Healthcare In Your Hands
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Worldwide Evaluation of Pyrrole Tests 003
07/09/2018
Worldwide Evaluation of Pyrrole Tests 003
Dan Hanson: Good morning and welcome to the Health Care in Your Hands podcast with Dr. Lloyd Fielder and Dan Hanson. Uh, today we wanna talk a little bit more about the Kryptopyrrole information that has been circulated, things that are coming about, questions that people have. Our goal is always to stay on top of the news, uh be as far ahead of the research and you know really look for ways that we can always improve and always help other people and just educate people with things that we know but also take questions and so you know, I'd like to start out by um bringing some of Lloyd's content to the table and and seeing hey, you know looks like we got some stuff here. I know you guys can't see us this morning, but Lloyd's got some um laid out, well laid notes I'd like to say, and um I'd love to let you have the floor if you don't mind Lloyd and talk a little bit about the the source of HPL and um what you're thinking this morning that would be meaningful to share. Dr. Fielder: Yeah, awesome Dan. You know, I think to be straightforward, we go to many conferences throughout the year and the biggest one that we've, um are doing at those conferences are interacting and talking with caregivers and especially physicians that are um curious about Kryptopyrrole testing, Pyroluria, and or and those that are already doing it and um we get just such great questions all over the board and what's just been happening a little bit more frequently and Dan and um myself felt that it was really necessary to address which is really some confusion and misconceptions about the um what is actually being tested and why and what it is and what it's not. And um this some people out there that apparently have a lot of misinformation and really, that's our mission in part is is actually the large part is educating not only patients but practitioners to exactly what we're testing and what the benefit is gonna be for the patients and the practitioners in their practices so people can get better. And the most recent thing that had come up was the confusion between what we heard as KP versus HP or Kryptopyrrole testing versus Heme Pyrrole testing and um Dan, would you say it's it's pretty um it was confusing at first because we thought that potentially there was something out there to that we weren't covering? Dan Hanson: Right, absolutely. It it seemed like some of the consumers in the marketplace, meaning caregivers or physicians were exploring the opportunities to use Kryptopyrrole testing or measuring Pyrroles to put it in a in a more blunt and basic level and ultimately, they were maybe abroad or they were working with laboratories outside the US that are saying they're identifying the molecules differently and they're also identifying where the molecules generate from or or generally how they become elevated a little bit differently. There are, there are main three main theories really to what causes the Pyrrole molecule to become elevated and so what we've noticed is there's a retitling of the test, there is a different way of reporting the results, there is a different theory um being presented as the primary or only theory that really determines why Pyrrole's become elevated, and that's what causes confusion. The physicians that we speak with um particularly in this case, international physicians are saying well, this is a genetic marker and we're measuring HPU, we're measuring um KPU. We're measuring different values that I don't think you guys are measuring and sometimes, because we're not always there at the conferences, the representatives who work on behalf of DHA are less knowledgeable about how to answer those questions so they, they have the best intentions of reporting back to us to say hey, we think there's research going on with the Kryptopyrrole testing. Um, we think that there might be other molecules being tested, you know please let us know how we can best respond to practitioners, patients and um people really like and marketing groups or media groups that want to promote advanced nutrient therapy and advanced health care. You know, what can we tell them that's important? And so, we've done a little bit about clearing the confusion up in the past, but you know I think that we can go a little bit deeper today into what we're testing, why it's important, and really where some of those misconceptions are. Dr. Fielder: Right, and I think that's, that's awesome, so specifically that last conference, someone had come over and said you guys are testing KPU. We're interested in HPU and the reason that these international practitioners uh had said we want HPU it's because that's, that's testing for the genetic um cause for Pyroluria, and you guys are doing KPU, which is not the genetic form of Pyroluria, and that couldn't be the furthest thing from the truth. After like, we were a bit confused by it, and it didn't take honestly but five minutes to realize that they were just making a mistake. That uh, they uh I don't know if it's from any instructors or where this misinformation is being propagated, but uh we're talking about in essence, the same thing but there's some different research articles, so people are just trying to um I don't know if if it's some people are erroneously or mistakenly trying to do a selling point, to push a certain product, and and again, I can't speak to something else, but very simply, for anybody that's listening that um HPU and KPU are essentially the same thing. What I think some people have mistakenly assumed is if you go back to 10 years ago, um there's a couple of articles uh uh a journal articles and it was titled Discerning the Mauve Factor. There's a part one and part two, and it was by um I believe it was McGuiness who led the study and they addressed right off the bat that there are certain terminologies that are used interchangeably, whether that is Kryptopyrrole, Pyrrole, um Heme Pyrrole, you know Dan, there are some other ones. Mauve Factor, there was I think a a couple of of other different um terminologies, but they were all used interchangeably, and so I think that the um international people tend to use still some of the older nomenclature, um especially referring to it as KPU or Kryptopyrrole you know and so when we're actually testing is it's hydroxyhemopyrrolin-2-one. Correct? Dan Hanson: Absolutely. Dr. Fielder: Yeah, and so that's can be looked at is potentially being used as HPU, I think and this, they're identifying this term Heme, hydroxyhemopyrrolin or um seeing an H instead of a K, they suddenly thought this was something new, not realizing that this is what we've always been testing for um on the better part of two decades? Dan Hanson: Absolutely. Dr. Fielder: You know, and and they're just learning now with different nomenclature, different terminology, they think suddenly there's something new being tested um and I think that's the most important thing that we had to bring forward to everybody is that we are testing hydroxyhemopyrrolin-2-one which is the only um metabolic that should be being tested if you want to assess Pyroluria and um I think it's pretty fair to say that we do it better than anybody else. Dan Hanson: Oh, absolutely and I think what would be great is to back that statement up a little bit and start again so we could break out sections that are really meaningful, um one of them I think is is the genetic potential. So, we started out by saying that you know some other people that we've spoken with determine that there was a a genetic test and what's really important to understand about genetics is that right now um we are leading a mass movement of genetic information in the health care provider world and the laboratory testing world, and what's being done is you know, we're identifying what snips our single nucleotide polymorphisms are related to specific conditions, and when or you know uh all kinds of traits for that same matter. We're looking at the genetic history of your ancestry, so when we're looking at that and and we're looking at these specific snips, we're saying you know if this particular snip is present, if this particular single nucleotide polymorphism is is present in a patient's DNA, they're more susceptible to specific epigenetic occurrences, excuse me like environmental insults, etcera and what's important to know there is that genetics are you know what or excuse me, the genetic theory that that's why people produce elevated Pyrroles, it's been passed down through genes is one of the three major theories on why Pyrroles become overproduced. Dr. Fielder: Right, and so right and I'm with you 100 percent, so I think what'll also help clear up some of the confusion for some of the docs and some of the caregivers and even patients out there is that um there's really not been any snip or polymorphism that's been strongly identified to um increase the HPL um in the urine directly. There has been one that has been identified pretentiously. It's called C Pox, I believe. It's C-P-O-X and um but again, what you're, what you cannot make the mistake is that does not cause Pyroluria. What the genetic snips do is they affect things like iron deficiency, um unstable hemoglobin, red red blood cell hemolysis, um heme synthesis, so we have identifiable snips for those conditions, but not directly for Pyroluria or elevated Pyrroles in the urine. So, they're as best as we know and we're really researched and we're really well read, that there is not any kind of single nucleotide polymorphism that is responsible directly for the increase in HPL. There are associated snips that will affect indirectly or you can, associated is the best way that you can really put with it, but um not direct, so anybody out there saying that we do the testing that is for the genetic Pyroluria or the genetic increase in HPU or HPL in in the urine is incorrect as best as we can tell. Dan Hanson: Absolutely, unless they can show you the snip and they can show you the research behind this particular snip and uh you know that that would be a great way to perceive. We've never seen it. It's not out there. I'm not familiar with it. It's not on the forefront of research for really any major reason. Um, and you know further even if the snip was present, this is a probability game. When somebody has a snip, that doesn't mean that that snip is present and expressing itself in the patient. We see that a lot with methylation status. Uh, we look at the MTHFR snip profile to determine if a patient is at risk for a methylation issue, and ultimately there are people out there who have double snips in that pathway and methylate optimally, and that's why in our in the model that really DHA has dfounded to support, the model of advanced nutrient therapy that was developed by Doctor Carl Pfeiffer, Doctor William Walsh, practiced by thousands of physicians today um you know they're looking at advanced markers that determine methylation status. You know, how is the methyl chemical being produced and how is it being uh dumped or excreted from the body appropriately because hey, you can have a snip but that doesn't mean it presents in the patient. Dr. Fielder: Right, which is why especially as the laboratory, we are really um adamant about being tested. This is why testing is primary. Um, questionnaires are great interviewing. History's a great um you know taking even some supplementation can be beneficial without you know doing anything else, but it's a shot in the dark. So, our recommendation always is you know test incorporate that in, make your clinical um recommendations, and then retest and so that you can see actually how somebody's functioning uh because we do know just as Dan just really just nailed it right now is that because you have a polymorphism does not mean that it is influencing your physiology the way you think it should. Dan Hanson: Absolutely, and the terminology since we've backed up and we went to the beginning of Doctor Fielder's original statement, and we talked about genetics then excuse me, two major terms that were mentioned there were HPU and KPU, and this is something that we really work to cover in the clearing up confusion podcast, but it's absolutely worth repeating. These terminologies, how you determine you're going to name a test is completely up to the laboratory that's providing with you the test. If I come up with a test tomorrow that determines the PH of my body, I can call it the Dan Hanson test if I like, and if you refer to it as the Dan Hanson test to another laboratory, chances are they won't be really familiar with what you're talking about and that will lead to confusion. So, when we're talking about people using the term HPU, they realistically, the derivative is the HPL molecule, the hydroxyhemopyrrolin-2-one molecule, um with the term urine added to the end of it, and and that's what they're doing. You'll notice that famous physicians like Doctor Dietrich Klinghardt are using terms like KPU and that's because that's the way that they're familiar expressing the test. They call it Kryptopyroluria, that term is developed um in Doctor Klinghardt's work and he utilizes that successfully to uh get the practitioner audience and the patient audience that he's speaking with engaged in the conversation and it works successfully. Are all of those terms something that are 100 percent accurate to use when you're relating to the molecule? No. You know, the Kryptopyrrole is the name we put on the test. It's the name that was most commonly utilized for the test. Uh, the Kryptopyrrole quantitative urine is a drawn out name that lets you know this is a historically determined version of measuring HPL. What's important here is that when you're looking through all the research, when you're looking through the basis of the developing uh advanced nutrient therapies and treating patients who suffer from mental and emotional conditions, I think Doctor Fielder referred to a great uh publication uh research document that was Discerning the Mauve Factor, part one and part two. You will notice that the test itself is referred to in various ways but the molecule is always referred to as a shortened version of HPL, which again stands for hydroxyhemopyrrolin-2-one uh Lloyd refers to it a little differently. How do you say the word heme? Is it used as heme, is that, is that what you said? Dr. Fielder: Yeah, it's again, yes. That's correct. Dan Hanson: I'm sure that uh Doctor Fielder's correct on that. Dr. Fielder: Oh. (laughs) Dan Hanson: (laughs) And I'm mispronouncing it. Dr. Fielder: And again, it's because you have porpho, bili, biligens, you have porphyrins, you have um Kryptopyrrole, you have Pyrroles, you have a lot of words that can be interchangeable and it can be confusing. That's why we use clearing up the confusion as much as possible, and I think you using the example of Doctor Dietrich Klinghardt and his use of KPU um and also some of the practitioners that followed him using HPU versus KPU, I think it's a really strong uh point because this growing understanding of the association between Pyrroles, Kryptopyrrole, HPL, HPU and Lyme Disease. Lyme Disease is a huge subject these days. It is um epidemically affecting not only people in this country, but you know others and so what we're trying to do is get people the right information so that they can make the best decision possible in the best interest of their patients, so with Doctor Klinghardt's use of Lyme Disease and identifying KPU, Pyroluria, and addressing that which is awesome. We just wanna make sure that these practitioners which is many of them are doing the right thing, because to then take it to the next level is we just are really, really um adamant about how precise you have to be with regards to capturing the samples from the patients, how you ship those samples to our lab, and then how that specimen is handled so that you get accurate um numbers so that you can assess properly and intervene correctly. Dan Hanson: Absolutely. During the process of researching, hey what other tests are out there? What are people talking about? We encountered a laboratory that is working out of Australia and they are providing Pyrrole results. They are performing a Kryptopyrrole test, and they actually mention in the reference of the result that Kryptopyrrole is not a scientifically correct name for the molecule, which is a great way to present that. What we also noticed when we were measuring those results was is excuse me several items that were absolutely incorrect in terms of calculations, in terms of uh viability of particular specimen volumes and and specimen um indicators for quality. So, it's really important to work with people that can help you understand in a given instance what is most appropriate for a specimen and what is not appropriate for a specimen and where the science lies behind that and that opens the floor for any listener to deliver results directly to the laboratory and allow us the opportunity to explain where inconsistencies in terms of whether that's just a label on a molecule or that's a label on the test, or that's a confusion between why we're calling something a particular name over another or why we feel there could be a um you know a a a process or there could be a point in the process that would basically cause those results to be void. As this is not FDA regulated testing, it's imperative to work with the leaders in the industry who are educated on all of the factors that would cause deterioration of results or cause results to be voided, and I certainly believe that the team here at DHA, and this is based on years of being integrated into functional medicine, are the leaders in being able to describe these inconsistencies, uh describe these deterioration points and provide the research that backs them accordingly. So you know again, I wanna open the floor if there's any practitioners or um even patients out there that are really interested in knowing did I get an accurate test? Why do you think this isn't accurate? What molecules are we measuring? Is this HPU? Is this KPU? Is this HPL? Are we talking about the same things? What's the difference in the Kryptopyrrole name in your test and the Kryptopyrrole name here? Send the questions our way. We'll personally answer them for you and if we feel it's something we should address to everybody that we somehow missed in this podcast, we'd be happy to bring it up on a future podcast and make sure we clarify it for the entire audience. Dr. Fielder: Absolutely. I am in full agreement with you. Dan Hanson: So, you know that kinda, in my you know recent history here has has wrapped up most of the inconsistencies that I've seen. We've dug as we said deep into these questions, into looking into genetic markers for Kryptopyrrole, genetic markers for HPL, um claims based on what other physicians were stating were available in other countries and what we found were massive inconsistencies between the information the physicians were providing and the information the laboratories were were reporting, and we clarified those with all the parties included, and of course we wanted to include you. Dr. Fielder: Yeah, and so let me just say lastly too Dan, is I think the thing that we can't ever overlook is that we have access to and we're, I think we're absolutely privileged to is our connection to the Walsh Research Institute and Doctor William Walsh. We have been his laboratory of choice for many, many years and because we have that relationship, we also have access to something that nobody else does, which is literally was it fair to say it's almost one hundred thousand different lab tests that he's done? His- Dan Hanson: Yeah, I I wanna say that you know I might've heard again, we're just speaking on behalf of Doctor Walsh's work and and I'm not here to cite anything at this very moment, but I have heard that it's the world's largest database of...
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Kryptopyrrole: Clearing up the Confusion 002
04/16/2018
Kryptopyrrole: Clearing up the Confusion 002
Dan Hanson: Good morning. Welcome to the Healthcare in Your Hands podcast with Dr. Lloyd Fielder, and myself, Dan Hanson. Today, we're going to talk about Kryptopyrrole Quantitative Urine testing. It's a mouthful of a word and there's some confusion around the Kryptopyrrole test that we want to start by clearing up. And then, we're going to go on some details. Pyrroles are super important for looking at advanced nutrients that are critical to brain health. It's a common topic that we're seeing across several videos, several podcasts, lots of articles online. And with a hot topic like this and a lot of confusions, it's really our job to step in and kind of clear up that confusion because we're both somewhat really well-versed on the topic. A lot of history and Dr. Fielder recently released an article that we're frequently asked questions about really the test itself and questionnaires, clearing up some other confusion. Dan Hanson: So what I want to do is just jump right in to what the test is and ultimately, what's some of these strange words are and why they exist and how they all got involved in being used together. And just make sense out of all that for everybody. So let's start out with the test name and then kind of break it down. Dan Hanson: The test itself is the Kryptopyrrole Quantitative Urine. And so, Kryptopyrrole is really the name for the test. And quantitative talks about the value. Meaning that we've got a quantitative results in numeric value with an optimal range as opposed to a qualitative result, which could be something like a yes or a no. And it's done in a urine specimen. So that kind of breaks down that major chunk of words, Kryptopyrrole Quantitative Urine. But what's really confusing about the word Kryptopyrrole is that people who are educated on the subject might call it HPL or might call it pyrroles or might talk a little bit about the pyrrole molecule, or we've even heard it called KPU. And so, let's unpack those a little bit. Dan Hanson: The pyrrole test itself or the Kryptopyrrole Quantitative Urine is measuring an actual molecule and that molecule is problematic, right? The reason why people are using this is because that molecule when it's over produced, it's responsible for depleting the body on zinc and B-6. It's produced during red blood cells synthesis. Everybody makes pyrroles. It's a normal byproduct of hemoglobin synthesis, but it can become over produced. That's when it's problematic. And so, your bodies since that it's really an unnecessary chemical, just a byproduct. It has a great way of eliminating it through the urinary tract, but when it's over produced, that's when it's going to start attaching the zinc and B6 and removing it through the urinary tract as well and really rendering it biounavailable. Dan Hanson: And what's important to understand about the Kryptopyrrole Quantitative Urine and how we're going to get into more detail about what this actually means is that krypto and pyrrole are part of the test. And we're looking to test a particular molecule that's actually hydroxyhemopyrrolin-2-one. And since that's just really a mouthful, people start to abbreviate in different ways. Hydroxyhemopyrrolin-2-one is most commonly, in the scientific world, referred to as HPL. That's an abbreviation for those terms. HPL again is an abbreviation for hydroxyhemopyrrolin-2-one. And that is what the Kryptopyrrole Quantitative Urine test is measuring. But since you're getting the work pyrrole in, out of that major work there, people also call them pyrroles. And it's referred to as the pyrrole test. And we frequently have people call the laboratory or look into the research and Google pyrroles. And so, it's important to make the connection when you're doing a Kryptopyrrole test, you're measuring pyrroles, which are really nickname, or HPL also is really a nickname for hydroxyhemopyrrolin-2-one. Dan Hanson: And so, let's look at this as a big picture. You've got a test name, you've got some nicknames. And then you've got the actual molecule name. And that's where a lot of this just gets mixed up. Ultimately, that's confusing enough, but what we also see are that practitioners and patients kind of start to generate their own terms. We've heard it called kryptos, we've heard it called KPU, which has been considered kryptopyrrole uria. I think that's a common term, that was more defined by ... Yeah, in Europe and more defined by Dr. Dietritch Klinghardt. Dr. Klinghardt is a highly regarded specialist in the field of all different types of medicine, but really globally recognized for treating patients who suffer from Lyme and correlating pyrrole testing or Kryptopyrrole Quantitative Urine testing to that patient population. And so, he's also very commonly regarded as the main use of the term KPU, Kryptopyrrole Uria. Dan Hanson: So everybody has kind of a different term for the test. And it's just really important that regardless of what anybody's calling it that in order for you to receive an accurate test and for physicians to receive an accurate test and to have something that's clinically relevant, that you're looking at the true molecule of hydroxyhemopyrrolin-2-one. And so, that should help clear up the confusion. One more time, you've got the Kryptopyrrole Quantitative Urine test and that can be referred to as pyrroles. That can be referred to as HPL. That can be referred to as KPU, but what's most important there is that we're measuring that key molecule hydroxyhemopyrrolin-2-one. And we're doing it in an accurate way. Dan Hanson: And so, I kind of got a little bit into that. Why that testing is important and I think that would be a great ... Dr. Fielder you want to jump in and talk a little bit about why you think it's important outside of- Dr. Fielder: Yeah. Absolutely. And I think also, to add ... Just a little bit, just to what you're saying because you did an unbelievable explanation. If you go back to its first inception, some of the other terminology, you might also see Mauve Factor. So Mauve Factor is the original descriptor that they used because of the way that they did a chromatography on the samples and how it would stand in using I think Mauve Factor was- Dan Hanson: Right. It's a colorimetric assay. Dr. Fielder: Right. Dan Hanson: So the specimen actually turns a color during the process. And a depth in that color is utilize to ultimately determine the density of the pyrolle molecule. And that's what Dr. Fielder's referring to. Dr. Fielder: Right. But in terms of the importance the lab test itself, it is invaluable when assessing brain health, brain functions and emotional symptomatology, which was how this all started with doctors Abram Hoffer, Dr. Carl Pfeiffer, William Walsh, Dr. Mensah today and many many others, that they notice that with certain nutrients applications, symptomatology for some of these mental and emotional conditions were improving. And so, they were able to ultimately identify the molecule of HPL to be able to actively and accurately measure it and see when it was potentially problematic and address things more specifically. So what that means is, in modern days, it's an accurate assessment for the potential loss of B-6 and zinc in an individual, which has a huge effect. Dr. Fielder: And the reason for that is that zinc and B-6 as I'm sure Dan, you know, you talk about this so much every day, but it has a huge effect on neurotransmitters especially dopamine and GABA. What ends up happening I think, really to make a long story short, even especially currently at this day, so many doctors are overprescribing or trying to figure out how to best intervene with medications, which are ultimately, potentially, unnecessary because their trying to address something, which is just nothing more than a simple nutrient imbalance. And that's where pyroluria pyrroles come in, is that we are looking at this being the cause of the depletion of B-6 and zinc, which leads to the imbalance in neurochemistry, which then leads to an imbalance and symptoms. Dr. Fielder: So what can you add to what we're starting to talk here about? Dan Hanson: Yeah. Well, I think what's also important to address in this subject of the topic is where pyrroles fall in line with specific conditions because we can tell that hey, zinc and B-6 are two key nutrients necessary to producing GABA to producing dopamine, to producing norepinephrine. But when you're looking at key research and some of the research I'd like to throw out and that we like to reference as well is generally featured in one of the great locations to find it is Dr. William Walsh. Dr. William Walsh has a great book called Nutrient Power: Heal Your Biochemistry and Heal Your Brain. There is a chart, a table that talks about the incidence of pyrrole overload in clinical population. And so, these clinical populations will show various types of negative symptomatology and whether in this particular chard, it studied ADHD or excuse me, patients who suffer from ADHD behavioral disorders, autism, depression, bipolar disorders, schizophrenia, post traumatic stress, Alzheimer's. And also, there's a fair amount of test on unhealthy controls. Dan Hanson: And so, what they've done is, is looked at 40,000 urine pyrroles and ultimately looked at percentages of these patient populations that have elevated pyrroles. And what's really interesting is then correlating that study to various patient populations like, schizophrenia, also patients who suffer from depression and looking at this as a key element or one of they call the biotypes. One of the main reasons why people get the negative symptoms or some negative symptoms of these conditions. And so, there are a fair amount of negative symptoms that can be treated and a healthy amount of case studies that are shown in these particular book. Again, it's Nutrient Power: Heal Your Biochemistry and Heal Your Brain by Dr. William Walsh. Dan Hanson: And so, we like to reference that book specifically to talk about patient populations that are well-studied. Look at a test that really reviews pyrroles or the Kryptopyrrole Quantitative Urine in a large scale. Again, there's this table Dr. Walsh's work is referencing 40,000 urine pyrrole results for people with mental and emotional conditions. Dr. Fielder: Which I don't think you can emphasize enough. I mean the amount of work that he has put in. The amount of research and I don't know anybody else that has even remotely, the amount of data that he's accumulated over the last several decades especially just referencing the fact that he has a database of over 40,000 Kryptopyrrole test. Dan Hanson: Right. Dr. Fielder: And that's not the only test, he does a bunch of other testing as well as doing things like questionnaires and he's able to, across the board, put it all together. So it's not just simply he did 40,000 kryptopyrrole testing, that's all he has, he's got a ton of other ... I mean it's probably fair to say this, he got well over hundred thousand test all together to really put everything in much more comprehensive picture. And that's what I love about the book is that, it's not book about pyroluria, it's a book about mental health. And he is just ... I think, I don't know anybody that has put in the time, energy, research and concrete data that he has, to put it kind of all together. Dr. Fielder: And I think one of the perfect examples is understanding that someone who is excreting excessive amounts of HPL, because of its affinity zinc and B-6, what's going to end up happening is someone ... A depletion of zinc at a very high level. It's going to affect things like copper. And this is why he doesn't only test for pyrroles, he's also looking at things that are extremely integral like, copper levels as well. Dan Hanson: Right. Dr. Fielder: And that's why I think the book is great for anybody who's interested in this topic, to really learn the importance of testing for other things like copper and understanding its role in mental health as well. Dan Hanson: Right. I hundred percent agree and that couldn't have been said better. I think that ... And to touch on some of the data. I've heard numerous researchers and numerous physicians and Dr. Walsh himself, say that there are in total, and could be incorrect here, but I want to say that it was over a million chemistries in total, across a large number of patients. And all of those patients are falling into negative symptoms that relate to mental and emotional conditions. And so, he's considered to have the world's largest database of nutritional chemistries for patients that suffer from autism spectrum disorders. And that comes with a great deal of weight. Dan Hanson: Dr. Walsh is not a traditional physician. He's not out here supporting any of the companies that produce these particular tests in an outgoing way, outside of looking for good results. And- Dr. Fielder: He's not selling himself from us. He's not trying to make a buck from anything. Dan Hanson: Right. What he's doing is writing a non for profit, that's based in research. And he's really leading that game well. And he stays true to the idea of science. I want to say that he was originally from Argonne National Laboratory and took a personal liking to this particular field. And really dedicated his life to understanding brain chemistry and how the development of the brain works and how certain people can have epigenetic events that change the way that DNA is expressed and why one person might be some way in a particular environment and another person in the same environment might be another way and really focusing on mental and emotional conditions. So really special work there. Dan Hanson: But to again, touch a little bit further into what Dr. Fielder said, is that pyrroles are a huge part. Looking at a kryptopyrrole test is a huge part, just one piece of puzzle and I think of the book Nutrient Power is really powerful because it talks about the repeat offenders. It's saying, "Hey, we looked at all these patients. And we have all these case studies. And we rent all types of labs, not just these labs, not just the ones that I'm going to talk about, but thousands of different chemistries across the board and what we found was there were repeat offenders. And so, in our research we determine that methylation is extremely important in mental health." Free copper and percentage of free copper or unbound copper is extremely important in mental health. Dan Hanson: They're looking at zinc is really important. And that's why pyrroles can be this real cause, but also when you're looking at copper and you're looking at zinc, you're getting this great functional copper to zinc ratio, which is extremely important for measuring the brain's capability to produce key neurotransmitters. And that's what that model is all about. And that's why the Kryptopyrrole Quantitative Urine or the Kryptopyrrole test, you know, when it's measuring HPL or this crazy word, this hydroxyhemopyrrolin-2-one, what it's really saying is, we're trying to get to the root cause of what helps you produce neurotransmitters. And we're trying to as a laboratory or as a test relate that to the right patient populations. Dr. Fielder: Right. And that's why as a practitioner or a patient, you're out there and you come across all these different terminologies especially pyroluria. Pyroluria has been probably the most common diagnostic maybe that I hear other practitioner's using. And we really go into it, into a much greater detail in the article that I've written about ... It's a questionnaire, the kind of questionnaire that diagnosed me as having pyroluria, or is it more effective than the test itself. And just to cover that really briefly, I think it's really important to understand what pyroluria is in terms of the actual word. And it was according to medical dictionary, it just means that there is a presence of pyrroles in your urine. And it's become synonymous to mean that you have this genetic error, where your excreting way too many pyrroles. Dr. Fielder: And so, we're taking it from that standpoint, that what pyroluria is pyrrole disorder truly is. Is this genetic predisposition? And the genetics refer to probably morphisms or SNP, single-nucleotide polymorphisms. Sometimes practitioners just call them SNPs. And that means like what Dan was saying about, the biotypes and the different types and the reason it's so important identify pyroluria as far as part of your intervention and diagnosis for patients is that, this, according to all the research, it shows that it does not change. Meaning that once a person has this genetic predisposition, they're always going to be this way. Doesn't mean that you can't address it and make it improve so that it's affecting patient any longer, but it does mean that more than likely their going to need to be in zinc, B-6, and potentially, some other supplementation for a lifetime. Dr. Fielder: And if you just simply as a practitioner, give somebody zinc, B-6, Evening Primrose Oil and they improve and they get better, and they don't know that they don't have this condition of pyrrole disorder, then what happens is they get off it and then they get worse. And they do not understand why. And so, it's important as a practitioner they you identify this. And this is a percentage of these conditions. And this is also what leads to confusion because someone thinks that they have pyroluria or practitioner doesn't do the testing and only does the questionnaire and think that someone does have a pyroluria and they administer zinc and B-6, and the person, in short term, improves, they then say, "Oh, that's confirmatory." And therefore, they're addressing the pyroluria. Dr. Fielder: Well, what happens is, if they do not in fact, have this consistent loss of zinc and B-6, in a very short time, they could become overloaded in zinc and B-6. And that can cause a whole host of other issues that we see probably the short term, one of the most frequent things, insomnia, agitation, anxiety because they do not have pyroluria and have been misdiagnosed as having pyroluria. And intervene what they thought was the right way. And unfortunately, it was not the right thing to do. Dr. Fielder: So we really can't emphasize enough testing, not only for pyrroles, but copper, zinc, ceruloplasmin, other things as well, but that's just what I want to add to that Dan. Dan Hanson: Yeah. Absolutely. That's wonderful. I greatly appreciate you going into detail there. It's really important that people understand that this is an acid that's critical to an effective treatment. And if you're looking at a holistic approach to optimizing neurotransmitters, to optimizing the environment for producing neurotransmitters and really effectively taking an integrated prefunctional approach to reducing negative symptom ology, that you accurate test result, and you treat appropriately based on those test results and follow up appropriately. And so, the idea of a questionnaire in our mind is absolutely absurd and with anybody who's listening would like to give us the other side, I'm certainly open to learning more about why certain people do value questionnaires. And I'd love to have my mind change, but science says, it's just not going to happen. Dr....
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Welcome to the World Episode 001
04/16/2018
Welcome to the World Episode 001
Dan Hanson: Good morning and welcome to the Healthcare In Your Hands podcast. It's Dan Hanson and Dr. Lloyd Fielder talking about how key chemistries help patients and practitioners. Really quickly, since it's our first podcast, I wanted to take a moment and talk a little bit about myself and Dr. Fielder and really introduce the topic. DHA Laboratory has been specializing in bringing key chemistries to patients and practitioners, and we felt it was a great opportunity to really bring some healthy content to that topic as we've had so many intrigued customers, so many intrigued practitioners, about the cutting edges of healthcare. The cutting edges of laboratory testing, education, and, really, we're the first ones out here on the market making something like this available on a weekly agenda, hopefully, that we can really bring everything to light here for patients and practitioners in the same place and comprehensively run over topics. Dan Hanson: I work hands-on in the healthcare field looking specifically at chemistries that are relevant to brain chemistry and chemistries that are relevant across the board in digestive health and immunoglobulin response and all kinds of ... That's allergy testing for everybody out there that's interested in learning more. We also work in prenatal care and other topics as well. Dr. Fielder's been working with myself in terms of considering education for practitioners and patients and consultation services and has a couple healthy practices here in Illinois that allow patients the opportunity to get some face time with Dr. Fielder so we really wanted to pull this together and have a great opportunity to chat with you guys. So good morning Dr. Fielder. Dr. Fielder: Good morning, Dan. Dan Hanson: Today, as I kind of mentioned through that introduction, we're going to talk a little bit about advanced laboratory testing. I got involved in developing a wide variety of available laboratory testing for patients and practitioners because we knew there was a huge need out there for people to take health care to the next level. Whether that was practitioners looking at how they can apply functional chemistries to their practice and make a change in their patient's life, or it was patients that were really taking health care in their own hands to discover what they could do to advance a condition and its treatment or what they could do to understand a topic better that might influence their personal health. It was our opportunity to really get together with the experts in our field and provide those laboratory tests. Dan Hanson: So, what we did was generate a series of laboratory tests that are available to practitioners and the public, that really run through advanced topics like methylation, percentage of free copper, digestive health, allergy response, adrenal stress, various markers. Small intestinal bacterial overgrowth. It's our job to take all of the cutting edge topics and make them available. Make those tests available in an easy to order, easy to interpret format for practitioners and for patients so that we can help advance the agenda in the health care field. I got involved in that because we knew there was a huge market out there of people that were really interested in making that available to them. Dr. Fielder: Yeah, I think that's really awesome information, Dan. From my standpoint as a practitioner, as a chiropractor, when you get out of school you do have way more education in terms of nutrients and nutrition and that aspect, way more than a conventional medical doctor does, but you're still at a loss. What's real popular, and especially chiropractic profession, would be something like applied kinesiology, which for most people know that better as muscle testing. Today, we're not going to get into the pros and cons of muscle testing, but I can speak on behalf of myself that that was just not something that I was ready to use as my sole objective method to tell somebody they need or don't need certain nutrients or something that they might have been eating as part of their lifestyle or like an allergy or something of that nature. Dr. Fielder: So I had to find laboratory testing on my own, and this is almost 20 years ago. That's how we eventually hooked up. I started using your DHA Laboratory as my laboratory of choice to then do some blood work and some other things. Coming from a background of doing a whole bunch of different testing, but all over the board and not really having one kind of clearinghouse, so to speak. One home base where I can do all of my testing through. It just, for me, the objective data, you don't have to guess. You don't have to infer, and, certainly, you do not have to be wrong about how to go about doing an intervention. Dr. Fielder: For me that was everything and really transformed the way I really took care of my patients. Not only that I can do it with a much clearer conscience, but the results. They spoke for themselves, and that's what I really enjoy doing and I love doing here. I think what ... You and I have had so many conversations, which was really the reason why we decided that this was absolutely something we have to do, is have this podcast, is that there's a lot of confusion. Both from patient's point of view and practitioner point of view. For patient, they go to their caregiver, their doctor, their physician, their chiropractor, their medical doctor and they're kind of ... It's up to that practitioner to give them the right information. Dr. Fielder: The most common questions we get is "Are they right? Is this what I need?" So we need to give better education out there for just the regular lay person so that they can better take control of their own health and they can do something. A great example would be Vitamin D testing. We see it yet so much more prevalent in terms of what's out there in the public and people have never been more educated and aware of Vitamin D testing yet a lot of conventional medical doctors still don't regularly test for that. And yet a lot of patients are taking Vitamin D, mostly on their own, and so that's something that when we get the questions "How much should I take every day?" The answer is "I don't know." You need to get tested so that we can see what your level is and then create a plan, an appropriate amount based upon what your number is. Dr. Fielder: Also, for the average person, they don't necessarily need to run to their practitioner all the time and incur the expense and potentially the misinformation around Vitamin D when they can just get online, order a test through DHA Lab and go find out what their number is, and then have a correct supplement amount so that they do not over or under dose themselves with regards to getting to the number that they need to be as healthy as they can. That's just an example. From the practitioner aspect it is also a lot of practitioners that we talk to, they do not know where to start. Dr. Fielder: They don't know which test might be most appropriate, and they certainly don't know which company perhaps had the best research and the best science behind their individual testing. So that's what we've gone ahead and done, is done all the hard work. From a practitioner standpoint, understanding which labs would be most congruent and best for that practitioner's type of practice, and also for the patient who doesn't know exactly where they should start as well. That's just a little bit of a background from all different aspects. Dan Hanson: Sure. That's great. Dr. Fielder: Yeah. Do you want to talk a little bit about what practitioners can do? Dan Hanson: Absolutely. Well, I think it really starts out with education. Regardless if it's patients or practitioners, what we want to encourage is that everybody listening to this podcast becomes educated about their health, and that's what we want to help do. When we talk about thing like Vitamin D, it might be more knowledgeable between people like ourselves that ... Hey, you know, in order to move the marker on Vitamin D there are specific amounts. We recently went over a study that showed a patient or somebody, anybody taking Vitamin D would need 400 IUs of Vitamin D in a daily regimen to move their marker in terms of laboratory testing in a meaningful direction if they were low. Dan Hanson: The majority of supplements ... In this case we were looking at, prenatals really contained almost a tenth of that value. So it's super important, like you said, in terms of vitamins and nutrients and really all elements of laboratory testing, that we become educated on why it's important. Really what that causes for the person. Ultimately, what the right tests are, where you want to see those numbers, and then the effective treatments that are available out there and the practitioners that specialize in them so that they can really make a difference. What practitioners can do is really become educated on the topics that they see are most valuable in their practice. Dan Hanson: I think that comes from hearing your patients and taking a more patient centric approach. Listening to what people are coming and talking about. What are the common themes that you hear patients and clients speaking about in their day to day health and in their day to day concerns? I think that trends will appear. You'll see that, hey, more and more people have heard about Vitamin D. More and more people have heard about candida. More and more people are considering a gluten free diet and maybe we're on the tail end of that or still the fore end of that trend, but, ultimately, those trends appear in your day to day environment and it's your responsibility to intercept those waves. Dan Hanson: Hear what the people are saying and bring that to the forefront of your practice so that you're at the cutting edge and work with people like us who are also day to day on the phone with practitioner that are listening and patients that are talking and curating laboratory tests that are at the highest quality and also consultation services that are at the highest quality so that when there's a need for someone's health history and there's a requirement for support that you can use data driven answers and really credible practitioners to work hands on with. I think that's what practitioners can really do. Dan Hanson: Also, it's about locating the right solutions for their practice to say "Hey, I want to make sure we're advancing our agenda in terms of increasing the availability for high quality labs." Increasing the availability for a wide spread of treatment that we understand thoroughly and increasing the ability to connect with our patients by ultimately accepting those wavelengths, accepting the conversation and being open to how they feel in the moment and, realistically, everything that concerns them. So, practitioner wise, stay on top of the key labs. Stay on top of the key subjects. Stay on top of what people are talking about and stay on top of collaborating with sources like our laboratory that focus specifically on education. I think that that's an over all, a widespread shot approach at understanding what they can do. What do you think? Dr. Fielder: Yeah. No, I think that's awesome. I think above and beyond for ... If a practitioner's listening currently right now to this, is that not only do you have to actively order things, but you can just go to our website. We have great resources, great articles. We have videos, we have all kinds of information available as well as the podcast itself, which we'll talk a little bit more about at the end, you know, inviting you to send us an email at info@dhalab.com so that ... Let us know what you would like us to talk about because we're here to ... We're passionate about educating practitioners and patients. Dr. Fielder: The other thing is that we make available through social media on Twitter and Facebook, primarily. Every day we post the latest cutting edge research that impacts your patient's lives and also tries to create some clarity around laboratory testing. If you're not following us on Twitter or Facebook, get on our website and just click the link and like us or follow us so that you can get great articles every day. That's actually, also, free content for you to put on your own website, which is a great thing to do for your patients as well. The other thing is patients themselves. We really want to educate patients as much as practitioners. Dr. Fielder: We really feel like that health is something that people need to take control over in themselves and work with their practitioners so that it actually is a synergistic kind of result. Meaning that rather than just having to be a passive person in this process, the better educated a patient is the more easy it is for them to ... They have a better why as to implementing rather than just being at the other end from the practitioner telling them whatever. Any healthy relationship is based on healthy communication. From a practitioner's standpoint, sometimes it feels like a bit of a pain that you have to answer a lot of questions or you just want someone just to follow what you're saying to do. Dr. Fielder: We find that the best practices are ones where the patients are the best educated. They have a better understanding as to why they're actually doing what the doctor's asking of them so we want the patients to be educated as well. Again, if you're a patient listening, we really want you to send us as many of your questions as possible too at info@dhalab.com and let us know what you would like us to talk about because this is just the first of many podcasts. Again, we're here for you so let us know what you would like to hear us talk about. Let me just touch on one little example of that for patients is that you're online, as we all are, we're all surfing the net and we're Googling different questions. Dr. Fielder: We might see things on Facebook or Twitter and you click on it and they're little videos and they're little tutorials and they usually have tag lines that get you hooked into clicking on things. We really want to help you differentiate between a sales pitch and strong internet marketing versus what's actually grounded in correct data and hardcore science. Things that are actually what they are meant to be and not what somebody's selling you on. We're very, very protective of our clientele, of doctors and caregivers and patients out there. We don't want to see what we, unfortunately, are seeing more and more of, which is a really great sales copy or a really great video or a great webinar and people spending, literally, thousands of dollars on crap. Dr. Fielder: On stuff that just is not based on science and is not really meant to help. It's meant to put more money in someone else's pocket and less in yours. That's another thing that we want to address as well going down the road. It's really important how to identify a high quality lab, and that's really what we take pride in here. Dan Hanson: Absolutely. It comes down to that really the information is getting diluted. We see a great opportunity, and when you look at to from a business aspect, people that are in the industry see a great opportunity to promote products in ways that are just unprecedented up until this time. The programs that are being developed to help people and help practitioners are growing. The conferences are growing and being launched at all times. While that's going on, you're seeing more stringent regulation on continuing medical education because of the influx of material that just generally doesn't hold weight. You're seeing a lot of different discussions going on online where people are supporting one particular treatment model and maybe necessarily not supporting more of an individualized approach based on that person. Dan Hanson: That's really one of the strong points is that being passionate about integrative health care. Being directly involved in speaking with practitioners, speaking with patients, working with up and coming companies, being at all the top integrative health care conferences and having a strong intuition for business and really what makes people tick, we have a really unique perspective on what people are learning and what's coming out. You'll notice that our daily health care topics that we share are from top researchers, and they are very science based. Dan Hanson: That's really how DHA got started. It got started, and looking at the top science and integrative and functional approaches to treating patients who suffer from mental and emotional conditions and supporting that with the leading physicians, the top labs, and making that available to everybody. That's only led to us being more passionate in a wider scope of areas and being more intrigued to gain education and really starting things like this where we can help spread that education and keep the conversation open. I certainly encourage everybody to write in about any questions that they have, whether it's regarding a program, their health, a topic that's coming up in the media. Something at all about what we said. Dan Hanson: It's all appropriate for discussion here. We want it to be like your living room where you can just speak up because, realistically, this is what we were doing before we put the microphone in front of us. We were talking about the top issues, the top topics. We're looking at the best podcasts, we're looking at all the top researchers and we're speaking with them live at the leading conferences or at the leading events in our industry. With that type of access and our knowledge and our ability to just stay really on the top of the questions and what we think is important is something that we really want to share with everybody. I think that both of us are really passionate about that and have a lot to share today. Dr. Fielder: Absolutely. Dan Hanson: Or even in general. Dr. Fielder: Yeah, I think this is exciting. I'm looking forward to everything that you just said, especially answering questions for patients and practitioners. It's really one of, I think, our strongest points. As far as any kind of closing thought, the first order of business that, again, I just want to make sure ... When we talked about a number earlier, we said 400 IUs of Vitamin D. I think the actual number is 4,000 IUs of Vitamin D, so don't want to talk about how much we know, and then give you some incorrect information. That's just ... we're already ... We're on top of that stuff. We're not only talking, but we also listen. Again, that email is info I-N-F-O @dhalab, so it's info@dhalab.com. Send us your questions about testing, even about conditions. We're here to help and it's really, again, our pleasure to help you sort out the myriad of information that's out there and create as much of a clear path for you as a practitioner to help patients get well and you as a patient, help yourself get well. Dan Hanson: Absolutely. Dr. Fielder: I think that sounds about it for this first one. What do you think, Dan? Dan Hanson: Absolutely. Yeah, thanks for tuning in. We look forward to receiving some questions and we'll catch up with you guys soon. Dr. Fielder: All right. Take it easy guys. Dan Hanson: Have an awesome day. Dr. Fielder: That wasn't too ...
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