Sigma Nutrition Radio
The podcast for lovers of nutrition science! Listen to detailed discussions with researchers and leading experts about the science of nutrition, dietetics and health.
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#571: Is Zone 2 Training Actually Best for Health? – Prof. Brendon Gurd
07/29/2025
#571: Is Zone 2 Training Actually Best for Health? – Prof. Brendon Gurd
In recent years “Zone 2 training” has gained immense popularity in fitness and health circles, often being proclaimed the “best” cardiovascular training for metabolic health. Zone 2 training is sustained, low-intensity exercise below the lactate threshold that is commonly employed by many elite level endurance athletes, with a variety of proposed performance benefits. This led to interest from health-conscious folks about its ability to improve markers like VO2 max and mitochondrial function, which are associated with better health outcomes and longevity. Prof. Brendon Gurd, an exercise physiologist at Queen’s University, is the co-author of a recent review published in Sports Medicine that examined some of the claims made around zone 2 training and health in the general population. This episode looks at whether the evidence truly supports Zone 2 as a uniquely effective training zone or if this hype has outpaced the research. These insights help professionals and individuals make evidence-based recommendations and avoid unintended negative consequences of following certain ideas. About The Guest Dr. Brendon Gurd is a Professor in the School of Kinesiology and Health Studies at Queen’s University, where his research focuses on exercise physiology and skeletal muscle adaptation. His work explores how different intensities and types of exercise influence mitochondrial content and function in muscle tissue, with the goal of understanding how to optimize health and performance through training. Timestamps [03:23] Discussion with Professor Brendan Gurd [05:56] Zone two training: Mechanisms and misconceptions [10:56] Practical applications and recommendations [22:16] Research gaps and future directions [35:47] Key ideas segment (Sigma Nutrition Premium) Links to Resources Subscribe to Join the for free Enroll in the next cohort of our course List of Sigma's Review paper: Lecture Slides:
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#570: Fructose: Metabolism, Claims & Context for Risk – Scott Harding, PhD
07/22/2025
#570: Fructose: Metabolism, Claims & Context for Risk – Scott Harding, PhD
Fructose has often been labeled a uniquely damaging nutrient, blamed for obesity, diabetes, and other metabolic diseases. But does fructose truly have unique harmful effects or are the risks associated with it related to context and quantity? The episode explores how fructose is metabolized in the body, why it gained a reputation for being problematic, and what the scientific evidence says about fructose in our diets. You will gain insight into why fructose was singled out in the past (e.g., its unique pathway in the liver and lack of insulin response), and how newer studies put those concerns into context. It covers important nuances for practitioners and health-conscious individuals, especially given public confusion and fear around fructose (even in fruit). Guest Information Dr. Scott Harding, Ph.D., is an Associate Professor of Nutritional Biochemistry in the Department of Biochemistry at Memorial University of Newfoundland. His research explores the complex interactions between diet, metabolism, and chronic disease, with a particular emphasis on the metabolic effects of dietary sugars (especially fructose), the role of fats and phytosterols in lipid metabolism, and how public health policies like sugar taxation influence population health outcomes. Timestamps [02:58] Dr. Harding’s academic background [08:45] Fructose metabolism in detail [12:51] Fructose in diet and public health [23:07] Current research [29:53] Identifying biomarkers for fructose overconsumption [31:12] Fructose impact on health [40:58] The food matrix [45:10] Personalized nutrition and future research directions [54:06] Key ideas segment (premium-only) Related Resources Subscribe to Join the for free Enroll in the next cohort of our course Related podcast episodes: #476, #468, #155 See Sigma's
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SNP42: Is Vitamin A Good or Bad for Bone Health?
07/15/2025
SNP42: Is Vitamin A Good or Bad for Bone Health?
Vitamin A is often one of the less-discussed micronutrients in relation to bone health, taking a back seat to nutrients like calcium and vitamin D. Yet this fat-soluble vitamin plays a fundamental role in skeletal development, remodeling, and mineral homeostasis. It influences gene expression in both osteoblasts and osteoclasts, and contributes to the regulation of bone turnover throughout the lifespan. But what makes vitamin A particularly interesting, and controversial, is that its effects on bone appear to follow a double-edged pattern. While it’s essential for bone formation, several large epidemiological studies have suggested that chronically high intakes of preformed vitamin A may actually increase the risk of osteoporosis and fracture, especially when consumed as retinol from supplements or high-liver diets. And yet, the picture is not so clear-cut. This raises compelling questions: Is the concern over vitamin A and bone health justified, or is it a case of context-dependent risk? Can vitamin A, when combined with adequate levels of D and K, actually support bone strength? And are there thresholds above or below which risk increases? In this episode, we explore the human evidence on vitamin A and skeletal health, looking not only at fracture outcomes and bone mineral density data, but also at nutrient interactions, mechanistic plausibility, and the implications for supplement use in well-nourished populations. Note: This is a Premium-exclusive episode, so you will only hear a preview on this public feed. Timestamps [00:23] Vitamin A and bone health: an overview [02:50] Forms of vitamin A: retinol and carotenoids [04:16] Mechanisms of vitamin A in bone physiology [17:52] Nutrient interactions: vitamin A, D, and K [31:03] Practical takeaways and recommendations Related Resources Subscribe to Join the for free Go to Enroll in the next cohort of our course
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#569: The History of Fat, Cholesterol & Heart Disease
07/08/2025
#569: The History of Fat, Cholesterol & Heart Disease
The idea that saturated fat might be harmful to our health has sparked controversy for decades. In recent years, counter-narratives have surged: suggesting that concerns over saturated fat were overblown, that LDL cholesterol doesn’t matter, or that the original diet-heart hypothesis has been debunked. These claims have become especially popular in online wellness spaces and certain dietary communities, often wrapped in compelling but misleading rhetoric. So what does the best available evidence actually say? And how should we think about saturated fat, LDL cholesterol, and cardiovascular risk in the current day? In this wide-ranging interview, originally recorded for the Chasing Clarity podcast, Alan and Danny explore the scientific consensus around saturated fat’s impact on blood lipids, why LDL and apoB are central to atherosclerotic disease, and how dietary patterns can meaningfully reduce risk. Importantly, they also address some of the most persistent myths and half-truths that fuel confusion, from flawed interpretations of the Seven Countries Study to misrepresentations of newer meta-analyses. Timestamps [03:41] How do we know saturated fat impacts LDL-C? [05:28] Metabolic ward studies and key findings [11:13] The Keys equation and subsequent research [17:17] Epidemiology and long-term studies [31:48] The Seven Countries Study [44:25] Understanding the impact of saturated fat on blood lipids [47:23] Historical and research perspectives on saturated fat [50:43] Practical dietary strategies for improving blood lipids [53:48] The Portfolio Diet and other dietary interventions [58:07] The role of pharmacology in managing blood lipids [01:00:58] Addressing misconceptions and common claims [01:13:57] Key ideas segment (premium-only) Related Resources Subscribe to Join the for free Enroll in the next cohort of our course Alan Flanagan’s Related episodes to add to your podcast queue: 532, 525, 515, 493, 481, 439
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#568: Does the Maternal Diet Impact Risk of ADHD & Autism? – David Horner, PhD
07/01/2025
#568: Does the Maternal Diet Impact Risk of ADHD & Autism? – David Horner, PhD
To what extent can maternal nutrition during pregnancy influence a child’s later cognitive or behavioural development? While genetic and environmental factors are known to contribute to neurodevelopmental outcomes such as ADHD and autism, growing attention is being paid to the potential role of prenatal exposures, including dietary patterns. Yet, evidence in this area remains limited, and causality is difficult to establish. One recent study aimed to explore this question by analysing how maternal diet quality during pregnancy (specifically, adherence to a Western-style dietary pattern) related to neurodevelopmental outcomes in children assessed clinically at age 10. In this episode, Dr. David Horner discusses the findings from this prospective cohort study, the use of metabolic markers to complement dietary data, and the implications for future research into modifiable prenatal risk factors. About The Guest Dr. David Horner is a researcher in maternal nutrition and cardiometabolic health, based at the University of Copenhagen, Denmark. He is also a qualified medical doctor from Queen’s University of Belfast. His research is driven by a keen interest in modifiable determinants of health, aiming to better understand and improve health outcomes. Having worked as a medical doctor for 2 years in the UK, in 2017 Dr. Horner then moved to Copenhagen, where he completed a Master’s in Global Health and a PhD examining the impact of maternal dietary patterns during pregnancy on child health. Timestamps [02:47] Introduction to the study [07:08] Strengths and findings of the study [21:17] Genetic factors and gene-environment interactions [25:42] Metabolomics and potential mechanisms [30:12] Interpreting the study’s findings [38:03] Future research directions [42:50] Key ideas segment (Sigma Nutrition Premium) Related Resources Subscribe to Join the for free Enroll in the next cohort of our course See Sigma's Email: [email protected] Study: (with discussion in the comments)
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#567: Did Big Sugar Hijack the Food Pyramid? Were Low-fat Diets a Scam that Damaged Our Health?
06/24/2025
#567: Did Big Sugar Hijack the Food Pyramid? Were Low-fat Diets a Scam that Damaged Our Health?
For decades, dietary guidelines—and the Food Pyramid in particular—have been at the center of heated debates and considerable controversy. These guidelines have often been accused of being influenced by industry interests, oversimplifying nutritional nuance, or even directly contributing to rising obesity and metabolic disease rates. In this episode, we critically assess common claims surrounding the Food Pyramid, including whether it was truly shaped by vested industry interests, if it encouraged harmful dietary shifts toward excessive carbohydrate and sugar consumption, and whether the subsequent health outcomes seen at the population level can be fairly attributed to these guidelines. Additionally, we evaluate the role of the sugar industry in funding key studies and publications, examining the implications such conflicts of interest may have had on nutritional science. Drawing on historical context, rigorous examination of scientific evidence, and an evaluation of how nutritional recommendations have evolved, this discussion aims to clarify misunderstandings, highlight legitimate criticisms, and separate fact from persistent myths regarding dietary guidance and its implications for health. Timestamps [01:37] Common claims and narratives [03:15] Historical context of dietary guidelines [21:57] Sugar industry influence on dietary research [36:17] The mcgovern report [40:49] Misconceptions about dietary guidelines [44:28] Changes in food supply and consumption [58:15] Critiques and conflicts of interest [01:06:47] Key ideas segment (Premium-only) Links & Resources Go to (with linked resources) Subscribe to Join the for free Do you want to be skilled in reading nutrition studies? Enroll in the next cohort of our course Alan Flanagan’s - latest training and nutrition research relevant to strength trainees is the best online database for looking at the evidence of diets, foods and supplements on a range of health outcomes.
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SNP41: Do Certain Foods Really Cause Inflammation – And Are Anti-Inflammatory Diets the Answer?
06/17/2025
SNP41: Do Certain Foods Really Cause Inflammation – And Are Anti-Inflammatory Diets the Answer?
Inflammation has become a nutrition buzzword, often used in extreme or misleading ways. This episode aims to clarify what inflammation is, how it relates to diet and health, and whether specific foods truly provoke inflammatory responses in the body. The episode provides a nuanced, evidence-based look at inflammation and diet. It explains the difference between acute and chronic inflammation, outlines the role of chronic low-grade inflammation in disease, and emphasizes that overall dietary patterns – rather than any single food – are what influence our inflammatory status. Commonly demonized foods (such as sugar, wheat, and dairy) are scrutinized, and the conversation debunks myths about them being uniformly “inflammatory.” In this episode, Danny takes a look at what the scientific evidence actually shows about anti-inflammatory diets. Note: This is a -exclusive episode. Timestamps 01:06 Understanding Inflammation: Basics and Biomarkers 04:02 Acute vs. Chronic Inflammation 14:21 Biomarkers of Inflammation 22:51 Dietary Patterns and Inflammation 34:53 Specific Foods and Nutrients Impacting Inflammation 47:01 Practical Takeaways for an Anti-Inflammatory Diet 51:30 Conclusion Related Resources Subscribe to Enroll in the next cohort of our course Related podcast episodes: Sigma Statement:
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#566: Can We Maintain Weight Loss? Pharmacology and Behavior – Tara Schmidt, RD
06/10/2025
#566: Can We Maintain Weight Loss? Pharmacology and Behavior – Tara Schmidt, RD
GLP-1 receptor agonists have changed the landscape of obesity treatment, offering levels of weight loss once thought unattainable without surgery. But what happens after the weight is lost? And can we really talk about success without talking about maintenance? While much of the public discourse fixates on dramatic weight loss numbers, the harder question is what comes next. Can lifestyle interventions alone sustain weight loss after GLP-1 cessation? How do metabolic adaptations and behavioral relapse factor in? And what does the data actually show about relapse rates, nutritional adequacy, and lean mass preservation when using these medications? In this episode, Danny sits down with Tara Schmidt, dietitian at the Mayo Clinic, to examine the intersection of pharmacology and behavior in long-term weight management. Tara Schmidt is a registered dietitian and an instructor of nutrition at Mayo Clinic. As the lead dietitian for the Mayo Clinic Diet, she provides guidance rooted in evidence-based principles. She hosts the Mayo Clinic On Nutrition podcast and co-authored The Mayo Clinic Diet: Weight Loss Medications Edition. Timestamps [05:17] Understanding weight loss maintenance [08:44] Defining success in weight loss maintenance [11:54] Predictors of maintenance: self-monitoring and behavioral strategies [23:37] Pharmacological interventions: GLP-1 receptor agonists [31:06] Dietary considerations for those taking GLP-1 RAs [37:07] Addressing misconceptions about weight loss drugs [42:48] Final thoughts and takeaways [48:49] Key ideas (Premium-only) Links/Resources Subscribe to Go to Join the for free Enroll in the next cohort of our course Visit
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#565: How Zinc Insufficiency Impacts Inflammation, Immunity & Aging – Prof. Emily Ho
06/03/2025
#565: How Zinc Insufficiency Impacts Inflammation, Immunity & Aging – Prof. Emily Ho
Zinc is an essential micronutrient that often flies under the radar, despite being vital for hundreds of enzymes and transcription factors involved in immunity, antioxidant defense, and DNA repair. A surprisingly large segment of the population may not get enough – an estimated 10% of U.S. individuals consume less than half the recommended zinc intake, putting them at risk of deficiency. In this episode, Prof. Emily Ho discusses how even mild zinc insufficiency can impair immune function, promote chronic inflammation, and accelerate aspects of aging. She delves into the concept of “inflammaging” – the chronic, low-grade inflammation that develops with age – and explains how inadequate zinc status can aggravate this process. The conversation also highlights emerging research on zinc’s role in DNA integrity and how restoring zinc levels can reverse certain damage, underscoring zinc’s broader significance in healthy aging and disease prevention. Overall, this episode provides a deep scientific look at why maintaining adequate zinc status is crucial for immune resilience and mitigating age-related inflammatory and oxidative damage. About the Guest Emily Ho, PhD is the Director of the Linus Pauling Institute and professor in the College of Health at Oregon State University. Her research focuses on understanding the mechanisms by which nutrient status and healthy foods affect the initiation and/or progression of chronic diseases such as cancer. Her work has helped drive dietary requirements and recommendations for micronutrients such as zinc for communities with susceptibility to poor nutrition. Timestamps [02:10] Interview begins [03:58] The roles of zinc [06:31] Zinc deficiency and insufficiency [14:26] Prevalence and risk factors of zinc deficiency [21:12] Zinc and age-related inflammation [29:39] Zinc’s impact on chronic diseases [31:20] Practical advice on zinc supplementation [41:14] Final thoughts Related Resources Go to (includes related research) Join the for free Subscribe to Enroll in the next cohort of our course
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#564: Is Protein’s Appetite-Suppressing Power Overstated?
05/27/2025
#564: Is Protein’s Appetite-Suppressing Power Overstated?
In this episode, we take a deep dive into the commonly held belief that protein is the most satiating macronutrient. It’s an idea that shows up frequently in both clinical guidance and popular nutrition discourse: if you want to feel fuller, eat more protein. But how robust is that claim when you drill into the details of the evidence? To explore this, Alan and Danny examine the complex interplay between protein intake, satiety, and energy intake. We look at both historical and recent literature, including work from Kevin Hall’s group, that raises important questions about how much of protein’s supposed appetite-suppressing effect is due to the protein itself versus other influential variables—such as eating rate, food texture, and energy density. This is an important topic, not just for academic curiosity, but for its practical implications. If our assumptions about protein and satiety are oversimplified or overstated, that has knock-on effects for how we design diets aimed at appetite regulation, weight management, or obesity prevention. So whether you’re a researcher, a clinician, or simply someone interested in understanding the mechanisms behind how we eat, this episode aims to provide clarity on where the science currently stands—and where it might be leading. Timestamps [03:18] The impact of protein on satiety [04:49] Historical context of protein and satiety [07:30] Mechanisms of protein-induced satiety [16:31] Research methods and measurements [21:39] Studies on protein and satiety [27:51] Analyzing specific studies [35:51] Understanding high protein meals and their effects [37:31] Acute vs. chronic effects of high protein intake [45:59] Other meal characteristics [53:21] Real-world implications of protein intake [01:01:19] Summarizing the impact of protein on satiety Related Resources Subscribe to Join the for free Enroll in the next cohort of our course Go to Related studies:
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#563: The Financialization of the Food System – Prof. Martin Caraher
05/20/2025
#563: The Financialization of the Food System – Prof. Martin Caraher
Global food systems have been increasingly subjected to financial speculation, leading to adverse consequences for growers, consumers, and public health. But what are the systemic vulnerabilities that impact food security, equitable access to nutritious food, and the broader socio-political frameworks influencing these outcomes? Understanding the financial mechanisms shaping food production and distribution is highly relevant for health professionals, policy makers, and researchers concerned with nutrition, equity, and global health systems. This episode urges a critical re-evaluation of current food policies and invites consideration of more ethical, resilient approaches to safeguarding food systems. Professor Martin Caraher is Emeritus Professor of Food and Health Policy at the Centre for Food Policy, City St. Georges, University of London. His research encompasses food poverty, food security, the role of food aid, and the broader implications of food systems on public health. Timestamps [01:12] Financialization of food: an overview [05:27] Speculation and its impact on food prices [13:10] Global food security and policy responses [17:20] Corporate concentration in food systems [34:03] Potential solutions and future directions Related Resources Go to Join the for free Subscribe to Enroll in the next cohort of our course Episode #344: X: and
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SNP40: Do Seed Oils Cause Inflammation & Chronic Disease?
05/13/2025
SNP40: Do Seed Oils Cause Inflammation & Chronic Disease?
Seed oils have recently become a hotly debated topic in nutrition, fueled by sensational claims on social media. In this episode, the central theme is examining whether seed oils are truly harmful or if they’ve been unjustly demonized. The discussion tackles prevalent claims – that seed oils drive inflammation, oxidation, and chronic disease – and compares them against the current scientific evidence. This is highly relevant to nutrition science and clinical practice today, as many patients and practitioners are encountering conflicting information about vegetable oils. By exploring the origins of seed oils, their biochemical effects, health outcome data, and the misinformation ecosystem, the episode aims to clarify how omega-6 rich seed oils fit into a healthy diet and what evidence-based guidelines say. Timestamps 01:00 Understanding terms: PUFA, Linoleic Acid, Omega-6 05:20 Do seed oils cause inflammation? 12:44 Omega-3 and omega-6 16:43 Inflammatory markers and linoleic acid 19:22 Oxidation and cooking oils 26:25 Refining processes and health concerns 30:32 Health outcomes and polyunsaturated fats 35:18 Evidence cited by anti-seed oil proponents 43:48 Conclusions Related Resources Join the for free Subscribe to Enroll in the next cohort of our course Sigma Statement: Related podcast episodes:
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#562: How to Detoxify Yourself – Quack Asylum Special
05/06/2025
#562: How to Detoxify Yourself – Quack Asylum Special
In this Quack Asylum episode, Danny and Alan critically examine the claims surrounding “detoxification protocols” – specialized diets, cleanses, or supplements marketed to eliminate toxins from the body for better health. The central theme is whether these detox plans actually improve health outcomes or if they’re built on pseudoscience and fear. Many alternative health proponents argue that modern life exposes us to countless toxins that accumulate in our bodies, causing chronic diseases, and thus we must undergo periodic detox regimens to cleanse ourselves. There is genuine concern about environmental pollutants and chemicals – indeed, numerous substances in our food, water, and air can be harmful at sufficient doses. Nutritional science also recognizes that certain nutrients (e.g. vitamins, antioxidants) play roles in the body’s natural detox pathways. However, there’s a large gap between acknowledging real toxic exposures versus endorsing commercial “detox” diets or products. Many people, including health professionals, encounter patients or clients interested in detox plans, so understanding the science (or lack thereof) behind these claims is important. Timestamps [03:20] Claim 1 – Mark Hyman [06:10] The purpose of today’s episode [08:22] Claim 2 – Chris Kresser [11:30] Detoxification Pathways in the Body [25:46] Glutathione, heavy metals and other nutrients [50:30] Do nutrients support detox pathways [55:20] Unhinged claims: Mold and mycotoxin toxicity [01:04:54] One more unhinged claim [01:09:10] Conclusions Related Resources Subscribe to Join the for free Go to Enroll in the next cohort of our course
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#561: Emulsifiers in the Modern Diet: Health Risk or Harmless Additive?
04/29/2025
#561: Emulsifiers in the Modern Diet: Health Risk or Harmless Additive?
Emulsifiers are a ubiquitous component of the modern food supply, found in everything from salad dressings and dairy products to pastries and sauces. Traditionally regarded as safe by regulatory agencies, emulsifiers play a vital role in enhancing the texture, stability, and shelf-life of countless processed foods. Yet, in recent years, emerging research has prompted a reevaluation of this assumption, raising intriguing questions about whether regular consumption of these additives might have previously overlooked health consequences. Recent epidemiological studies have suggested possible associations between higher emulsifier intake and chronic health issues. Concurrently, mechanistic research has provided some biological pathways through which emulsifiers could disrupt gut health. This episode aims to critically examine the scientific literature surrounding dietary emulsifiers, differentiating credible evidence from speculation, and outlining what can—and cannot—be concluded about their potential risks. Timestamps [01:18] Emulsifiers in food: definition, function, and common uses [05:15] Regulatory approval and traditional safety evaluations [09:32] Epidemiological studies on emulsifiers: nutriNet-santé cohort [14:55] Emulsifiers and cardiovascular disease risk [26:12] Emulsifiers and type 2 diabetes risk [30:01] Emulsifiers and cancer risk [35:05] Mechanistic insights: emulsifiers, gut health, and inflammatory bowel disease (IBD) [47:15] Practical recommendations and clinical implications Related Resources Subscribe to Go to (with study links) Join the for free Enroll in the next cohort of our course
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#560: Neurodiversity & Nutrition: Choline, ADHD, Dyslexia, and Beyond – Emma Derbyshire, PhD
04/22/2025
#560: Neurodiversity & Nutrition: Choline, ADHD, Dyslexia, and Beyond – Emma Derbyshire, PhD
Nutrition is increasingly being considered as a modifiable factor that may influence neurodevelopmental outcomes. While severe deficiencies in certain nutrients are known to have dramatic effects, there is growing interest in the potential impact of more subtle insufficiencies — particularly during critical windows such as pregnancy, infancy, and early childhood. In conditions like ADHD, dyslexia, and autism spectrum condition (ASC), questions have been raised around whether specific nutrients may play a role in cognitive performance, attention, or learning. Could low choline intake be a contributing factor to altered brain function? Are individuals with neurodevelopmental conditions more likely to have different nutrient needs or metabolic profiles? And how might practical dietary strategies fit into a broader management approach? In this episode, Dr. Emma Derbyshire discusses the evidence on choline and other brain-related nutrients in the context of neurodiversity. Timestamps [02:02] Guest background [05:38] Choline: what it is and why it matters [07:26] Research challenges: measuring choline and study design issues [10:49] Maternal intake: choline’s role in fetal brain development [14:24] Choline & neurodevelopmental disorders (ADHD, ASC, dyslexia) [17:14] The choline gap: intake vs. requirements [23:05] Supplementation: adequacy vs. excess and safety concerns [25:05] Food sources: choline in the diet & intake planning [30:14] Nutrition as a tool in ADHD and dyslexia management [38:45] Other key nutrients (omega-3s, iron, iodine, magnesium, water) Related Resources Go to Join the for free Subscribe to Enroll in the next cohort of our course Book: Dr. Derbyshire’s website:
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Do Lipids Increase During Weight Loss? (SNP39)
04/15/2025
Do Lipids Increase During Weight Loss? (SNP39)
This is a segment from one of our Premium-exclusive AMA (ask me anything) episodes, where we answer questions submitted by Premium subscribers. To listen to the full episode, you’ll need to be a and access the episode on the private Premium feed. Questions Answered in This Episode [02:00] Why does the Mediterranean diet emphasize monounsaturated fats over polyunsaturated fats when the latter seem more beneficial for heart health? [08:48] What dietary patterns or foods best support strength and recovery in premenopausal women, especially on a plant-based diet? [20:33] Are there specific foods or supplements that help regenerate or protect connective tissue in conditions like EDS? [28:39] What does the current evidence say about the keto diet during cancer treatment, and are there specific cancers where it might be beneficial? [43:31] What are the biochemical processes behind fat loss, including fat mobilization, transport, and any potential short-term cardiovascular risks? [59:48] What is the most effective system for organizing, structuring, and retrieving accumulated knowledge over time? [1:10:37] Do you agree with Dr. Tom Dayspring that a significant percentage of people are hyper-absorbers of dietary cholesterol, making food cholesterol impactful for them? [1:14:35] Is consuming 2g of protein per pound of body weight safe if calorie intake is high and well-balanced? Links Subscribe to Go to
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#559: Skin Health & Nutrition – Thivi Maruthappu, PhD
04/08/2025
#559: Skin Health & Nutrition – Thivi Maruthappu, PhD
The intersection of nutrition, dermatology, and skin health is an area of growing interest, yet one that remains riddled with misinformation and oversimplified claims. The influence of dietary patterns, specific nutrients, and lifestyle factors on conditions such as acne, eczema, psoriasis, and skin aging has been widely debated, with varying levels of evidence supporting different interventions. While some nutritional strategies may play a role in optimizing skin health, the challenge lies in distinguishing practical, evidence-based approaches from overstated or anecdotal claims. A significant issue in this space is the naturalistic fallacy—the belief that diet alone can replace medical treatments, or that conventional dermatological interventions should be avoided in favor of “natural” approaches. This has led to widespread vilification of certain foods, such as dairy, gluten, and sugar, despite a lack of strong supporting data. Similarly, supplements and probiotics are often promoted with broad claims, while their actual efficacy is highly context-dependent—varying based on individual nutrient status, disease severity, and baseline dietary intake. In this episode, Dr. Thivi Maruthappu, a consultant dermatologist and researcher in nutritional dermatology, joins Danny Lennon to explore the current state of evidence in this field. Guest Information Dr Thivi Maruthappu MA PhD FRCP ANutr is a consultant dermatologist, nutritionist and leading researcher. As the UK’s first and only dual-qualified dermatologist and nutritionist, her pioneering expertise bridges the gap between diet and skin health. Dr Thivi continues to work in the NHS and has her own practice based at London’s renowned Cleveland Clinic. Dr Thivi studied Medicine at Oxford University and completed Dermatology training in London. She undertook a PhD to understand the links between our skin and internal health and this research featured in top tier scientific journals. She is one of a handful of dermatologists to have completed training in severe eczema and psoriasis during a fellowship at St John’s Institute of Dermatology, London and achieved a Certificate in Nutrition Science from Stanford Medical School, USA. Timestamps [02:52] Start of interview [03:37] Dr. Maruthappu’s background and expertise [05:57] Sunscreen and skin health: myths and facts [12:15] Effective skincare ingredients [16:07] The role of nutrition in skin health [20:25] Dairy and skin conditions [24:10] Collagen supplements: do they work? [27:45] Probiotics for skin health [31:35] Research outcomes and challenges [35:20] Practical applications in clinical practice [43:05] Key ideas segment (premium-only) Related Resources Join the for free Subscribe to Enroll in the next cohort of our course
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#558: Rethinking Ultra-Processed Foods in the Modern Food System – Duane Mellor, PhD
04/01/2025
#558: Rethinking Ultra-Processed Foods in the Modern Food System – Duane Mellor, PhD
Discussions around ultra-processed foods (UPFs) and their role in public health have gained significant traction in recent years. While some advocate for categorizing and regulating these foods due to their potential negative health effects, others argue that such classifications can oversimplify the issue and detract from more actionable dietary changes. In this episode, Dr. Duane Mellor, a registered dietitian and researcher, joins us to explore the complexities of the UPF debate. Rather than dismissing the concept outright, Dr. Mellor emphasizes the importance of nuanced discussion, bridging the gap between research findings and practical, evidence-based dietary guidance. Throughout this conversation, we unpack the broader implications of ultra-processed foods in the food system, consider how added fat, salt, and sugar contribute to public health challenges, and explore realistic approaches for dietary improvements. Guest Information Dr. Duane Mellor, PhD is a registered dietitian, academic researcher and science communicator. Dr. Mellor is currently working in clinical dietetics, working to support people, families and carers living with diabetes. Previously Dr. Mellor worked in medical education at Aston University, holding the position of Associate Dean for Public Engagement in the College of Health and Life Sciences. After initially working in the areas of clinical trials, Dr. Mellor’s other research interests focused on improving nutrition and health by working with communities to celebrate their heritage through food and help tackle barriers resulting from societal inequalities. Timestamps [03:02] Interview start [06:39] Understanding the NOVA classification [09:53] Potential pitfalls and policy implications [14:52] Food science and technology perspectives [20:47] Challenges in food classification [26:13] Health equity and policy considerations [42:31] Communication and public perception [50:30] Final thoughts and advice [51:15] Key ideas segment (Premium-only) Related Resources Join the for free Subscribe to Enroll in the next cohort of our course Paper: Go to
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#557: Health Psychology & Eating Behaviour – Prof. Jane Ogden
03/25/2025
#557: Health Psychology & Eating Behaviour – Prof. Jane Ogden
In the realm of health psychology, our understanding of eating behaviors extends beyond mere physiological hunger cues. Research indicates that factors such as learned associations, cultural influences, and individual perceptions play pivotal roles in shaping our dietary choices. Recognizing this complexity is essential for developing effective dietary interventions that move beyond simplistic recommendations, acknowledging the intricate web of cognitive, emotional, and societal factors at play. A significant discussion within nutrition science centers on the regulation of eating patterns, particularly the balance between internal cues and external structures. While intuitive eating emphasizes responding to one’s internal hunger signals, studies suggest that these signals are often influenced by external factors such as distractions and learned behaviors. An alternative approach, known as “pinned eating,” proposes structuring meals around fixed times and contexts. In this episode Prof. Jane Ogden, Professor of Health Psychology at the University of Surrey, discusses these concepts and some of the research her group has carried out. Guest Information Professor Jane Ogden is a distinguished health psychologist at the University of Surrey, with over three decades of experience in researching eating behavior, weight management, and women’s health. She earned her PhD from the Institute of Psychiatry in London in 1990 and has since contributed extensively to the field through her research and publications. Throughout her career, Professor Ogden has authored several influential books, including “Health Psychology: A Textbook,” now in its seventh edition, and “Thinking Critically about Research.” Her work is widely recognized, leading to her receiving an honorary Doctor of Science from the University of Buckingham in 2022. Timestamps [02:01] Interview start [02:41] Understanding eating behaviors and influences [10:33] Integrating psychology into nutrition practice [13:58] Pinned Eating [16:46] Critique of Intuitive Eating [21:30] Eating behaviors and hunger as a perception [26:34] Taste preferences and acquisition in children [29:10] Cultural and contextual meanings of food [33:25] Disgust and food presentation [35:29] Health communication and obesity [44:28] Future research in health psychology [47:23] Key ideas segment (Premium-only) Links: Subscribe to Join the for free Go to Enroll in the next cohort of our course Study:
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SNP38: What is Quality Sleep?
03/18/2025
SNP38: What is Quality Sleep?
Sleep is one of the most critical yet often overlooked components of health, performance, and overall well-being. Poor sleep quality or insufficient sleep can disrupt circadian rhythms, impair glucose metabolism, and alter hunger signals, leading to increased food intake, reduced insulin sensitivity, and other undesirable outcomes. In this episode, we bring together expert discussions from some of the leading researchers in sleep science, to explore what defines high-quality sleep, the mechanisms behind sleep regulation, and the factors that influence sleep-wake cycles, from light exposure to psychological stress. Timestamps Note: Full episode only available on . [02:14] The importance of sleep duration and timing [05:32] Exploring sleep intensity and architecture [07:50] Defining good quality sleep [12:46] The two process model of sleep regulation [19:06] What is sleep? [24:47] Socioeconomic factors and sleep [34:30] The impact of blue light on sleep [47:10] Wake drive and sleep pressure [52:44] Stress, anxiety, and sleep [58:27] Common sleep disorders [01:06:26] Sleep and eating behavior Related Resources Join the for free Subscribe to Enroll in the next cohort of our course Episodes referenced:
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#556: Can We Restore the Gut Microbiome Through Dietary Changes? – Anissa Armet, PhD
03/11/2025
#556: Can We Restore the Gut Microbiome Through Dietary Changes? – Anissa Armet, PhD
There is research suggesting that industrialization has significantly altered the composition of our gut microbiota, with certain microbial species now absent in many industrialized populations. Given the known associations between gut microbiome diversity and health, researchers have begun investigating whether restoring lost microbial species and adopting dietary patterns similar to those of non-industrialized populations could lead to measurable health benefits. In a newly-published study, the investigators aimed to explore whether L. reuteri could be successfully reintroduced into the microbiome through the “Restore Diet” and whether such a shift would result in improvements in key cardiometabolic and inflammatory markers. One of the authors, Dr. Anissa Armet, is on the podcast to discuss this area and both the potential and limitations of microbiome restoration efforts. Timestamps [03:48] Interview start [08:45] Understanding gut microbiome restoration [11:44] Challenges in microbiome research [21:03] Study design and objectives [43:23] Key findings and results [47:46] Future research directions [01:04:04] Key ideas segment (premium-only) Links Join the for free Subscribe to Enroll in the next cohort of our course Free Book: Paper: Dr. Armet’s free, open-access
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#555: What Should the Dietary Guidelines Say? – Prof. Christopher Gardner
03/04/2025
#555: What Should the Dietary Guidelines Say? – Prof. Christopher Gardner
Every five years, the U.S. Dietary Guidelines are updated based on the latest scientific evidence to help shape national nutrition recommendations. A panel of experts was assembled to review the existing research, evaluate new findings, and provide recommendations that will inform the next edition of the guidelines. One of the committee members involved in this process is Professor Christopher Gardner, a leading nutrition scientist at Stanford University, who joins us to share key insights from the committee’s work. In this discussion, Professor Gardner provides an inside look into how the committee evaluated dietary patterns, the role of plant-based proteins, and the ongoing debate surrounding ultra-processed foods. He explains the rigorous process of reviewing scientific literature, the challenges in translating research into policy, and the critical role of health equity in shaping the recommendations. By exploring these themes, this episode aims to provide clarity on the scientific foundation behind the upcoming dietary guidelines. Whether you’re a nutrition professional, researcher, or someone interested in how dietary recommendations are formed, this conversation sheds light on the key discussions shaping the future of nutrition policy. Timestamps [03:38] Interview begins [07:18] The rigorous process behind formulating dietary guidelines [12:10] Key questions addressed and major findings from the report [25:41] Identifying nutrients of concern and refining dietary patterns [33:39] The importance of health equity in dietary recommendations [36:04] Reassessing dairy’s role in different population groups [41:05] Shifting the focus towards plant-based protein sources [47:52] The debate on ultra-processed foods and public health implications [58:24] Key Ideas segment (Premium-only) Related Resources Enroll in the next cohort of our course Subscribe to Join the for free Previous episode with Prof. Gardner:
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#554: Crucial Ideas for Understanding Nutrition Science
02/25/2025
#554: Crucial Ideas for Understanding Nutrition Science
Understanding the complexities of diet-disease relationships requires a nuanced approach to nutritional science. Unlike other scientific disciplines, nutrition research often grapples with the inherent challenges of studying dietary patterns and nutrient intakes in free-living populations over long periods. The cumulative effects of dietary exposures, combined with the necessity to control for confounding factors such as total energy intake and population-specific dietary habits, highlight the need for rigorous study designs and careful interpretation of findings. Despite their utility, these methods are often misunderstood or misrepresented in public discourse. Addressing these misunderstandings requires a clear communication of key principles underpinning nutritional science, including the role of cumulative exposure, the importance of contextualizing absolute and relative risks, and the necessity of evaluating the long-term effects of dietary patterns. This episode aims to provide a comprehensive overview of these essential ideas, equipping readers with the tools to critically appraise the evidence and engage meaningfully with the ongoing conversation around nutrition research. Timestamps [03:26] Understanding nutrition science: core concepts [06:01] Standards of proof in nutrition research [19:39] Unique challenges in nutrition research [26:30] High vs. low exposure in nutrition studies [34:34] Challenges in nutrition randomized control trials [39:29] Understanding null by design in nutrition trials [41:58] The importance of temporal relationships in diet and disease [43:55] Relative risk vs. absolute risk [57:16] The role of substitution and adjustment in nutrition studies Related Resources Enroll in the next cohort of our course Join the for free Subscribe to Episodes referenced:
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#553: Healthy Habits for Fertility and Reproductive Health – Marjorie Nolan Cohn, RD
02/18/2025
#553: Healthy Habits for Fertility and Reproductive Health – Marjorie Nolan Cohn, RD
This episode focuses on the intersection of nutrition, lifestyle, and women’s health, with a particular emphasis on managing complex conditions such as PCOS, endometriosis, and premenstrual dysphoric disorder (PMDD). Registered dietitian Marjorie Nolan Cohn shares insights from over two decades of clinical practice, highlighting the importance of addressing foundational health behaviors—such as adequate sleep, hydration, and nutrient-dense dietary patterns—before introducing targeted interventions like supplementation. Marjorie explores the nuanced relationship between body weight, metabolic health, and fertility, while addressing misconceptions around weight loss as a primary health goal. The episode examines the role of long-term, individualized care in improving symptoms and outcomes for women experiencing significant menstrual-related challenges. Practical considerations for practitioners, including strategies to build trust, identify key barriers, and provide holistic support, are outlined alongside the importance of interdisciplinary collaboration to improve care quality. Marjorie Nolan Cohn is a registered dietitian with a Masters Degree in Food and Nutrition Science from the Indiana University of Pennsylvania. She is the Clinical Director of Berry Street, a company providing virtual in-network nutritional counseling to people across the US. Timestamps [04:32] Beginning of the interview [08:39] The role of nutrition in fertility [13:40] Understanding PCOS and endometriosis [16:28] Barriers to accurate women’s health diagnoses [19:03] Exploring diet and lifestyle strategies [23:28] Addressing challenges in women’s health and nutrition [39:01] Closing remarks and final takeaways Related Resources Join the for free Subscribe to Enroll in the next cohort of our course Guest website:
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#552: Diet & Sleep Interactions – Marie-Pierre St. Onge, PhD
02/11/2025
#552: Diet & Sleep Interactions – Marie-Pierre St. Onge, PhD
Over the past couple of decades, renowned researcher Dr. Marie-Pierre St-Onge has uncovered fascinating links between how we sleep and what we eat, revealing how these two lifestyle factors influence energy balance, cardiovascular health, and metabolic function. In this episode we’ll explore Dr. St-Onge’s findings on sleep regularity and its association with reduced mortality risk, providing actionable insights for optimizing your lifestyle. With a focus on combining rigorous methodologies and controlled dietary interventions, her research sheds light on the complex mechanisms connecting sleep, diet, and metabolic health. Timestamps: [03:39] Dr. St-onge's academic journey and evolution of her research interests [07:03] Overcoming methodological challenges in sleep and nutrition research [10:20] The importance of sleep regularity for health [15:44] Exploring the bidirectional connection between diet and sleep [23:40] Unpacking the mechanisms linking diet to sleep quality [37:33] Practical recommendations for optimizing sleep and diet Links: Join the for free Subscribe to Enroll in the next cohort of our course Article: Go to
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Multivitamin Nihilism: Is it Actually Worthless to Supplement? (SNP37)
02/04/2025
Multivitamin Nihilism: Is it Actually Worthless to Supplement? (SNP37)
Multivitamin and multimineral supplements have long been a topic of both scientific inquiry and public debate. While they are often marketed as convenient solutions for achieving nutritional adequacy, their true value remains contentious. Are these supplements essential insurance policies against nutrient deficiencies, or are they merely expensive placebos? Importantly, how should we weigh their potential benefits against the lack of robust evidence for long-term health outcomes such as reduced mortality or chronic disease risk? These questions demand a nuanced exploration, grounded in the context of specific populations and individual needs. Ultimately, the role of multivitamin supplements cannot be assessed in isolation but must be viewed through the lens of context and specificity. How do we balance the biological plausibility of benefits against the variability of individual diets, the presence of fortification policies, and the challenges of achieving dietary adequacy in certain life stages? These considerations invite a more thoughtful and less binary discussion about whether, when, and for whom multivitamins are a worthwhile addition to the diet. Timestamps [00:22] The debate on multivitamins: worthless or beneficial? [00:53] Rationale behind multivitamin use [04:04] Modern nutritional adequacy and multivitamins [07:10] Evidence supporting multivitamin use [23:39] Long-term health outcomes and multivitamins [41:43] Cognitive outcomes [50:18] Pregnancy and multivitamin use Related Resources Join the for free Subscribe to Enroll in the next cohort of our course Shaun Ward Article: Studies mentioned:
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#551: How to Shift from Short-term Dieting to Sustainable Lifestyle Changes – Laurin Conlin
01/28/2025
#551: How to Shift from Short-term Dieting to Sustainable Lifestyle Changes – Laurin Conlin
While the fitness industry often emphasizes short-term goals such as rapid weight loss or aesthetic improvements, a growing body of evidence highlights the importance of fostering long-term habits for health and wellbeing. Understanding how psychological frameworks intersect with physical health behaviors is key to empowering clients and overcoming the challenges posed by rigid dieting practices or the influence of social media culture. Bodybuilding and fitness culture serve as both a microcosm and an extreme example of the challenges faced in this space. As the boundaries between physique sports and general fitness blur, many enthusiasts adopt unsustainable habits without fully understanding their long-term implications. How can fitness professionals effectively guide clients toward intrinsic motivations and healthier relationships with food and exercise while balancing the reality of external pressures? In this episode, Laurin Conlin offers her insights based on her coaching experiences, as well as formal training in exercise sciences and mental health counselling. Dr. Eric Trexler co-hosts the episode with Danny Lennon. Timestamps [05:41] Challenges in dieting and coaching practices [09:58] Bridging physical and mental health through coaching practices [13:15] Recognizing and navigating disordered eating behaviors in fitness clients. [22:01] The physiological and psychological challenges in physique sports. [34:52] Fitness culture and social media influence [37:19] Misunderstanding intuitive eating [41:23] Using motivational interviewing and reflective listening to guide clients [52:13] Integrating mental health practices in fitness and nutrition coaching [62:13] Key Ideas segment (Premium-only) Related Resources Go to Join the for free Subscribe to Enroll in the next cohort of our course Get and collegues
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#550: Eating Disorder Risk in Sport, Wellness & Fitness – Jillian Lampert, PhD, RD
01/21/2025
#550: Eating Disorder Risk in Sport, Wellness & Fitness – Jillian Lampert, PhD, RD
Eating disorders and disordered eating behaviors represent complex, multifaceted challenges that affect individuals across all demographics, yet they remain widely misunderstood and under-recognized. These issues often extend beyond the stereotypical images associated with eating disorders, touching everything from rigid “clean eating” obsessions to the normalized extremes of diet culture. At the heart of these behaviors lies a disruption in one’s relationship with food, often fueled by societal pressures, unrealistic body ideals, and a pervasive focus on aesthetics over health. While these challenges are tenacious, recovery and improved relationships with food are possible with the right interventions, resources, and awareness. In this episode, Danny talks to Dr. Jillian Lampert, a registered dietitian with a PhD in public health nutrition, with a speciality in eating disorders and disordered eating. Timestamps [02:56] – What are eating disorders? a breakdown of core concepts [05:15] – Beyond stereotypes: the widespread impact of eating disorders [14:41] – Disordered eating in sports and fitness: risks and realities [19:41] – Guidance for practitioners: recognizing and addressing red flags [22:50] – Barriers in treating eating disorders: challenges and solutions [43:50] – Advocacy and systemic change: the future of eating disorder care Related Resources Join the for free Subscribe to Enroll in the next cohort of our course Go to
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#549: Are We Doomed? Trust, Misinformation, and the Future of Health & Fitness Science – Joe Klemczewski, PhD
01/15/2025
#549: Are We Doomed? Trust, Misinformation, and the Future of Health & Fitness Science – Joe Klemczewski, PhD
In a world flooded with information, discerning fact from fiction in fitness and nutrition has never been more challenging—or more important. The rise of social media and democratized science has given everyone a platform, but not all voices are equal. How do we navigate a landscape where influencers with massive followings wield the same credibility as seasoned experts? Why do pseudoscientific trends gain traction while nuanced evidence gets lost in the noise? In this episode we also dive into the evolution of coaching, examining how the obsession with quantifiable metrics has shifted the focus away from human connection. How can professionals balance the drive for scalable success with the need for meaningful client relationships? And what lessons can we draw from decades of shifts in the fitness industry to stay resilient amid rapid societal and technological changes? Timestamps [04:33] Eric’s personal journey and influence [06:08] Evolution of bodybuilding coaching [10:32] Challenges in interpreting scientific research [17:35] Historical trends in diet and nutrition [25:49] Information overload and misinformation [43:07] Understanding fractional counting in hypertrophy [44:24] Challenges in communicating scientific concepts [47:27] The psychology of persuasion [49:07] The role of marketing in science communication [54:46] Balancing data and intuition in coaching [01:03:59] Navigating the future of nutrition coaching [01:08:34] Building trust and connection with clients Related Resources Go to Join the for free Subscribe to Enroll in the next cohort of our course Dr. Helms’ is a monthly publication that includes easy-to-read breakdowns of the latest training and nutrition research
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IGF-1 and Diet: Cause For Concern? (SNP36)
01/08/2025
IGF-1 and Diet: Cause For Concern? (SNP36)
IGF-1 (Insulin-Like Growth Factor 1) has emerged as a hot topic in health and nutrition discussions, often linked to longevity, cancer risk, and metabolic health. On one hand, IGF-1 is essential for growth, repair, and metabolic regulation; on the other, it is sometimes associated with disease processes, including cancer and cognitive decline. For those intrigued by the intersection of nutrition, biomarkers, and disease prevention, IGF-1 offers an opportunity to explore how science grapples with these complexities. Claims about manipulating IGF-1 through dietary changes — whether by reducing protein or adopting fasting protocols — are common. But does the evidence support these claims? If you’re curious about IGF-1 and the relationships between diet, disease, and healthy aging, in this Premium-exclusive episode Danny and Alan discuss this fascinating topic. To listen to the full episode, subscribe to Timestamps [02:21] IGF-1 and Diet: Examining the Relationship [09:15] IGF-1 as a Biomarker: Challenges with Sensitivity and Specificity [11:54] IGF-1 and Cancer Risk: Insights and Complexities [25:51] IGF-1 in Aging: Cognitive Function and Longevity Considerations [43:38] Key Takeaways: IGF-1, Diet, and Practical Advice Related Resources Join the for free Subscribe to Enroll in the next cohort of our course
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