Probably Science

Three professional comedians and incompetent scientists take you through this week in science. Incompetently. Featuring Matt Kirshen, Andy Wood, Jesse Case and a rotating cast of special guests.

Episode 585 - Jeff Zenisek 11/14/2025

Episode 585 - Jeff Zenisek Comedian () joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, , Jeff's hair care regimen, , , , t and the banger . /episode/index/show/probablyscience/id/39041735

Episode 584 - Drew Droege 11/10/2025

Episode 584 - Drew Droege Comedian/playwright Drew Droege () joins Matt, Jesse and Andy to talk about his new off-Broadway play , and . /episode/index/show/probablyscience/id/38973190

Episode 583 - Mehran Khaghani 10/29/2025

Episode 583 - Mehran Khaghani Wonderful NY comic Mehran Khagani () joins Jesse and Matt to talk about escaping from Iran, working at the Harvard School of Public Health, hyrax marks, Canadian and the in the universe! In the patreon bonus we get into penguin micronaps. /episode/index/show/probablyscience/id/38819780

Episode 582 - Jen Kober 10/20/2025

Episode 582 - Jen Kober Comedian/actor () joins Andy, Jesse and Matt to talk about comedy in Louisiana, , buxom wenches, , , , and . /episode/index/show/probablyscience/id/38650465

Episode 581 - NASA Exoplanet Science Ambassador Anjali Tripathi 10/05/2025

Episode 581 - NASA Exoplanet Science Ambassador Anjali Tripathi NASA astrophysicist and JPL Exoplanet Science Ambassador joins Andy, Jesse and Matt to talk about exoplanets and the different ways of finding them including , the challenges of studying planetary atmospheres, why telescopes are built in deserts or in space, Anjali's time at the White House Office of Science and Technology Policy, science communication projects like the , the upcoming Nancy Grace Roman Space Telescope, dark matter, lasers in astronomy, Halloween at the White House, the odd “smells” of other planets and how to take a . /episode/index/show/probablyscience/id/38474315

Episode 580 - Michelle Murphy 09/27/2025

Episode 580 - Michelle Murphy Comedian Michelle Murphy () joins Andy, Matt and Jesse to talk about playing tennis for Grinnell, , , and , Burning Man missionaries, and . /episode/index/show/probablyscience/id/38375580

Episode 579 - Ken Reid 09/17/2025

Episode 579 - Ken Reid Comedian Ken Reid () joins Jesse, Matt and Andy to talk about growing up a child of television, mud wrestling, , , , , , , , , and . /episode/index/show/probablyscience/id/38260000

Episode 578 - Ryan O'Flanagan 09/09/2025

Episode 578 - Ryan O'Flanagan Comedian () joins Matt, Jesse and Andy to talk about Ryan and Andy's chance encounter in a bar in Leadville, , , , and . /episode/index/show/probablyscience/id/38137060

Episode 577 - Myq Kaplan 08/29/2025

Episode 577 - Myq Kaplan Comedian () returns to the show to talk to Andy, Jesse and Matt about growing out his eyebrows during the pandemic, babies distinguishing Ps from Bs, linguistics, sign language variations, standups aping Shane Gillis, the Mr. Beast voice, , , , whether you should pay for bad art, what sequels always get wrong and . /episode/index/show/probablyscience/id/38016345

Episode 576 with Macey Isaacs! 08/20/2025

Episode 576 with Macey Isaacs! Comedian and host of the podcast joins the gang to talk about a that’s ! AI and ! And some before Andy’s connection quit in a fury! In the we find out why living near the ocean extends your life. Follow and check out her podcast, and her Don’t Tell special when it drops! /episode/index/show/probablyscience/id/37895255

Episode 575 - Matt Parker 08/11/2025

Episode 575 - Matt Parker Comedian/mathematician//author () joins Jesse, Andy and Matt to talk about his new book , his podcast , his , , , , , , and . /episode/index/show/probablyscience/id/37765785

Episode 574 - Josh Gondelman 08/01/2025

Episode 574 - Josh Gondelman Comedian () joins Andy and Matt to talk about , , , , , , ass/gas/grass bumper stickers, , and . /episode/index/show/probablyscience/id/37643100

Episode 573 - Kai Humphries 07/25/2025

Episode 573 - Kai Humphries Comedian Kai Humphries () joins Matt, Andy and Jesse to talk about , the passing of Hulk Hogan, , the Air Bud cinematic universe and . /episode/index/show/probablyscience/id/37547580

Episode 572 - Eric Rocha 07/22/2025

Episode 572 - Eric Rocha Comedian Eric Rocha () joins Andy, Jesse and Matt to talk about competing namesakes, fezzes, last suppers, Jesse's macronutrient gas, sleep hygiene, comedy on airplanes, , , and . /episode/index/show/probablyscience/id/37500655

Episode 571 - Bryan Cook 07/12/2025

Episode 571 - Bryan Cook Comedian and Jimmy Kimmel Live! writer Bryan Cook () returns to the show for a technical difficulty-laden episode in which Jesse and Andy talk with Matt while he's on a cruise ship, covering topics including comedy on a boat, candlepin bowling, , crypto failures, , , , and Andy's upcoming Colorado tour with . /episode/index/show/probablyscience/id/37385775

Episode 570 - Matt, Jesse and Andy 06/24/2025

Episode 570 - Matt, Jesse and Andy The gang's back together again to talk about , , and . /episode/index/show/probablyscience/id/37140595

Episode 569 - JT Habersaat 06/11/2025

Episode 569 - JT Habersaat Comedian and author of new book JT Habersaat () to talk about the other books on ! Making bespoke action figures! Changing your brainwaves ! Infrared for night vision! Other contact lenses to ! How joke magazine “work”! A ! And whether the ! In the we hear about a new Chinese space mission and a paragliding mishap. Please go and see Matt Jul 16 in , Jul 31 in , or Oct 12 in . /episode/index/show/probablyscience/id/36964415

Episode 568 - Tom Rhodes 06/03/2025

Episode 568 - Tom Rhodes Globetrotting headliner Tom Rhodes () has a new special, The Ripest Zebras, available on his website. He joins Jesse and Matt to talk about growing up in NASA’s backyard! The ! Wasps having surprisingly ! While ! Tom’s hummingbird facts! Plus how to ! And ! In the we hear about an update to the classic marshmallow test and Tom’s key to a good relationship. /episode/index/show/probablyscience/id/36829840

Episode 567 - Ron Placone 05/24/2025

Episode 567 - Ron Placone Comedian and filmmaker () joins Andy, Jesse and Matt to talk about his new movie , , , and . /episode/index/show/probablyscience/id/36700285

Episode 566 - Amy Silverberg 05/07/2025

Episode 566 - Amy Silverberg Comedian, writer and author of upcoming novel “” Amy Silverberg () joins the gang to talk about Andy’s spotting! The optimal amount of ! Andy’s adventures! Lions gladiators! Men gorillas! And which to avoid the fight yourself! In the Patreon bonus we talk about lucid dreaming and a new state of mind. Please go and see Matt Jul 16 in , Jul 31 in , or Oct 12 in . And Andy’s band on May 31 at in Joshua Tree. /episode/index/show/probablyscience/id/36476685

Episode 565 - Tony Camin 05/02/2025

Episode 565 - Tony Camin Great stand-up and co-creator of the Tony Camin () joins Jesse and Matt to talk about crows’ ! Tony helping one of the ! Why seals ! Unlikely ! And whether your month of conception ! Tony’s new album, An Ass Pocket of Whimsy will come out on and you can find him at . /episode/index/show/probablyscience/id/36408055

Episode 564 - Samantha Hale 04/26/2025

Episode 564 - Samantha Hale Comedian and Samantha Hale () joins Jesse and Matt to talk about: A layer of life ! The dire wolves! The Earth’s ! and Reagan’s ! In the we talk about bending sounds. /episode/index/show/probablyscience/id/36320610

Episode 563 - Live from Perth with Wil Anderson and Robyn Perkins 04/17/2025

Episode 563 - Live from Perth with Wil Anderson and Robyn Perkins Friend of the show Wil Anderson () joins Matt live in Perth along with marine biologist-turned-comedian Robyn Perkins () to talk all things coral, nudibranchs, poisonous sea creatures and surprising things to do with dry ice and mouths. /episode/index/show/probablyscience/id/36205195

Episode 562 - Shawn Carlow 03/31/2025

Episode 562 - Shawn Carlow Writer/comedian () joins Jesse, Andy and Matt to talk about his new book , , and . /episode/index/show/probablyscience/id/35950365

Episode 561 - Live from Perth with Ross Noble, Kirsty Webeck and Paul Savage 03/18/2025

Episode 561 - Live from Perth with Ross Noble, Kirsty Webeck and Paul Savage Live from Perth, Matt is joined by , and to talk about , , and . /episode/index/show/probablyscience/id/35767065

Episode 560 - James P. Connolly 03/07/2025

Episode 560 - James P. Connolly Comedian () joins Andy, Jesse and Matt on location from the to talk about centaurs and minotaurs, plum grenades, forcing comedy on bar patrons, , , Jesse's update on the state of Nashville, and . /episode/index/show/probablyscience/id/35570435

Episode 559 - Aidan Jones 02/08/2025

Episode 559 - Aidan Jones Comedian () joins Matt, Andy and Jesse to talk about , returning to classical music after a long break, , , , , , and . /episode/index/show/probablyscience/id/35205750

Episode 558 - Alice Fraser 01/24/2025

Episode 558 - Alice Fraser Comedian () returns to the show to talk with Jesse, Andy and Matt about Jesse's mistimed melatonin, Alice's new book , , , , , Andy's Naked Attraction obsession, , and . /episode/index/show/probablyscience/id/35000065

Episode 557 - Mary Lynn Rajskub 01/15/2025

Episode 557 - Mary Lynn Rajskub (Note: This episode was recorded before the Los Angeles fires) Comedian/actor () joins Jesse, Andy and Matt to talk about filming her upcoming show in Nunavut, , , , , and . /episode/index/show/probablyscience/id/34870530

Episode 556 - Laura Hayden 01/07/2025

Episode 556 - Laura Hayden Comedian and physical therapist () joins Jesse, Andy and Matt to talk about her penile pictorial book , , sciatica advice, , Matt's upcoming Australia tour and . /episode/index/show/probablyscience/id/34766075

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