JAMA Clinical Reviews

Interviews with expert clinicians and researchers about topics relevant to clinical practice and patient care, including updates in management of common conditions from JAMA, the Journal of the American Medical Association.

Mpox Treatment Strategies, Clinical Presentation, and Diagnostic Approaches 11/19/2024

Mpox Treatment Strategies, Clinical Presentation, and Diagnostic Approaches Mpox is an evolving global health threat, and clinicians should be aware of characteristic signs and symptoms to ensure timely diagnosis and appropriate management. Author Jason Zucker, MD, MS, of Columbia University Irving Medical Center... /episode/index/show/jamaclinicalreviews/id/33986177

Calcific Aortic Stenosis: Symptoms, Diagnosis, and Treatment 11/11/2024

Calcific Aortic Stenosis: Symptoms, Diagnosis, and Treatment Calcific aortic stenosis affects approximately 12% of people >75 years in the US and worldwide leads to more than 100 000 deaths each year. Catherine M. Otto, MD, PhD, of the University of Washington School of Medicine, Seattle,... /episode/index/show/jamaclinicalreviews/id/33852222

CAR T Cells and T-Cell Therapies for Cancer 11/04/2024

CAR T Cells and T-Cell Therapies for Cancer CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins... /episode/index/show/jamaclinicalreviews/id/33774427

Diagnosis and Treatment of Peptic Ulcer Disease 10/28/2024

Diagnosis and Treatment of Peptic Ulcer Disease Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil, MD, a gastroenterologist from the University of Wisconsin, Madison, discusses current... /episode/index/show/jamaclinicalreviews/id/33616477

Strategies for Helping Patients Navigate High Prescription Drug Costs 10/21/2024

Strategies for Helping Patients Navigate High Prescription Drug Costs High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowest drug costs. Author Hussain S. Lalani, MD, MPH, MSc, of Brigham and Women's Hospital and... /episode/index/show/jamaclinicalreviews/id/33547187

Preexposure Prophylaxis (PrEP) Options for HIV 10/14/2024

Preexposure Prophylaxis (PrEP) Options for HIV Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monica Gandhi, MD, MPH, of the University of California San Francisco joins JAMA Senior Editor... /episode/index/show/jamaclinicalreviews/id/33448787

Update on Over-the-Counter (OTC) Contraception 10/09/2024

Update on Over-the-Counter (OTC) Contraception In July 2023, the US Food and Drug Administration (FDA) approved Opill, a daily progestin-only oral contraceptive for over-the-counter sale to people of all ages. Daniel Grossman, MD, discusses this and more with JAMA Associate Editor... /episode/index/show/jamaclinicalreviews/id/33376832

Dialysis for Chronic Kidney Failure 10/02/2024

Dialysis for Chronic Kidney Failure Selection of hemodialysis or peritoneal dialysis and timing of dialysis initiation are influenced by patient symptoms, laboratory trajectories, patient preferences, and therapy cost and availability; shared decision-making is key. Jennifer... /episode/index/show/jamaclinicalreviews/id/33282882

Diagnosis and Treatment of Chronic Spontaneous Urticaria 09/26/2024

Diagnosis and Treatment of Chronic Spontaneous Urticaria Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, impairs patients’ quality of life, and is associated with multiple comorbidities. Pavel Kolkhir, MD, discusses the current evidence on the... /episode/index/show/jamaclinicalreviews/id/33187702

Diagnosis and Treatment of Community-Acquired Pneumonia (CAP) 09/16/2024

Diagnosis and Treatment of Community-Acquired Pneumonia (CAP) Community-acquired pneumonia is associated with approximately 740 000 hospitalizations and 41 000 deaths in the US annually. JAMA Review authors Scott A. Flanders, MD, and Valerie M. Vaughn, MD, MSc, discuss diagnosis and treatment of community-acquired pneumonia with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content: /episode/index/show/jamaclinicalreviews/id/33070097

Scabies, Bedbug, and Body Lice Infestations 09/09/2024

Scabies, Bedbug, and Body Lice Infestations Infestations by ectoparasites such as scabies, bedbugs, and body lice are common. Diagnosis requires history, including social drivers of health such as living environment, and physical examination. Author Aileen Y. Chang, MD, MSPH, of... /episode/index/show/jamaclinicalreviews/id/32972002

Acute Pericarditis 09/05/2024

Acute Pericarditis Pericarditis accounts for up to 5% of emergency department visits for nonischemic chest pain in North America and Western Europe. JAMA Review author Paul C. Cremer, MD, MS, discusses the recommended treatments for acute pericarditis and... /episode/index/show/jamaclinicalreviews/id/32896232

JAMA Highlights From ESC 2024 09/02/2024

JAMA Highlights From ESC 2024 JAMA Editor in Chief Kirsten Bibbins-Domingo reviews 4 JAMA trials presented at this year’s European Society of Cardiology (ESC) Congress on antihypertensive continuation before elective surgery, potassium supplementation after cardiac... /episode/index/show/jamaclinicalreviews/id/32809262

Renal Cell Carcinoma 08/28/2024

Renal Cell Carcinoma Renal cell carcinoma has an estimated lifetime prevalence of 2.3% for men and 1.3% for women in the US. Affected patients in early stages can have >94% cancer-specific survival. Author William Y. Kim, MD, of the University of North... /episode/index/show/jamaclinicalreviews/id/32752287

USPSTF Recommendation: Iron Deficiency During Pregnancy 08/20/2024

USPSTF Recommendation: Iron Deficiency During Pregnancy Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA... /episode/index/show/jamaclinicalreviews/id/32605472

Diagnosis, Treatment, and Prevention of Genital Herpes 08/14/2024

Diagnosis, Treatment, and Prevention of Genital Herpes Genital herpes is a common sexually transmitted infection that is caused by HSV-1 or HSV-2 and may result in ulcers, neonatal herpes infection, and increased risk of HIV acquisition. Author Christine Johnston, MD, University of Washington,... /episode/index/show/jamaclinicalreviews/id/32558922

Perioperative Management of Patients Taking Direct Oral Anticoagulant Medications 08/12/2024

Perioperative Management of Patients Taking Direct Oral Anticoagulant Medications Direct oral anticoagulants (DOACs) are commonly used to treat patients with atrial fibrillation and venous thromboembolism. Author James D. Douketis, MD, from McMaster University discusses with JAMA Deputy Editor Kristin L. Walter, MD, MS,... /episode/index/show/jamaclinicalreviews/id/32537702

Obesity in Adolescents 08/05/2024

Obesity in Adolescents About 20% of adolescents in the US are living with obesity. Author Aaron S. Kelly, PhD, of the University of Minnesota Medical School joins JAMA Senior Editor Karen E. Lasser, MD, MPH, to discuss Obesity in Adolescents: A Review. /episode/index/show/jamaclinicalreviews/id/32441787

Heat-Related Illness and Athletes 07/25/2024

Heat-Related Illness and Athletes Exertional heat illness at its extreme may cause heat stroke and altered mental status (confusion, delirium, stupor, or unconsciousness), which can result in organ failure and death. Author Francis G. O’Connor, MD, MPH, discusses... /episode/index/show/jamaclinicalreviews/id/32278457

Obesity Medications 07/22/2024

Obesity Medications New weight-loss drugs have transformed care for people with obesity. In this Clinical Reviews podcast, Robert F. Kushner, MD, MS, of Northwestern University Feinberg School of Medicine joins JAMA Deputy Editor Mary McGrae McDermott, MD, to... /episode/index/show/jamaclinicalreviews/id/32218882

Medical Practice and Climate Change 07/17/2024

Medical Practice and Climate Change Medical practice accounts for 8% of carbon emissions in the US. Author Wendy Levinson, MD, discusses simple changes that clinicians can make to reduce adverse effects of health care on the climate and the environment with JAMA Deputy... /episode/index/show/jamaclinicalreviews/id/32162692

Essential Tremor 07/08/2024

Essential Tremor Essential tremor is a common movement disorder. Author Binit B. Shah, MD, of the University of Virginia joins JAMA Deputy Editor Christopher C. Muth, MD, to discuss the diagnostic evaluation and treatment of essential tremor, including... /episode/index/show/jamaclinicalreviews/id/32025492

Why Should Insurers Care About Clinical Trials? 07/01/2024

Why Should Insurers Care About Clinical Trials? The US is a global leader in introducing new medical products, but the ability to generate evidence to inform clinical practice in postmarket settings must improve. Insurers may have an important role to play. Robert M. Califf, MD, of the... /episode/index/show/jamaclinicalreviews/id/31882157

Update: Diagnosis and Management of Celiac Disease 06/26/2024

Update: Diagnosis and Management of Celiac Disease What are the common signs and symptoms of celiac disease and how is this disease diagnosed and managed? Author Kerstin Austin, MD, from the University of Wisconsin-Madison, discusses this and more with JAMA Associate Editor David L. Simel, MD, MHS. /episode/index/show/jamaclinicalreviews/id/31867802

Hospital Gun Restrictions 06/26/2024

Hospital Gun Restrictions Hospitals are on the frontlines of the US gun violence epidemic, both through the treatment of shooting victims and as sites of firearm violence. At least 240 shootings occurred on US hospital grounds from 2000 to 2016 alone. Author Joseph... /episode/index/show/jamaclinicalreviews/id/31886157

USPSTF Recommendation: Interventions for High BMI in Children and Adolescents 06/18/2024

USPSTF Recommendation: Interventions for High BMI in Children and Adolescents Interview with John M. Ruiz, PhD, USPSTF member and coauthor of Management of BMI in Children: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. /episode/index/show/jamaclinicalreviews/id/31771077

Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections 06/12/2024

Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections Severe pulmonary infections are a leading cause of death in adults worldwide. Romain Pirracchio, MD, MPH, PhD, of the University of California-San Francisco, joins JAMA Deputy Editor Kristin L. Walter, MD, MS, to discuss Low-Dose... /episode/index/show/jamaclinicalreviews/id/31697952

Managing Depression in Adults 06/10/2024

Managing Depression in Adults Approximately 9% of US adults experience major depression each year, with lifetime prevalence nearly 17% for men and 30% for women. Effective first-line depression treatments include forms of psychotherapy and medication. Close monitoring... /episode/index/show/jamaclinicalreviews/id/31652012

Homelessness and Health Care 06/05/2024

Homelessness and Health Care Homelessness is detrimental to health and clinicians can play an important role in mitigating the deleterious effects of homelessness. Margot Kushel, MD, University of California, San Francisco, discusses this and more with JAMA Senior... /episode/index/show/jamaclinicalreviews/id/31586617

USPSTF Recommendation: Interventions to Prevent Falls in Community-Dwelling Older Adults 06/04/2024

USPSTF Recommendation: Interventions to Prevent Falls in Community-Dwelling Older Adults Interview with Li Li, MD, PhD, MPH, USPSTF member and coauthor of Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten... /episode/index/show/jamaclinicalreviews/id/31587082

JAMA Clinical Reviews

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