Probably Science

Three professional comedians with so-so STEM pedigrees take you through this week in science. Incompetently. Featuring Matt Kirshen, Andy Wood, Jesse Case and a rotating cast of special guests.

Episode 610 - Kirk Smith 07/06/2026

Episode 610 - Kirk Smith Comedian () joins Jesse, Andy and Matt to talk about his books and , pools and jacuzzis, , , and . /episode/index/show/probablyscience/id/41970110

Episode 609 - Ryan Conner 06/26/2026

Episode 609 - Ryan Conner Comedian/author () returns to the show to talk with Jesse, Andy and Matt about his new memoir , Vietnamese refugees, , British soccer fans cleaning up in the US, , 2020 vs. 1968, hipster nostalgia, stomp clap tall bikes and . /episode/index/show/probablyscience/id/41812485

Episode 608 - Laura Sams Jordan 06/18/2026

Episode 608 - Laura Sams Jordan Zoologist/producer/composer/podcaster () Jordan joins Jesse, Matt and Andy to talk about fliming grizzly bears in Alaska, studying hyenas in Africa, , , interviewing six-year-olds, , , , , and . /episode/index/show/probablyscience/id/41691550

Episode 607 - Diana Hong 06/04/2026

Episode 607 - Diana Hong Comedian () joins Jesse, Andy and Matt to discuss cat ownership, , and the , Diana's golf career, , , battery types, , , , , , , and . /episode/index/show/probablyscience/id/41530685

Episode 606 - Charles Star 05/29/2026

Episode 606 - Charles Star Lawyer-turned-comedian and self-professed podcast slut Charles Star () returns to the show to talk about his podcast , celebrity roasts, , bad abbreviations, , , and . /episode/index/show/probablyscience/id/41469865

Episode 605 - James Frey 05/18/2026

Episode 605 - James Frey Comedian and former paramedic James Frey () joins Andy, Jesse and Matt to talk about firefighter dreams and emergency medicine reality, , giving CPR in civilian life, () who couldn't burp, getting fobbed off, , and . /episode/index/show/probablyscience/id/41336725

Episode 604 - Shane Mauss 05/11/2026

Episode 604 - Shane Mauss Comedian () returns to the show to talk about , , , , and . /episode/index/show/probablyscience/id/41257555

Episode 603 - Brandie Posey 05/03/2026

Episode 603 - Brandie Posey Comedian () returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label and her new comedy special , , , , , and . /episode/index/show/probablyscience/id/41134025

Episode 602 - Chandler Dean 04/25/2026

Episode 602 - Chandler Dean Comedian/speechwriter () joins Jesse, Andy and Matt to talk about his show , , , , , Jesse's obsessions with , and , , , and . /episode/index/show/probablyscience/id/41011285

Episode 601 - Amber Preston 04/17/2026

Episode 601 - Amber Preston Comedian () returns to help Andy, Jesse and Matt celebrate the big six-oh-one and talk about Artemis II, , , , and . /episode/index/show/probablyscience/id/40909120

Episode 600 - Katie Novotny 04/06/2026

Episode 600 - Katie Novotny Comedian () joins Matt and Andy to discuss her special , , , , , and . /episode/index/show/probablyscience/id/40746125

Episode 599 - Monica Nevi 03/29/2026

Episode 599 - Monica Nevi Comedian () joins Andy, Jesse and Matt to talk about , what VO2 max means, esports scholarships, , , , and . /episode/index/show/probablyscience/id/40660730

Episode 598 - Matthew Coe 03/19/2026

Episode 598 - Matthew Coe Comedian () joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, , , , and . /episode/index/show/probablyscience/id/40545640

Episode 597 - Jackie Kashian 03/05/2026

Episode 597 - Jackie Kashian Comedian () returns to the show to talk with Jesse and Matt about her new standup special , , and a . See Matt on tour in and , and . /episode/index/show/probablyscience/id/40333805

Episode 596 - Forrest Shaw 02/26/2026

Episode 596 - Forrest Shaw Comedian and former marine biologist () returns to the show to talk with Matt, Andy and Jesse about his new live show , his addiction podcast , , , , and . /episode/index/show/probablyscience/id/40247615

Episode 595 - Aisha Alfa 02/17/2026

Episode 595 - Aisha Alfa Comedian () joins Jesse, Andy and Matt to talk about comedy in Winnipeg, , , , , , , Jesse's artificial lung cat bed, and . /episode/index/show/probablyscience/id/40132245

Episode 594 - David Huntsberger 02/04/2026

Episode 594 - David Huntsberger Comedian returns to the show to talk with Matt, Jesse and Andy about his podcast , , , , , , , , , , , and . /episode/index/show/probablyscience/id/39998115

Episode 593 - Diya Basrai 01/30/2026

Episode 593 - Diya Basrai Comedian/neuroscientist Diya Basrai () joins Jesse, Andy and Matt to talk about , whether there's something meat-specific about intelligence, , , and . /episode/index/show/probablyscience/id/39930720

Episode 592 - Jon Stringer 01/21/2026

Episode 592 - Jon Stringer Comedian () joins Andy, Jesse and Matt to talk about living in a converted rural Kansas church, the intricacies of comedy competitions and cruise ship comedy, dry ice PVC soupcan launchers, , retail blowguns , vibe-coding a band manager, , and . /episode/index/show/probablyscience/id/39818720

Episode 591 - Imaan Hadchiti 01/13/2026

Episode 591 - Imaan Hadchiti Comedian Imaan Hadchiti () joins Jesse, Andy and Matt to talk about Rima syndrome, , , , , and . /episode/index/show/probablyscience/id/39719785

Episode 590 - Waen Shepherd 01/04/2026

Episode 590 - Waen Shepherd Comedian/actor/writer/composer () joins Andy, Jesse and Matt to talk about , , , , and the music of . /episode/index/show/probablyscience/id/39602275

Episode 589 - Chris Duffy 12/28/2025

Episode 589 - Chris Duffy Comedian/host/author () returns to the show to talk with Jesse, Andy and Matt about his new book , , , , , and /episode/index/show/probablyscience/id/39547460

Episode 588 - Buddy Fitzpatrick 12/16/2025

Episode 588 - Buddy Fitzpatrick Comedian Buddy Fitzpatrick () joins Andy, Matt and Jesse to talk about , , , , and . /episode/index/show/probablyscience/id/39430605

Episode 587 - Adam Burke 12/09/2025

Episode 587 - Adam Burke Comedian () joins Andy, Jesse and Matt to talk about , , classic '80s Arnold movies, Matt and Jesse performing together in Nashville, , , , and . /episode/index/show/probablyscience/id/39331720

Episode 586 - Ophira Eisenberg 11/28/2025

Episode 586 - Ophira Eisenberg Comedian/writer/ () joins Andy, Jesse and Matt to talk about her podcast , her upcoming special produced by Lewis Black, , , , and . /episode/index/show/probablyscience/id/39200285

Episode 585 - Jeff Zenisek 11/14/2025

Episode 585 - Jeff Zenisek Comedian () joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, , Jeff's hair care regimen, , , , t and the banger . /episode/index/show/probablyscience/id/39041735

Episode 584 - Drew Droege 11/10/2025

Episode 584 - Drew Droege Comedian/playwright Drew Droege () joins Matt, Jesse and Andy to talk about his new off-Broadway play , and . /episode/index/show/probablyscience/id/38973190

Episode 583 - Mehran Khaghani 10/29/2025

Episode 583 - Mehran Khaghani Wonderful NY comic Mehran Khagani () joins Jesse and Matt to talk about escaping from Iran, working at the Harvard School of Public Health, hyrax marks, Canadian and the in the universe! In the patreon bonus we get into penguin micronaps. /episode/index/show/probablyscience/id/38819780

Episode 582 - Jen Kober 10/20/2025

Episode 582 - Jen Kober Comedian/actor () joins Andy, Jesse and Matt to talk about comedy in Louisiana, , buxom wenches, , , , and . /episode/index/show/probablyscience/id/38650465

Episode 581 - NASA Exoplanet Science Ambassador Anjali Tripathi 10/05/2025

Episode 581 - NASA Exoplanet Science Ambassador Anjali Tripathi NASA astrophysicist and JPL Exoplanet Science Ambassador joins Andy, Jesse and Matt to talk about exoplanets and the different ways of finding them including , the challenges of studying planetary atmospheres, why telescopes are built in deserts or in space, Anjali's time at the White House Office of Science and Technology Policy, science communication projects like the , the upcoming Nancy Grace Roman Space Telescope, dark matter, lasers in astronomy, Halloween at the White House, the odd “smells” of other planets and how to take a . /episode/index/show/probablyscience/id/38474315

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