Neural Implant podcast - the people behind Brain-Machine Interface revolutions
This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to complement scientific papers on new neural research in an easy, digestable way. Innovators and professionals can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space.
info_outline
*FIXED* Pawel Soluch on launching the Medtech Coaching program with me
06/13/2023
*FIXED* Pawel Soluch on launching the Medtech Coaching program with me
Pawel Soluch is a returning guest who goes over his work at , then his consulting at , and now finally he talks about the program that he is launching with me! Top 3 Takeaways: Pawel and I (Ladan) are launching the Medtech Coaching program which will be aimed at helping medical device executives gain success in their businesses Coaching is different from consulting in that we do not generate anything for you but instead help you to become the best medtech executive you can possibly be In addition to group coaching we will also be offering individual coaching and also a retreat in January 2024 0:45 Do you want to reintroduce yourself 2:45 Do you want to talk about Neuro Device? 5:15 Do you want to talk about your work as a consultant? 7:15 Do you want to talk about your experience in my original group coaching? 9:15 What's the difference between coaching and consulting? 12:00 "Who is this for and who is it not for?" 15:00 What was the return on investment for the group coaching that you attended? 19:15 What does the individual coaching look like? 23:00 What does the retreat look like? 24:30 What's the role of trust in the meetings? https://medtechcoach.com/
/episode/index/show/neuralimplant/id/27115242
info_outline
Mounya Elhilali on her auditory processing selectivity research
05/29/2023
Mounya Elhilali on her auditory processing selectivity research
did the keynote talk at the . I was able to sit down with her and talk to learn more about her auditory processing selectivity research. Top 3 Takeaways: Nurses especially can get used to beeping and alarms which can be dangerous for patients. "Under anesthesia, you see some basic responses, but they are different than when you engage the, let's say, an animal in an awake state, and then when they are awake and actually behaving and engaging with the system" Audio recordings can be tuned to remove ambient noise but they need to be perfectly calibrated to distances between microphones. 0:45 "Do you want to describe your work a little bit?" 3:00 Can you talk about the Cocktail Party Problem? 4:30 How are alarms and beeping override our attention 8:30 How do you gather your data, what kinds of devices? 10:00 What is the role of awake vs non-awake states in auditory processing? 11:15 How did you get into this? 13:00 How are you involved in the translation of the science? 16:15 Why are recordings harder to hear than in real life? 17:15 Is there anything we didn't talk about?
/episode/index/show/neuralimplant/id/26919324
info_outline
Suraj Mudichintala on investing in bioelectronic medicine companies with Action Potential Venture
03/27/2023
Suraj Mudichintala on investing in bioelectronic medicine companies with Action Potential Venture
Suraj Mudichintala is a Senior Associate at Action Potential Capital which is GSK's bioelectronic medicine venture fund. Top 3 Takeaways: "Our fund is different in that we invest actually directly off of GSK's balance sheet. So we're what's called an evergreen fund where we don't actually have a fund size" "The way that I think about it is that a VC is really paid to allocate capital but really is really paid to think. You really have to think about what is the next space or the next technology that could disrupt a space? And because of that, it's a much you often have to take a much more longitudinal view. And it takes a lot of patience and tracking a space oftentimes for years" "When you reach out to a VC having a pitch, first of all, sending a non-confidential pitch deck is mandatory, I think. And that deck is essentially where we're making the first decision as to whether or not to do a call with you" 0:45 Do you want to introduce yourself better than I just did? 1:15 "Do you wanna talk about Action Potential, what it is, who it was formed by, and the investment thesis?" 2:30 Do you want to talk about the expansion of the AP investment thesis? 4:30 What does traditional Venture Capital look like and how is it different in that you are funded by GSK? 6:15 What do the positions within a VC firm look like? 7:45 How has it been for you going from Analyst to Associate? 8:45 What does your due diligence look like? 11:45 "A lot of VCs have a target size range, be it seed or angel or, maybe larger institutional stuff. But it sounds like you guys don't really have that?" 12:45 "How did you get into this space?" 14:45 "So how does consulting compare to the VC life?" 18:45 "What would you suggest is the best way to get your attention?" 24:00 What are some tips and tricks to reaching out to you? 27:00 What was the worst pitch deck you ever saw? 28:30 " Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/26234421
info_outline
Balint Varkuti on turning neuromodulation technologies into Brain-Computer-Interfaces using software by CereGate
03/20/2023
Balint Varkuti on turning neuromodulation technologies into Brain-Computer-Interfaces using software by CereGate
Balint Varkuti is the CEO of CereGate which unlocks new capabilities for existing neuromodulation technologies using software. Top 3 Takeaways: "the brain is naturally wired for pattern perception for learning, and that's really what we do. We send signals that the brain very quickly can pick up." "You do not need to exclusively be focused mentally, consciously on interpreting these signals. Rather it becomes second nature. Our favourite analogy is saying it is like braille for the brain." "With hardware, you sometimes have simply the disadvantage that you are married to the time point when you started. So if you started a long time ago, you started with that technology and you have a whole regulatory documentation that's building on that. So fundamentally pivoting in hardware down the road almost becomes impossible." 0:45 Do you want to introduce yourself? 3:00 What is special about the software that hasn't already been done? 11:30 The brain is plastic and the software is changing so how does it work with these two systems fighting? 13:30 How can this approach be used to treat Parkinson symptoms such as Freezing of Gait ?" 14:15 Can you read braille? 15:30 "How fast does a patient learn to use this?" 19:00 " How can a company work with you?" 21:15 You guys have been in stealth mode for 4 years, why did it take 4 years and do you have any success stories so far? 23:45 "Do you wanna talk about the regulatory pathway and how it was how to do a software versus a hardware solution?" 27:00 How did your background in behavioral sciences shape your outlook to the company? 30:15 You didn't mention coding in your background, can you talk about starting a software company without much coding experience? 31:30 You have 25 people involved in the company but doesn't seem that you have raised much money, why such a big team? 35:15 "What does the next four years look like? What's on your horizon?" 37:00 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/26234064
info_outline
Kevin Tracey returns to the podcast to give an update about his work at the Feinstein Institutes, the field of bioelectronic medicine and exciting vagus nerve clinical trials underway
03/13/2023
Kevin Tracey returns to the podcast to give an update about his work at the Feinstein Institutes, the field of bioelectronic medicine and exciting vagus nerve clinical trials underway
returns to the podcast to give an update about his work at the and the work at . Top 3 Takeaways: "Two years we discovered that a drug called Famotidine, which is sold as a generic drug Pepcid AC is actually a pharmacological or a drug-based vagus nerve stimulator. And we proved first in mice that famotidine placed directly in very small amounts placed directly in the brains of mice activates the vagus nerve. And this in turn turned off cytokine storm, which of course is a big problem in Covid 19" "A company that I've co-founded, Setpoint Medical, is currently deep into clinical trials in the United States called ResetRA, which is on clinical trials.gov or on the SetPoint website for rheumatoid arthritis patients. And that trial is enrolling many patients up to, I think 250 patients will be studied according to the websites and we're hoping that goes very well. And we're hoping, I'm hoping that leads to FDA approval for vagus nerve stimulation in the US in the coming days or coming in the coming months" "I think we're very close now to vagus nerve stimulation becoming a reality for millions of patients. And I, I hope, and I see a time when patients have the. Of choosing vagus nerve stimulation as a simple, safe therapy instead of dangerous, expensive drugs with black box warnings that are minimally effective." 0;30 "Do you wanna introduce yourself and talk about some of your work, especially as neuromodulation pertains to the immune system?" 2:45 "So the last time when we talked it was 2020. So pandemic, everything was upside down. But then you were telling me before we started recording that it was also especially busy for you at that time. So what were you up to around then?" 6:00 What were the quantitative takeaways of the Famotidine Covid trials? 8:15 "Why didn't it become standard practice?" 11:00 "You're saying the famotidine has this effect on the vagus nerve. Does this mean we no longer need vagus nerve stimulators? Can we just take Pepcid, AC?" 15:00 Do you want to talk about the Bioelectronic Medicine Summit? 17:30 What were some of the highlights of the Summit? 19:30 "You mentioned some interesting results. Is that something you can share now or is that something that we should be on the lookout for?" 21:30 "You were also featured recently in the Wall Street Journal and New York Times, what was that like and what were the articles about?" 23:15 "So what's exciting you now for 2023 and what's on the horizon for you for the next few years?" 27:15 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/26114430
info_outline
Israel Gasperin on measuring cannabis effects quanitatively with EEG with Zentrela
03/06/2023
Israel Gasperin on measuring cannabis effects quanitatively with EEG with Zentrela
is the founder and CEO of which uses wearable EEG caps to quantitatively measure cannabis experiences. Top 3 Takeaways: "The reason why the government funded us was to use this for safety and law enforcement" "The combination of features that AI is finding is something that we haven't really focused on studying and trying to understand. It's a black box today that, is accurately and objectively characterizing the psychoactive effects, but we don't exactly know what they mean." "Based on this neuroscience-driven research proving the onset time of the beverage, within two weeks [the company] increased their sales by 7% and they achieved record volume cells after. So what we did, or they did, was to educate the retailers to speak about their product based on this scientific publication, rather than, providing their subjective opinion" 0:45 Do you want to describe yourself better than I just did? 1:00 "We're talking about marijuana, we're talking about getting high. What are you measuring or what's the reasoning behind this?" 11:00 " You're saying that you can tell if people are high or not. What kind of confidence do you have and, what shows up in high people's brains?" 14:15 Do you want to talk about one of your success stories working with a company? 22:45 "How many people have you had come through your labs and run through your system?" 24:00 "Of the 20,000 sessions, how many are yours?" 27:45 "You've been working on this for six years. What do the next six years look like?" 32:15 "What are some challenges?" 35:45 "Is there anything that we didn't cover that you wanted to mention?"
/episode/index/show/neuralimplant/id/26114109
info_outline
Colin Kealey on the non-pharmaceutical adolescent ADHD treatment with NeuroSIgma
02/13/2023
Colin Kealey on the non-pharmaceutical adolescent ADHD treatment with NeuroSIgma
is the President and CEO of which is commercializing the Monarch eTNS System, the first non-drug treatment for pediatric ADHD cleared by the FDA. Top 3 Takeaways: NeuroSigma is commercializing the Monarch eTNS system, a wearable medical device that stimulates the trigeminal nerve on the forehead, as a treatment for neurologic and neuropsychiatric indications. The Monarch eTNS System is FDA cleared as a treatment for pediatric ADHD, ages 7 – 12. Clinical trials in this population show a response rate of 50% with a only mild side effects observed in clinical trials to date. NeuroSigma is also developing its eTNS technology for other indications including epilepsy and depression and is currently running two large double-blind randomized controlled trials in ADHD to expand the label into adolescents, and for using the device as adjunctive therapy. 0:45 "Do you want to introduce yourself better than I just did?" 7:15 What is the efficacy of your device? 8:45 "What are some typical side effects of pharmaceutical ADHD treatments and what are some typical side effects of your guys' treatment?" 16:45 That was the pharmaceutical side effects, how about the neurostimulator side effects? 20:00 How does it work sleeping with a wired system? 21:45 "Were you guys able to cross-reference with any other sleep metrics to see if the quality of sleep diminished or maybe even increased?" 24:30 What's the protocol for using this device? 26:30 Could adults use this also? 28:30 Will college students use this as a study aid? 29:30 "What does your funding look like?" 35:15 How will you prevent Chinese knockoffs? 38:30 " Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/25876512
info_outline
Craig Mermel on working at Google and Apple and now at Precision Neuroscience
12/19/2022
Craig Mermel on working at Google and Apple and now at Precision Neuroscience
is the President and Chief Product Officer at which is a company looking to commercialize Brain-Computer Interfaces using a minimally implantation method and a soft electrode device. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways "The combination of both the nature of our thin film and the surgical innovations that we bring enables us to bring cortical surface neurotechnology to patients in a minimally invasive fashion." "Having 10 times the amount of money at an early stage before you actually solve some of the key problems can be a problem because it pushes off some of the hard questions you have to ask yourself." "We're thinking ahead to the future where you have tens of thousands, hundreds of thousands, or millions of interfaces. The amount of damage you do will become a limiting factor at some point." 0:45 Do you want to introduce yourself better than I just did? 1:30 Why did you leave Apple and Google? 2:30 What is Precision and why is it special? 6:00 What's the funding look like? 8:00 "Why hasn't this been done before?" 10:00 Are you thinking about licensing out the technology? 11:15 ad sponsorship 12:00 What's your role now in Precision?" 12:45 "What are some of your biggest challenges?" 15:30 You guys raised $12M, why specifically this number? 19:00 "What are some, best practices or traps to avoid?" 21:45 Let's do a deeper dive into your work at Google and Apple 27:30 How would you compare working at Google and Apple vs being in a startup? 29:15 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/25308009
info_outline
Lothar Krinke on adaptive Deep Brain Stimulation at Newronika
12/10/2022
Lothar Krinke on adaptive Deep Brain Stimulation at Newronika
Lothar Krinke is the CEO and Board Member of Newronika which is an adaptive Deep Brain Stimulator company looking to improve patient outcomes in things like Parkinson's and Essential Tremor. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "the one thing we do need to address is really the cost. The cost driver of Deep Brain Stimulation isn't the manufacturing of the system. Now, that's not cheap either it's certainly less than $10,000. How expensive is brain surgery, particularly functional brain surgery? How expensive is it to have all the pre-operation preparation? So I think the field needs to think about how we can lower the cost of Deep Brain Stimulation to make it available to not hundreds of thousands of patients, but literally millions of patients." "I don't think AI or even machine learning has been sufficiently applied in our space. People do it and they talk about it, but if you look at other fields, even EEG, use of AI or machine learning are much more penetrated." "In my mind it is almost unconscionable that only 15% of patients that could benefit from Parkinsons, from DBS do. So somehow we need to have a battle cry. We need to have the responsibility to make this therapy available to more people. And the way to do that is less invasive more automation and lower cost" 0:45 Do you want to introduce yourself better than I just did? 2:15 "Why is Deep Brain Simulation so exciting for you?" 3:15 "Can explain what Deep Brain Stimulation is and what it's a treatment for?" 5:30 "How did you get into the field?" 6:30 ad sponsorship 7:15 You thought earlier that DBS was too invasive but now changed your mind, why? 8:15 What are the biggest impediments to DBS? 12:15 Why is the Newronika DBS better than the alternatives? 14:30 Why is adaptive DBS better? 16:30 "What are some of the biggest challenges right now at Newronika?" 20:30 You are in Minneapolis, West Virginia, and Milan, how are you able to travel so much? 21:30 "Why aren't you in Gainesville? I was surprised how big the DBS field is here." 22:15 "For people starting out in the field, do you have any advice?" 25:30 " What's a big mistake or wrong direction that you see researchers or people on your field going down?" 27:45 "Could you explain the beta and gamma waves?" 32:45 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/25285710
info_outline
Damiano G. Barone on being a neurosurgeon and improving patient quality of life through surgery
11/28/2022
Damiano G. Barone on being a neurosurgeon and improving patient quality of life through surgery
is a neurosurgery clinical lecturer at the University of Cambridge and fellow at The Walton Centre in Liverpool, UK. He is interested in tackling basic and translational challenges for the development of the next generation of neural bioelectronics. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "My favorite procedure is the procedure that works and you see the patient after that is is a changed patient." "You come out from medical school like age 23 or 24. Then you get to a general medical program which in the United Kingdom lasts 2 years in and then you get to the residency, which is 8 years. And then 10 years after you are age 34 practicing the neurosurgeon. I personally took what is called an 'out of programme for research/. So basically I halted my neurosurgery residency. I stepped out and I stepped in a PhD program while still covering what is called the on-call rota, which is basically doing emergency work in neurosurgery just to keep my clinical skills going." This added a few more years of training to the list. "Quality of life procedures, to be offered to the patients, will have to have a 70 to 80% improvement to justify the risks the patient will have to go through." 0:45 Do you want to introduce yourself better than I just did? 2:45 You spent 20 years in training for this, did you know this at the outset? 4:00 "What's it like to get only a few hours of sleep for years?" 5:00 Why did you choose to go the PhD route as well? 7:45 What's it like to be digging around in the body? 9:45 Sponsorship by 10:00 "What's your favorite procedures and what's your least favorite procedures?" 12:15 "What percentage of patients see improvements?" 14:30 "What are some, risks other than it not working, what are maybe some damage or maybe even death is that a possibility?" 16:45 "It's much more dangerous to have, a large device versus a small device. Is that kinda what you've seen?" 18:45 "Have you been involved in electrode design or device design?" 19:45 "What are you working on now?" 25:00 "What are the next steps?" 28:00 "What would you recommend or what kind of advice do you have for people considering this?"
/episode/index/show/neuralimplant/id/25133520
info_outline
Jon Sakai on interacting with your target patients and the neural sleeve made by Cionic
11/08/2022
Jon Sakai on interacting with your target patients and the neural sleeve made by Cionic
is the Head of Commercialization at , a wearable neurostimulator sleeve for those with neuromuscular disease ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "There isn't any individualized training that needs to happen. What needs to happen is the identification of which muscle groups need support and have those turned on and programmed in intensity appropriately." "We were able to improve door sub selection and inversion in more than 90% of our participants." "There's nothing like getting an appreciation for a problem like the acuity of a problem when you just watch someone for five minutes struggle with something that's probably unimaginable if it's a condition that you're not familiar with." 0:45 "Do you want to introduce yourself better than I just did?" 2:45 "There are algorithms that go behind it and it can actually predict how you're walking. How does that work?" 3:45 "Is there a learning process for the algorithms?" 5:00 "Do you guys use hydrogels as well? And how do you have gels inside of your leggings?" 5:45 ad sponsorship 6:30 "What kind of improvement is there?" 8:30 How can your algorithm predict the end of a walking cycle before it has started? 9:15 What was it like getting FDA approval? 9:45 What are the next steps for the company after raising your next round of funding? 10:30 How is this going to be sold? In clinics, prescriptions, or normal retail? 11:45 What is Head of Commercialization and how does one get that role? 14:45 "You guys have been around for four years. What do the next four years look like?" 16:30 "What are some big challenges that are facing?" 17:30 "If you had unlimited funding, what would you do?" 18:30 What is some career advice you have? 22:45 " Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24922371
info_outline
Hannah Claridge on helping small neurotech companies with R&D work at TTP
11/01/2022
Hannah Claridge on helping small neurotech companies with R&D work at TTP
is the Head of Neurotechnology at which is a consultancy that helps neurotech companies create the next generation of medical devices. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "I think consulting is really fantastic for the variety that it offers you. Not just in terms of seeing problems, but also working with different types of companies, different types of technologies, and having different day-to-day activities as well" "There have been cases where we've worked with very small companies where the company is composed of two or three founders whose sole role is the concept of the idea and the thinking behind what's the business case, and then gathering in the funding and passing that funding through for us to carry out the product development work. Now that's pretty unusual in most cases." "You need to be able to balance the efficacy of treatment with the side effects that are usually created. And if you go too far in one direction or the other, then that treatment stops being helpful. So if you stimulate too strongly, and the effect might be really effective but if the side effects are too strong, then patients aren't going to tolerate that." 0:45 Do you want to introduce yourself better than I just did? 1:45 "Let's talk about clinical translation, what does that entail?" 4:45 ad sponsorship 5:45 "What's a typical contract length and what does it look like from beginning to end?" 9:00 "It really sounds like you guys do everything. You could just take an idea and then bring it almost all the way to market" 10:15 "Do you wanna share the neurotech projects you've worked on?" 11:15 "What's a common problem that you see?" 17:15 "How does a company recover, like from having so much help to not having any help? Is that typical too?" 19:45 "What does your day-to-day look like? What are you usually doing?" 22:30 What's a typical pathway into the career of consulting? 25:15 "If you had unlimited funding or if a company had unlimited funding, what would you do?" 28:00 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24860676
info_outline
Lindsey Jardine talks all about clinical trials for neurotech
10/24/2022
Lindsey Jardine talks all about clinical trials for neurotech
is a clinical project manager at Boston Scientific which had acquired , a cardiac ablation medical device company she was working in. She runs clinical trials for medtech companies and had done so for neurotech companies as well. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "One of the most difficult things that I've found while you're actually running the study, is making sure those devices are getting to the sites, which is depending on where your manufacturer is" Hiring a Contract Research Organization (CRO) or hiring clinical trial specialists in-house depends on what the plan for the company is, whether it will be acquired or do an IPO "My biggest problem with startups is wanting to do too much. Because if you're trying to develop eight things at once, you're not gonna get there and you're gonna run outta money. And that's how I see a lot of startups fail" 0:45 Do you want to introduce yourself better than I just did? 1:15 "What is a clinical trial?" 2:45 "How do medical devices maybe neurotechnology, compare to pharmaceuticals?" 4:15 "What's a timeline?" 6:00 "Where does the time get used up and then where does the money get used up?" 8:45 ad sponsorship 9:15 "Let's talk about budgets and how they vary, why they vary" 11:30 "What does your day-to-day look like?" 17:45 "How did you get into it?" 21:45 What would be the formal path to get into clinical trials? 26:15 "What's a common mistake for startups?" 29:30 "Do the big guys have a speed advantage?" 31:00 "Is there anything that we didn't talk about that, that you wanted to mention?"
/episode/index/show/neuralimplant/id/24716625
info_outline
Dan Brounstein on how closed loop Spinal Cord Stimulation has better efficacy at Saluda
10/17/2022
Dan Brounstein on how closed loop Spinal Cord Stimulation has better efficacy at Saluda
Dan Brounstein is Chief Strategy Officer at Saluda Medical where he is using his 15 years of Spinal Chord Stimulator experience to help deliver closed-loop pain relief directly to the spinal cord. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "We're stimulating with milliamps and we're trying to measure in microvolts, and we always use the analogy trying to listen to a pin drop next to a shotgun shot" "There's a lot of literature on loss of efficacy? It's just a therapy issue. When you deliver open-loop therapies blind across a neural target, you're ultimately going to create, over-stimulation in a lot of times under stimulation. On top of that, over time things change" "Patients come in between four and five times a year on average in perpetuity with open loop systems" 0:45 " Do you want to introduce yourself and the company better than I just did?" 6:00 "Your guys' device reprograms on its own? And then what signals does it take in and how does it change the stimulation patterns based on that?" 9:00 ad sponsorship 9:45 "What is your input and output for your guys' device?" 11:45 "In February of 2023, you guys got FDA approval for this. Do you wanna talk a little bit about this?" 14:15 "Is it like 5% better than open loop or is that something that's gonna be coming out published later?" 17:00 "Is there another indication?" 18:15 "The last I guess seven years for you has been very exciting. Is there anything on the horizon for the next seven years?" 20:15 "You guys have 300 people and have raised 200 million. What's it like working in such a big company" 22:45 "Is it getting too big for you?" 23:45 "What advice do you have for people in your situation?" 26:00 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24698292
info_outline
Dr Angelique Johnson on starting a Medical Device Outsource Manufacturer, MEMStim
10/12/2022
Dr Angelique Johnson on starting a Medical Device Outsource Manufacturer, MEMStim
is the founder and CEO of which is a leading global medical device outsource manufacturer (MDO) serving the neurostimulation market, based in Louisville, KY. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "Our true competitors are actually not microfab but actually hand assembly, manual assembly" "I'm an accidental entrepreneur- the more I pitched, the more I thought about the business idea, the more I talked to actual customers the more I realized like, Hey, there's actually a need and we actually have a pretty good revenue model for meeting that need." "Kentucky actually matches investment and grant dollars depending on where your grants come from." 0:45 "Do you wanna introduce yourself better than I did?" 2:45 How did you make 3D cochlear device out of 2D microfabrication? 4:40 "Tell me about the founding of MEMStim" 8:00 Are you guys moving away from MEMS and towards 3D printing only? 9:00 Is the future 3D printed soft materials? 10:15 ad sponsorship 11:00 "Who are your customers right now?" 13:45 "What does the design process look like?" 16:15 "Have you helped companies get through ISO certifications and FDA approvals?" 18:30 "Do you guys do the implantable pulse generator or do you just do the electrodes?" 21:00 "Are you guys also prepared to ramp that up into actual production?" 22:45 "Do you have any advice for how you've survived for so long? 29:45 "What are the last five years that looked like and what are the next five years look like?" 31:00 "You're based in Kentucky, Louisville. Is there any reason for that?" 33:15 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24648795
info_outline
John Seymour on directional depth arrays and the future of neurosurgery
09/26/2022
John Seymour on directional depth arrays and the future of neurosurgery
is an in Neurosurgery and at where his lab works on electrophysiology studies, biophysics modeling, and applying machine learning models to decoding of neural activity. A major project in our lab is focused on developing a long-term brain-machine interface for the treatment of aphasia or locked-in syndrome. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "Your job as the engineer is to create a high resolution map of a crowd's vocalization during some live event, the rules are, you only get the place, say 10 or 20 devices throughout the stadium but only on these devices. At some point you realize more and more microphones on these poles are going to generate redundant information and they won't help us in our challenge to map the vocalization of this massive stadium. People have a very good intuition for sounds and we all understand sound is directional. Neural signals act the same way." "A rough rule of thumb is if the substrate diameter is on the order of magnitude of the source size, then there is good directionality in that situation." One day neural devices will be based on the patient's anatomy and will be printed on-demand to match the patient 0:45 "Do you want to introduce yourself better than I just did?" 2:45 "Geographically, how close are Rice and UT health?" 3:15 "You're saying the future of neural implants is additive depth electrodes. What does that mean?" 13:45 Sponsorship by 14:15 "What's the solution, to try to make them directional?" 16:30 "So you basically need your collector to be as small as possible?" 18:30 "So by finding the right size of the electrode and the substrate diameter you're able to have directional electrodes?" 22:45 "What's the advantage of your technology? What does it change?" 28:00 " If you had unlimited funding, what would you be able to do with it?" 33:00 What kind of differences of electrode design would you expect patient to patient? 34:45 "These few years ago, you said you were at Rice before, exclusively, and then now moved to both UT Health and Rice. What's that been like?" 42:00"Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24425334
info_outline
Andre Mercanzini on revolutionizing Deep Brain Stimulation using small directional probes by Aleva Neuro
09/19/2022
Andre Mercanzini on revolutionizing Deep Brain Stimulation using small directional probes by Aleva Neuro
is the Co-Founder and Chief Technology Officer at which has worked in directional Deep Brain Stimulation (DBS) device leads for Parkinson's and other diseases. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "We realized during that time that the intervention that could benefit the most from the miniaturization technologies was by far and away, deep brain stimulation." "MEMS allowed us to align every single electrode into its position, have it almost prewired and decrease the amount of touch time that an operator would have to spend on the device as they're manufacturing it, which, which gives us a price advantage as well." "My advice to PhD students postdocs, physician inventors, and professors working on neuro technologies is that you have to work on something that will make a major change in patient outcomes. It cannot just be incremental. If it has any signs of only being incremental, it will be very difficult to get funded. It will be very difficult to get your early adopters to sign up and use or test your device. It's always a difficult metric to determine what that means. Is it a 20% improvement in symptoms? Is it a 40% improvement in symptoms? Is it treating a disease that is not treatable today? That is really the major choice you have to make as an entrepreneur in your own technology is whether your work will make a significant change in patient outcomes." 0:30 "Do you want to explain what Aleva does a little bit and a little bit of your background?" 3:30 "What would you say that is a special thing in Lausanne that maybe other places could copy or are not able to copy?" 5:00 "Let's talk about Aleva" 6:45 " ad sponsorship" 7:15 "What's DBS and how did Aleva get started? You were saying this spun out of your PhD work. What did that look like then? And maybe how has it changed now?" 13:15 "Why is having directional leads was such a design problem?" 16:45 "What has the evolution been in the last decade, and then maybe what's future directions?" 20:30 You raised $70 million to get through the regulatory pathway, this seems like alot, couldn't you do it with 5 or 10 million? 23:30 Surgeons often like to stick with what they know, do you know if there would be a demand for what you are making? 25:45 Do you want to talk about wearables and how this fits in with your company? 29:00 "What advice do you have for people who want to follow in your footsteps and want to, create, raise $70 million and do you have to be in Switzerland to do this?" 31:45 "You've raised a lot of money and so is that good or bad and aren't you worried about being diluted too much?" 34:00 " Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24355890
info_outline
Vasiliki Giagka on Neural Interface Packaging and why it's the most important
09/12/2022
Vasiliki Giagka on Neural Interface Packaging and why it's the most important
is an and where she conducts research on the design and fabrication of active neural interfaces. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "Water vapor is not dangerous for neural devices, it will not cause your metals to corrode, as long as it remains in the form of vapor. The moment it condenses into liquid water and you have ions in there, is when corrosion can start, and that is the beginning of the end" Conformal polymer coatings have been implanted in bodies for decades but we lack means to prove upfront the amount of time a certain coated device would last in the body "Our aim is not to create startup ourselves, but it is really to help this ecosystem by supporting companies working on this" 0:30 "How do you work in Berlin and the Hague in the Netherlands at the same time? 2:30 "Why especially neural device packaging?" 5:15 "What's the size of your guys' device or packing?" 7:15 "Do you want to, do you wanna describe the neural implant network mesh a little bit more and how does it work and why is it necessary?" 9:15 Sponsorship by 9:45 "So let's talk about maybe conformal coatings. What is it, how does it work? Why is it necessary?" 19:00 "So what are some rough numbers, is one method better than the other, and then how many years of simulated life can one survive versus the other?" 21:45 "So how do we test it? How do we do the accelerated testing to be able to simulate a human lifespan?" 25:00 "So now you also work on the wireless power delivery, wireless transmission. How is this, how does this work? Why is this important?" 31:00 "Neurons fire with electrical signals and you're using ultrasound. So how does that work? Why is it able to work?" 32:00 "How does the power usage compare with electrical or ultrasound cuffs?" 33:30 "Let's talk about your graphene work." 37:30 "These three areas that you're working on, these all seem like very good candidates for, a spinoff company or some kind of, patents. Have you thought about this?" 42:00 "If you had unlimited funding, what would you do?" 43:45 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24205692
info_outline
Jacob George on implantable and wearable neurotech research at the University of Utah
09/05/2022
Jacob George on implantable and wearable neurotech research at the University of Utah
is an assistant professor at the University of Utah where his seeks to augment biological neural networks with artificial neural networks and bionic devices to treat neurological disorders and to further our understanding of neural processing. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "I'm 28 years old. So very young still getting stuff set up and really kickstarting it. The average age that NIH states for someone to get an R01 is somewhere around 47 years old and they really wanna change that. They wanna get people into science earlier. And so that's the mechanism that I went through and so very fortunate to have that funding to kick start stuff." "The idea is, you had a stroke, you wake up in a hospital, you get the fitted with this bionic arm that helps you move immediately. So it's like nothing happened. And as you're doing these things in your real world life, all of a sudden. You don't need the exoskeleton anymore because your hand's back to use because you have rehabilitated yourself." "A one-off grant is great, that's luck, if you get one thing that's luck, but repeatedly, being successful in funding starts to show a pattern of success that is more and more unlikely that it was just luck." 0:45 "Do you want to introduce yourself?" 2:30 "You're also a pretty new professor. How old are you also?" 4:30 "How did you get into this field?" 6:15 Sponsorship by 7:00 "Do you want to go in a little bit more in-depth about the different aspects of your research and maybe we could start with the Luke arm." 13:45 "So what does the training look like for the patients?" 17:00 "That calibration sounds tedious. How long is it?" 19:45"Is glial scarring also a problem in the peripheral nervous system or is it worse, better? How does it compare to the central nervous system?" 21:00 "Do you wanna talk a little bit about exoskeletons?" 25:45 "Which one do you love more, invasive or noninvasive?" 30:30 "What's especially motivating you to deal with this specific patient population?" 33:00 "Do you have any tips for people who might want to fall in your footsteps of being a young professor?" 36:45 "How similar is your training between, what you're doing at the PhD, working at the bench versus, being a professor and, needing to find those dollar bills?" 39:45 What specific exercises would you recommend for finding funding? 44:45 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24204969
info_outline
Ana Maria Porras on inclusive science communication in different languages
08/29/2022
Ana Maria Porras on inclusive science communication in different languages
Ana Maria Porras is an working on human-microorganism interactions and science communication especially in different languages. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "Sometimes we see science communication as a way to convince more people to work in STEM but I think it's important beyond that. It's important that you understand the basis of how we do science and why we do science" "We think of science communication as what's happening when people go viral. But you can do a ton of great science communication in your immediate community. With your family, with your friends, with people in your community around wherever it is that you live." "Sometimes you learn a ton of stuff and then you realize it was all the wrong stuff. I think science communication is like any other scientific discipline. There are scholars, there are best practices. There are people who have been doing the research." So just like in any other scientific discipline, it's like important to acknowledge that there's like a whole ton of work that other people have done so that we don't always have to go and reinvent the wheel." 0:45 "Do you wanna introduce yourself better than I just did?" 1:30 "What exactly do you study and why is it important?" 4:45 Sponsorship by 5:00 "Let's talk a little bit about your experience with science communication. Why is it important?" 10:30 "Let's talk about the science communication and different languages" 13:15 "What's the reception been like?" 15:45 "For people who want to learn a little bit more about science communication, what do you recommend?" 19:00 "Are the science communication groups helpful or how much of what percentage of what you've learned has come from that versus just doing it?" 21:15 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/24158955
info_outline
Giacomo Valle on working with patients, animals, and computational models for neurotech
08/15/2022
Giacomo Valle on working with patients, animals, and computational models for neurotech
is a post-doc researcher at ETH Zurich working in the to find tools for neurologically disabled amputees and diabetic persons. They look at how to decode from devices and what that would look like for the development of new devices. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "We're working on the sensory feedback restoration in people where there is a sensory loss due to neuropathy. The limbs are there there is sensory loss due to the degeneration and neuropathic degeneration. And then with electrical simulation is possible to provide sensation back," The secret to having an H-index of 17 as a Post-Doc is to have a passion for what you do an to work long hours with great people Simulations can take a long time to set up and one bad variable can mess up a week's worth of work but gives you flexibility to work anywhere; Animal work means you can't take vacations but you can do more experiments; Patient work is rewarding because you develop bonds with them but sometimes are limited by experiments 0:45 "Do you want to introduce yourself?" 3:30 "How does your work work?" 6:15 "What kind of devices do you use and what kind of bandwidth is involved?" 9:00 Sponsorship by 9:30 "You do seem to have a lot about computation and modeling. What role does this play in your research?" 13:00 "How good are the simulation predictions?" 19:30 "5 or 10 years down the line, what would your research lead to?" 22:45 "You have an H index of 17, which is crazy for a post-doc. What's your secret?" 25:45 "You've worked with patients, computational work, and animal work. You have these three perspectives of research, which is the easiest, which is the hardest, what are the advantages and disadvantages of all of those?" 30:30 "What do you think will be some future breakthroughs in this work and what does the future look like?" 33:15 "How much longer before you get implanted?" 34:45 "If you had unlimited funding, what would you spend it on?" 37:30 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/23930070
info_outline
Jotthe Kannappan on being a Venture Capitalist for minimally invasive medical technologies
08/08/2022
Jotthe Kannappan on being a Venture Capitalist for minimally invasive medical technologies
is an associate at which is all about converging robotic systems, digital tools, and clinical needs in search of new ways to understand, diagnose, treat and manage disease. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "It's not about rejection. It's about enabling the best possible fit between an entrepreneur and an investor who is able to who's able to really do what the company needs for them" "The typical things that stand out are really well clearly articulated message again about an unmet medical needs is something that comes across really strongly in a first interaction with a VC" "It's a common pitfall to be a technology that's searching for a need as opposed to a need-driven technology." 1:00 "Do you want to talk about the thesis of Intuitive Ventures?" 2:30 "How long has Intuitive Surgical, the parents company been around? And do you want to talk about some of your investments so far?" 4:15 "What's your guys' thoughts on neurotechnology and brain-computer interfaces? What's attractive about neuro technology or maybe not attractive?" 6:00 "When a company might want to come to you and is looking for funding, what what are you looking for?" 8:45 ad sponsorship 9:30 "It sounds like the companies you invest in are a little bit further stage, or do you invest in early stage as well?" 10:15 "What's exciting for you guys at the moment?" 12:30 What percentage of people do you reject? 15:15 "What other tips or tricks are there to and you get your attention and maybe get a successful interaction out of it?" 17:15 "What are some of your biggest challenges?" 18:45 "If you had unlimited funding, what would you do with it?" 23:15 How do world political issues like the Covid pandemic and Ukraine-Russia war affect the investment landscape? 26:15 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/23929974
info_outline
Benjamin Stecher on being a Parkinson's patient advocate
08/01/2022
Benjamin Stecher on being a Parkinson's patient advocate
runs a blog called the where he talks about his battle with Parkinson's disease. He has been implanted with a Deep Brain Stimulator an is also on the patient advisory board of Rune Labs where he gives them a perspective from the patient's point of view. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "It got to the point where the Livadopa medication on-off fluctuations were so impairing to my daily life that I had maybe like an hour where I felt normal per day" "But to compare it to the medication now, it's night and day. It brought my baseline to the point where I felt more or less normal. Now I'm still not completely normal, things need to be optimized, but it's night and day compared to what it was before. It's very easy now for me to have these moments where I even forget that I have this disease at all " "There's nothing in my brain that anybody can point to and say, okay, this is what Parkinson's disease is. I don't believe that Parkinson's Disease exists" 1:00 Do you want to talk about your background? 2:45 "You were pretty young when you were diagnosed with Parkinson's disease. Do you want to talk about that?" 3:30 "What was the timeline of the disease?" 6:15 "You decided to crack your skull open and then put something in there. What was that kind of decision like? And then what were the results of that as well?" 7:30 Sponsorship by 7:45 "What's it been like and maybe how does it compare to the medication and was the results immediate?" 9:15 "You have an adaptive DBS implanted. Do you want to explain what this is?" 14:15 "Let's talk about your blog Tomorrow Edition" 15:30 "Let's talk about your work at Rune labs" 17:30 "Let's talk about your book to Brain Fables" 23:00 "If you had a magic wand, what would you be doing and what kind of improvements would you want to do?" 27:15 "Is there anything that we didn't talk about that you wanted to mention?" [email protected]
/episode/index/show/neuralimplant/id/23929536
info_outline
Dr Melanie Ecker on conformal soft neural electrodes in the gut-brain axis
07/18/2022
Dr Melanie Ecker on conformal soft neural electrodes in the gut-brain axis
is a professor at the focusing on smart polymers for biomedical applications. She has worked on conformal and biocompatible neural devices to study the electrophysiology of the enteric nervous system. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: The neurons in the gut-brain axis have not been investigated much by neural probes because of the softness of the intestines "The beauty about the intestines is in comparison to the brain, our probes, the electrodes don't need to be that tiny" The key to recruiting lots of good student volunteers is to bring donuts to group meetings! 1:00 Do you want to introduce yourself and talk about your work? 2:30 "What are shape memory polymers and how does it relate to neurotechnology?" 4:30 What were you working on in the Voit lab and what are you working on now? 9:30 Sponsorship by 10:30 Are traditional neural probes too stiff for the intestines? 17:15 What are the conductive components of the flexible interfaces? 19:15 Do these conductive polymers last long in the body or are they dissolved quickly? 20:45 "If you had unlimited funding, what would you do?" 23:15 Do you have any tips on how to recruit so many students? 24:30 "Is there anything that we didn't cover that you wanted to mention?"
/episode/index/show/neuralimplant/id/23771501
info_outline
Dima Gazda and the prosthetic arm that learns with you by Esper Bionics
07/11/2022
Dima Gazda and the prosthetic arm that learns with you by Esper Bionics
Dima Gazda is the CEO and founder of which is a company that makes a prosthetic arm that gains abilities overtime with you. They plan to use this 'simple' neurotech solution to springboard them solve other larger neurotech problems. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: We are building an ecosystem and will be building more products in addition to the robotic arm. Next will be a better user control system and then a robotic leg A physician can only add about 3000 patient-years of life but an engineer and entrepreneur can add millions because their inventions can impact more people Neurotechnology will be as big of a change for humanity as cars and computers were 0:30 Do you want to introduce yourself? 4:45 "So what is more difficult than a prosthetic arm that has many degrees of freedom?" 7:15 "Do you want to describe the device?" 8:30 "Does that improvement of control work only for a single user?" 10:30 How has the Russia-Ukraine conflict affected you as you are from Ukraine? 12:15 "Have you had any agreements with any governments like the Ukrainian government to recover injured soldiers?" 13:30 "What are some what are some of your biggest challenges?" 14:45 ad sponsorship 15:30 "Do you have any timelines?" 17:15 Do you want to talk about the number of lives improved by being an engineer versus being a physician? 22:00 What's the technology that would add a billion patient lives in the next 10 years? 29:00 "Is there anything that we didn't talk about that you wanted to mention?" Contact [email protected]
/episode/index/show/neuralimplant/id/23324033
info_outline
Lindsay Hartland on recruiting and being recruited at the highest levels in neurotech
07/04/2022
Lindsay Hartland on recruiting and being recruited at the highest levels in neurotech
partners with Neuromodulation Device company Owners, Leaders, and Investors across the US & Europe to source the talent they need in order to succeed with Hanison Green Ltd. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: Sometimes it's better to not hire somebody but rather have a part-time position or even have them work for free in exchange for shares or honor "The main challenge any company will find when looking to grow their business is the best people tend to be working in jobs that they quite like. There's a talent shortage. There's not enough people to go around." "I used to assume that when you've got to get somebody more money, it's not. Most person's main driver is job fulfillment. They want to get up each morning and feel good about what they're going to work for and what the company's striving toward. Are they being developed, is there growth within that company? Money is important to all of us, but it's not the main driver." 0:30 Do you want to describe yourself? 3:00 "Why is this important for any startup to recruit?" 5:00 "How do you know who's a good person?" 7:15 Do you help early stage companies figure themselves out too? 9:45 "What's your opinion on that, hire a consultant versus hiring an employee?" 12:30 ad sponsorship 13:15 "Let's say hypothetically, I want to earn 250k how would I do that?" 15:45 "What's the mechanics of all this, of this poaching business that you're in?" 21:15 Do you sometimes find these leaders of companies in academia or in other fields or is the switch hard to make? 24:15 "How do you make money?" 30:15 "Is there anything that we didn't talk about?"
/episode/index/show/neuralimplant/id/23323166
info_outline
Anuj Bhardwaj on the noninvasive ultrasound therapy for treating inflammation and pain from SecondWave Systems
06/20/2022
Anuj Bhardwaj on the noninvasive ultrasound therapy for treating inflammation and pain from SecondWave Systems
is the CEO of which is a wearable ultrasound noninvasive therapy especially for suppressing chronic inflammation and pain signals. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "We're going to use a disposable coupling component that a patient uses to adhere this and couple it to the body for 18 minutes while they remain in a reasonably sedentary condition. They would do that once a day." "The cost of the healthcare system is often between one to $200,000 per year for patients that take biologics like Enbrel. So that's a huge burden on the system" "My advice to other companies like us would be to look at the SBIR program. We're very strong advocates of it. It's really been the main engine that launched us. I'd advise looking at NIH, BARDA, and others too. Then consider if they fit within the mission of what a company is doing and apply." 0:30 "Do you want to describe yourself and your technology?" 2:30 "Let's talk about the technology, who's it for?" 9:15 ad sponsorship 10:15 "You're not using electricity, but you're using ultrasound, which is something that's a little bit more rarely used. Why are you using this and how does it work?" 12:15 "What kind of treatments would you guys be able to provide?" 15:30 "So what fraction of the $100,000-$200,000 / year Rheumatoid Arthritis costs would you guys represent?" 16:30 Do you want to talk about the FDA approval process for a wearable? 18:15 Do you want to talk about your sources of funding so far? 22:30 "What is one of the biggest challenges in this work?" 25:00 "Are you looking for people to join or are you looking for anything in particular?"
/episode/index/show/neuralimplant/id/23322734
info_outline
Giovanni Lauricella how Neurotech Companies should find investments for their startups
06/13/2022
Giovanni Lauricella how Neurotech Companies should find investments for their startups
is the cofounder and managing partner at where they find people, money and insight for MedTech startup companies. Giovanni comes on a second time to talk about how to find investment for neurotech startups ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "If you take bad money it could really ruin a company. Good money simplistically saying is- You find an investor who really knows how to add value to your company beyond simply writing you a check." "An investible story from the eyes of an investor is number one. And number two, when you finally do click send make sure that you're doing the due diligence on the investors with that who ultimately you're reaching out to. That they make sense." "Everything else after that can be shared throughout the diligence process, which typically takes 2, 3, 4, 5 months. You have ample time to share a lot of information with them once they're already interested." 1:00 "Do you want to introduce yourself again?" 4:30 "How do you raise money in a med tech startup?" 9:45 ad sponsorship 10:15 "What is an example of bad money and how bad can bad get?" 18:15 "What are some tips for companies as they're raising money?" 22:00 "How do you get in contact with these people?" 28:15 "What's a wrong direction that a lot of people go down that could be easily fixed?" 35:15 "What percentage of that slide deck should be about the people in the company versus the technology? And then where can people find you?" Contact
/episode/index/show/neuralimplant/id/23322359
info_outline
Dr. Talya Miron-Shatz on designing better neural devices using psychology and user interfaces
06/06/2022
Dr. Talya Miron-Shatz on designing better neural devices using psychology and user interfaces
is an author, researcher, and speaker who is the author of "" which is a book about medical decision making. She talks about the data generated from neuro devices and what patients can do with it. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: There is an opportunity to turn data generated by neuro medical devices into insights that are easy to digest "free, the data, free the data! And I was thinking - to whom? And what are they going to do with it? It's like someone delivering boxes upon boxes of papers to your front door. And you're like I don't know what to do with it. Free the data is great, but to help me make sense of it is even greater." "If you want to design for better usage and for better outcomes, you need to think psychology as well as technology" 0:45 "Do you want to introduce yourself?" 3:45 "How does your work fit into neuro technology?" 5:15 Sponsorship by 6:15 "What's your kind of solution forward with this?" 9:30 "The trend of medical devices and neurotechnology generating more data to have to sift through, is that helping the problem or is that worsening the problem" 11:15 Is app and user experience design of these new devices going to be one of the most important factors? 13:45 "So what's the solution for this? Is it just hiring more designers and psychologists?" 20:30 "What point in the development cycle of a medical device or neuro technology, should people start thinking about this?" 22:45 Is this different if the technology is implantable? 25:15 "Is there anything that we didn't talk about that you wanted to mention?" https://talyamironshatz.com/
/episode/index/show/neuralimplant/id/23147249
info_outline
Dr Josh Siegle on large-scale electrophysiology and his Open Ephys Platform
05/30/2022
Dr Josh Siegle on large-scale electrophysiology and his Open Ephys Platform
is a senior scientist working at the Allen Institute working on large-scale electrophysiology using tools like the Neuropixels probe. He is also heavily involved in the design and distribution of which is an open-source electrophysiology tool. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top three takeaways: "The dark matter problem is where the number of cells that we record is almost always less than the number of cells that we actually know to be in the tissue around the electrodes. This could be because there are neurons near the electrodes that just don't fire action potentials, their action potentials look very similar to other nearby neurons, or maybe the listening radius of our electrodes is not quite as large as we would expect it to be." "A big advantage of working at the Allen Institute is that we have very generous internal funding from Paul Allen. And so although we do apply for grants when it makes sense, for most people at the Allen Institute, getting grant funding is not an existential threat to their research." Open Ephys has recently started offering virtual 1-on-1 training sessions to help people get up and running with their tools. This is aligned with their goal of making open-source tools even more accessible throughout the neuroscience community. 0:45 Ladan introduces the episode and the guest, Dr. Josh Siegle 4:00 "What is the Neuropixels probe and how does it work? Why is it important?" 8:00 What capabilities does working with IMEC bring? 11:15 How exactly were you working with IMEC? 12:30 Sponsorship by 13:15 How does the pitch of the Neuropixels probe compare to biology? 16:45 What is the Allen Institute like? 20:15 What kind of mix of people work at the Allen Institute? 21:15 "What's the stated aims of the Institute again?" 22:00 What is the Open Ephys project you had worked on before? 27:45 What is the Open Ephys training like? 29:30 Do companies love or hate Open Ehpys? 31:00 "Is there anything that we didn't talk about that you wanted to mention?"
/episode/index/show/neuralimplant/id/23146643