodcast/id/27547818

DEVICE Trial Results 07/06/2023

DEVICE Trial Results Profs Matthew Prekker (Minneapolis) and Matthew Semler (Nashville) present the results of the DEVICE trial, comparing direct with video laryngoscopy for emergency intubation in the critically ill. Prof Ellen O'Sullivan (Dublin) delivers an editorial, followed by a panel discussion including Prof David Harrison (London), Dr Caroline Leech (Coventry), Dr Fiona Kelly (Bath) and Prof Alistair Nichol (Dublin). The session was chaired by Dr Catriona Kelly (Dublin). These results were presented at the Critical Care Reviews Meeting 2023, held in Titanic Belfast on June 16th. The DEVICE trial was simultaneously published in the New England Journal of Medicine. /episode/index/show/ccrpodcast/id/27390165

MERCY Trial Results 06/29/2023

MERCY Trial Results Profs Giovanni Landoni and Giacomo Monti present the results of the MERCY trial, comparing bolus administration with continuous infusion of meropenem in critically ill patients with sepsis and septic shock. The results were presented at the Critical Care Reviews Meeting 2023, in Titanic Belfast. Prof Flavia Machado (Sao Paulo) delivers an editorial. The panel discussion incldues Profs Kathy Rowan (London), Victoria Cornelius (London), Ivor Douglas (Denver) and Ewan Goligher (Toronto). The session was chaired by Chris Nutt (Belfast). /episode/index/show/ccrpodcast/id/27324483

SuDDICU Trial Presentation 10/26/2022

SuDDICU Trial Presentation John Myburgh and Ian Seppelt (Sydney) present the results of the SuDDICU trial at the Critical Care Reviews Meeting 2022, in Titanic Belfast. SuDDICU investigates selective digestive decontamination in critically ill mechanically ventilated patients. Naomi Hammond (Sydney) follows with a presentation of a systematic review and meta analysis also on SDD. John Marshall (Toronto) delivers an editorial. Danny McAuley (Belfast), Bodil Steen Rasmussen (Aalborg) and Victoria Cornelius (London) join the presenters for a panel discussion. The session is chaired by Chris Seymour (Pittsburgh). /episode/index/show/ccrpodcast/id/24810891

PILOT Trial Result Livestream 10/25/2022

PILOT Trial Result Livestream Matthew Semler presents the results of the PILOT trial, comparing low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Paul Young delivers an editorial and Chris Nutt asks questions from the viewers. The expert panel discussion includes Victoria Cornelius, Angelique de Man, Bodil Steen Rasmussen and Gilles Capellier. The paper was simultaneously published in the New England Journal of Medicine. /episode/index/show/ccrpodcast/id/24794487

Prague Out-of-Hospital Cardiac Arrest Study 10/11/2022

Prague Out-of-Hospital Cardiac Arrest Study Prof Jan Belohlavek (Prague, Czech Republic) presents the Prague Out-of-Hospital Cardiac Arrest Study at the Critical care Reviews Meeting 2022. This study investigates the efficacy of an eCPR programme in patients with refractory out-of-hospital cardiac arrest. Dr Liz Wilcox (Toronto, Canada) follows with an editorial on the trial. /episode/index/show/ccrpodcast/id/24644070

VAM-IHCA Trial Presentation at CCR22 09/18/2022

VAM-IHCA Trial Presentation at CCR22 Lars Andersen (Aarhus, Denmark) presents the VAM-IHCA trial on June 15th at the Critical Care Reviews Meeting 2022, in Titanic Belfast. The VAM-IHCA trial investigates the combination of vasopressin and methylprednisolone in in-hospital cardiac arrest. Chris Seymour (Pittsburgh, USA) delivers an editorial after the trial presentation. The session is chaired by Catriona Kelly (Dublin, Ireland). /episode/index/show/ccrpodcast/id/24410484

TTM2 Trial Presentation at CCR22 09/01/2022

TTM2 Trial Presentation at CCR22 /episode/index/show/ccrpodcast/id/24238254

RePHILL Trial Presentation at CCR22 08/21/2022

RePHILL Trial Presentation at CCR22 Nick Crombie (Birmingham, England) presents the RePHILL trial, comparing pre-hospital administration of saline with blood products in patients with trauma-related haemorrhagic shock. Liz Wilcox (Toronto, Canada) delivers an editorial. The session is chaired by Catriona Kelly (Dublin, Ireland). /episode/index/show/ccrpodcast/id/24121239

PREPARE II Trial Result Presentation 08/03/2022

PREPARE II Trial Result Presentation Derek Russell (Birmingham, USA) and Jon Casey (Nashville, USA) presents the results of the PREPARE II trial, investigating fluid bolus therapy for the prevention of cardiovascular collapse during emergency intubation. Anthony Gordon (London, England) delivers an editorial, which is followed by a panel discussion including Lennie Derde (Utrecht, the Netherlands), Andrew Althouse (Pittsburgh, USA), Elizabeth Wilcox (Toronto, Canada) and Lars Andersen (Aarhous, Denmark). The session is chaired by Chris Seymour from the USA. PREPARE II was simultaneously published in JAMA. /episode/index/show/ccrpodcast/id/23940306

Critical Care Reviews Podcast

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