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AMJ Podcast | Episode 4: Capivasertib in the Clinic: Strategies to Manage Adverse Events
11/25/2025
AMJ Podcast | Episode 4: Capivasertib in the Clinic: Strategies to Manage Adverse Events
AMJ Podcast | Episode 4 Capivasertib in the Clinic: Strategies to Manage Adverse Events This content was funded by AstraZeneca, and is intended for US Healthcare Professionals. Expert opinions are shared in this program and may differ from the approved capivasertib (TRUQAP®) labeling. Please see full , including when making treatment decisions. Indication and Usage Capivasertib (TRUQAP®) in combination with fulvestrant is indicated for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN alteration as detected by an FDA-approved test following progression on at least one endocrine-based regimen in the metastatic setting or recurrence on or within 12 months of completing adjuvant therapy. Description In this practical, case-based discussion, a breast oncology pharmacist and nurse practitioner walk through how they anticipate and manage the most common adverse events seen with capivasertib in HR-positive/HER2-negative advanced breast cancer. Drawing on real-world clinic workflows, they share stepwise approaches to counseling, prophylaxis, and early intervention for diarrhea, rash, and hyperglycemia, including when to escalate monitoring or treatment and how to coordinate roles across the care team. You’ll hear communication scripts, tips for using tools such as stool diaries and home glucometers, and strategies to keep patients on therapy safely and confidently. Chapters 00:00 – 03:24 | Introduction 03:24 – 05:18 | When to consider capivasertib 05:18 – 08:51 | Introducing adverse events 08:51 – 16:18 | Diarrhea management 16:18 – 20:35 | Rash management 20:35 – 25:07 | Hyperglycemia management 25:07 – 27:31 | Care team best practices 27:31 – 31:18 | Top Tips & Takeaways Speakers: Heather Moore – Breast Oncology Pharmacist, Duke University Medical Center Sarah Donohue – Breast Oncology Nurse Practitioner, UCSF Health Breast Care Center Select Safety Information About capivasertib (TRUQAP®) tablets TRUQAP is contraindicated in patients with severe hypersensitivity to TRUQAP or any of its components. Serious adverse reactions include hyperglycemia, including diabetic ketoacidosis and fatal outcomes; diarrhea; and cutaneous adverse reactions. Monitor fasting glucose and hemoglobin A1C levels regularly. May cause fetal harm when administered to a pregnant woman. Among the 355 patients who received TRUQAP in CAPItello-291, the most common (≥20%) adverse reactions, including laboratory abnormalities, were diarrhea (72%), cutaneous adverse reactions (58%), increased random glucose (57%), decreased lymphocytes (47%), decreased hemoglobin (45%), increased fasting glucose (37%), nausea and fatigue (35% each), decreased leukocytes (32%), increased triglycerides (27%), decreased neutrophils (23%), increased creatinine (22%), vomiting (21%), and stomatitis (20%). Please see full , including for TRUQAP.
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