JAMA Clinical Reviews

Interviews with expert clinicians and researchers about topics relevant to clinical practice and patient care, including updates in management of common conditions from JAMA, the Journal of the American Medical Association.

Diagnosis and Treatment of Hemorrhoidal Disease 08/18/2025

Diagnosis and Treatment of Hemorrhoidal Disease Hemorrhoidal disease, pathology of the tissue lining the anal canal, affects approximately 10 million individuals in the US. Author Jean H. Ashburn, MD, of Wake Forest University School of Medicine and JAMA Senior Editor Karen E. Lasser,... /episode/index/show/jamaclinicalreviews/id/37843030

Treatment of Complicated Staphylococcus aureus Bacteremia 08/13/2025

Treatment of Complicated Staphylococcus aureus Bacteremia Dalbavancin, a long-acting IV lipoglycopeptide, may be an option for the treatment of complicated Staphylococcus aureus bacteremia without requiring long-term IV access. Author Thomas L. Holland, MD, MSc, from Duke University School of Medicine discusses key points of the DOTS randomized clinical trial and more with JAMA Deputy Editor Preeti Malani, MD, MSJ. Related Content: ----------------------------------- /episode/index/show/jamaclinicalreviews/id/37776685

Diagnosis and Management of Prostatitis 08/11/2025

Diagnosis and Management of Prostatitis Prostatitis affects approximately 9.3% of men in their lifetime and includes acute and chronic bacterial infection and nonbacterial chronic prostatitis with chronic pelvic pain syndrome. Author Minh N. Pham, MD, from University of North... /episode/index/show/jamaclinicalreviews/id/37734760

Geroscience in Medicine 08/07/2025

Geroscience in Medicine Geroscience aims to define and modify biologic pathways associated with aging and age-related diseases. Author Stephen B. Kritchevsky, PhD, of the Wake Forest University School of Medicine and JAMA Deputy Editor Mary M. McDermott, MD,... /episode/index/show/jamaclinicalreviews/id/37704255

Managing Adverse Effects of Obesity Medications 07/29/2025

Managing Adverse Effects of Obesity Medications New medications for obesity, such as semaglutide and tirzepatide, are highly effective but can be associated with adverse effects that reduce adherence. Obesity expert and author Robert Kushner, MD, joins JAMA Deputy Editor Mary... /episode/index/show/jamaclinicalreviews/id/37594070

Patent Foramen Ovale-Associated Stroke 07/28/2025

Patent Foramen Ovale-Associated Stroke A patent foramen ovale (PFO) is present in approximately 25% of all adults. Author David M. Kent, MD, MS, of Tufts Medical Center and JAMA Associate Editor David Simel, MD, MHS, discuss how to evaluate the likelihood that a PFO was causal... /episode/index/show/jamaclinicalreviews/id/37550935

Diverticulitis: Diagnosis and Management 07/24/2025

Diverticulitis: Diagnosis and Management Approximately 200 000 people are hospitalized for diverticulitis each year in the US, and the incidence of diverticulitis is increasing, particularly among younger people. Author Anthony Charles, MD, MPH, of the University of Vermont and... /episode/index/show/jamaclinicalreviews/id/37521685

Ovarian Cancer: Clinical Risk Factors and Treatment 07/21/2025

Ovarian Cancer: Clinical Risk Factors and Treatment A recent Review discusses the epidemiology, risk factors, diagnosis, and treatment of ovarian cancer. William Cliby, MD, and John Weroha, MD, PhD, both from the Mayo Clinic in Rochester, Minnesota, discuss this and more with JAMA Associate... /episode/index/show/jamaclinicalreviews/id/37462730

Early-Onset Gastrointestinal Cancers 07/17/2025

Early-Onset Gastrointestinal Cancers Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review summarizes current data on early-onset colorectal, pancreatic, and esophagogastric... /episode/index/show/jamaclinicalreviews/id/37418545

Managing Lower Urinary Tract Symptoms in Men 07/14/2025

Managing Lower Urinary Tract Symptoms in Men Approximately 40% of men older than 50 have urinary frequency or urgency that affects their quality of life. Author John T. Wei, MD, MS, of the University of Michigan Department of Urology and JAMA Deputy Editor Mary M. McDermott, MD,... /episode/index/show/jamaclinicalreviews/id/37398820

West Nile Virus 07/07/2025

West Nile Virus In the 25 years since its emergence in the US, West Nile virus has become the leading cause of domestic mosquito-borne disease. It causes more than 1200 neuroinvasive disease cases and 120 deaths annually in the US. Coauthor Carolyn Gould,... /episode/index/show/jamaclinicalreviews/id/37306870

Treatment and Management of Osteoporosis 06/30/2025

Treatment and Management of Osteoporosis Worldwide, 1 in 3 women and 1 in 5 men older than 50 years experience osteoporotic fractures in their lifetime. Author Suzanne N. Morin, MD, MSc, of McGill University and JAMA Deputy Editor Mary M. McDermott, MD, discuss the diagnosis and... /episode/index/show/jamaclinicalreviews/id/37198065

Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment 06/23/2025

Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment Which tests can be used to diagnose type 2 diabetes? When should injectable medications for type 2 diabetes be started? These are just some of the questions clinicians may have when diagnosing and treating type 2 diabetes in adults. Author... /episode/index/show/jamaclinicalreviews/id/37095030

Adrenal Insufficiency in Adults 06/16/2025

Adrenal Insufficiency in Adults Adrenal insufficiency is a syndrome of cortisol deficiency. A recent JAMA Review summarizes the pathophysiology, diagnosis, and treatment of adrenal insufficiency and adrenal crisis. JAMA Associate Editor David Simel, MD, MHS, discusses... /episode/index/show/jamaclinicalreviews/id/37025215

From the JAMA Network: Comprehensive Review of Foley Catheter Management 06/12/2025

From the JAMA Network: Comprehensive Review of Foley Catheter Management Interview with Anne P. Cameron, MD and Glenn T. Werneburg, MD, PhD, authors of Foley Catheter Management: A Review. Hosted by Amalia Cochran, MD. Related Content: /episode/index/show/jamaclinicalreviews/id/36970390

How to Improve Patients' Treatment Expectations 06/04/2025

How to Improve Patients' Treatment Expectations Patients' treatment expectations may affect their treatment outcomes. Coauthor Johannes A. C. Laferton, PhD, joins JAMA Senior Editor Anne Cappola, MD, ScM, to discuss the latest article in JAMA's Communicating Medicine series, which... /episode/index/show/jamaclinicalreviews/id/36839415

Lipoprotein(a): What Clinicians Should Know 06/03/2025

Lipoprotein(a): What Clinicians Should Know Elevated levels of lipoprotein(a) are associated with higher rates of cardiovascular events. Author Samia Mora, MD, MHS, of Brigham and Women’s Hospital and Harvard Medical School discusses measurement and interpretation of lipoprotein (a)... /episode/index/show/jamaclinicalreviews/id/36819040

Platelet Transfusion: Best Practice Guidelines 05/29/2025

Platelet Transfusion: Best Practice Guidelines A central question in platelet transfusion is whether to follow a restrictive or liberal strategy in decisions about which patients should receive platelets. Author Ryan Metcalf, MD, University of Utah, discusses new clinical guidelines... /episode/index/show/jamaclinicalreviews/id/36759965

Immune Thrombotic Thrombocytopenic Purpura (iTTP) 05/19/2025

Immune Thrombotic Thrombocytopenic Purpura (iTTP) Immune thrombotic thrombocytopenic purpura (iTTP) is a rare coagulopathic disorder characterized by immune-mediated thrombocytopenia and microangiopathic hemolytic anemia, that can cause life-threatening thrombosis. Coauthor Allyson M.... /episode/index/show/jamaclinicalreviews/id/36624325

Microbiome and Risk for Cancer Outcomes 05/12/2025

Microbiome and Risk for Cancer Outcomes The human microbiome appears to influence risk for development and progression of cancer and response to treatment. Author Jennifer Wargo, MD, University of Texas M.D. Anderson Cancer Center, discusses basic science and clinical evidence... /episode/index/show/jamaclinicalreviews/id/36513565

Diagnosis and Treatment of Endometriosis 05/05/2025

Diagnosis and Treatment of Endometriosis Endometriosis, a common cause of pelvic pain, affects approximately 10% of reproductive-age females. Author Sawsan As-Sanie, MD, MPH, University of Michigan, discusses the epidemiology, pathophysiology, diagnosis, and treatment of... /episode/index/show/jamaclinicalreviews/id/36412440

Strategies for Talking With Parents About Vaccines 04/30/2025

Strategies for Talking With Parents About Vaccines What is the single most important thing to recognize when communicating with families about vaccines? Author Sean T. O’Leary, MD, MPH, of the University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado joins JAMA Senior... /episode/index/show/jamaclinicalreviews/id/36349695

Non–Cystic Fibrosis (CF) Bronchiectasis in Adults 04/28/2025

Non–Cystic Fibrosis (CF) Bronchiectasis in Adults Non-cystic fibrosis (CF) bronchiectasis, which affects approximately a half million people in the US, is a chronic lung condition that involves permanent bronchial dilation and inflammation; it is characterized by a productive cough and... /episode/index/show/jamaclinicalreviews/id/36337640

Vitamin D Guidelines for Healthy Children and Adults 04/23/2025

Vitamin D Guidelines for Healthy Children and Adults A JAMA Clinical Guidelines Synopsis summarizes the Endocrine Society’s most recent recommendations on vitamin D supplementation for disease prevention. Author Sherri-Ann M. Burnett-Bowie, MD, MPH, discusses this and more with JAMA... /episode/index/show/jamaclinicalreviews/id/36250655

Discussing Surgery With Patients 04/16/2025

Discussing Surgery With Patients What are 3 fundamental communication skills needed when discussing surgery with patients? Author Lauren J. Taylor, MD, of the Central Virginia VA Health Care System discusses this and more with JAMA Senior Editor Anne Cappola, MD, ScM. /episode/index/show/jamaclinicalreviews/id/36160625

Treatment of Small Cell Lung Cancer 03/31/2025

Treatment of Small Cell Lung Cancer Small cell lung cancer (SCLC) is a smoking-related malignancy that presents at an advanced stage in 70% of patients. Author Anne C. Chiang, MD, PhD, of the Yale University School of Medicine joins JAMA Senior Editor Karen Lasser, MD, MPH,... /episode/index/show/jamaclinicalreviews/id/35926500

Diagnosis, Treatment, and Prognosis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Adults 03/24/2025

Diagnosis, Treatment, and Prognosis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Adults Polycystic kidney disease is the most common genetic kidney disease worldwide and is characterized by progressive development of kidney cysts. Author Nerra Dahl, MD, PhD, Mayo Clinic, discusses the pathophysiology, clinical presentation,... /episode/index/show/jamaclinicalreviews/id/35814255

Chronic Myeloid Leukemia: A Review 03/17/2025

Chronic Myeloid Leukemia: A Review Chronic myeloid leukemia is a myeloproliferative neoplasm that affects approximately 5 million people worldwide. Tyrosine kinase inhibitors, such as imatinib, have substantially improved survival in patients with chronic myeloid leukemia.... /episode/index/show/jamaclinicalreviews/id/35723865

USPSTF Recommendation: Screening for Food Insecurity 03/11/2025

USPSTF Recommendation: Screening for Food Insecurity Interview with Tumaini Rucker Coker, MD, MBA, USPSTF member and coauthor of Screening for Food Insecurity: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. /episode/index/show/jamaclinicalreviews/id/35560050

Localized and Metastatic Prostate Cancer 03/10/2025

Localized and Metastatic Prostate Cancer Prostate cancer is the most common nonskin cancer in men in the US and the second most common cancer in men worldwide. Author R. Bruce Montgomery, MD, of the University of Washington joins JAMA Senior Editor Karen Lasser, MD, MPH, to... /episode/index/show/jamaclinicalreviews/id/35596690

JAMA Clinical Reviews

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