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Paul Meadows on helping found IFESS and Imthera neurostimulation

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Release Date: 09/05/2023

Miguel Nicolelis on Neuralink and performing in front of a billion people at the 2014 World Cup show art Miguel Nicolelis on Neuralink and performing in front of a billion people at the 2014 World Cup

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Although the is best known for pioneering studies in neuronal population coding, Brain-Machine Interfaces (BMI) and neuroprosthetics in human patients and non-human primates, they have also developed an integrative approach to studying neurological and psychiatric disorders including Parkinsons disease and epilepsy. Top 3 Takeaways: "Every Brazilian kid dreams to play for the Brazilian national team in a world cup game, I didn't quite fulfill the dream, but I got as close as a scientist can get. And we had about 65,000 people in the stadium that day in about 1.2 billion people watching the...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

leads the Bioelectronic Medicines Laboratory at the , with the goal of developing next-generation neuromodulation therapies that use minimally invasive strategies to highjack the nervous system to treat circuit dysfunction and deliver biomolecules to target areas with unprecedented precision. Prior to Wisconsin, Dr. Ludwig served as the Program Director for Neural Engineering at the National Institutes of Health. He co-led the Translational Devices Program at NINDS, led the NIH BRAIN Initiative programs to catalyze implantable academic and clinical devices to stimulate and/or record from the...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is a Life Sciences Research Technical Fellow at but before that he was Director of Biological Technologies office at DARPA. Top 3 Takeaways "You'll never be able to establish your academic career unless you go and move to another place. I'm like, guys, this doesn't make any sense to me. What's most important is to do great work in the field and establish a foundation of the field." "I still had my university job for a couple of years while I was serving at DARPA. And if my time at DARPA and everybody's term-limited at DARPA. When that term ended, I could have gone back to Miami." "I...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is the founder and CEO of , a sacral nerve stimulation neuromodulation company and VP of Technology at TRI, Trans Stimulation Incorporated. He also worked at Galvani, a joint venture between Google and GSK as well as working in academia before.  Top 3 Takeaways "When you try to speak to potential investors who consider themselves experts in medical devices, they typically fall into three categories: One is no experience with neuromodulation and another bucket is experienced with wearable neuromodulation. And the third very small bucket is experience with implantable class three...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is at Stanford University. He has had many successful technologies spun off into companies or patents including those involving retinal prosthetics, optical imaging and spectroscopy, laser-tissue interactions, and retinal plasticity. Top 3 Takeaways "The [size] limitation for a retinal prosthesis is not in a fabrication side. The limitation is an interface with neurons" Allergan acquired Oculeve but then didn't do much with it seemingly because they already had a more profitable drug on the market "Stanford is industry-friendly, encouraging commercialization, basically making things...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is a corporate executive with thirty years of corporate, governance and strategy consulting experience. She oversees ’s global programs, including its centers and their services. These include: board evaluations, professional certification and training, its global registry of qualified directors, Board Bona Fide®, its strategic partnership programs and its Boardwise center.  Top 3 Takeaways  "It's really important to know that if we want to be good at our work, then we've got to explore things outside of our normal swim lanes. And when we do that, it gives us a different view or...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is the program officer at the in the National Institutes of Health (NIH). They are launching the NIH Blueprint Medtech (links below) which aims to help incubate growing neurotech companies go from Bench to Bedside.    Top 3 Takeaways  "We're funding individual projects and trying to help groups in the past have struggled... to get funding and to get all the way to in human trials. The Blueprint Medtech resource is meant to derisk later investment and grants for companies "We saw some great programs... having difficulty when they come in - Can we decrease the activation...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Jon is the founder of (quality management software exclusively for medical device companies) & a medical device guru with nearly 20 years industry experience. Jon knows the best medical device companies in the world use quality as an accelerator. That's why he created Greenlight Guru to help companies move beyond compliance to True Quality.   Top 3 Takeaways If it isn't documented, it didn't happen. One particular audit didn't take four days. It took two days because the Greenlight system made it so much simpler. Greenlight Guru also has an academy to teach people about the...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Professor is the Professor of AI & Neuroscience at the Dept. of Computing and the Dept. of Bioengineering at Imperial College London. His work is in Machine Learning and eye tracking to improve neurotechnologies. Top 3 Takeaways "What we do is we get people to move into our living lab/studio flat and they live their daily lives, and we record everything that they do, how they do, where they look, we record the eye movements, the body movements, and everything." "The more subjects you add to your dataset from different datasets, the worse the performance of the system becomes." A...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is the Co-Founder and Chairman of which has the Utah Electrode Array, the only FDA-approved neural implantable device. Blackrock Neurotech recently closed a $10 million financing round, led by Christian Angermayer's re.Mind Capital with participation from Peter Thiel, German entrepreneur Tim Sievers, and Sorenson Impact's University Venture Fund II.   Top 3 Takeaways "In the end, you have to have the drive. It has to be a passion. And then you will find a way because very often in life, you will find that, just when you need it, all that you really need is one door opening at the right...

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Paul Meadows is one of the founding members of IFESS and a  veteran in the neurotech industry. He is currently the Chief Technology Officer at Imthera in the development of neurostimulation device for obstructive sleep apnea. The company was recently acquired by LivaNova. Previous Meadows was involved with neurotech development at Advanced Bionics as well as the Alfred E. Mann Foundation.

Takeaways:
1. Current technology transfer developments are influenced by peer-reviewed published research.
2. Learn from the past so we don’t repeat in the future, applies to neurotech applications.
3. We still have technology challenges in such areas as cybersecurity and battery technology as well as systemic in clinical technology adoption.


[0:00] Ladan introduces the episode and joins the conversation with Paul Meadows and Jen French.
[1:02] Paul Meadows describes his involvement and various positions with IFESS since the inception of the organization.
[1:46] Discussion of his view of the evolution of IFESS over the years.
[2:35] Meadows describes the importance of peer-reviewed publications and the need to
review past research.
[3:43] There are obstacles for technology adoption such as clinical physical therapist curriculum.
[3:58] Meadow’s outlook for exciting developments in the next 5 years in miniaturization, packaging and user-friendly interfaces. This is accompanied by identified risks such as cybersecurity.
[5:52] Identifying that there is some basic science that is limiting technology advancements such as battery technology.