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Christina Salchow-Hommen and Dimitry Sayenko on electrode placement and neuroplasticity

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Release Date: 09/06/2023

Jeremy Greenberg on  Data Flows and Privacy Risks of Brain-Computer Interfaces show art Jeremy Greenberg on Data Flows and Privacy Risks of Brain-Computer Interfaces

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Jeremy Greenberg works for the nonprofit and has written . The report is an extensive look into some of the challenges of privacy in the BCI space. Top 3 Takeaways: "A lot of the risks in this base really stem from the fact that neuro data is sensitive personal information. This is biological. It relates to mental privacy. These devices can be used to derive inferences about a person's likes their dislikes, their fears, emotions. So this is, this involves very sensitive and intimate details or inferences about an individual." "I think that the involuntary nature of this data is something...

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Tim Jorgensen on the history of bioelectronics over the centuries up to today show art Tim Jorgensen on the history of bioelectronics over the centuries up to today

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

Tim Jorgensen is the author of Spark: The Life of Electricity and the Electricity of Life which looks at the history of bioelectrics all the way from prehistory to the modern era. The book is very informative and shows that current neurotechnology has very deep roots. Top 3 Takeaways:  "The word electricity comes from the Greek Latin word for Amber. That's where it originally comes from because that was the only way to create it. They would rub Amber with wool and you would get static electricity" "One of these tricks actually was called the flying boy. They would suspend a child from...

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Paul Grand about bringing the world's best ecosystem to the world's best companies with Medtech Innovator show art Paul Grand about bringing the world's best ecosystem to the world's best companies with Medtech Innovator

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is the CEO of which is an accelerator for startups in the medical technology space. It has been going for many years and the companies that they select to go through the 4 month process have gone on to be very successful. Apply for this year's cohort, deadline January 31st   Top 3 Takeaways: "MedTech innovator as an accelerator is the world's largest accelerator for medical technology" "1,800 companies applied last year across all of our cohorts.  We accept around 4% of that." "Some of the benchmarks we've got: over 90 products in the market, $3.5 billion in follow on funding to...

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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is the founder of which is a community of neurotechnology enthusiasts with over 18,000 members from around the world started in 2014. They have also held in-person events to help bring people together. Due to this large community, Yannick has also started NeurotechX Services which brings together this large community to help companies and people. Top 3 Takeaways:  "we don't have any outside funding, government funding. We needed to bootstrap everything. The organization was and still is mainly volunteer-driven" three pillars: community, education, and, innovation "More money isn't...

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Marc Russo on running clinical trials in Australia and the INS show art Marc Russo on running clinical trials in Australia and the INS

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is the president of the which is a nonprofit group of clinicians, scientists and engineers dedicated to the scientific development and awareness of neuromodulation. Dr Russo runs a large multidisciplinary pain clinic in Australia. He has conducted a number of first-in-man studies of novel neuromodulation implants as well as designing unique leads and waveforms in spinal cord stimulation (SCS). Top 3 Takeaways: "Over more than a 20 year journey now we understand that these patients are best treated early rather than later. The best traded with as close to zero levels of opioids. And that...

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Gautam Sadarangani on the importance of measuring and gamifying physical therapy exercises show art Gautam Sadarangani on the importance of measuring and gamifying physical therapy exercises

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is the President & COO/CTO of by BioInteractive Technologies, a digital health system that provides a better way to retrain movement for the hand, wrist, and elbow.   Top 3 Takeaways: "Our core competence here is the fact that we're able to measure the limb with sufficient accuracy and sufficient resolution for rehabilitation purposes while being very unobtrusive for the person to wear essentially 24/7" "Quantifying and motivating is a big deal. It's not different than when you're trying to lose weight and use a weighing scale. You need those parameters to tell you if you're moving...

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John Doucet on helping companies get FDA approval at MCRA show art John Doucet on helping companies get FDA approval at MCRA

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is a neuroscientist and biomedical engineer with 10+ years of FDA experience in medical device regulation, and 13+ years of Johns Hopkins experience in discovery science, and 6+ years of management experience at FDA and Johns Hopkins School of Medicine. He has extensive knowledge of medical device regulatory pathways to drive technologies from conception to market.   Top 3 Takeaways: "That's what clients are paying for, I can detect the signal from the noise and all the stuff the company is doing, bring that to the FDA in a way that they can digest it "Everyone wants breakthrough...

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Ni-Ka Ford on the importance of medical illustration show art Ni-Ka Ford on the importance of medical illustration

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

is a that works with both 2D and 3D sketches often in the neurotech space. Top 3 Takeaways:  "I was doing an illustration for a procedure. And what happened was the surgeon actually ended up changing his manuscript after seeing my illustration." There are 4 accredited graduate programs for Medical Illustration "When I do something that's more a schematic, I could finish an illustration in maybe a week. More rendered illustrations that are high in details may take me about a month to complete."   0:45 "Can you describe what you do?" 2:45 "How did you get into this?" 5:00 "It...

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Dr Paul Tubig and Dr Darcy McCusker on neuroethics workshops show art Dr Paul Tubig and Dr Darcy McCusker on neuroethics workshops

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

and are graduates from the University of Washington. Dr Tubig now works at at Georgia Southern University teaching neuroethics and is teaching social and political philosophy, bioethics, neuroethics, and philosophy of disability.   Top 3 Takeaways: "There have been reports and testimonies of users who have experienced a sense of depersonalization, a sense of alienation and a sense that they are no longer themselves [after using implanted neurotechnology]." "It turns out that when you have an ethicist in the room, you end up asking really different kinds of questions of your...

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Seth Hays pairing VNS with rehab for better patient outomes show art Seth Hays pairing VNS with rehab for better patient outomes

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

's research focus at the University of Texas at Dallas is enhancing neuroplasticity, or the ability of the brain to change, in order to treat neurological disease. The majority of current studies evaluate the ability of vagus nerve stimulation (VNS), a putative targeted plasticity therapy, to improve recovery in models of motor dysfunction Top 3 Takeaways: "VNS itself  is not a thing unto itself. It's really the combination of VNS with the rehabilitation that's producing the effects that we see" "We think this is most effective when there's really some deficit that you have trouble...

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More Episodes

Narrative Salchow and Sayenko

Dual interview episode:
Christina Salchow-Hommen from Charité Universitätsmedizin in Berlin, Germany. Her presentation at RehabWeek2019 was titled “Characterization Of Optimal Electrode Configurations For Transcutaneous Spinal Cord Stimulation.” The talk presented her findings from a small trial which included 5 participants living with spinal cord injuries. In the trial, they were trying to find the optimal placements and size of surface stimulation electrodes to elicit a response rectus femoris and the tibialis anterior muscles. The study found variability in electrode placement but some commonalities at the T11 level spinal circuit level. Let’s catch up with her in our interview.

Dimitry Sayenko from the Center for Neurogeneration at Houston Methodist Research Institute gave a talk about Neuromodulation of Spinal Networks to Recover Motor Function: Underlying Mechanisms and Clinical Translations.” His talk discussed the differences in the epidural spinal stimulation clinical trials being conducted at the University of Louisville, UCLA and at EPFL in Geneva Switzerland. There were differences among the labs but he found the key is enabling versus inducing movement with stimulation and argued that the intense exercise regimes from some of these studies is not necessary. Let’s listen in on his interview.

Takeaways:
Electrode placement, along with stimulation parameters plays an important part in the responses to transcutaneous spinal cord stimulation.

[0:00] Ladan introduces the episode with an interview by Jen French of Neurotech Reports with Christina Salchow-Hommen at RehabWeek 2019.
[1:10] Salchow-Hommen introduces herself and her affilitation with technology for people with impairments for restoration of mobility.
[1:38} Discussion of the importance of electrode placement, adjustment of stimulation parameters between the 5 volunteers and patient reported preferences for transcutaneous spinal cord stimulation for people with paralysis.
[3:35] Salchow-Hommen discusses the need to better monitor the brain during stimulation and better measurement tools to quantify reported feedback.
[4:44] Ladan introduces the episode with an interview by Jen French of Neurotech Reports with Dimitry Sayenko at RehabWeek 2019.
[5:17] Sayenko introduces himself and addresses his perspective of how the brain reacts to spinal cord stimulation for the restoration of motor response after paralysis due to SCI. Nearly 80% of spinal cord injuries result in some form of residual function.
[6:41] Involvement of the brain with restoration of movement along with neuroplasticity for connections in the brain.
[8:28] Coupling traditional therapy with spinal cord stimulation. He finds that the intense rehab is not necessary but the first few sessions are critical. Still the technology has an accumulative effect.
[9:45} Discussion of the introduction of electrical stimulation following a spinal cord injury. When to introduce it in therapy.
[10:50] Restoration of gait and the timing of stimulation. His lab found timing was not critical.
[11:50] The introduction of machine learning into this therapy would be helpful. Sayenko expresses his excitement at RehabWeek.