Immune
A podcast about the body's defenders against disease.
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Immune 78: Tolerance and tolerating many vaccines
03/26/2024
Immune 78: Tolerance and tolerating many vaccines
Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode Adaptive immune responses preserved in (Lancet) Synthetically glycosylated antigens for of established immune responses (Nat Biomed Eng) Gut bacteria–derived serotonin in early life (Sci Immunol) Immune correlates of viral control after in adults (Sci Immunol) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 77: Squeezing the most killing out of neutrophils
02/27/2024
Immune 77: Squeezing the most killing out of neutrophils
Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode activates neutrophil killing (Immunity) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 76: Macrophages to the rescue with Juliet Morrison
01/30/2024
Immune 76: Macrophages to the rescue with Juliet Morrison
Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts: , , , and Guest: Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free): , . , Become a of Immune! Links for this episode is broken (Solving for Science) Pleural macrophages during influenza (PNAS) Time stamps by . Thanks! Music by Steve Neal Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 75: Ang Cui unveils the cytokine symphony
12/28/2023
Immune 75: Ang Cui unveils the cytokine symphony
Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts: , , and Guest: Subscribe (free): , . , Become a of Immune! Links for this episode is broken (Solving for Science) Immune (Nature) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 74: Germinal center dynamics with Carla Nowosad
12/11/2023
Immune 74: Germinal center dynamics with Carla Nowosad
Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts: , , and Guest: Subscribe (free): , . , Become a of Immune! Links for this episode and the intestinal microbiome (Sem Immunol) in gut germinal centres (Nature) B cell (Methods Mol Biol) Immune synapse (Nat Immunol) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 73: Big macs
11/08/2023
Immune 73: Big macs
Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts: , , and Subscribe (free): , . , Become a of Immune! Links for this episode in the human body (PNAS) on Immune 73 Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 72: After dark in the library with Ellen Rothenberg
09/23/2023
Immune 72: After dark in the library with Ellen Rothenberg
From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hosts: and Guest: Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free): , . , Become a of Immune! Links for this episode (Nature) (Nat Immunol) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 71: Can parasitic worms prevent pandemics?
09/08/2023
Immune 71: Can parasitic worms prevent pandemics?
Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts: , , and Subscribe (free): , . , Become a of Immune! Links for this episode murine SARS-CoV-2 infection (Sci Immunol) Pandemic (ScienceInsider) on Immune 71 Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 70: Immunology of picky eating
07/26/2023
Immune 70: Immunology of picky eating
Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts: , , and Subscribe (free): , . , Become a of Immune! Links for this episode and immune avoidance behavior (Nature) Immune sensing of food allergens (Nature) Immunology that underlies (Nature) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 69: Lung cancer and retroviruses
06/15/2023
Immune 69: Lung cancer and retroviruses
Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer. Hosts: , , , and Guest: Subscribe (free): , . , Become a of Immune! Links for this episode Antibodies against (Nature) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 68: Sins and blessings of immunity
05/18/2023
Immune 68: Sins and blessings of immunity
Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: , , and Download (45 MB .mp3, 76 min) Subscribe (free): , . , Become a of Immune! Links for this episode Immunological (Immunity) imprinting (bioRxiv) Original (J Inf Dis) Are (LJII) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 67: Can T cells live forever?
05/03/2023
Immune 67: Can T cells live forever?
Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode T cells capable of (Nature) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 66: COVID-19 immune memory - what you need to know
04/04/2023
Immune 66: COVID-19 immune memory - what you need to know
Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode COVID-19 (Imm Rev) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 65: Infection infidelities with Jonathan Kagan
02/20/2023
Immune 65: Infection infidelities with Jonathan Kagan
Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts: , , , and Guest: Subscribe (free): , . , Become a of Immune! Links for this episode Approaching the (Cold Spring Harb Symp Quant Biol) I drive innate immunity (Science) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 64: A tangled web of wires
01/24/2023
Immune 64: A tangled web of wires
Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode Tangled (Nature) Path to group A (Clin Inf Dis) Immune end-types (Nat Immunol) after SARS-CoV-2 mRNA vaccination (Sci Immunol) B cells (Immunity) Streptococcus monoclonal (EMBO Mol Med) Predictor of (Nat Immunol) Impact of on antibody an T cell response (Cell Rep Med) and RSV infection (Science) Commensals (Sci Immunol) Continuous and immune response diversity (Cell) Time stamps by . Thanks! Music by Steve Neal Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 63: Immune, promptly
12/20/2022
Immune 63: Immune, promptly
Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode CAR T for (Nat MEd) Maternal gut IgG (Sci Immunol) Long-primed (Nature) against SARS-CoV-2 VOC (bioRxiv) Dark side of (Nat Med) against infection (Nature) Regulators of inflammatory response to (Nature Immunol) and protection against RSV (Cell) antibodies (bioRxiv) Endogenous retroviruses and (Cell) CD8 T cells and against SARS-CoV-2 (Sci Immunol) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 62: Every cell is an immune cell with De'Broski Herbert
12/02/2022
Immune 62: Every cell is an immune cell with De'Broski Herbert
De’Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: , , , and Guests Subscribe (free): , . , Become a of Immune! Links for this episode Immunology of (Ann Rev Immunology) Neuroimmune (J Leuk Biol) Every cell is an (Immunity) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 61: Training immune cells with Julia Bohannon and Musa Mhlanga
11/08/2022
Immune 61: Training immune cells with Julia Bohannon and Musa Mhlanga
From SLB22 on the Island of Hawai’i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts: , , , and Guests: and Subscribe (free): , . , Become a of Immune! Links for this episode (Richmond Register) Innate immune (J Immunol) Epigenetics and metabolism in (Immunity) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 60: Immunoeducation with Sumali Pandey and Phil Mixter
09/22/2022
Immune 60: Immunoeducation with Sumali Pandey and Phil Mixter
Somali and Phil join Immune to discuss their approaches to immunology education. Hosts: , , , and Guest: and Subscribe (free): , . , Become a of Immune! Links for this episode ASMCUE: Upcoming ASM Webinars: free Microedu Live! discussions: Friday, October 14, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be the assessment of learning. Friday, November 4, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be microbiology laboratory biosafety. . Journals with relevant education resources: AAI ImmunoHorizons Journal of Microbiology and Biology Education (ASM; open-source, see Tips & Tools for examples): CBE Life Sciences Education How to tell your professional story effectively – for instruction-focused scientists (including external review): ASM Carski Award for Educators: Undergraduate degree program in Immunology at University of Alabama-Birmingham (only one in the USA): 3D printable antibody-antigen epitope models Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 59: Forks in the road: Th17 cells with Mandy McGeachy
08/19/2022
Immune 59: Forks in the road: Th17 cells with Mandy McGeachy
At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be ‘good’ or ‘bad’ in their function. Hosts: , , , and Guest: Subscribe (free): , . , Become a of Immune! Links for this episode in health and disease (Immunity) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 58: Gut B cells awry in ulcerative colitis
08/03/2022
Immune 58: Gut B cells awry in ulcerative colitis
Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode Gut B cell dysbiosis in (Nat Med) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 57: Bacteria, the new cure for wounds?
06/30/2022
Immune 57: Bacteria, the new cure for wounds?
Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode Bacteria induce via IL-1beta (Cell Host Microbe) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 56: Flip flops on the thymic beach with Al Singer
06/01/2022
Immune 56: Flip flops on the thymic beach with Al Singer
Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts: , , , and Guest: Subscribe (free): , . , Become a of Immune! Links for this episode reveal lineage determination (Nat Immunol) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 55: Cells that suck at their job
05/03/2022
Immune 55: Cells that suck at their job
Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode KIR+CD8+ (Science) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 54: Asthma and aging
04/06/2022
Immune 54: Asthma and aging
Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts: , , , and Subscribe (free): , . , Become a of Immune! Links for this episode reduction in asthmatic pathology (J Immune) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 53: Dendritic cell robbers
02/21/2022
Immune 53: Dendritic cell robbers
Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts: , Cynthia Leifer, and Subscribe (free): , . , Become a of Immune! Links for this episode Trogocytosis in from dendritic cells (Science) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 52: B cell boot camp with Gabriel Victora
01/29/2022
Immune 52: B cell boot camp with Gabriel Victora
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts: , , , and Guest: Subscribe (free): , . , Become a of Immune! Links for this episode Concerto in B () Visualizing antibody (Science) Restricted after boosting (Cell) Time stamps by . Thanks! Music by Steve Neal. Immune logo image by Send your immunology questions and comments to [email protected]
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Immune 51: Teenage NINJA mice with Nikhil Joshi
12/22/2021
Immune 51: Teenage NINJA mice with Nikhil Joshi
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.
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Immune 50: Red blood cells are immune sentinels
11/11/2021
Immune 50: Red blood cells are immune sentinels
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.
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Immune 49: I fell in love with worms with Keke Fairfax
10/13/2021
Immune 49: I fell in love with worms with Keke Fairfax
Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.
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