TWiEVO 106: What's old immunity is new againNels and Vincent explain how homology searches of anti-phage systems in eukaryotic genomes can be used to discover proteins of the human immune system. Hosts: and Subscribe (free): , , of TWiEVO Links for this episode Join the from antiphage systems (Cell Host Micro) Timestamps by Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/33267237
TWiEVO 105: Not every rose has its thornNels and Vincent look at how plant prickles, sharp epidermal projections that provide defense from predators and other advantages, arose by convergent evolution, the emergence of analogous traits in distantly related species. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the of plant prickles (Science) Timestamps by Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/33266577
TWiEVO 104: Wooly mammoth prosciuttoNels and Vincent discuss the genome sequence of an ancient wooly mammoth, which shows that the three-dimensional architecture of the DNA can persist after 50,000 years. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Three dimensional architecture of genome (Cell) Timestamps by Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/32366157
TWiEVO 103: Change the world by duplicating yourselfNels and Vincent explore a direct experimental test of Ohno’s Hypothesis, which states that gene duplication can help genes tolerate new mutations and thus facilitates the evolution of new phenotypes. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Direct test of (eLive) Timestamps by Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/32058592
TWiEVO 102: Kelp gets some viral helpNels and Vincent explain how deep genomics of macroalgae illuminate multiple paths to aquatic, photosynthetic multicellularity. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Paths to aquatic, (Mol Plant) Timestamps by Science Picks Nels – Vincent – and the follow up Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/31213442
TWiEVO 101: 99 problems but a tail ain't oneNels and Vincent review the genetic basis for tail-loss evolution in humans and apes. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Genetic basis of in apes (Nature) Timestamps by Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/31205152
TWiEVO 99: A shocking means to move genesNels and Vincent reveal how electric organ discharge from the electric eel facilitates the introduction of DNA into teleost larvae. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the moves DNA into cells (Peer J) Timestamps by Science Picks Nels – Vincent – and G Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/31203907
TWiEVO 100: Spaces that celebrate scienceRich Condit joins Nels and Vincent at the Science Mill in Johnson City, Texas, where Director of STEM Education Jeehyun Park talks about the goals of the childrens’ museum. Hosts: , , and Guest: Subscribe (free): , , , of TWiEVO Links for this episode Join the Timestamps by Science Picks Nels – and Rich – Vincent – SXSW Session ““ Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/31479582
TWiEVO 98: The worms strike back!Nels and Vincent discuss how behavioural individuality determines infection risk in clonal ant colonies. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Infection risk in (Nat Comm) Timestamps by Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/30133793
TWiEVO 97: Germs trapping wormsNels and Vincent review a study of the key processes required for the different stages of fungal carnivory by a nematode-trapping fungus. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Fungal carnivory by a (Plos Biol) Timestamps by Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/30117283
TWiEVO 96: Going bananas over the origins of corn Nels and Vincent discuss the origins of two modern day agriculturally important plants: a role for two different wild teosintes in making modern maize, and the origin and evolution of the triploid cultivated banana genome. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Two teosintes made modern maize (Science) (Native Seeds) Evolution of triploid (Nature) Science Picks Nels – Vincent – Science’s 2023 and Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/29233268
TWiEVO 95: Watering the viruses until they bloomNels and Vincent discuss how the rewetting of seasonally dried soils, a critical event in Mediterranean grasslands that reactivates dormant soil microorganisms, leading to pulses of carbon and nitrogen mineralization, and is accompanied by a bloom of viral diversity, followed by extensive viral community turnover. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Join the Science Picks Nels - Vincent - Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/28645533
TWiEVO 94: A bacteria, a phage, and a selfish element walk into a cryptomonadNels and Vincent take apart an amazing symbiosis consisting of two bacteria, one bacteriophage, and seven different genomes all within a single-celled alga. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode •Join the •A single crowded (Curr Biol) • on TWiEVO 94 Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/28180514
TWiEVO 93: Faster than a speeding bacteriaNels and Vincent review a collision of synthetic biology and experimental evolution, using a minimal synthetic bacterial cell with only 473 genes, the smallest genome of any known organism that can be grown in lab culture. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode •Join the • Evolution of a (Nature) Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/27846015
TWiEVO 92: There's algae in the jarNels and Vincent explain a study of how interspecies competition between two algae influences evolution of metabolism and size. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode •Join the • during competition (Curr Biol) Science Picks Nels – () Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/27531840
TWiEVO 91: Meet your very distant cousinsNels and Vincent discuss new findings using phylogenetic approaches about how complex eukaryotic cells emerged from prokaryotic ancestors, which firmly place eukaryotes as a clade nested within the Asgard archaea. Hosts: and S Subscribe (free): , , , of TWiEVO Links for this episode •Join the •Heimdallarchaeial (Nature) Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/27492117
TWiEVO 90: The mystery of the mouse mummiesNels and Vincent provide insights into the mystery of mouse mummies on the summits of >6000 m Andean volcanoes, including whether they were living there and if so why? Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode •Join the •Mystery of (bioRxiv) Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/26823624
TWiEVO 89: On the outer rim of tumor evolutionNels and Vincent discuss the observation that cells on a boundary of a solid tumor have higher growth rates compared to those in the center and how to model this difference using genome sequencing data. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode •Join the •Evolutionary models of (Nat Ecol Evol) Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/26642112
TWiEVO 88: Dog days of evolution in the shadows of ChernobylNels and Vincent review a study of the dogs of Chernobyl which reveals that genetically distinct populations with different amounts of western breed contributions to their genomes, the first step in assessing the effects of exposure to long-term ionizing radiation. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode •Join the • of Chernobyl (Science Adv) •What the dogs of Chernobyl (Stat) • on TWiEVO 88 Science Picks Nels – and Vincent – Listener Pick Walter – and Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/26342541
TWiEVO 87: Nathan Clark's revolutionary hair care adviceNathan joins Nels and Vincent to discuss his approach to understanding how species adopt novel traits to overcome challenges, and its application to identifying coding and noncoding sequence changes that underlie mammalian hairlessness. Hosts: and Guest: Subscribe (free): , , , of TWiEVO Links for this episode •Join the •Gene loss in marine mammals () •Gene change underlying (eLife) • on TWiEVO 87 Science Picks Nels – Vincent – by Anna Marie Skalka Nathan – G Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/26004150
TWiEVO 86: Pulling out the stops in genetic code evolutionNels and Vincent discuss how evolution of changes in stop codon assignment might occur, and a novel mechanism for altering the meaning of translation stop codons discovered in a trypanosomatid with the apropos name, Blastocrithidia nonstop. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode •Join the •Novel mechanisms (Nature) Science Picks Nels – Vincent – discussed on Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/25833219
TWiEVO 85: Teaching old dogs new genetic tricksNels and Vincent discuss the use of genome sequence data for over 4,000 domestic, semi-feral, and wild canids to understand the genetic drivers of canine behavior. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Genetic drivers of (Cell) Time stamps by . Thanks! Science Picks Nels – by C. Brandon Ogbunu Vincent – by Sean Carroll Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/25394631
TWiEVO 84: Decoding our defenses to the Black DeathNels and Vincent review the use of ancient DNA to identify loci that may have been under selection during the Black Death by studying populations before, during, and after the pandemic. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Evolution of immune genes associated with (Nature) ERAP2 and (medRxiv) Time stamps by . Thanks! Science Picks Nels – and Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/24946794
TWiEVO 83: Evolution spreads its wings (and then loses them)Florian Maderspacher from Current Biology joins Nels and Vincent to discuss a special issue of the journal on birds. Hosts: and Guest: Subscribe (free): , , , of TWiEVO Links for this episode Current Biology bikes across the US (Audubon) Support (Go Fund Me) Time stamps by . Thanks! Science Picks Florian – Favorite birds of authors/contributors in Birds issue Nels – Vincent – Malaria at the Bronx Zoo () Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/24703566
TWiEVO 82: A genetic hack for the human brainNels and Vincent consider evidence that a single amino acid change in the TKTL1 gene might have led to greater neurogenesis in the frontal cortex of modern humans compared with Neanderthals. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Human TKTL1 implies (Science) Everyone’s a little bit Neanderthal () Tragic gene flow from Neanderthals () Time stamps by . Thanks! Science Picks Nels – Vincent – and Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/24483900
TWiEVO 81: Evolution's new and improved slime moldsNels and Vincent discuss how duplication of a gene encoding a transcription factor led to evolution of a novel cell type in the slime mold Dictyostelium. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode Gene duplication leads to (Current Biol) Evolution of multicellularity () on TWiEVO 81 Time stamps by . Thanks! Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/24158103
TWiEVO 80: Viruses of a feather bottleneck togetherLouise Moncla joins Nels and Vincent to review her use of genomics to understand emergence, evolution, and transmission of respiratory viruses including influenza virus H5N1, mumps virus, and SARS-CoV-2. Hosts: and Guest: Subscribe (free): , , , of TWiEVO Links for this episode Within-host (PLoS Path) in Washington (eLive) SARS-CoV-2 tight (PLoS Path) Time stamps by Jolene. Thanks! Science Picks Nels – Vincent – and Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/23924508
TWiEVO 79: When the immune system is away, SARS-CoV-2 will playNels and Vincent discuss an analysis of the drivers of evolution of SARS-CoV-2 during chronic infections, indicating that a tradeoff exists between antibody evasion and fitness. Hosts: and Click arrow to play Download (103 MB .mp3, 86 min) Subscribe (free): , , , of TWiEVO Links for this episode SARS-CoV-2 evolution during (Nat Med) on TWiEVO 79 Time stamps by Jolene. Thanks! Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/23613740
TWiEVO 78: The virus daily doubleNels and Vincent provide an update on cases of monkeypox, and summarize a biochemical view of three changes in the SARS-CoV-2 spike protein that may balance positive and negative selection. Hosts: and Subscribe (free): , , , of TWiEVO Links for this episode ECDC monkeypox risk assessment () Monkeypox virus (Nextstrain) of monkeypox virus genome sequencing (virological.org) Balancing in spike protein (Biochem) Time stamps by Jolene. Thanks! Science Picks Nels – Vincent – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/23237537
TWiEVO 77: The mutations of our livesAlex joins Nels and Vincent to discuss his work which demonstrates that somatic mutation rates scale with lifespan in mammals. Hosts: and Guest: Subscribe (free): , , , of TWiEVO Links for this episode and age (Nature) Zombie gene in elephants () Time stamps by Jolene. Thanks! Science Picks Alex – Nels – Vincent – Listener Pick Martha – Music on TWiEVO is performed by Send your evolution questions and comments to [email protected]/episode/index/show/twievo/id/22918331
